Mycophenolic acid supplier | CasNO.24280-93-1

Name
Mycophenolic acid
EINECS 246-119-3
CAS No. 24280-93-1
Article Data27
CAS DataBase
Density 1.29 g/cm³
Solubility Almost insoluble in cold water. Soluble in alcohol
Melting Point 141 °C
Formula C₁₇H₂₀O₆
Boiling Point 611.6 °C at 760 mmHg
Molecular Weight 320.342
Flash Point 225.8 °C
Transport Information
Appearance White to off-white powder
Safety 53-45-36/37
Risk Codes 22-61-40
Molecular Structure
Hazard Symbols Xn
Synonyms 4-Hexenoic acid,6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-, (E)- (8CI);(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoicacid;Melbex;
PSA 93.06000
LogP 2.73320

Synthetic route

: 32483-51-5
ethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methylhex-4-enoate

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
With lithium hydroxide In methanol for 12h;	98%
With lithium hydroxide In methanol at 23℃; for 5h;	93%
With lithium hydroxide In methanol; water at 25℃; for 1h;	71%

: 31858-66-9
methyl mycophenolate

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
With lithium hydroxide monohydrate In tetrahydrofuran; water at 25℃; for 24h;	96%
With lithium hydroxide In tetrahydrofuran for 3h; Ambient temperature;	85%
With water; lithium hydroxide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;	66%

: 31327-49-8
7-hydroxy-6-[(E)-6-hydroxy-3-methylhex-2-enyl]-5-methoxy-4-methyl-3H-2-benzofuran-1-one

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
With jones reagent In acetone at -30℃; for 5h;	61%

: 50-99-7
D-glucose

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
With manganese(II) sulfate; potassium permanganate; potassium dihydrogenphosphate; L-methionine; Penicillium brevicompactum No. 4-23-11 spores; magnesium sulfate; copper(II) sulfate; iron(II) sulfate; glycine; zinc(II) sulfate In water at 26℃; for 360h; Product distribution; effect of the spore concentration, effect of addition of various adsorbents;
With manganese(II) sulfate; potassium permanganate; potassium dihydrogenphosphate; L-methionine; Celite; Penicillium brevicompactum No. 4-23-11 spores; magnesium sulfate; copper(II) sulfate; iron(II) sulfate; glycine; zinc(II) sulfate In water at 26℃; for 360h; Product distribution; various drug-resistant, methionine or glutamate auxotrophic mutants, effect of L-methionine concentration, effect of L-glutamate concentration;

Yield

With manganese(II) sulfate; potassium permanganate; potassium dihydrogenphosphate; L-methionine; Penicillium brevicompactum No. 4-23-11 spores; magnesium sulfate; copper(II) sulfate; iron(II) sulfate; glycine; zinc(II) sulfate In water at 26℃; for 360h; Product distribution; effect of the spore concentration, effect of addition of various adsorbents;

With manganese(II) sulfate; potassium permanganate; potassium dihydrogenphosphate; L-methionine; Celite; Penicillium brevicompactum No. 4-23-11 spores; magnesium sulfate; copper(II) sulfate; iron(II) sulfate; glycine; zinc(II) sulfate In water at 26℃; for 360h; Product distribution; various drug-resistant, methionine or glutamate auxotrophic mutants, effect of L-methionine concentration, effect of L-glutamate concentration;

: 38877-93-9
7-O-Methylmycophenolic acid

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 189 mg / ethyl acetate 2: BCl3 / CH2Cl2 / 12 h / 20 °C 3: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme
Multi-step reaction with 3 steps 1: ethyl acetate 2: 86 percent / BCl3 / CH2Cl2 / 192 h 3: LiOH / H2O View Scheme

: 60435-90-7
5,7-dimethoxy-6-(5-methoxycarbonyl-3-methyl-2-pentenyl)-4-methylphthalide

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: BCl3 / CH2Cl2 / 12 h / 20 °C 2: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: 86 percent / BCl3 / CH2Cl2 / 192 h 2: LiOH / H2O View Scheme

: 545392-47-0
(E)-6-(4,6-Dimethoxy-7-methyl-3-oxo-1,3-dihydro-isobenzofuran-5-yl)-4-methyl-hex-4-enal

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: Jones reagent / acetone / 4 h / -30 °C 2: 189 mg / ethyl acetate 3: BCl3 / CH2Cl2 / 12 h / 20 °C 4: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme
Multi-step reaction with 4 steps 1: CrO3, acid / acetone / -30 °C 2: ethyl acetate 3: 86 percent / BCl3 / CH2Cl2 / 192 h 4: LiOH / H2O View Scheme

: 207398-37-6
6-((E)-3,7-Dimethyl-octa-2,6-dienyl)-5,7-dimethoxy-4-methyl-3H-isobenzofuran-1-one

