Trans-1,4-Cyclohexanedimethanol supplier

Name
TRANS-1,4-CYCLOHEXANEDIMETHANOL
EINECS
CAS No. 3236-48-4
Article Data26
CAS DataBase
Density 1.004 g/cm³
Solubility
Melting Point 61-66 °C
Formula C₈H₁₆O₂
Boiling Point 286.2 °C at 760 mmHg
Molecular Weight 144.214
Flash Point 161.1 °C
Transport Information
Appearance white crystalline powder
Safety 39-26
Risk Codes 36
Molecular Structure
Hazard Symbols
Synonyms (trans-4-Hydroxymethylcyclohexyl)methanol;trans-1,4-Bis(hydroxymethyl)cyclohexane;
PSA 40.46000
LogP 0.77740

Synthetic route

: 10412-78-9
trans-1,4-cyclohexylenedimethylene diacetate

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

Conditions

Conditions	Yield
With potassium carbonate Ambient temperature;	100%
With sodium hydroxide for 10h; Heating;	46.3%

: 619-82-9
1,4-cyclohexanedicarboxylic acid

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

Conditions

Conditions	Yield
With zinc borohydride pyridine complex In tetrahydrofuran for 0.4h; Heating;	96%
Stage #1: trans-hexahydroterephthalic acid With thionyl chloride In methanol at 0℃; for 4h; Reflux; Stage #2: With sodium tetrahydroborate In tetrahydrofuran for 0.5h; Reflux; Stage #3: With methanol In tetrahydrofuran for 12h; Reflux;	28.6%

: 180046-62-2
(±)-trans-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)cyclohexyl]methanol

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

Conditions

Conditions	Yield
With sodium tetrachloroaurate(III) dihydrate In methanol at 20℃; for 2h;	96%

: 3412-68-8
1,4-trans-cyclohexanediyldimethylene dibenzoate

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

Conditions

Conditions	Yield
With water; sodium hydroxide In methanol at 70℃;	88.55%

: 19145-96-1
diethyl cyclohexane-trans-1,4-dicarboxylate

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether at 20℃; Reduction;	77%

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

Conditions

Conditions	Yield
With Ni/NiO-diatomite at 200℃; for 3h; Reagent/catalyst; Autoclave; Inert atmosphere;	72.6%
Multi-step reaction with 2 steps 1: 52.1 percent / 140 - 165 °C 2: 46.3 percent / aq. NaOH / 10 h / Heating View Scheme

: 6308-18-5
1,4-cyclohexanedimethylene diacetate

A: 3236-48-4
trans-1,4-Cyclohexanedimethanol

B: ((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl acetate

C: cis-4-(hydroxymethyl)cyclohexylmethyl acetate

Conditions

Conditions	Yield
In acetone for 168h; Ambient temperature; lipase PS (Pseudomonas sp.) on Celite; Yields of byproduct given;	A 66% B n/a C n/a

...Expand

: 3399-22-2
dimethyl 1,4-cyclohexanedicarboxylate

A: 3236-48-4
trans-1,4-Cyclohexanedimethanol

B: 3236-47-3
(1s,4s)-cyclohexane-1,4-diyldimethanol

Conditions

Conditions	Yield
With methanol; sodium Trennung ueber die Dibenzoyl-Derivate;

: 3399-21-1
cis-dimethyl 1,4-cyclohexanedicarboxylate

A: 3236-48-4
trans-1,4-Cyclohexanedimethanol

B: 3236-47-3
(1s,4s)-cyclohexane-1,4-diyldimethanol

Conditions

Conditions	Yield
With methanol; sodium Trennung ueber die Dibenzoyl-Derivate;

: 115506-09-7
trans-1,4-bis-methanesulfonyloxymethyl-cyclohexane

A: 1004-24-6
4-methylene-1-cyclohexanemethanol

B: 3236-48-4
trans-1,4-Cyclohexanedimethanol

Conditions

Conditions	Yield
With potassium hydroxide

polymer, Mn 23500; diketene acetal (3,9-bis(ethylidene)-2,4,8,10-tetraoxaspiro<5,5>undecane); t-cyclohexane-1,4-dimethanol: polymer, Mn 23500; diketene acetal (3,9-bis(ethylidene)-2,4,8,10-tetraoxaspiro<5,5>undecane); t-cyclohexane-1,4-dimethanol

