As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryhigh quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryTRANS-1,4-CYCLOHEXANEDIMETHANOL Basic information Product Name: TRANS-1,4-CYCLOHEXANEDIMETHANOL Synonyms: trans-4-cyclohexanedimethanol;TRANS-1,4-CYCLOHEXYLENEDIMETHANOL;TRANS-1,4-DI
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
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inquiryProduct name: trans-cyclohexane-1,4-diyldimethanol CAS : 3236-48-4 Appearance: White powder Content: 99% Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Application:Organic synthesis Transportation
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryProduct Name: TRANS-1,4-CYCLOHEXANEDIMETHANOL CAS: 3236-48-4 MF: C8H16O2 MW: 144.21 EINECS: Mol File: 3236-48-4.mol TRANS-1,4-CYCLOHEXANEDIMETHANOL Structure TRANS-1,4-CYCLOHEXANEDIMETHANOL Chemical Properties Melting point 6
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
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inquiryTRANS-1,4-CYCLOHEXANEDIMETHANOL CAS:3236-48-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality or
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquirySuperior quality, moderate price & quick delivery. Appearance:white crystal powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Intermediate in the preparation of Apad
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inquiryProduct name: Trans-Cyclohexane-1,4-Diyldimethanol CAS No.:3236-48-4 Molecule Formula:C8H16O2 Molecule Weight:144.21 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquirytrans-1,4-cyclohexylenedimethylene diacetate
trans-1,4-Cyclohexanedimethanol
Conditions | Yield |
---|---|
With potassium carbonate Ambient temperature; | 100% |
With sodium hydroxide for 10h; Heating; | 46.3% |
Conditions | Yield |
---|---|
With zinc borohydride pyridine complex In tetrahydrofuran for 0.4h; Heating; | 96% |
Stage #1: trans-hexahydroterephthalic acid With thionyl chloride In methanol at 0℃; for 4h; Reflux; Stage #2: With sodium tetrahydroborate In tetrahydrofuran for 0.5h; Reflux; Stage #3: With methanol In tetrahydrofuran for 12h; Reflux; | 28.6% |
(±)-trans-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)cyclohexyl]methanol
trans-1,4-Cyclohexanedimethanol
Conditions | Yield |
---|---|
With sodium tetrachloroaurate(III) dihydrate In methanol at 20℃; for 2h; | 96% |
Conditions | Yield |
---|---|
With water; sodium hydroxide In methanol at 70℃; | 88.55% |
diethyl cyclohexane-trans-1,4-dicarboxylate
trans-1,4-Cyclohexanedimethanol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In diethyl ether at 20℃; Reduction; | 77% |
Conditions | Yield |
---|---|
With Ni/NiO-diatomite at 200℃; for 3h; Reagent/catalyst; Autoclave; Inert atmosphere; | 72.6% |
Multi-step reaction with 2 steps 1: 52.1 percent / 140 - 165 °C 2: 46.3 percent / aq. NaOH / 10 h / Heating View Scheme |
Conditions | Yield |
---|---|
In acetone for 168h; Ambient temperature; lipase PS (Pseudomonas sp.) on Celite; Yields of byproduct given; | A 66% B n/a C n/a |
dimethyl 1,4-cyclohexanedicarboxylate
A
trans-1,4-Cyclohexanedimethanol
B
(1s,4s)-cyclohexane-1,4-diyldimethanol
Conditions | Yield |
---|---|
With methanol; sodium Trennung ueber die Dibenzoyl-Derivate; |