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: O3 / methanol / -78 °C 1.2: Me2S / methanol / 3 h / -10 - 20 °C 2.1: Jones reagent / acetone / 4 h / -30 °C 3.1: 189 mg / ethyl acetate 4.1: BCl3 / CH2Cl2 / 12 h / 20 °C 5.1: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme
Multi-step reaction with 6 steps 1: 75.4 percent / NaOAc; m-CPBA / CH2Cl2 / 7 h / -70 °C 2: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C 3: Jones reagent / acetone / 4 h / -30 °C 4: 189 mg / ethyl acetate 5: BCl3 / CH2Cl2 / 12 h / 20 °C 6: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme
Multi-step reaction with 5 steps 1: O3, Me2S / CH2Cl2; pyridine / -78 °C 2: CrO3, acid / acetone / -30 °C 3: ethyl acetate 4: 86 percent / BCl3 / CH2Cl2 / 192 h 5: LiOH / H2O View Scheme

: 207398-36-5
3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-2,4-dimethoxy-5-methyl-benzoic acid methyl ester

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: 100 percent / K2CO3 / methanol / 6 h 2.1: O3 / methanol / -78 °C 2.2: Me2S / methanol / 3 h / -10 - 20 °C 3.1: Jones reagent / acetone / 4 h / -30 °C 4.1: 189 mg / ethyl acetate 5.1: BCl3 / CH2Cl2 / 12 h / 20 °C 6.1: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme
Multi-step reaction with 7 steps 1: 100 percent / K2CO3 / methanol / 6 h 2: 75.4 percent / NaOAc; m-CPBA / CH2Cl2 / 7 h / -70 °C 3: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C 4: Jones reagent / acetone / 4 h / -30 °C 5: 189 mg / ethyl acetate 6: BCl3 / CH2Cl2 / 12 h / 20 °C 7: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme
Multi-step reaction with 6 steps 1: K2CO3 / methanol 2: O3, Me2S / CH2Cl2; pyridine / -78 °C 3: CrO3, acid / acetone / -30 °C 4: ethyl acetate 5: 86 percent / BCl3 / CH2Cl2 / 192 h 6: LiOH / H2O View Scheme

: 207402-09-3
3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-formyl-2,4-dimethoxy-benzoic acid methyl ester

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 9 steps 1.1: 89 percent / NaBH4 / methanol / 0.5 h 2.1: Et3N / CH2Cl2 / 2.5 h / 25 °C 3.1: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C 4.1: 100 percent / K2CO3 / methanol / 6 h 5.1: O3 / methanol / -78 °C 5.2: Me2S / methanol / 3 h / -10 - 20 °C 6.1: Jones reagent / acetone / 4 h / -30 °C 7.1: 189 mg / ethyl acetate 8.1: BCl3 / CH2Cl2 / 12 h / 20 °C 9.1: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme
Multi-step reaction with 10 steps 1: 89 percent / NaBH4 / methanol / 0.5 h 2: Et3N / CH2Cl2 / 2.5 h / 25 °C 3: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C 4: 100 percent / K2CO3 / methanol / 6 h 5: 75.4 percent / NaOAc; m-CPBA / CH2Cl2 / 7 h / -70 °C 6: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C 7: Jones reagent / acetone / 4 h / -30 °C 8: 189 mg / ethyl acetate 9: BCl3 / CH2Cl2 / 12 h / 20 °C 10: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme
Multi-step reaction with 9 steps 1: 89 percent / NaBH4 / methanol 2: Et3N / CH2Cl2 / 1.5 h 3: NaBH4 / dimethylformamide 4: K2CO3 / methanol 5: O3, Me2S / CH2Cl2; pyridine / -78 °C 6: CrO3, acid / acetone / -30 °C 7: ethyl acetate 8: 86 percent / BCl3 / CH2Cl2 / 192 h 9: LiOH / H2O View Scheme

: 207402-10-6
3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-hydroxymethyl-2,4-dimethoxy-benzoic acid methyl ester

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1.1: Et3N / CH2Cl2 / 2.5 h / 25 °C 2.1: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C 3.1: 100 percent / K2CO3 / methanol / 6 h 4.1: O3 / methanol / -78 °C 4.2: Me2S / methanol / 3 h / -10 - 20 °C 5.1: Jones reagent / acetone / 4 h / -30 °C 6.1: 189 mg / ethyl acetate 7.1: BCl3 / CH2Cl2 / 12 h / 20 °C 8.1: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme
Multi-step reaction with 9 steps 1: Et3N / CH2Cl2 / 2.5 h / 25 °C 2: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C 3: 100 percent / K2CO3 / methanol / 6 h 4: 75.4 percent / NaOAc; m-CPBA / CH2Cl2 / 7 h / -70 °C 5: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C 6: Jones reagent / acetone / 4 h / -30 °C 7: 189 mg / ethyl acetate 8: BCl3 / CH2Cl2 / 12 h / 20 °C 9: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme
Multi-step reaction with 8 steps 1: Et3N / CH2Cl2 / 1.5 h 2: NaBH4 / dimethylformamide 3: K2CO3 / methanol 4: O3, Me2S / CH2Cl2; pyridine / -78 °C 5: CrO3, acid / acetone / -30 °C 6: ethyl acetate 7: 86 percent / BCl3 / CH2Cl2 / 192 h 8: LiOH / H2O View Scheme