A: 3236-48-4
trans-1,4-Cyclohexanedimethanol

B: pentaerythritol dipropionate

Conditions

Conditions	Yield
With dichloro-acetic acid; water In 1,4-dioxane-d8 at 37℃; Kinetics; Hydrolysis;

: 120-61-6
1,4-benzenedicarboxylic acid dimethyl ester

A: 3236-48-4
trans-1,4-Cyclohexanedimethanol

B: 3236-47-3
(1s,4s)-cyclohexane-1,4-diyldimethanol

Conditions

Conditions	Yield
With hydrogen; aluminum oxyhydroxide; rhodium In ethyl acetate at 22℃; under 760 Torr; for 46h; Title compound not separated from byproducts;

: 3399-22-2
dimethyl 1,4-cyclohexanedicarboxylate

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

Conditions

Conditions	Yield
In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate
With copper chromium; hydrogen at 210℃; under 152940 Torr;

: 100-21-0
terephthalic acid

A: 3236-48-4
trans-1,4-Cyclohexanedimethanol

B: 3236-47-3
(1s,4s)-cyclohexane-1,4-diyldimethanol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 6 h / 260 - 280 °C / 4535.33 Torr 2: dimethyl 1,4-cyclohexane dicarboxylate; Pd/Al2O3; hydrogen / 1 h / 200 °C / 93849.2 Torr / Autoclave 3: C16H30O; (4-methylcyclohexyl)methanol / 225 °C / 258581 Torr View Scheme
Multi-step reaction with 3 steps 1: 4 h / 280 °C / 4535.33 Torr / Large scale 2: ; hydrogen / 1 h / 200 °C / 93849.2 Torr / Autoclave 3: CrO4(2-)Ba(2+)Cr2CuO4*CuO; hydrogen / 5 h / 250 °C / 212036 Torr View Scheme
Multi-step reaction with 3 steps 1: 8.5 h / 260 - 280 °C / 4535.33 Torr / Large scale 2: Pd/Al2O3; hydrogen; dimethyl 1,4-cyclohexane dicarboxylate / 1 h / 200 °C / 93849.2 Torr / Autoclave 3: Pd/Al2O3; C16H30O; (4-methylcyclohexyl)methanol / 225 °C / 259341 Torr View Scheme
Multi-step reaction with 3 steps 1: 8.5 h / 260 - 280 °C / 4535.33 Torr / Large scale 2: Pd/Al2O3; hydrogen; (4-methylcyclohexyl)methanol / 180 - 225 °C / 93849.2 Torr 3: Pd/Al2O3; C16H30O; (4-methylcyclohexyl)methanol / 225 °C / 259341 Torr View Scheme

: 1420954-46-6
bis((4-methylcyclohexyl)methyl) cyclohexane-1,4-dicarboxylate

A: 3236-48-4
trans-1,4-Cyclohexanedimethanol

B: 3236-47-3
(1s,4s)-cyclohexane-1,4-diyldimethanol

C: 34885-03-5
(4-methylcyclohexyl)methanol

Conditions

Conditions	Yield
With CrO4(2-)Ba(2+)Cr2CuO4*CuO; hydrogen at 250℃; under 212036 Torr; for 5h; Pressure; Temperature;

...Expand

: 95623-88-4
terephthalic acid 1,4-bis(4-methylcyclohexyl)methyl ester

A: 3236-48-4
trans-1,4-Cyclohexanedimethanol

B: 3236-47-3
(1s,4s)-cyclohexane-1,4-diyldimethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Pd/Al2O3; hydrogen; dimethyl 1,4-cyclohexane dicarboxylate / 1 h / 200 °C / 93849.2 Torr / Autoclave 2: Pd/Al2O3; C16H30O; (4-methylcyclohexyl)methanol / 225 °C / 259341 Torr View Scheme