cis-dimethyl 1,4-cyclohexanedicarboxylate
A
trans-1,4-Cyclohexanedimethanol
B
(1s,4s)-cyclohexane-1,4-diyldimethanol
Conditions | Yield |
---|---|
With methanol; sodium Trennung ueber die Dibenzoyl-Derivate; |
trans-1,4-bis-methanesulfonyloxymethyl-cyclohexane
A
4-methylene-1-cyclohexanemethanol
B
trans-1,4-Cyclohexanedimethanol
Conditions | Yield |
---|---|
With potassium hydroxide |
A
trans-1,4-Cyclohexanedimethanol
Conditions | Yield |
---|---|
With dichloro-acetic acid; water In 1,4-dioxane-d8 at 37℃; Kinetics; Hydrolysis; |
1,4-benzenedicarboxylic acid dimethyl ester
A
trans-1,4-Cyclohexanedimethanol
B
(1s,4s)-cyclohexane-1,4-diyldimethanol
Conditions | Yield |
---|---|
With hydrogen; aluminum oxyhydroxide; rhodium In ethyl acetate at 22℃; under 760 Torr; for 46h; Title compound not separated from byproducts; |
Conditions | Yield |
---|---|
In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate | |
With copper chromium; hydrogen at 210℃; under 152940 Torr; |
terephthalic acid
A
trans-1,4-Cyclohexanedimethanol
B
(1s,4s)-cyclohexane-1,4-diyldimethanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 6 h / 260 - 280 °C / 4535.33 Torr 2: dimethyl 1,4-cyclohexane dicarboxylate; Pd/Al2O3; hydrogen / 1 h / 200 °C / 93849.2 Torr / Autoclave 3: C16H30O; (4-methylcyclohexyl)methanol / 225 °C / 258581 Torr View Scheme | |
Multi-step reaction with 3 steps 1: 4 h / 280 °C / 4535.33 Torr / Large scale 2: ; hydrogen / 1 h / 200 °C / 93849.2 Torr / Autoclave 3: CrO4(2-)*Ba(2+)*Cr2CuO4*CuO; hydrogen / 5 h / 250 °C / 212036 Torr View Scheme | |
Multi-step reaction with 3 steps 1: 8.5 h / 260 - 280 °C / 4535.33 Torr / Large scale 2: Pd/Al2O3; hydrogen; dimethyl 1,4-cyclohexane dicarboxylate / 1 h / 200 °C / 93849.2 Torr / Autoclave 3: Pd/Al2O3; C16H30O; (4-methylcyclohexyl)methanol / 225 °C / 259341 Torr View Scheme | |
Multi-step reaction with 3 steps 1: 8.5 h / 260 - 280 °C / 4535.33 Torr / Large scale 2: Pd/Al2O3; hydrogen; (4-methylcyclohexyl)methanol / 180 - 225 °C / 93849.2 Torr 3: Pd/Al2O3; C16H30O; (4-methylcyclohexyl)methanol / 225 °C / 259341 Torr View Scheme |
bis((4-methylcyclohexyl)methyl) cyclohexane-1,4-dicarboxylate
A
trans-1,4-Cyclohexanedimethanol
B
(1s,4s)-cyclohexane-1,4-diyldimethanol
C
(4-methylcyclohexyl)methanol
Conditions | Yield |
---|---|
With CrO4(2-)*Ba(2+)*Cr2CuO4*CuO; hydrogen at 250℃; under 212036 Torr; for 5h; Pressure; Temperature; |
terephthalic acid 1,4-bis(4-methylcyclohexyl)methyl ester
A
trans-1,4-Cyclohexanedimethanol
B
(1s,4s)-cyclohexane-1,4-diyldimethanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Pd/Al2O3; hydrogen; dimethyl 1,4-cyclohexane dicarboxylate / 1 h / 200 °C / 93849.2 Torr / Autoclave 2: Pd/Al2O3; C16H30O; (4-methylcyclohexyl)methanol / 225 °C / 259341 Torr View Scheme |
bis((4-methylcyclohexyl)methyl) cyclohexane-1,4-dicarboxylate
A
trans-1,4-Cyclohexanedimethanol
B
(1s,4s)-cyclohexane-1,4-diyldimethanol
Conditions | Yield |
---|---|
With C16H30O; (4-methylcyclohexyl)methanol at 225℃; under 258581 Torr; | |
With (4-methylcyclohexyl)methanol; hydrogen at 250℃; under 212036 Torr; for 5h; | A n/a B n/a |
With Pd/Al2O3; C16H30O; (4-methylcyclohexyl)methanol at 225℃; under 259341 Torr; | A n/a B n/a |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at -20 - 20℃; for 3h; Large scale; |