: 3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-methanesulfonyloxymethyl-2,4-dimethoxy-benzoic acid methyl ester

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1.1: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C 2.1: 100 percent / K2CO3 / methanol / 6 h 3.1: O3 / methanol / -78 °C 3.2: Me2S / methanol / 3 h / -10 - 20 °C 4.1: Jones reagent / acetone / 4 h / -30 °C 5.1: 189 mg / ethyl acetate 6.1: BCl3 / CH2Cl2 / 12 h / 20 °C 7.1: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme
Multi-step reaction with 8 steps 1: 372 mg / NaBH4 / dimethylformamide / 2.5 h / 25 °C 2: 100 percent / K2CO3 / methanol / 6 h 3: 75.4 percent / NaOAc; m-CPBA / CH2Cl2 / 7 h / -70 °C 4: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C 5: Jones reagent / acetone / 4 h / -30 °C 6: 189 mg / ethyl acetate 7: BCl3 / CH2Cl2 / 12 h / 20 °C 8: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme
Multi-step reaction with 7 steps 1: NaBH4 / dimethylformamide 2: K2CO3 / methanol 3: O3, Me2S / CH2Cl2; pyridine / -78 °C 4: CrO3, acid / acetone / -30 °C 5: ethyl acetate 6: 86 percent / BCl3 / CH2Cl2 / 192 h 7: LiOH / H2O View Scheme

: 545392-50-5
6-[5-(3,3-dimethyl-oxiranyl)-3-methyl-pent-2-enyl]-5,7-dimethoxy-4-methyl-3H-isobenzofuran-1-one

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: HIO4*2H2O / diethyl ether; tetrahydrofuran / 1 h / 0 °C 2: Jones reagent / acetone / 4 h / -30 °C 3: 189 mg / ethyl acetate 4: BCl3 / CH2Cl2 / 12 h / 20 °C 5: 92 mg / LiOH / methanol; H2O / 6 h / 20 °C View Scheme

: 207398-35-4
3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6-(2,2-dimethyl-propionyloxymethyl)-5-formyl-2,4-dihydroxy-benzoic acid methyl ester

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 10 steps 1: 88 percent / NaH / dimethylformamide 2: 89 percent / NaBH4 / methanol 3: Et3N / CH2Cl2 / 1.5 h 4: NaBH4 / dimethylformamide 5: K2CO3 / methanol 6: O3, Me2S / CH2Cl2; pyridine / -78 °C 7: CrO3, acid / acetone / -30 °C 8: ethyl acetate 9: 86 percent / BCl3 / CH2Cl2 / 192 h 10: LiOH / H2O View Scheme

: 24953-96-6
(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)acetaldehyde

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 86 percent / N,N-diisopropylethylamine / CH2Cl2 / 2 h / Ambient temperature 2: 67 percent / tetrahydrofuran / 0.67 h / -40 °C 3: pivalic acid / xylene / 6 h / 135 - 140 °C 4: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C 5: 98 percent / aq. LiOH / methanol / 12 h View Scheme

: 193277-88-2
4-Hydroxy-2-methoxy-5-methyl-3,6-dihydro-2H-benzo[2,1-b;3,4-c']difuran-8-one

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 1.) NaH / 1.) DMF, 0 ged C, 15 min, 2.) DMF, a) 0 deg C, 30 min, b) RT, 30 min 2: 100 percent / 89percent formic acid / 0.33 h / Ambient temperature 3: 86 percent / N,N-diisopropylethylamine / CH2Cl2 / 2 h / Ambient temperature 4: 67 percent / tetrahydrofuran / 0.67 h / -40 °C 5: pivalic acid / xylene / 6 h / 135 - 140 °C 6: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C 7: 98 percent / aq. LiOH / methanol / 12 h View Scheme

Yield

Multi-step reaction with 7 steps
1: 1.) NaH / 1.) DMF, 0 ged C, 15 min, 2.) DMF, a) 0 deg C, 30 min, b) RT, 30 min
2: 100 percent / 89percent formic acid / 0.33 h / Ambient temperature
3: 86 percent / N,N-diisopropylethylamine / CH2Cl2 / 2 h / Ambient temperature
4: 67 percent / tetrahydrofuran / 0.67 h / -40 °C
5: pivalic acid / xylene / 6 h / 135 - 140 °C
6: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C
7: 98 percent / aq. LiOH / methanol / 12 h
View Scheme

