Morpholin-4-ylacetic acid supplier

Name
MORPHOLIN-4-YL-ACETIC ACID
EINECS
CAS No. 3235-69-6
Article Data32
CAS DataBase
Density 1.202 g/cm³
Solubility
Melting Point 162-164 °C
Formula C₆H₁₁NO₃
Boiling Point 271.898 °C at 760 mmHg
Molecular Weight 145.158
Flash Point 118.24 °C
Transport Information
Appearance
Safety
Risk Codes 36
Molecular Structure
Hazard Symbols Xi
Synonyms 2-(4-Morpholinyl)aceticacid;2-(Morpholino)acetic acid;Morpholinoacetic acid;N-(Carboxymethyl)morpholine;
PSA 49.77000
LogP -0.65890

Synthetic route

: 88217-68-9
(4-morpholinyl)acetic acid 1,1-dimethylethyl ester

: 3235-69-6
morpholin-4-ylacetic acid

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.5h; Hydrolysis;	100%
In water; isopropyl alcohol at 160℃; for 0.4h; Solvent; Temperature; Flow reactor;	95%
With trifluoroacetic acid In dichloromethane at 20℃; for 5h;

: 53342-23-7
benzyl morpholino-acetate

: 3235-69-6
morpholin-4-ylacetic acid

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol for 40h;	98%
With potassium tert-butylate In tetrahydrofuran at 0℃; for 5h; Hydrolysis;	97%

: 3235-82-3
N-morpholylacetic acid ethyl ester

: 3235-69-6
morpholin-4-ylacetic acid

Conditions

Conditions	Yield
With hydrogenchloride In water at 95℃; for 16h; Temperature; Time;	96.3%
With water for 30h; Hydrolysis; Heating;	87%
With sodium hydroxide In water Heating;	65%

: 35855-10-8
methyl 2-morpholin-4-ylacetate

: 3235-69-6
morpholin-4-ylacetic acid

Conditions

Conditions	Yield
Stage #1: methyl 2-morpholin-4-ylacetate With methanol; sodium hydroxide; water In tetrahydrofuran at 50℃; for 1h; Stage #2: With hydrogenchloride In tetrahydrofuran; water pH=3;	90%
With water; lithium hydroxide In methanol at 20℃; for 3h; Inert atmosphere;

: 110-91-8
morpholine

: 79-08-3
bromoacetic acid

: 3235-69-6
morpholin-4-ylacetic acid

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	85.3%

: 110-91-8
morpholine

: 5292-43-3
bromoacetic acid tert-butyl ester

: 3235-69-6
morpholin-4-ylacetic acid

Conditions

Conditions	Yield
In tetrahydrofuran; hydrogenchloride; ethyl acetate	85%
In tetrahydrofuran; hydrogenchloride; ethyl acetate	85%

: 110-91-8
morpholine

: 5625-90-1
4-(morpholinomethyl)morpholine

: 151-50-8
potassium cyanide

: 3235-69-6
morpholin-4-ylacetic acid

Conditions

Conditions	Yield
With water

...Expand

: 110-91-8
morpholine

: 3926-62-3
sodium monochloroacetic acid

: 3235-69-6
morpholin-4-ylacetic acid

Conditions

Conditions	Yield
With water

: 5-(2-morpholinoacetamido)-3,3-di-p-tolyl-2-indolinone hydrochloride

A: 3235-69-6
morpholin-4-ylacetic acid

B: 5-Amino-3,3-di-p-tolyl-1,3-dihydro-indol-2-one

Conditions

Conditions	Yield
With hydrogenchloride; water In acetic acid at 69.9 - 95.9℃; Rate constant; Kinetics; Thermodynamic data; ΔS(activ.), ΔH(activ.), ΔG(activ.);

: 110-91-8
morpholine

: 105-39-5
chloroacetic acid ethyl ester

: 3235-69-6
morpholin-4-ylacetic acid

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane; benzene

: 3235-69-6
morpholin-4-ylacetic acid

: (S)-benzyl 2-((S)-2-((tert-butoxycarbonyl)amino)-4-phenylbutanamido)-4-methylpentanoate hydrogen chloride salt

: 1385032-88-1
(S)-benzyl 4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃;	98%

: 3235-69-6
morpholin-4-ylacetic acid

: (S)-2-amino-N4-(tert-butoxy)-N1-((S)-1-((naphthalen-1-ylmethyl)amino)-1-oxopropan-2-yl)succinamide

: (S)-N4-(tert-butoxy)-2-(2-morpholinoacetamido)-N1-((S)-1-((naphthalen-1-ylmethyl)amino)-1-oxopropan-2-yl)succinamide

Conditions

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide	98%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 3235-69-6
morpholin-4-ylacetic acid