trans-1,4-Cyclohexanedimethanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium tetrachloroaurate(III) dihydrate / methanol / 1 h / 20 °C 2: sodium tetrachloroaurate(III) dihydrate / methanol / 2 h / 20 °C View Scheme |
trans-1,4-Cyclohexanedimethanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 2: potassium carbonate; methanol / 17 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 2: potassium carbonate / methanol / 17 h / 20 °C View Scheme |
(2E,4E)-hexa-2,4-diene-1,6-diol
trans-1,4-Cyclohexanedimethanol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: triethylamine; dmap / dichloromethane / 16 h 2: m-xylene / 1 h / 250 °C / 11103.3 - 78334.3 Torr / Autoclave; Inert atmosphere 3: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 4: potassium carbonate; methanol / 17 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: t-butyl catechol / m-xylene / 12 h / 200 - 1217 °C / 11103.3 - 62819.5 Torr / Autoclave; Inert atmosphere; Sealed tube 2: triethylamine; dmap / dichloromethane / 1.75 h / 20 °C 3: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 4: potassium carbonate; methanol / 17 h / 20 °C View Scheme |
(2E,4E)-hexa-2,4-diene-1,6-diol
A
trans-1,4-Cyclohexanedimethanol
B
(1s,4s)-cyclohexane-1,4-diyldimethanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: t-butyl catechol / m-xylene / 12 h / 200 - 1217 °C / 11103.3 - 62819.5 Torr / Autoclave; Inert atmosphere; Sealed tube 2: hydrogen / isopropyl alcohol / 20 h / 3345.86 Torr / Autoclave View Scheme | |
Multi-step reaction with 4 steps 1: triethylamine; dmap / dichloromethane / 16 h 2: m-xylene / 1 h / 250 °C / 11103.3 - 78334.3 Torr / Autoclave; Inert atmosphere 3: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 4: potassium carbonate / methanol / 17 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: t-butyl catechol / m-xylene / 12 h / 200 - 1217 °C / 11103.3 - 62819.5 Torr / Autoclave; Inert atmosphere; Sealed tube 2: triethylamine; dmap / dichloromethane / 1.75 h / 20 °C 3: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 4: potassium carbonate / methanol / 17 h / 20 °C View Scheme |
trans-1,4-Cyclohexanedimethanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine; dmap / dichloromethane / 1.75 h / 20 °C 2: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 3: potassium carbonate; methanol / 17 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
With hydrogen In isopropyl alcohol under 3345.86 Torr; for 20h; Pressure; Reagent/catalyst; Solvent; Autoclave; stereoselective reaction; | A 15.1 %Chromat. B 78.6 %Chromat. |
Multi-step reaction with 3 steps 1: triethylamine; dmap / dichloromethane / 1.75 h / 20 °C 2: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 3: potassium carbonate / methanol / 17 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
With potassium carbonate In methanol at 20℃; for 17h; Overall yield = 1.02 g; | A 0.44 %Spectr. B 82.3 %Spectr. |
A
terephthalic acid
B
trans-1,4-Cyclohexanedimethanol
C
(1s,4s)-cyclohexane-1,4-diyldimethanol
Conditions | Yield |
---|---|
With methanol; potassium carbonate at 20℃; for 17h; | A 0.12 %Chromat. B 0.48 %Chromat. C 90.5 %Chromat. |
(2E,4E)-hexa-2,4-diene-1,6-diacetate