: 193277-77-9
2,4-Dimethoxy-5-methyl-3,6-dihydro-2H-benzo[2,1-b;3,4-c']difuran-8-one

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 100 percent / 89percent formic acid / 0.33 h / Ambient temperature 2: 86 percent / N,N-diisopropylethylamine / CH2Cl2 / 2 h / Ambient temperature 3: 67 percent / tetrahydrofuran / 0.67 h / -40 °C 4: pivalic acid / xylene / 6 h / 135 - 140 °C 5: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C 6: 98 percent / aq. LiOH / methanol / 12 h View Scheme

: 172151-14-3
[6-methoxy-4-(2-methoxyethoxymethoxy)-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl]-acetaldehyde

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 67 percent / tetrahydrofuran / 0.67 h / -40 °C 2: pivalic acid / xylene / 6 h / 135 - 140 °C 3: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C 4: 98 percent / aq. LiOH / methanol / 12 h View Scheme

: 193277-85-9
6-(2-hydroxy-3-methylbut-3-enyl)-5-methoxy-7-(2-methoxyethoxymethoxy)-4-methyl-3H-isobenzofuran-2-one

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: pivalic acid / xylene / 6 h / 135 - 140 °C 2: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C 3: 98 percent / aq. LiOH / methanol / 12 h View Scheme

: (E)-6-[6-Methoxy-4-(2-methoxy-ethoxymethoxy)-7-methyl-3-oxo-1,3-dihydro-isobenzofuran-5-yl]-4-methyl-hex-4-enoic acid ethyl ester

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C 2: 98 percent / aq. LiOH / methanol / 12 h View Scheme

: 24282-61-9
7-hydroxy-5-methoxy-4-methylisobenzofuran-1(3H)-one

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 79 percent / benzyl trimethyl ammonium dichloroiodate, NaHCO3 / CH2Cl2; methanol / Ambient temperature 2: 86 percent / iPr2NEt / CH2Cl2 / 1.5 h 3: 53 percent / Pd(dba)2, AsPh3, NMP / 4 h / 100 °C 4: 88 percent / H2SO4 / methanol; tetrahydrofuran / 0.75 h / Ambient temperature 5: 85 percent / LiOH*H2O / tetrahydrofuran / 3 h / Ambient temperature View Scheme
Multi-step reaction with 3 steps 1: N-iodo-succinimide / N,N-dimethyl-formamide / 10 h / 25 °C 2: tetrakis(triphenylphosphine) palladium(0); triphenylphosphine / N,N-dimethyl-formamide / 16 h / 20 - 100 °C / Inert atmosphere 3: lithium hydroxide monohydrate / water; tetrahydrofuran / 24 h / 25 °C View Scheme
Multi-step reaction with 3 steps 1: N-iodo-succinimide / N,N-dimethyl-formamide / 10 h / 25 °C 2: triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 24 h / 100 °C 3: lithium hydroxide monohydrate / water; tetrahydrofuran / 24 h / 25 °C View Scheme

: 188291-73-8
7-hydroxy-6-iodo-5-methoxy-4-methylisobenzofuran-1(3H)-one

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 86 percent / iPr2NEt / CH2Cl2 / 1.5 h 2: 53 percent / Pd(dba)2, AsPh3, NMP / 4 h / 100 °C 3: 88 percent / H2SO4 / methanol; tetrahydrofuran / 0.75 h / Ambient temperature 4: 85 percent / LiOH*H2O / tetrahydrofuran / 3 h / Ambient temperature View Scheme

: 188291-75-0
6-Iodo-5-methoxy-4-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-3H-isobenzofuran-1-one

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 53 percent / Pd(dba)2, AsPh3, NMP / 4 h / 100 °C 2: 88 percent / H2SO4 / methanol; tetrahydrofuran / 0.75 h / Ambient temperature 3: 85 percent / LiOH*H2O / tetrahydrofuran / 3 h / Ambient temperature View Scheme

: 188291-78-3
(E)-6-[6-Methoxy-7-methyl-3-oxo-4-(2-trimethylsilanyl-ethoxymethoxy)-1,3-dihydro-isobenzofuran-5-yl]-4-methyl-hex-4-enoic acid methyl ester

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 88 percent / H2SO4 / methanol; tetrahydrofuran / 0.75 h / Ambient temperature 2: 85 percent / LiOH*H2O / tetrahydrofuran / 3 h / Ambient temperature View Scheme

: 138768-43-1
Ethyl E-6-<1,3-Dihydro-4-(tert-butyldimethylsilyloxy)-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl>-4-methyl-4-hexenoate

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 98 percent / nBu4NF / tetrahydrofuran / 1 h 2: 93 percent / aq. LiOH / methanol / 5 h / 23 °C View Scheme
Multi-step reaction with 2 steps 1: 83 percent / n-Bu4NF / tetrahydrofuran / 0.25 h / 25 °C 2: 71 percent / LiOH / methanol; H2O / 1 h / 25 °C View Scheme