: 1420954-46-6
bis((4-methylcyclohexyl)methyl) cyclohexane-1,4-dicarboxylate

A: 3236-48-4
trans-1,4-Cyclohexanedimethanol

B: 3236-47-3
(1s,4s)-cyclohexane-1,4-diyldimethanol

Conditions

Conditions	Yield
With C16H30O; (4-methylcyclohexyl)methanol at 225℃; under 258581 Torr;
With (4-methylcyclohexyl)methanol; hydrogen at 250℃; under 212036 Torr; for 5h;	A n/a B n/a
With Pd/Al2O3; C16H30O; (4-methylcyclohexyl)methanol at 225℃; under 259341 Torr;	A n/a B n/a

: 94-60-0
dimethyl 1,4-cyclohexane dicarboxylate

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at -20 - 20℃; for 3h; Large scale;

: C20H44O2Si2

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium tetrachloroaurate(III) dihydrate / methanol / 1 h / 20 °C 2: sodium tetrachloroaurate(III) dihydrate / methanol / 2 h / 20 °C View Scheme

: (3R,6S)-cyclohex-1-ene-3,6-dimethanol diacetate

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 2: potassium carbonate; methanol / 17 h / 20 °C View Scheme

: (3R,6S)-cyclohex-1-ene-3,6-dimethanol diacetate

A: 3236-48-4
trans-1,4-Cyclohexanedimethanol

B: 3236-47-3
(1s,4s)-cyclohexane-1,4-diyldimethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 2: potassium carbonate / methanol / 17 h / 20 °C View Scheme

: 107550-83-4
(2E,4E)-hexa-2,4-diene-1,6-diol

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: triethylamine; dmap / dichloromethane / 16 h 2: m-xylene / 1 h / 250 °C / 11103.3 - 78334.3 Torr / Autoclave; Inert atmosphere 3: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 4: potassium carbonate; methanol / 17 h / 20 °C View Scheme
Multi-step reaction with 4 steps 1: t-butyl catechol / m-xylene / 12 h / 200 - 1217 °C / 11103.3 - 62819.5 Torr / Autoclave; Inert atmosphere; Sealed tube 2: triethylamine; dmap / dichloromethane / 1.75 h / 20 °C 3: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 4: potassium carbonate; methanol / 17 h / 20 °C View Scheme

: 107550-83-4
(2E,4E)-hexa-2,4-diene-1,6-diol

A: 3236-48-4
trans-1,4-Cyclohexanedimethanol

B: 3236-47-3
(1s,4s)-cyclohexane-1,4-diyldimethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: t-butyl catechol / m-xylene / 12 h / 200 - 1217 °C / 11103.3 - 62819.5 Torr / Autoclave; Inert atmosphere; Sealed tube 2: hydrogen / isopropyl alcohol / 20 h / 3345.86 Torr / Autoclave View Scheme
Multi-step reaction with 4 steps 1: triethylamine; dmap / dichloromethane / 16 h 2: m-xylene / 1 h / 250 °C / 11103.3 - 78334.3 Torr / Autoclave; Inert atmosphere 3: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 4: potassium carbonate / methanol / 17 h / 20 °C View Scheme
Multi-step reaction with 4 steps 1: t-butyl catechol / m-xylene / 12 h / 200 - 1217 °C / 11103.3 - 62819.5 Torr / Autoclave; Inert atmosphere; Sealed tube 2: triethylamine; dmap / dichloromethane / 1.75 h / 20 °C 3: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 4: potassium carbonate / methanol / 17 h / 20 °C View Scheme

: (3R,6S)-cyclohex-1-ene-1,4-dimethanol

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: triethylamine; dmap / dichloromethane / 1.75 h / 20 °C 2: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 3: potassium carbonate; methanol / 17 h / 20 °C View Scheme

: (3R,6S)-cyclohex-1-ene-1,4-dimethanol

A: 3236-48-4
trans-1,4-Cyclohexanedimethanol

B: 3236-47-3
(1s,4s)-cyclohexane-1,4-diyldimethanol

Conditions

Conditions	Yield
With hydrogen In isopropyl alcohol under 3345.86 Torr; for 20h; Pressure; Reagent/catalyst; Solvent; Autoclave; stereoselective reaction;	A 15.1 %Chromat. B 78.6 %Chromat.
Multi-step reaction with 3 steps 1: triethylamine; dmap / dichloromethane / 1.75 h / 20 °C 2: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 3: potassium carbonate / methanol / 17 h / 20 °C View Scheme

