Methyl isonicotinate supplier

Name
Methyl isonicotinate
EINECS 219-546-8
CAS No. 2459-09-8
Article Data96
CAS DataBase
Density 1.137 g/cm³
Solubility Slightly soluble in water.
Melting Point 8-8.5 °C(lit.)
Formula C₇H₇NO₂
Boiling Point 205.1 °C at 760 mmHg
Molecular Weight 137.138
Flash Point 77.8 °C
Transport Information
Appearance clear orange to brown liquid
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Isonicotinicacid, methyl ester (6CI,7CI,8CI);4-Carbomethoxypyridine;4-Methoxycarbonylpyridine;Methyl 4-pyridinecarboxylate;4-Pyridinecarboxylicacid, methyl ester;
PSA 39.19000
LogP 0.86820

Synthetic route

: 3783-38-8
methyl isonicotinate N-oxide

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With ammonium formate; palladium on activated charcoal In methanol for 0.0166667h; Ambient temperature;	98%
With sodium hypophosphite; palladium on activated charcoal In acetic acid at 60℃; for 1h;	98%
With ammonium formate; silica gel; zinc In methanol at 20℃; for 0.166667h; chemoselective reaction;	97%

: 872-85-5
pyridine-4-carbaldehyde

: 67-56-1
methanol

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With water; iodine; sodium nitrite at 20 - 70℃; chemoselective reaction;	96%
With potassium carbonate In water at 20℃; for 2h;	89%
With dibromamine-T; potassium carbonate at 20℃; for 1h;	83%

: 55-22-1
pyridine-4-carboxylic acid

: 67-56-1
methanol

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With sulfuric acid for 24h; Heating;	95%
With sulfuric acid for 72h; Reflux;	92%
With sulfuric acid Reflux;	80%

: 67-56-1
methanol

: 1570-45-2
isonicotinic acid ethylester

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With lanthanum complex grafted upon hydrotalcite for 4h; pH=10; Reflux;	95%

: 67-56-1
methanol

: 25108-37-6
potassium pyridine-4-carboxylate

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With tetrachloromethane; triphenylphosphine at 55 - 60℃;	91%

: 626-61-9
4-Chloropyridine

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 865-34-9
lithium methanolate

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With 1,1'-bis-(diphenylphosphino)ferrocene; 5 mol% Pd/C; sodium fluoride In 1,4-dioxane at 150℃; Inert atmosphere;	88%

...Expand

: 55-22-1
pyridine-4-carboxylic acid

: 74-88-4
methyl iodide

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 0.5h;	85%

: 108-89-4
picoline

: 67-56-1
methanol

A: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

B: 22796-40-3
4-trichloromethyl-pyridine

Conditions

Conditions	Yield
Stage #1: picoline With thionyl chloride for 3h; Reflux; Stage #2: methanol In water	A 18% B 82%

...Expand

: 67-56-1
methanol

: 1701-69-5
1-(4-pyridyl)-1-propanone

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With N,N-dimethyl-formamide dimethyl acetal for 16h; Heating;	71%

: 54-85-3
isoniazid

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With methanol; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In chloroform at 20℃; for 1h;	70%

: 55-22-1
pyridine-4-carboxylic acid

: 616-38-6
carbonic acid dimethyl ester

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With sulfuric acid for 17h; Neat (no solvent); Reflux;	67.5%

: 100-48-1
pyridine-4-carbonitrile

: 67-56-1
methanol

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate for 108h; Heating;	63%
With iron(III) chloride for 32h; Heating;	59%

: 55-22-1
pyridine-4-carboxylic acid

: 74-88-4
methyl iodide

A: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

B: 38117-49-6
4-methoxycarbonyl-1-methylpyridinium cation

Conditions

Conditions	Yield
Stage #1: pyridine-4-carboxylic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetone for 0.166667h; Stage #2: methyl iodide In acetone at 20℃; for 4h;	A 62% B n/a

...Expand

: 586-95-8
pyridine-4-methanol

: 67-56-1
methanol

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With manganese(IV) oxide; sodium cyanide; acetic acid In tetrahydrofuran at 20℃; for 72h;	55%
Stage #1: methanol With sodium tetrachloroaurate(III) dihyrate; potassium carbonate at 20℃; for 0.0166667h; Green chemistry; Stage #2: pyridine-4-methanol at 20℃; for 0.0333333h; Green chemistry; Stage #3: With oxygen at 80℃; under 760.051 Torr; Autoclave; Green chemistry;	2 %Chromat.