: 35334-60-2
(E)-6-acetoxy-4-methyl-4-hexenal

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 9 steps 1: 84 percent / NaBH4 / ethanol / 0.42 h / 25 °C 2: triethylamine / 4-(dimethylamino)pyridine / CH2Cl2 / 20 h / Ambient temperature 3: K2CO3 / methanol / 24 h / Ambient temperature 4: 1.) n-BuLi, 2.) methanesulfonyl chloride, 3.) Li2CuCl4 / 1.) THF/n-hexane, -78 deg C, 35 min, 2.) -78 deg C, 2 h, 3.) THF/n-hexane/diethyl ether -78 deg C to room temp. over 2.5 h then 25 deg C, 3 h 5: 73 percent / benzene / 14 h / 120 °C / in a sealed tube 6: 85 percent / Br2, tert butylamine / toluene / 4 h / -78 - 5 °C 7: 1.) CH3Li, LiBr, 2.) tert-BuLi / 1.) diethyl ether, 50 min, 2.) diethyl ether/pentane, -78 deg C, 1 h, 3.) -78 to 0 deg C, 30 min 8: conc. HCl / methanol / 4.5 h / Heating 9: 61 percent / Jones reagent / acetone / 5 h / -30 °C View Scheme

Yield

Multi-step reaction with 9 steps
1: 84 percent / NaBH4 / ethanol / 0.42 h / 25 °C
2: triethylamine / 4-(dimethylamino)pyridine / CH2Cl2 / 20 h / Ambient temperature
3: K2CO3 / methanol / 24 h / Ambient temperature
4: 1.) n-BuLi, 2.) methanesulfonyl chloride, 3.) Li2CuCl4 / 1.) THF/n-hexane, -78 deg C, 35 min, 2.) -78 deg C, 2 h, 3.) THF/n-hexane/diethyl ether -78 deg C to room temp. over 2.5 h then 25 deg C, 3 h
5: 73 percent / benzene / 14 h / 120 °C / in a sealed tube
6: 85 percent / Br2, tert butylamine / toluene / 4 h / -78 - 5 °C
7: 1.) CH3Li, LiBr, 2.) tert-BuLi / 1.) diethyl ether, 50 min, 2.) diethyl ether/pentane, -78 deg C, 1 h, 3.) -78 to 0 deg C, 30 min
8: conc. HCl / methanol / 4.5 h / Heating
9: 61 percent / Jones reagent / acetone / 5 h / -30 °C
View Scheme

: 100045-79-2
<(2E)-6-Hydroxy-3-methyl-2-hexenyl>acetat

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1: triethylamine / 4-(dimethylamino)pyridine / CH2Cl2 / 20 h / Ambient temperature 2: K2CO3 / methanol / 24 h / Ambient temperature 3: 1.) n-BuLi, 2.) methanesulfonyl chloride, 3.) Li2CuCl4 / 1.) THF/n-hexane, -78 deg C, 35 min, 2.) -78 deg C, 2 h, 3.) THF/n-hexane/diethyl ether -78 deg C to room temp. over 2.5 h then 25 deg C, 3 h 4: 73 percent / benzene / 14 h / 120 °C / in a sealed tube 5: 85 percent / Br2, tert butylamine / toluene / 4 h / -78 - 5 °C 6: 1.) CH3Li, LiBr, 2.) tert-BuLi / 1.) diethyl ether, 50 min, 2.) diethyl ether/pentane, -78 deg C, 1 h, 3.) -78 to 0 deg C, 30 min 7: conc. HCl / methanol / 4.5 h / Heating 8: 61 percent / Jones reagent / acetone / 5 h / -30 °C View Scheme

Yield

Multi-step reaction with 8 steps
1: triethylamine / 4-(dimethylamino)pyridine / CH2Cl2 / 20 h / Ambient temperature
2: K2CO3 / methanol / 24 h / Ambient temperature
3: 1.) n-BuLi, 2.) methanesulfonyl chloride, 3.) Li2CuCl4 / 1.) THF/n-hexane, -78 deg C, 35 min, 2.) -78 deg C, 2 h, 3.) THF/n-hexane/diethyl ether -78 deg C to room temp. over 2.5 h then 25 deg C, 3 h
4: 73 percent / benzene / 14 h / 120 °C / in a sealed tube
5: 85 percent / Br2, tert butylamine / toluene / 4 h / -78 - 5 °C
6: 1.) CH3Li, LiBr, 2.) tert-BuLi / 1.) diethyl ether, 50 min, 2.) diethyl ether/pentane, -78 deg C, 1 h, 3.) -78 to 0 deg C, 30 min
7: conc. HCl / methanol / 4.5 h / Heating
8: 61 percent / Jones reagent / acetone / 5 h / -30 °C
View Scheme