: 2,5-dioxopyrrolidin-1-yl 2-morpholinoacetate

Conditions

Conditions	Yield
With thionyl chloride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃;	96%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 1h;	78%
With thionyl chloride; N,N-dimethyl-formamide In tetrahydrofuran at 0 - 20℃;	67%
With thionyl chloride; N,N-dimethyl-formamide In tetrahydrofuran at 20℃;

: 3235-69-6
morpholin-4-ylacetic acid

: (8S,9S,10R,13S,14S,17S)-17-((E)-1-(hydroxyimino)ethyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)one

: 1364709-87-4
(8S,9S,10R,13S,14S,17S)-10,13-dimethyl-17-((E)-1-(2-morpholinoacetoxyimino)ethyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere;	94%

: 3235-69-6
morpholin-4-ylacetic acid

: 1364709-15-8
(8S,9S,10R,13S,14S,17S)-17-((E)-1-(hydroxyimino)ethyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one

: 1364709-87-4
(8S,9S,10R,13S,14S,17S)-10,13-dimethyl-17-((E)-1-(2-morpholinoacetoxyimino)ethyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere;	94%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere;	94%

: 3235-69-6
morpholin-4-ylacetic acid

: 21911-88-6
methyl 3-(4-chlorophenylamino)propanoate

: C16H21ClN2O4

Conditions

Conditions	Yield
Stage #1: morpholin-4-ylacetic acid With thionyl chloride In dichloromethane at 10 - 20℃; for 2h; Stage #2: methyl 3-(4-chlorophenylamino)propanoate With triethylamine In dichloromethane at 20℃; for 2.5h; Temperature;	92%

: 3235-69-6
morpholin-4-ylacetic acid

: C39H58O5

: C45H67NO7

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	92%

: 3235-69-6
morpholin-4-ylacetic acid

: (E)-4-(2-phenyl-1-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)but-1-en-1-yl)aniline

: (E)-2-morpholino-N-(4-(2-phenyl-1-(4-(2-(pyrrolidin-1-yl)-ethoxy)phenyl)but-1-en-1-yl)phenyl)acetamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere;	91%

: 3235-69-6
morpholin-4-ylacetic acid

: 1-adamantan-1-yl-2-(5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-ylamino)-ethanol

: 1-[4-(2-adamantan-1-yl-2-hydroxy-ethylamino)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidin-7-yl]-2-morpholin-4-yl-ethanone

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	90%

: 3235-69-6
morpholin-4-ylacetic acid

: C20H29N5O6

: C21H30N6O6

Conditions

Conditions	Yield
Stage #1: C20H29N5O6 With trifluoroacetic acid Stage #2: morpholin-4-ylacetic acid With HCTU; N-ethyl-N,N-diisopropylamine In dichloromethane	90%

: 3235-69-6
morpholin-4-ylacetic acid

: 626-01-7
3-Iodoaniline

: C12H15IN2O2

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide Inert atmosphere;	89.9%

: 3235-69-6
morpholin-4-ylacetic acid

: (S)-N-((S)-2-amino-1-cyclohexylethyl)-3-(6-isopropylbenzo[d]thiazol-2-yl)-2-propionamidopropanamide

: (S)-N-((S)-1-cyclohexyl-2-(2-morpholinoacetamido)ethyl)-3-(6-isopropylbenzo[d]thiazol-2-yl)-2-propionamidopropanamide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h;	87%

: 3235-69-6
morpholin-4-ylacetic acid

: 87439-12-1
2-Morpholinoessigsaeure-N-oxid

Conditions

Conditions	Yield
With dihydrogen peroxide In acetic acid at 60℃; for 12h;	86%

: 649735-46-6
Brivanib

: 3235-69-6
morpholin-4-ylacetic acid

: 1016195-07-5
C25H28FN5O5

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; dmap In N,N-dimethyl-formamide	85%

: 3235-69-6
morpholin-4-ylacetic acid

: 1021458-90-1
C31H34F26O5

: 1021458-80-9
C37H43F26NO7

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 72h;	84%

: 3235-69-6
morpholin-4-ylacetic acid

: 1021458-94-5
C41H52F12O7

: 1021458-71-8
C47H61F12NO9

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;	82%

: 3235-69-6
morpholin-4-ylacetic acid

: (E)-4-(1-(4-(2-morpholinoethoxy)phenyl)-2-phenylbut-1-en-1-yl)aniline

: (E)-2-morpholino-N-(4-(1-(4-(2-morpholinoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenyl)acetamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere;	82%