: trans-bromo(4-pyridylcarbonyl)bis(triphenylphosphine)palladium(II)

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With CH3OH In dichloromethane MeOH added under N2 to soln. of Pd complex in CH2Cl2, kept for 24 h; evapd. under reduced pressure, extd. with Et2O, evapd., dissolved in CD2Cl2; identified by NMR;	54%

: 1196959-81-5
methyl 3-(methylsulfonyloxy)-1-tosyl-1,2,3,6-tetrahydropyridine-4-carboxylate

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With potassium hexamethylsilazane In tetrahydrofuran at -78 - 0℃;	53%

: 94983-57-0, 62010-19-9
N-benzyl-4-(carbomethoxy)pyridinyl

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
In acetonitrile Product distribution; Quantum yield; Irradiation;	51%

: 1122-54-9
methyl (4-pyridyl) ketone

: 67-56-1
methanol

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With N,N-dimethyl-formamide dimethyl acetal for 16h; Heating;	42%

: 67-56-1
methanol

: 54-85-3
isoniazid

A: 55-22-1
pyridine-4-carboxylic acid

B: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene at 10℃; for 6h;	A n/a B 40%

...Expand

: 3783-38-8
methyl isonicotinate N-oxide

: 16420-13-6
N,N-Dimethylthiocarbamoyl chloride

A: C10H12N2O3S

B: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
In acetonitrile at 81℃; for 4h;	A 30% B 35%

...Expand

: 67-56-1
methanol

: 39178-35-3
isonicotinoyl chloride hydrochloride

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 186581-53-3, 908094-01-9
diazomethane

: 55-22-1
pyridine-4-carboxylic acid

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
In diethyl ether

: 74578-59-9
1,2-Dimethyl-4-oxo-8-(pyridine-4-carbonyl)-1,8-diaza-spiro[4.5]deca-2,6,9-triene-3-carboxylic acid ethyl ester

A: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

B: (E)-3-Methylamino-2-(pyridine-4-carbonyl)-but-2-enoic acid ethyl ester

Conditions

Conditions	Yield
With methanol Ambient temperature;

: 90610-01-8
n-propyl isonicotinate

: 74-88-4
methyl iodide

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
1) Et4NBF4, electrolysis; Yield given. Multistep reaction;

silver salt of pyridine-dicarboxylic acid-(3.4)-methyl ester-(4): silver salt of pyridine-dicarboxylic acid-(3.4)-methyl ester-(4)

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
durch Destillation im Wasserstoffstrom;

: 1-Iodo-4-methoxycarbonyl-pyridinium

A: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

B I(1+): I(1+)

Conditions

Conditions	Yield
at 59.9℃; Thermodynamic data; gas-phase;

: 55-22-1
pyridine-4-carboxylic acid

: 1445-45-0
Trimethyl orthoacetate

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 55-22-1
pyridine-4-carboxylic acid

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With sulfuric acid; sodium carbonate In methanol
Multi-step reaction with 2 steps 1.1: thionyl chloride / 0.17 h / 0 - 20 °C / Inert atmosphere 2.1: 0.17 h / 0 - 20 °C 2.2: pH ~ 6 View Scheme

: 934-32-7
1H-benzimidazol-2-amine

3-pyridinecarboxylic acid methyl ester (methyl nicotinate): 3-pyridinecarboxylic acid methyl ester (methyl nicotinate)

A: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

B: 27111-31-5
N-(1H-benzoimidazol-2-yl)-nicotinamide

Conditions

Conditions	Yield
In methanol

...Expand

: 7584-05-6
3-methyl-4-cyanopyridine

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 1071017-66-7
3-(2-oxo-2-pyridin-4-yl-ethyl)isonicotinonitrile

Conditions

Conditions	Yield
With sodium hydride In 1,2-dimethoxyethane at 95℃; for 16h;	100%
With sodium hydride In 1,2-dimethoxyethane at 95℃;	100%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: C60H84O8Rh2*0.19H2O*0.5CHCl3