: 100045-80-5
(E)-6-((tert-butyldimethylsilyl)oxy)-3-methylhex-2-en-1-yl acetate

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: K2CO3 / methanol / 24 h / Ambient temperature 2: 1.) n-BuLi, 2.) methanesulfonyl chloride, 3.) Li2CuCl4 / 1.) THF/n-hexane, -78 deg C, 35 min, 2.) -78 deg C, 2 h, 3.) THF/n-hexane/diethyl ether -78 deg C to room temp. over 2.5 h then 25 deg C, 3 h 3: 73 percent / benzene / 14 h / 120 °C / in a sealed tube 4: 85 percent / Br2, tert butylamine / toluene / 4 h / -78 - 5 °C 5: 1.) CH3Li, LiBr, 2.) tert-BuLi / 1.) diethyl ether, 50 min, 2.) diethyl ether/pentane, -78 deg C, 1 h, 3.) -78 to 0 deg C, 30 min 6: conc. HCl / methanol / 4.5 h / Heating 7: 61 percent / Jones reagent / acetone / 5 h / -30 °C View Scheme

Yield

Multi-step reaction with 7 steps
1: K2CO3 / methanol / 24 h / Ambient temperature
2: 1.) n-BuLi, 2.) methanesulfonyl chloride, 3.) Li2CuCl4 / 1.) THF/n-hexane, -78 deg C, 35 min, 2.) -78 deg C, 2 h, 3.) THF/n-hexane/diethyl ether -78 deg C to room temp. over 2.5 h then 25 deg C, 3 h
3: 73 percent / benzene / 14 h / 120 °C / in a sealed tube
4: 85 percent / Br2, tert butylamine / toluene / 4 h / -78 - 5 °C
5: 1.) CH3Li, LiBr, 2.) tert-BuLi / 1.) diethyl ether, 50 min, 2.) diethyl ether/pentane, -78 deg C, 1 h, 3.) -78 to 0 deg C, 30 min
6: conc. HCl / methanol / 4.5 h / Heating
7: 61 percent / Jones reagent / acetone / 5 h / -30 °C
View Scheme

: 100045-81-6
(E)-3-methyl-6-<(tert-butyldimethylsilyl)oxy>-2-hexen-1-ol

: 24280-93-1
mycophenolic acid

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 1.) n-BuLi, 2.) methanesulfonyl chloride, 3.) Li2CuCl4 / 1.) THF/n-hexane, -78 deg C, 35 min, 2.) -78 deg C, 2 h, 3.) THF/n-hexane/diethyl ether -78 deg C to room temp. over 2.5 h then 25 deg C, 3 h 2: 73 percent / benzene / 14 h / 120 °C / in a sealed tube 3: 85 percent / Br2, tert butylamine / toluene / 4 h / -78 - 5 °C 4: 1.) CH3Li, LiBr, 2.) tert-BuLi / 1.) diethyl ether, 50 min, 2.) diethyl ether/pentane, -78 deg C, 1 h, 3.) -78 to 0 deg C, 30 min 5: conc. HCl / methanol / 4.5 h / Heating 6: 61 percent / Jones reagent / acetone / 5 h / -30 °C View Scheme

Yield

Multi-step reaction with 6 steps
1: 1.) n-BuLi, 2.) methanesulfonyl chloride, 3.) Li2CuCl4 / 1.) THF/n-hexane, -78 deg C, 35 min, 2.) -78 deg C, 2 h, 3.) THF/n-hexane/diethyl ether -78 deg C to room temp. over 2.5 h then 25 deg C, 3 h
2: 73 percent / benzene / 14 h / 120 °C / in a sealed tube
3: 85 percent / Br2, tert butylamine / toluene / 4 h / -78 - 5 °C
4: 1.) CH3Li, LiBr, 2.) tert-BuLi / 1.) diethyl ether, 50 min, 2.) diethyl ether/pentane, -78 deg C, 1 h, 3.) -78 to 0 deg C, 30 min
5: conc. HCl / methanol / 4.5 h / Heating
6: 61 percent / Jones reagent / acetone / 5 h / -30 °C
View Scheme

: 67-56-1
methanol

: 24280-93-1
mycophenolic acid

: 31858-66-9
methyl mycophenolate

Conditions

Conditions	Yield
With sulfuric acid for 2h; Heating;	100%
With sulfuric acid for 20h; Ambient temperature;	95%
With toluene-4-sulfonic acid for 2h; Reflux;	95.86%

: 24280-93-1
mycophenolic acid

: sodium mycophenolate

Conditions

Conditions	Yield
With sodium methylate In methanol; ethyl acetate at 20℃; for 1h; Product distribution / selectivity; Charcoal;	97%
With sodium methylate In methanol; ethyl acetate at 20℃; for 0.5h; Product distribution / selectivity;	94%
With sodium methylate In methanol; ISOPROPYLAMIDE at 20℃; for 0.166667h; Product distribution / selectivity;	92%