: (1R,4S)-cyclohexane-1,4-dimethanol diacetate

A: 3236-48-4
trans-1,4-Cyclohexanedimethanol

B: 3236-47-3
(1s,4s)-cyclohexane-1,4-diyldimethanol

Conditions

Conditions	Yield
With potassium carbonate In methanol at 20℃; for 17h; Overall yield = 1.02 g;	A 0.44 %Spectr. B 82.3 %Spectr.

: (1R,4S)-cyclohexane-1,4-dimethanol diacetate

A: 100-21-0
terephthalic acid

B: 3236-48-4
trans-1,4-Cyclohexanedimethanol

C: 3236-47-3
(1s,4s)-cyclohexane-1,4-diyldimethanol

Conditions

Conditions	Yield
With methanol; potassium carbonate at 20℃; for 17h;	A 0.12 %Chromat. B 0.48 %Chromat. C 90.5 %Chromat.

...Expand

: 63621-97-6, 81759-81-1
(2E,4E)-hexa-2,4-diene-1,6-diacetate

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: m-xylene / 1 h / 250 °C / 11103.3 - 78334.3 Torr / Autoclave; Inert atmosphere 2: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 3: potassium carbonate; methanol / 17 h / 20 °C View Scheme

: 63621-97-6, 81759-81-1
(2E,4E)-hexa-2,4-diene-1,6-diacetate

A: 3236-48-4
trans-1,4-Cyclohexanedimethanol

B: 3236-47-3
(1s,4s)-cyclohexane-1,4-diyldimethanol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: m-xylene / 1 h / 250 °C / 11103.3 - 78334.3 Torr / Autoclave; Inert atmosphere 2: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; ethyl acetate / 18 h / 3345.86 Torr 3: potassium carbonate / methanol / 17 h / 20 °C View Scheme

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 83447-96-5
trans-1,4-bis-iodomethyl-cyclohexane

Conditions

Conditions	Yield
With 1H-imidazole; iodine; triphenylphosphine In toluene at 60℃; for 2h;	92%

: 1187857-70-0
4-(dimethylamino)-1-((3-fluorophenyl)(phenyl)carbamoyl)pyridinium chloride

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 1187857-71-1
((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl-3-fluorophenyl(phenyl)carbamate

Conditions

Conditions	Yield
With pyridine In acetonitrile at 53℃; for 18h; Large scale;	83%
With dmap In acetonitrile at 53℃; for 18h;

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 180046-62-2
(±)-trans-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)cyclohexyl]methanol

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 29h;	82%
With pyridine In dichloromethane at 0 - 20℃; for 21h;	68%
With dmap; triethylamine In N,N-dimethyl-formamide at 0 - 25℃; for 22h;	66%

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 109-92-2
ethyl vinyl ether

: C16H30Br2O4

Conditions

Conditions	Yield
With N-Bromosuccinimide In dichloromethane at 4℃; for 6h;	79%

: 108-22-5
Isopropenyl acetate

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

A: 10412-78-9
trans-1,4-cyclohexylenedimethylene diacetate

B: di-isopropenyl trans-1,4-cyclohexanedimethanol ether

C: C13H22O3

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; sodium carbonate In toluene at 100℃; for 6h; Inert atmosphere;	A n/a B 75% C n/a

...Expand

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 57702-84-8
trans-1,4-Bis(bromomethyl)cyclohexane

Conditions

Conditions	Yield
With phosphorus tribromide In N,N-dimethyl-formamide; toluene at 100℃; for 1.5h; Cooling with ice;	71.28%
at 135 - 140℃; Einleiten von HBr;
With hydrogen bromide
With pyridine; phosphorus tribromide In chloroform
With phosphorus tribromide In benzene Title compound not separated from byproducts;