: C67H91NO10Rh2

Conditions

Conditions	Yield
In chloroform for 0.0833333h;	100%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 36016-40-7
mesitylenesulfonylhydroxylamine

: 59247-63-1
1-amino-4-(methoxycarbonyl)pyridin-1-ium 2,4,6-trimethylbenzene-1-sulfonate

Conditions

Conditions	Yield
Stage #1: 4-pyridinecarboxylic acid, methyl ester; mesitylenesulfonylhydroxylamine In acetonitrile at 30℃; for 0.0166667h; Flow reactor; Stage #2: With sodium hydroxide In N,N-dimethyl-formamide at 30℃; for 0.0433333h; Flow reactor;	100%
In dichloromethane at 0 - 20℃; for 21h; Inert atmosphere;	72%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 100-39-0
benzyl bromide

: 94983-57-0
1-benzyl-4-(methoxycarbonyl)pyridin-1-ium

Conditions

Conditions	Yield
In methanol at 80℃; for 2h; Inert atmosphere;	100%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 3783-38-8
methyl isonicotinate N-oxide

Conditions

Conditions	Yield
Stage #1: 4-pyridinecarboxylic acid, methyl ester With dihydrogen peroxide; methyltrioxorhenium(VII) In dichloromethane; water at 20℃; for 18h; Stage #2: With manganese(IV) oxide In dichloromethane at 20℃; for 2h;	99%
With bis-trimethylsilanyl peroxide; per-rhenic acid In dichloromethane; water at 24℃; for 6h;	98%
With dihydrogen peroxide; methyltrioxorhenium(VII) In dichloromethane; water at 24℃; for 17h;	98%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 4-(((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)methyl)pyridine

Conditions

Conditions	Yield
With {Cp'2Th(μ-H)H}2 at 70℃; for 24h;	99%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 4427-22-9
4-pyridinecarbohydroxamic acid

Conditions

Conditions	Yield
With hydroxylamine In methanol at 20℃; for 72h;	98%
Stage #1: 4-pyridinecarboxylic acid, methyl ester With hydroxylamine hydrochloride; potassium hydroxide In methanol; water at 40℃; for 72h; Stage #2: With hydrogenchloride In methanol; water pH=5.5;	93%
With hydrogenchloride; methanol; hydroxylamine; sodium methylate

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 586-95-8
pyridine-4-methanol

Conditions

Conditions	Yield
With sodium tetrahydroborate; sodium methylate In methanol at 25℃; for 3h; Inert atmosphere;	98%
Stage #1: 4-pyridinecarboxylic acid, methyl ester With sodium tetrahydroborate In tetrahydrofuran at 70℃; for 0.25h; Stage #2: In tetrahydrofuran; methanol at 70℃; for 1h;	52%
With lithium aluminium tetrahydride In diethyl ether for 0.5h;	38%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 75-05-8
acetonitrile

: 1-cyano-2-oxo-2-(pyridin-4-yl)ethane sodium salt

Conditions

Conditions	Yield
Stage #1: 4-pyridinecarboxylic acid, methyl ester With sodium hydroxide In toluene at 0℃; for 0.166667h; Stage #2: acetonitrile In toluene at 80℃; for 4h;	98%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: methyl trifluoromethyl propiolate

: 70-11-1
α-bromoacetophenone

: dimethyl 3-benzoyl-2-(trifluoromethyl)indolizine-1,7-dicarboxylate

Conditions

Conditions	Yield
Stage #1: 4-pyridinecarboxylic acid, methyl ester; α-bromoacetophenone In acetonitrile at 40℃; for 4h; Stage #2: methyl trifluoromethyl propiolate With N-ethyl-N,N-diisopropylamine In acetonitrile for 7h;	98%

...Expand

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 74-88-4
methyl iodide

: 7630-02-6
4-(methoxycarbonyl)-1-methylpyridinium iodide

Conditions

Conditions	Yield
In methanol	97.2%
Methylation;	95%
In dichloromethane at 30℃;	87%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 368-39-8
triethyloxonium fluoroborate

: N-ethyl methyl isonicotinate tetrafluoroborate

Conditions

Conditions	Yield
In dichloromethane at 20℃; Glovebox;	97%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 1027513-97-8
2,2-difluoro-2-(4-methoxyphenyl)acetic acid