trans-1,4-Cyclohexanedimethanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: m-xylene / 1 h / 250 °C / 11103.3 - 78334.3 Torr / Autoclave; Inert atmosphere 2: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 3: potassium carbonate; methanol / 17 h / 20 °C View Scheme |
(2E,4E)-hexa-2,4-diene-1,6-diacetate
A
trans-1,4-Cyclohexanedimethanol
B
(1s,4s)-cyclohexane-1,4-diyldimethanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: m-xylene / 1 h / 250 °C / 11103.3 - 78334.3 Torr / Autoclave; Inert atmosphere 2: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 3: potassium carbonate / methanol / 17 h / 20 °C View Scheme |
trans-1,4-Cyclohexanedimethanol
trans-1,4-bis-iodomethyl-cyclohexane
Conditions | Yield |
---|---|
With 1H-imidazole; iodine; triphenylphosphine In toluene at 60℃; for 2h; | 92% |
4-(dimethylamino)-1-((3-fluorophenyl)(phenyl)carbamoyl)pyridinium chloride
trans-1,4-Cyclohexanedimethanol
((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl-3-fluorophenyl(phenyl)carbamate
Conditions | Yield |
---|---|
With pyridine In acetonitrile at 53℃; for 18h; Large scale; | 83% |
With dmap In acetonitrile at 53℃; for 18h; |
trans-1,4-Cyclohexanedimethanol
tert-butyldimethylsilyl chloride
(±)-trans-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)cyclohexyl]methanol
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 29h; | 82% |
With pyridine In dichloromethane at 0 - 20℃; for 21h; | 68% |
With dmap; triethylamine In N,N-dimethyl-formamide at 0 - 25℃; for 22h; | 66% |
Conditions | Yield |
---|---|
With N-Bromosuccinimide In dichloromethane at 4℃; for 6h; | 79% |
Isopropenyl acetate
trans-1,4-Cyclohexanedimethanol
A
trans-1,4-cyclohexylenedimethylene diacetate
Conditions | Yield |
---|---|
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; sodium carbonate In toluene at 100℃; for 6h; Inert atmosphere; | A n/a B 75% C n/a |
trans-1,4-Cyclohexanedimethanol
trans-1,4-Bis(bromomethyl)cyclohexane
Conditions | Yield |
---|---|
With phosphorus tribromide In N,N-dimethyl-formamide; toluene at 100℃; for 1.5h; Cooling with ice; | 71.28% |
at 135 - 140℃; Einleiten von HBr; | |
With hydrogen bromide | |
With pyridine; phosphorus tribromide In chloroform | |
With phosphorus tribromide In benzene Title compound not separated from byproducts; |
methyl 6-methyl-4-(2H-tetrazol-5-yl)picolinate
trans-1,4-Cyclohexanedimethanol
Conditions | Yield |
---|---|
With di-tert-butyl-diazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 18h; | 67% |
trans-1,4-Cyclohexanedimethanol
trans-1,4-Bis-cyclohexane
Conditions | Yield |
---|---|
With tetrachloromethane; triphenylphosphine | 64% |
Conditions | Yield |
---|---|
With (4,4′-di-tert-butyl-2,2′-dipyridyl)Ni(o-tolyl)(Br); 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 80℃; for 24h; Inert atmosphere; Sealed tube; UV-irradiation; | 62% |
Conditions | Yield |
---|---|
With pyridine at 0℃; for 2h; Esterification; | 61% |
Conditions | Yield |
---|---|
Stage #1: trans-1,4-Cyclohexanedimethanol With sodium hydride In tetrahydrofuran at 0 - 20℃; for 1h; Stage #2: benzyl bromide With tetra-(n-butyl)ammonium iodide In tetrahydrofuran at 20 - 60℃; for 15h; | 60% |
Stage #1: trans-1,4-Cyclohexanedimethanol With 15-crown-5; sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: benzyl bromide In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 1h; | 45% |