: 24280-93-1
mycophenolic acid

: 100-39-0
benzyl bromide

: 1186295-41-9
benzyl (4-O-benzyl)mycophenolate

Conditions

Conditions	Yield
With trimethylbenzylammonium bromide; potassium carbonate In N,N-dimethyl-formamide at 20℃; for 17h;	96%

: 24280-93-1
mycophenolic acid

: 106-95-6
allyl bromide

: (E)-allyl 6-(4-(allyloxy)-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 20℃; for 18h;	93%

: 64-17-5
ethanol

: 24280-93-1
mycophenolic acid

: 32483-51-5
ethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methylhex-4-enoate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid for 2h; Reflux;	92%

: 24280-93-1
mycophenolic acid

A: 26675-76-3
7-hydroxy-5-methoxy-4-methyl-6-(2-(2-methyl-5-oxotetrahydrofuran-2-yl)ethyl)isobenzofuran-1(3H)-one

B: 24243-38-7
mycochromanic acid

Conditions

Conditions	Yield
With sulfuric acid In acetic acid for 4h; Heating;	A 5% B 90%

: 24280-93-1
mycophenolic acid

: trimethylsilyldiazomethane

: 60435-90-7
5,7-dimethoxy-6-(5-methoxycarbonyl-3-methyl-2-pentenyl)-4-methylphthalide

Conditions

Conditions	Yield
In methanol at 20℃; for 12h;	90%

: 645-66-9
lauric anhydride

: 24280-93-1
mycophenolic acid

: 59058-47-8
(E)-6-(1,3-dihydro-4-dodecanoyloxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid

Conditions

Conditions	Yield
With pyridine; dmap at 20℃; for 120h;	90%

: 24280-93-1
mycophenolic acid

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1451181-22-8
(E)-6-(4-tert-butyldimethylsilyloxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide for 1h; Inert atmosphere;	89%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 88h;	60%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 24280-93-1
mycophenolic acid

: C21H23NO8

Conditions

Conditions	Yield
Stage #1: 1-hydroxy-pyrrolidine-2,5-dione; mycophenolic acid In acetonitrile Cooling with ice; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile for 24.5h;	89%

: 24280-93-1
mycophenolic acid

: 31858-65-8
nor-O-methylmycophenolic acid

Conditions

Conditions	Yield
With lithium iodide	88.5%
With pyridine; 2,3,5-trimethyl-pyridine; lithium iodide at 120℃; for 18h;	74%

: 24280-93-1
mycophenolic acid

: 5680-79-5
glycine ethyl ester hydrochloride

: methyl ester N-mycophenoylglycine

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 50h;	86%

: 24280-93-1
mycophenolic acid

: 362-75-4
2',3'-isopropylidene adenosine

: 1532533-29-1
C30H35N5O9

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine Inert atmosphere;	86%

: 24280-93-1
mycophenolic acid

: 75-64-9
tert-butylamine

: 1000853-04-2
6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid t-butylamine salt

Conditions

Conditions	Yield
In ethyl acetate at 22 - 60℃; for 1h; Product distribution / selectivity;	85.6%

: 622-40-2
2-(morpholin-4-yl)ethanol

: 24280-93-1
mycophenolic acid

: 115007-34-6
mycophenolate mofetil

Conditions

Conditions	Yield
toluene-4-sulfonic acid at 160℃; for 5h; Product distribution / selectivity;	84%
(1S)-10-camphorsulfonic acid at 150 - 155℃; for 8h; Product distribution / selectivity;	84%
at 160℃; for 5h; Product distribution / selectivity;	84%

: 24280-93-1
mycophenolic acid

: 263162-13-6
tert-butyl (2-((2-aminoethyl)(methyl)amino)ethyl)carbamate

: 1333040-76-8
(E)-tert-butyl 2-((2-(6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enamido)ethyl)(methyl)amino)ethylcarbamate

Conditions

Conditions	Yield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile at 20℃; for 18h;	84%

: 125074-46-6, 31246-62-5, 31246-63-6, 31246-66-9, 53261-25-9
(OC-6-33)-(diammine)dichloridodihydroxidoplatinum(IV)

: 24280-93-1
mycophenolic acid

: C34H44Cl2N2O12Pt

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide at 40℃; for 60h; Temperature; Darkness;	83.9%

: 24280-93-1
mycophenolic acid

: 108-24-7
acetic anhydride

: 31377-08-9
7-O-Acetylmycophenolic acid

Conditions

Conditions	Yield
With pyridine; dmap at 0℃;	83%
With pyridine; dmap at 20℃;	62%

: 24280-93-1
mycophenolic acid

: 127828-22-2
tert-butyl 2-(2-aminoethoxy)ethylcarbamate

: 1333040-60-0
(E)-tert-butyl 2-(2-(6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enamido)ethoxy)ethylcarbamate