: methyl 2-(difluoro(4-methoxyphenyl)methyl)isonicotinate

Conditions

Conditions	Yield
With ammonium peroxydisulfate; silver nitrate In dichloromethane; water at 50℃; for 24h; Minisci Aromatic Substitution; Inert atmosphere; Sealed tube; regioselective reaction;	97%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: cobalt(II) sulphate heptahydrate

: 120-18-3
naphthalene-2-sulfonate

: 7732-18-5
water

: C14H22CoN2O8(2+)*2C10H7O3S(1-)

Conditions

Conditions	Yield
Stage #1: cobalt(II) sulphate heptahydrate; naphthalene-2-sulfonate In hexane at 40℃; for 0.5h; Stage #2: 4-pyridinecarboxylic acid, methyl ester; water In methanol; ethanol at 40℃; for 2h;	96.6%

...Expand

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 742-25-6
2,4-dinitrophenyl 4-methylbenzenesulfonate

: 1-(2,4-dinitrophenyl)-4-(methoxycarbonyl)pyridin-1-ium p-toluenesulfonate

Conditions

Conditions	Yield
In toluene for 16h; Reflux;	96%
In toluene for 48h; Reflux;	25%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 100-61-8
N-methylaniline

: 252930-65-7
N-methyl-N-phenyl-4-pyridinecarboxamide

Conditions

Conditions	Yield
With [(Me3Si)2N]3La(μ-Cl)Li(THF)3 In tetrahydrofuran at 30℃; for 0.333333h; Inert atmosphere; Schlenk technique;	96%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 54-85-3
isoniazid

Conditions

Conditions	Yield
With hydrazine hydrate In methanol at 70℃; for 0.00111111h;	95.6%
With hydrazine hydrate In ethanol at 20℃; for 3h;	94.1%
With hydrazine hydrate In ethanol at 23℃; for 16h;	86%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: potassium tetrachloroaurate(III) dihydrate

: 129915-44-2
trichloro(methyl isonicotinate)gold(III)

Conditions

Conditions	Yield
In water KAuCl4*2H2O in H2O treated dropwise with stoich. amount of nitrogen donor base in H2O under stirring, pptd.; ppt. filtered off, washed (H2O) 3 times, dried (vac.), elem. anal.;	95%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: methyl 2‐carbamoylpyridine‐4‐carboxylate

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; oxygen; sodium formate; silver nitrate at 80℃; for 5h; Catalytic behavior; Reagent/catalyst; Temperature; Schlenk technique; regioselective reaction;	95%
With dipotassium peroxodisulfate; oxygen; sodium acetate; silver nitrate In water at 80℃; for 4h; Green chemistry;	95%
With iron(III) sulfate; sulfuric acid; dihydrogen peroxide at 10 - 20℃; for 8h; Temperature;	80.4%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: copper(ll) sulfate pentahydrate

: 79-31-2
isobutyric Acid

: C30H42Cu2N2O12

Conditions

Conditions	Yield
Stage #1: copper(ll) sulfate pentahydrate; isobutyric Acid In hexane at 39℃; for 0.583333h; Stage #2: 4-pyridinecarboxylic acid, methyl ester In methanol; ethanol; water at 39℃; for 2.16667h;	95%

...Expand

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 100-44-7
benzyl chloride

: 1216-01-9
1-Benzyl-4-methoxycarbonyl-pyridinium; iodide

Conditions

Conditions	Yield
In methanol for 24h; Heating;	94%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: di-μ-chloro-bis[bis(cyclo-octene)rhodium]

: 36989-07-8
1-diphenylphosphinomethyl-1,2-dicarba-closo-dodecaborane

: hydridochlorobis{4-(methoxycarbonyl)pyridine}{1-{(diphenylphosphino)methyl}-o-carbaboranyl-B3(6),P}rhodium

Conditions

Conditions	Yield
In hexane Ar-atmosphere, to a stirred suspn. of Rh-compd. the pyridine-base is added,after 5-10 min. a soln. of the B-compd. added and the mixt. boiled for 1h; after cooling ppt. filtered off, washed with hexane and dried, elem. anal.;	94%

...Expand

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 12092-47-6
di-μ-chloro-bis(1,5-cyclooctadiene)dirhodium