In tetrahydrofuran; ethyl acetate |
(4-chlorophenyl)(phenyl)carbamic chloride
trans-1,4-Cyclohexanedimethanol
((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl (4-chlorophenyl)(phenyl)carbamate
Conditions | Yield |
---|---|
With pyridine Reflux; Large scale; | 60% |
With pyridine Sealed tube; Reflux; | 57% |
With pyridine Reflux; |
Conditions | Yield |
---|---|
Stage #1: trans-1,4-Cyclohexanedimethanol; terephthaloyl chloride With triethylamine In tetrahydrofuran at 20℃; for 13h; Inert atmosphere; Stage #2: With water; triethylamine In tetrahydrofuran | 59.6% |
trans-1,4-Cyclohexanedimethanol
p-toluenesulfonyl chloride
trans-4-(hydroxymethyl)cyclohexylmethyl 4-methylbenzenesulfonate
Conditions | Yield |
---|---|
With pyridine In chloroform for 4h; | 55.1% |
With dmap; triethylamine In dichloromethane for 36h; Ambient temperature; | 47% |
With triethylamine In dichloromethane at -20 - 20℃; for 10h; |
Conditions | Yield |
---|---|
Stage #1: trans-1,4-Cyclohexanedimethanol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: acetyl chloride In tetrahydrofuran; mineral oil at 15℃; for 3h; Inert atmosphere; | 53% |
trans-1,4-Cyclohexanedimethanol
phenyl isocyanate
((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl phenylcarbamate
Conditions | Yield |
---|---|
In pyridine at 20℃; for 5h; | 51.5% |
With pyridine at 20℃; for 5h; |
trans-1,4-Cyclohexanedimethanol
trans-1,4-cyclohexanedicarboxylic acid dichloride
Conditions | Yield |
---|---|
Stage #1: trans-1,4-Cyclohexanedimethanol; trans-1,4-cyclohexanedicarboxylic acid dichloride With triethylamine In tetrahydrofuran Inert atmosphere; Stage #2: With water; triethylamine In tetrahydrofuran | 50.9% |
trans-1,4-Cyclohexanedimethanol
3-(1-piperazinyl)-1,2-benzisothiazole
methanesulfonyl chloride
Conditions | Yield |
---|---|
Stage #1: trans-1,4-Cyclohexanedimethanol; methanesulfonyl chloride With triethylamine In ethyl acetate at 0 - 20℃; for 3h; Stage #2: 3-(1-piperazinyl)-1,2-benzisothiazole With sodium carbonate; potassium iodide In acetonitrile for 22h; Reflux; | 44.1% |
trans-1,4-Cyclohexanedimethanol
methyl iodide
(4-Methoxymethyl-cyclohexyl)-methanol
Conditions | Yield |
---|---|
With potassium hydride | 44% |
bromoacetic acid tert-butyl ester
trans-1,4-Cyclohexanedimethanol
tert-butyl 2-(((1r,4r)-4-(hydroxymethyl)cyclohexyl)methoxy)acetate
Conditions | Yield |
---|---|
With tetra-(n-butyl)ammonium iodide; sodium hydroxide In water; benzene at 20℃; for 2h; | 44% |
With tetra-(n-butyl)ammonium iodide; sodium hydroxide In water; benzene at 20℃; for 2h; |
trans-1,4-Cyclohexanedimethanol
4-(bromomethyl)cyclohexylmethanol
Conditions | Yield |
---|---|
With bromine; triphenylphosphine In N,N-dimethyl-formamide | 41% |
N-(3-methoxybenzyl)-6-methyl-4-(2H-tetrazol-5-yl)picolinamide
trans-1,4-Cyclohexanedimethanol
N-(3-methoxybenzyl)-4-(2-(((trans)-4-(hydroxymethyl)cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpicolinamide
Conditions | Yield |
---|---|
With di-tert-butyl-diazodicarboxylate In tetrahydrofuran for 18h; regioselective reaction; | 37% |
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran for 16h; Heating; | A 30% B 32% |
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