: 3235-69-6
morpholin-4-ylacetic acid

: (S)-3-(3-(7-(3-aminopropoxy)-5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1H-benzo[d]imidazol-1-yl)propyl)-2-(1-ethyl-4-fluoro-3-methyl-1H-pyrazole-5-carboxamido)-3,4-dihydro-5-oxa-1,2a-diazaacenaphthylene-7-carboxamide hydrochloride

: (S)-3-(3-(5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-(2-morpholinoacetamido)propoxy)-1H-benzo[d]imidazol-1-yl)propyl)-2-(1-ethyl-4-fluoro-3-methyl-1H-pyrazole-5-carboxamido)-3,4-dihydro-5-oxa-1,2a-diazaacenaphthylene-7-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; HATU In N,N-dimethyl-formamide at 20 - 27℃;	81%

: 3235-69-6
morpholin-4-ylacetic acid

: 251105-80-3
N-(3S-amino-2R-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitro-benzenesulfonamide hydrochloride

: N-((2S,3R)-3-hydroxy-4-((N-isobutyl-4-nitrophenyl)sulfonamido)-1-phenylbutan-2-yl)-2-morpholinoacetamide

Conditions

Conditions	Yield
Stage #1: morpholin-4-ylacetic acid; N-(3S-amino-2R-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitro-benzenesulfonamide hydrochloride With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 25℃; Inert atmosphere; Sealed tube; Stage #2: With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; Inert atmosphere; Sealed tube;	80%

: 3235-69-6
morpholin-4-ylacetic acid

: 1190307-88-0
sofosbuvir

: isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyl-3-(2-morpholinoacetoxy)tetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

Conditions

Conditions	Yield
Stage #1: morpholin-4-ylacetic acid; sofosbuvir With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.0833333h; Stage #2: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In dichloromethane for 20h;	76%

: 3235-69-6
morpholin-4-ylacetic acid

: C37H56O4

: C43H65NO6

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	75.9%

: 3235-69-6
morpholin-4-ylacetic acid

: C11H15N3O3

: C17H24N4O5

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 24h; Enzymatic reaction;	75%

: 3235-69-6
morpholin-4-ylacetic acid

: 159005-71-7
N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-methoxybenzenesulfonamide

: N-((2S,3R)-3-hydroxy-4-((N-isobutyl-4-methoxyphenyl)sulfonamido)-1-phenylbutan-2-yl)-2-morpholinoacetamide

Conditions

Conditions	Yield
Stage #1: morpholin-4-ylacetic acid; N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-methoxybenzenesulfonamide With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 25℃; Inert atmosphere; Sealed tube; Stage #2: With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; Inert atmosphere; Sealed tube;	75%

: 3235-69-6
morpholin-4-ylacetic acid

: C13H18N2O4*C2HF3O2

: 1620107-79-0
(S)-methyl 3-(4-methoxyphenyl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propanoate

Conditions

Conditions	Yield
With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran for 1h;	75%

Morpholin-4-ylacetic acid Chemical Properties

Molecular Formula: C₆H₁₁NO₃
Molecular Weight: 145.16 g/mol
Canonical SMILES: O=C(O)CN1CCOCC1
InChI: InChI=1/C6H11NO3/c8-6(9)5-7-1-3-10-4-2-7/h1-5H2,(H,8,9)
Mol File: 3235-69-6.mol
Product Categories: Amino Acids and Derivatives
Nominal Mass: 145
Average Mass: 145.1564
Monoisotopic Mass: 145.073893
H bond acceptors: 4
H bond donors: 1
#Freely Rotating Bonds: 2
Polar Surface Area: 38.77
Index of Refraction: 1.483
Molar Refractivity: 34.5 cm³
Molar Volume: 120.7 cm³
Polarizability: 13.68×10^-24cm³
Surface Tension: 43.1 dyne/cm
Density: 1.202 g/cm³
Flash Point: 118.2 °C
Enthalpy of Vaporization: 56.15 kJ/mol
Boiling Point: 271.9 °C at 760 mmHg
Vapour Pressure of 4-Morpholineacetic acid (CAS NO.3235-69-6): 0.00175 mmHg at 25 °C

Morpholin-4-ylacetic acid Safety Profile

Hazard Codes: Xi
HazardClass of 4-Morpholineacetic acid (CAS NO.3235-69-6): Irritant

Morpholin-4-ylacetic acid Specification

4-Morpholineacetic acid (CAS NO.3235-69-6), its synonyms are 2-(4-Morpholinyl)acetic acid ;
Morpholineacetic acid ; Morpholin-4-yl-acetic acid ; 4-Morpholine acetic acid .

Product Name

MORPHOLIN-4-YL-ACETIC ACID

Synthetic route

Morpholin-4-ylacetic acid Chemical Properties

Morpholin-4-ylacetic acid Safety Profile

Morpholin-4-ylacetic acid Specification

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