: 890127-04-5
methyl 6-methyl-4-(2H-tetrazol-5-yl)picolinate

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: methyl 4-(2-(((trans)-4-(hydroxymethyl)cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpicolinate

Conditions

Conditions	Yield
With di-tert-butyl-diazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 18h;	67%

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 86218-00-0
trans-1,4-Bis-cyclohexane

Conditions

Conditions	Yield
With tetrachloromethane; triphenylphosphine	64%

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 99-91-2
para-chloroacetophenone

: 1-(4-(((1r,4r)-4-(hydroxymethyl)cyclohexyl)methoxy)phenyl)ethan-1-one

Conditions

Conditions	Yield
With (4,4′-di-tert-butyl-2,2′-dipyridyl)Ni(o-tolyl)(Br); 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 80℃; for 24h; Inert atmosphere; Sealed tube; UV-irradiation;	62%

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 3282-30-2
pivaloyl chloride

: trans-4-(pivaloyloxymethyl)cyclohexanemethanol

Conditions

Conditions	Yield
With pyridine at 0℃; for 2h; Esterification;	61%

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 100-39-0
benzyl bromide

: (trans-4-((benzyloxy)methyl)cyclohexyl)methanol

Conditions

Conditions	Yield
Stage #1: trans-1,4-Cyclohexanedimethanol With sodium hydride In tetrahydrofuran at 0 - 20℃; for 1h; Stage #2: benzyl bromide With tetra-(n-butyl)ammonium iodide In tetrahydrofuran at 20 - 60℃; for 15h;	60%
Stage #1: trans-1,4-Cyclohexanedimethanol With 15-crown-5; sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: benzyl bromide In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 1h;	45%
In tetrahydrofuran; ethyl acetate

: 1187856-44-5
(4-chlorophenyl)(phenyl)carbamic chloride

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 1187856-45-6
((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl (4-chlorophenyl)(phenyl)carbamate

Conditions

Conditions	Yield
With pyridine Reflux; Large scale;	60%
With pyridine Sealed tube; Reflux;	57%
With pyridine Reflux;

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 100-20-9
terephthaloyl chloride

: 32726-47-9
C24H24O8

Conditions

Conditions	Yield
Stage #1: trans-1,4-Cyclohexanedimethanol; terephthaloyl chloride With triethylamine In tetrahydrofuran at 20℃; for 13h; Inert atmosphere; Stage #2: With water; triethylamine In tetrahydrofuran	59.6%

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 98-59-9
p-toluenesulfonyl chloride

: 170811-08-2
trans-4-(hydroxymethyl)cyclohexylmethyl 4-methylbenzenesulfonate

Conditions

Conditions	Yield
With pyridine In chloroform for 4h;	55.1%
With dmap; triethylamine In dichloromethane for 36h; Ambient temperature;	47%
With triethylamine In dichloromethane at -20 - 20℃; for 10h;

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 75-36-5
acetyl chloride

: ((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl acetate

Conditions

Conditions	Yield
Stage #1: trans-1,4-Cyclohexanedimethanol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: acetyl chloride In tetrahydrofuran; mineral oil at 15℃; for 3h; Inert atmosphere;	53%

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 103-71-9
phenyl isocyanate

: 1187856-29-6
((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl phenylcarbamate

Conditions

Conditions	Yield
In pyridine at 20℃; for 5h;	51.5%
With pyridine at 20℃; for 5h;

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 13170-66-6, 14571-47-2, 19988-54-6
trans-1,4-cyclohexanedicarboxylic acid dichloride

: C24H36O8

Conditions

Conditions	Yield
Stage #1: trans-1,4-Cyclohexanedimethanol; trans-1,4-cyclohexanedicarboxylic acid dichloride With triethylamine In tetrahydrofuran Inert atmosphere; Stage #2: With water; triethylamine In tetrahydrofuran	50.9%

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 87691-87-0
3-(1-piperazinyl)-1,2-benzisothiazole

: 124-63-0
methanesulfonyl chloride

: (trans-4-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)methyl)cyclohexyl)methyl methanesulfonate

