Mosapride Citrate supplier | CasNO.112885-42-4

Name
Mosapride citrate
EINECS 601-211-6
CAS No. 112885-42-4
Article Data7
CAS DataBase
Density
Solubility
Melting Point 143-145°
Formula C₂₁H₂₅ClFN₃O₃^.C₆H₈O₇
Boiling Point 549.2 °C at 760 mmHg
Molecular Weight 616.014
Flash Point 286 °C
Transport Information
Appearance white powder
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Gasmotin;Benzamide, 4-amino-5-chloro-2-ethoxy-N-((4-((4-fluorophenyl)methyl)-2-morpholinyl)methyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1);Benzamide,4-amino-5-chloro-2-ethoxy-N- [[4-[(4-fluorophenyl)methyl]-2-morpholinyl]- methyl]-,2-hydroxy-1,2,3-propanetricarboxylate (1:1);(+-)-4-Amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide citrate;Gasmotin (TN);4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide; 2-hydroxypropane-1,2,3-tricarboxylic acid;AS 4370;（±）- 4 –Amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide citrate dihydrate;4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-benzamide 2-hydroxy-1,2,3-propanetricarboxylate;
PSA 227.41000
LogP 2.62370

Synthetic route

: 112885-41-3
mosapride

: 77-92-9
citric acid

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
In ethanol; water at 70 - 75℃; for 0.5h; Temperature;	97.2%
at 80 - 110℃; for 0.5h; Product distribution / selectivity;	95.45%
In ethanol; water at 50℃; for 1h; Solvent; Temperature;	94.7%
In ethanol; water at 20℃; for 2h;	89%

: 112885-34-4
4-acetylamino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide

: 77-92-9
citric acid

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
In methanol; water at 50 - 65℃; Temperature;	88.7%

: (RS)-4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluoro-benzyl)-2-morpholinyl]-methyl}-benzamide dihydrochloride

: 77-92-9
citric acid

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
Stage #1: (RS)-4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluoro-benzyl)-2-morpholinyl]-methyl}-benzamide dihydrochloride With sodium hydroxide In dichloromethane; water for 0.5h; Heating / reflux; Stage #2: citric acid In water at 0℃; for 0.5h; Heating / reflux;	88%

: 112885-41-3
mosapride

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
With citric acid In water at 0℃; Heating / reflux;	86%

: 636582-76-8
(RS)-4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluoro-benzyl)-2-morpholinyl]-methyl}-benzamide trifluoroacetate

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
Stage #1: (RS)-4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluoro-benzyl)-2-morpholinyl]-methyl}-benzamide trifluoroacetate With sodium hydroxide In dichloromethane; water Stage #2: With citric acid In water	83%

: 4-(4-fluorobenzyl)-2-aminomethylmorpholine sulfate

: C13H16ClNO4

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 2: methanol; water / 50 - 65 °C View Scheme

: 4-(4-fluorobenzyl)-2-aminomethylmorpholine hydrochloride

: C13H16ClNO4

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 2: methanol; water / 50 - 65 °C View Scheme

: 4-(4-fluorobenzyl)-2-aminomethylmorpholine phosphate

: C13H16ClNO4

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 2: methanol; water / 50 - 65 °C View Scheme

: C12H17FN2O4S

: C13H16ClNO4

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 2: methanol; water / 50 - 65 °C View Scheme

: 133-10-8
sodium p-aminosalicylate

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: water / 4 h / 45 °C 2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 3: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 80 °C 4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 5: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 5 steps 1: water / 4 h / 45 °C 2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 3: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 80 °C 4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 5: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 5 steps 1: water / 4 h / 45 °C 2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 3: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 80 °C 4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 5: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 5 steps 1: water / 4 h / 45 °C 2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 3: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 80 °C 4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 5: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 5 steps 1: water / 4 h / 45 °C 2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 3: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 80 °C 4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 5: methanol; water / 50 - 65 °C View Scheme

: 50-86-2
4-acetamidosalicylic acid

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 2: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 80 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 4: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 4 steps 1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 2: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 80 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 4: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 4 steps 1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 2: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 80 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 4: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 4 steps 1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 2: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 80 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 4: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 4 steps 1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 2: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 80 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 4: methanol; water / 50 - 65 °C View Scheme