: 36989-07-8
1-diphenylphosphinomethyl-1,2-dicarba-closo-dodecaborane

: hydridochlorobis{4-(methoxycarbonyl)pyridine}{1-{(diphenylphosphino)methyl}-o-carbaboranyl-B3(6),P}rhodium

Conditions

Conditions	Yield
In hexane Ar-atmosphere, to a stirred suspn. of Rh-compd. the pyridine-base is added,after 5-10 min. a soln. of the B-compd. added and the mixt. boiled for 1h; after cooling ppt. filtered off, washed with hexane and dried, elem. anal.;	94%

...Expand

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: di(rhodium)tetracarbonyl dichloride

: 36989-07-8
1-diphenylphosphinomethyl-1,2-dicarba-closo-dodecaborane

: hydridochlorobis{4-(methoxycarbonyl)pyridine}{1-{(diphenylphosphino)methyl}-o-carbaboranyl-B3(6),P}rhodium

Conditions

Conditions	Yield
In hexane Ar-atmosphere, to a stirred suspn. of Rh-compd. the pyridine-base is added,after 5-10 min. a soln. of the B-compd. added and the mixt. boiled for 1h; after cooling ppt. filtered off, washed with hexane and dried, elem. anal.;	94%

...Expand

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: di(rhodium)tetracarbonyl dichloride

: 1005760-23-5
cis-[Rh(CO)2Cl(methyl isonicotinate)]

Conditions

Conditions	Yield
In dichloromethane (Rh(CO)2Cl)2 dissolved in CH2Cl2, methyl isonicotinate added, stirred atroom temp. for 10 min; evapn. under vac., washing (diethyl ether), elem. anal.;	94%

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: methyl trifluoromethyl propiolate

: 619-41-0
4-(bromoacetyl)toluene

: dimethyl 3-(4-methoxybenzoyl)-2-(trifluoromethyl)indolizine-1,7-dicarboxylate

Conditions

Conditions	Yield
Stage #1: 4-pyridinecarboxylic acid, methyl ester; 4-(bromoacetyl)toluene In acetonitrile at 40℃; for 4h; Stage #2: methyl trifluoromethyl propiolate With N-ethyl-N,N-diisopropylamine In acetonitrile for 7h;	94%

...Expand

Methyl isonicotinate Chemical Properties

IUPAC Name: Methyl pyridine-4-carboxylate
Canonical SMILES: COC(=O)C1=CC=NC=C1
InChI: InChI=1S/C7H7NO2/c1-10-7(9)6-2-4-8-5-3-6/h2-5H,1H3
InChIKey: OLXYLDUSSBULGU-UHFFFAOYSA-N
Molecular Weight: 137.13598 [g/mol]
Molecular Formula: C₇H₇NO₂
XLogP3: 0.9
H-Bond Donor: 0
H-Bond Acceptor: 3
EINECS: 219-546-8
storage temp. 2-8 °C
Appearance: clear orange to brown liquid
Melting Point: 8-8.5 °C(lit.)
Index of Refraction: 1.511
Molar Refractivity: 36.11 cm³
Molar Volume: 120.5 cm³
Surface Tension: 41.6 dyne/cm
Density: 1.137 g/cm³
Flash Point: 77.8 °C
Enthalpy of Vaporization: 44.13 kJ/mol
Boiling Point: 205.1 °C at 760 mmHg
Vapour Pressure: 0.255 mmHg at 25 °C
Product Categories of Methyl isonicotinate (CAS NO.2459-09-8): C7 and C8; Heterocyclic Building Blocks; Pyridines

Methyl isonicotinate Uses

Methyl isonicotinate (CAS NO.2459-09-8) is used for pharmaceutical intermediates.

Methyl isonicotinate Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
F: 10
Hazard Note of Methyl isonicotinate (CAS NO.2459-09-8): Irritant

Methyl isonicotinate Specification

Methyl isonicotinate (CAS NO.2459-09-8), its Synonyms are 4-Methoxycarbonylpyridine ; Isonicotinic acid methyl ester ; Methyl 4-pyridinecarboxylate ; N-Methylisonicotinate ; Isonicotinic acid, methyl ester (8CI) .

Product Name

Methyl isonicotinate

Synthetic route

Methyl isonicotinate Chemical Properties

Methyl isonicotinate Uses

Methyl isonicotinate Safety Profile

Methyl isonicotinate Specification

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