Conditions

Conditions	Yield
Stage #1: trans-1,4-Cyclohexanedimethanol; methanesulfonyl chloride With triethylamine In ethyl acetate at 0 - 20℃; for 3h; Stage #2: 3-(1-piperazinyl)-1,2-benzisothiazole With sodium carbonate; potassium iodide In acetonitrile for 22h; Reflux;	44.1%

...Expand

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 74-88-4
methyl iodide

: 110928-47-7
(4-Methoxymethyl-cyclohexyl)-methanol

Conditions

Conditions	Yield
With potassium hydride	44%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 1187856-42-3
tert-butyl 2-(((1r,4r)-4-(hydroxymethyl)cyclohexyl)methoxy)acetate

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; sodium hydroxide In water; benzene at 20℃; for 2h;	44%
With tetra-(n-butyl)ammonium iodide; sodium hydroxide In water; benzene at 20℃; for 2h;

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 23791-91-5
4-(bromomethyl)cyclohexylmethanol

Conditions

Conditions	Yield
With bromine; triphenylphosphine In N,N-dimethyl-formamide	41%

: 1112181-71-1
N-(3-methoxybenzyl)-6-methyl-4-(2H-tetrazol-5-yl)picolinamide

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 1112174-74-9
N-(3-methoxybenzyl)-4-(2-(((trans)-4-(hydroxymethyl)cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpicolinamide

Conditions

Conditions	Yield
With di-tert-butyl-diazodicarboxylate In tetrahydrofuran for 18h; regioselective reaction;	37%

: 3236-48-4
trans-1,4-Cyclohexanedimethanol

: 75-03-6
ethyl iodide

A: 4-(ethoxymethyl)-1-(hydroxymethyl)cyclohexane

B: 1,4-bis(ethoxymethyl)cyclohexane

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran for 16h; Heating;	A 30% B 32%

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Trans-1,4-Cyclohexanedimethanol Chemical Properties

IUPAC Name: [4-(Hydroxymethyl)cyclohexyl]methanol
Structure of Trans-1,4-Cyclohexanedimethanol (CAS NO.3236-48-4):

Empirical Formula: C₈H₁₆O₂
Molecular Weight: 144.2114 g/mol
Index of Refraction: 1.47
Density: 1.004 g/cm³
Melting point: 61-66 °C
Flash Point: 161.1 °C
Boiling Point: 286.2 °C at 760 mmHg
Vapour Pressure: 0.000303 mmHg at 25 °C
Appearance of Trans-1,4-Cyclohexanedimethanol (CAS NO.3236-48-4): White crystalline powder
Canonical SMILES: C1CC(CCC1CO)CO
InChI: InChI=1S/C8H16O2/c9-5-7-1-2-8(6-10)4-3-7/h7-10H,1-6H2
InChIKey: YIMQCDZDWXUDCA-UHFFFAOYSA-N

Trans-1,4-Cyclohexanedimethanol Toxicity Data With Reference

Trans-1,4-Cyclohexanedimethanol (CAS NO.3236-48-4) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65. And the toxicological properties have not been fully investigated.

Trans-1,4-Cyclohexanedimethanol Safety Profile

Risk Statements: 36
36: Irritating to the eyes
Safety Statements: 39-26
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
39: Wear eye/face protection.

Trans-1,4-Cyclohexanedimethanol Specification

Trans-1,4-Cyclohexanedimethanol ,its cas register number is 3236-48-4. It also can be called 1,4-Cyclohexanedimethanol, trans- . It is hazardous,so the first aid measures and others should be known. Such as: When on the skin: first,should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly,Get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While ,it's Inhaled: Remove from exposure and move to fresh air immediately.Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product : Wash mouth out with water,and get medical aid immediately.
In addition, Trans-1,4-Cyclohexanedimethanol (CAS NO.3236-48-4) could be stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: carbon monoxide and carbon dioxide.

Product Name

TRANS-1,4-CYCLOHEXANEDIMETHANOL

Synthetic route

Trans-1,4-Cyclohexanedimethanol Chemical Properties

Trans-1,4-Cyclohexanedimethanol Toxicity Data With Reference

Trans-1,4-Cyclohexanedimethanol Safety Profile

Trans-1,4-Cyclohexanedimethanol Specification

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