: 459-57-4
4-fluorobenzaldehyde

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: sodium tetrahydroborate / methanol / 4 h / 65 °C 2.1: 3 h / 70 - 80 °C 2.2: 2.5 h / 70 - 145 °C 2.3: 1.5 h 3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 4.1: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 4 steps 1.1: sodium tetrahydroborate / methanol / 4 h / 65 °C 2.1: 3 h / 70 - 80 °C 2.2: 2.5 h / 70 - 145 °C 2.3: 1.5 h 3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 4.1: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 4 steps 1.1: sodium tetrahydroborate / methanol / 4 h / 65 °C 2.1: 3 h / 70 - 80 °C 2.2: 2.5 h / 70 - 145 °C 2.3: 1.5 h 3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 4.1: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 4 steps 1.1: sodium tetrahydroborate / methanol / 4 h / 65 °C 2.1: 3 h / 70 - 80 °C 2.2: 2.5 h / 70 - 145 °C 2.3: 2 h 3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 4.1: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 4 steps 1.1: sodium tetrahydroborate / methanol / 4 h / 65 °C 2.1: 3 h / 70 - 80 °C 2.2: 2.5 h / 70 - 145 °C 3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 4.1: methanol; water / 50 - 65 °C View Scheme

: 2486-67-1
4-acetylamino-2-ethoxy-benzoic acid ethyl ester

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 80 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 3: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 3 steps 1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 80 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 3: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 3 steps 1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 80 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 3: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 3 steps 1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 80 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 3: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 3 steps 1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 80 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 3: methanol; water / 50 - 65 °C View Scheme

: C13H16ClNO4

: 112914-13-3
2-aminomethyl-4-(4-fluoro-benzyl) morpholine

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 2: methanol; water / 50 - 65 °C View Scheme

: 22116-33-2
2-(4-fluoro-benzyl-amino)-ethanol

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: 3 h / 70 - 80 °C 1.2: 2.5 h / 70 - 145 °C 1.3: 1.5 h 2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 3.1: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 3 steps 1.1: 3 h / 70 - 80 °C 1.2: 2.5 h / 70 - 145 °C 1.3: 1.5 h 2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 3.1: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 3 steps 1.1: 3 h / 70 - 80 °C 1.2: 2.5 h / 70 - 145 °C 1.3: 1.5 h 2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 3.1: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 3 steps 1.1: 3 h / 70 - 80 °C 1.2: 2.5 h / 70 - 145 °C 1.3: 2 h 2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 3.1: methanol; water / 50 - 65 °C View Scheme
Multi-step reaction with 3 steps 1.1: 3 h / 70 - 80 °C 1.2: 2.5 h / 70 - 145 °C 2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 1 h / -10 - -5 °C 3.1: methanol; water / 50 - 65 °C View Scheme

: 392-09-6
2-fluoro-4-nitro-benzoic acid methyl ester

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: ethanol / 4 h / 40 °C 2: iron(III) chloride; N-chloro-succinimide / N,N-dimethyl-formamide / 4 h / 50 °C 3: N,N-dimethyl-formamide / 6 h / 100 °C 4: iron; ammonium chloride / ethanol; water / 5 h / Reflux 5: ethanol; water / 2 h / 20 °C View Scheme
Multi-step reaction with 5 steps 1: ethanol / 4 h / 40 °C 2: iron(III) chloride; N-chloro-succinimide / N,N-dimethyl-formamide / 4 h / 50 °C 3: triethylamine / N,N-dimethyl-formamide / 6 h / 100 °C 4: iron; ammonium chloride / ethanol; water / 5 h / Reflux 5: ethanol; water / 2 h / 20 °C View Scheme

: 403-24-7
2-fluoro-4-nitrobenzoic acid

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: sulfuric acid / 4 h / Reflux 2: ethanol / 4 h / 40 °C 3: iron(III) chloride; N-chloro-succinimide / N,N-dimethyl-formamide / 4 h / 50 °C 4: N,N-dimethyl-formamide / 6 h / 100 °C 5: iron; ammonium chloride / ethanol; water / 5 h / Reflux 6: ethanol; water / 2 h / 20 °C View Scheme
Multi-step reaction with 6 steps 1: sulfuric acid / 4 h / Reflux 2: ethanol / 4 h / 40 °C 3: iron(III) chloride; N-chloro-succinimide / N,N-dimethyl-formamide / 4 h / 50 °C 4: triethylamine / N,N-dimethyl-formamide / 6 h / 100 °C 5: iron; ammonium chloride / ethanol; water / 5 h / Reflux 6: ethanol; water / 2 h / 20 °C View Scheme

: 24091-87-0
methyl 2-ethoxy-4-nitrobenzoate

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: iron(III) chloride; N-chloro-succinimide / N,N-dimethyl-formamide / 4 h / 50 °C 2: N,N-dimethyl-formamide / 6 h / 100 °C 3: iron; ammonium chloride / ethanol; water / 5 h / Reflux 4: ethanol; water / 2 h / 20 °C View Scheme
Multi-step reaction with 4 steps 1: iron(III) chloride; N-chloro-succinimide / N,N-dimethyl-formamide / 4 h / 50 °C 2: triethylamine / N,N-dimethyl-formamide / 6 h / 100 °C 3: iron; ammonium chloride / ethanol; water / 5 h / Reflux 4: ethanol; water / 2 h / 20 °C View Scheme

: 2-ethoxy-4-nitro-5-chlorobenzoic acid methyl ester

: 112885-42-4
mosapride citrate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: triethylamine / N,N-dimethyl-formamide / 6 h / 100 °C 2: iron; ammonium chloride / ethanol; water / 5 h / Reflux 3: ethanol; water / 2 h / 20 °C View Scheme
Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide / 6 h / 100 °C 2: iron; ammonium chloride / ethanol; water / 5 h / Reflux 3: ethanol; water / 2 h / 20 °C View Scheme

: 112885-42-4
mosapride citrate

: 112885-41-3
mosapride

: 112885-42-4
mosapride citrate

: 77-92-9
citric acid

A: C27H31ClFN3O9

B: C27H31ClFN3O10

Conditions

Conditions	Yield
at 105℃; for 17h;

...Expand

Mosapride Citrate Specification

The CAS register number of Mosapride Citrate is 112885-42-4. It also can be called as Benzamide, 4-amino-5-chloro-2-ethoxy-N-((4-((4-fluorophenyl)methyl)-2-morpholinyl)methyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) and the IUPAC name about this chemical is 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide; 2-hydroxypropane-1,2,3-tricarboxylic acid. The molecular formula about this chemical is C₂₇H₃₃ClFN₃O₁₀and the molecular weight is 614.02. It belongs to the Gastroprokinetic Agent.

Physical properties about Mosapride Citrate are: (1)ACD/LogP: 2.82; (2)ACD/LogD (pH 5.5): 1.98; (3)ACD/LogD (pH 7.4): 2.79; (4)ACD/BCF (pH 5.5): 11.7; (5)ACD/BCF (pH 7.4): 76.6; (6)ACD/KOC (pH 5.5): 116.16; (7)ACD/KOC (pH 7.4): 760.78; (8)#H bond acceptors: 6; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 8; (11)Polar Surface Area: 45.25Å²; (12)Flash Point: 286 °C; (13)Enthalpy of Vaporization: 82.9 kJ/mol; (14)Boiling Point: 549.2 °C at 760 mmHg; (15)Vapour Pressure: 4.11E-12 mmHg at 25°C.

The Mosapride Citrate is used for functional dyspepsia with heartburn, belching, nausea, vomiting, early satiety, the abdominal distension, gastrointestinal symptoms such as upper abdominal pain. In addition, this chemical can also be used for gastroesophageal reflux disease, diabetic gastroparesis, and gastric resection in patients with dysfunction of the stomach.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)C(O)(CC(=O)O)CC(=O)O.Clc1cc(c(OCC)cc1N)C(=O)NCC3OCCN(Cc2ccc(F)cc2)C3
(2)InChI: InChI=1/C21H25ClFN3O3.C6H8O7/c1-2-28-20-10-19(24)18(22)9-17(20)21(27)25-11-16-13-26(7-8-29-16)12-14-3-5-15(23)6-4-14;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-6,9-10,16H,2,7-8,11-13,24H2,1H3,(H,25,27);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
(3)InChIKey: HUZTYZBFZKRPFG-UHFFFAOYAN
(4)Std. InChI: InChI=1S/C21H25ClFN3O3.C6H8O7/c1-2-28-20-10-19(24)18(22)9-17(20)21(27)25-11-16-13-26(7-8-29-16)12-14-3-5-15(23)6-4-14;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-6,9-10,16H,2,7-8,11-13,24H2,1H3,(H,25,27);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
(5)Std. InChIKey: HUZTYZBFZKRPFG-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 400mg/kg (400mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 3343, 1993.
mouse	LD50	intraperitoneal	914mg/kg (914mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 3343, 1993.
mouse	LD50	oral	> 3gm/kg (3000mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 3343, 1993.
mouse	LD50	subcutaneous	> 1gm/kg (1000mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 3343, 1993.
rat	LD50	intraperitoneal	> 1gm/kg (1000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LIVER: OTHER CHANGES	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 3343, 1993.
rat	LD50	oral	> 3gm/kg (3000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 3343, 1993.
rat	LD50	subcutaneous	> 1gm/kg (1000mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 3343, 1993.

Product Name

Mosapride citrate

Synthetic route

Mosapride Citrate Specification

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