Conditions

Conditions	Yield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile at 20℃; for 18h;	83%

: 24280-93-1
mycophenolic acid

: 31848-65-4
3-(5-Carboxy-3-methyl-pent-2t-enyl)-4-hydroxy-6-hydroxymethyl-2-methoxy-toluol; 6-(6-Hydroxy-4-hydroxymethyl-2-methoxy-3-methyl-phenyl)-4-methyl-hex-4t-ensaeure

Conditions

Conditions	Yield
With lithium hydroxide In water for 96h; Heating;	82%

: 24280-93-1
mycophenolic acid

: α,β-D-glucuronate

: mycophenolic acid-O-acyl-β-D-glucopyranuronoside benzyl ester

Conditions

Conditions	Yield
Stage #1: mycophenolic acid; α,β-D-glucuronate With 4-methyl-morpholine In acetonitrile at 20℃; for 2h; Molecular sieve; Inert atmosphere; Stage #2: With 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate In acetonitrile at 20℃; for 3h; Inert atmosphere; Molecular sieve;	82%

: 24280-93-1
mycophenolic acid

: 5845-53-4, 6322-53-8, 7517-19-3
(R)-leucine methyl ester hydrochloride

: methyl ester N-mycophenoyl-D-leucine

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 50h;	81%

: 24280-93-1
mycophenolic acid

: 106-96-7
propargyl bromide

: prop-2-yn-1-yl (E)-6-(6-methoxy-7-methyl-3-oxo-4-(prop-2-yn-1-yloxy)-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene; acetonitrile at 20℃; for 48h;	81%

: 24280-93-1
mycophenolic acid

: 320-51-4
4-chloro-3-trifluoromethyl-aniline

: (E)-N-(4-chloro-3-(trifluoromethyl)phenyl)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enamide

Conditions

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;	80%

: 24280-93-1
mycophenolic acid

: 121-44-8
triethylamine

: 66341-85-3
6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid triethylamine salt

Conditions

Conditions	Yield
In ethyl acetate at 10 - 60℃; for 1h; Product distribution / selectivity;	78.7%
In ethyl acetate for 0.5h;

: 24280-93-1
mycophenolic acid

: 14316-06-4
D-alanine methyl ester hydrochloride

: methyl ester N-mycophenoyl-D-alanine

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 50h;	77%

: 24720-64-7
2-(triphenylphosphoranylidene)propionaldehyde

: 24280-93-1
mycophenolic acid

: 24280-92-0
(E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-2-methylbut-2-enal

Conditions

Conditions	Yield
Stage #1: mycophenolic acid With osmium(VIII) oxide; 4-methylmorpholine N-oxide In tetrahydrofuran; water; acetone at 20℃; for 1.5h; Stage #2: 2-(triphenylphosphoranylidene)propionaldehyde In benzene at 90℃; for 24h; Inert atmosphere;	77%

: 24280-93-1
mycophenolic acid

: 75-31-0
isopropylamine

: 1000853-03-1
6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid isopropylamine salt

Conditions

Conditions	Yield
In ethyl acetate at 11 - 55℃; for 2h;	75.1%

Mycophenolic acid Chemical Properties

Molecular Structure of Mycophenolic acid (CAS NO.24280-93-1):

CAS Number: 24280-93-1
Molecular Formula: C₁₇H₂₀O₆
Molecular Weight: 320.37
H bond acceptors: 6
H bond donors: 2
Freely Rotating Bonds: 7
Polar Surface Area: 71.06 Å²EINECS: 246-119-3
Density: 1.29 g/cm³
Melting Point: 141^oC
Boiling Point: 611.6^oC at 760 mmHg
Flash Point: 225.8^oC
Solubility: Almost insoluble in cold water. Soluble in alcohol
Appearance: White to off-white powder
Properties: Needles from hot water.
Storage temp: 2-8^oC
Solubility:methanol: 50 mg/mL, clear, colorless to faintly yellow
Form: powder
Merck: 13,6352
Product Categories: Active Pharmaceutical Ingredients; Aromatics Compounds; Aromatics; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals
InChI
InChI=1/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
Smiles
c12c(c(c(C\C=C(\CCC(O)=O)C)c(c1C)OC)O)C(=O)OC2

Mycophenolic acid Toxicity Data With Reference

1.	dni-mus:lym 200 nmol/L	CNREA8 Cancer Research. 45 (1985),5512.
2.	oms-mus:lym 400 nmol/L	CNREA8 Cancer Research. 45 (1985),5512.
3.	orl-rat LD50:352 mg/kg	TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. 29 (1982),400.
4.	ivn-rat LD50:450 mg/kg	PMDCAY Progress in Medical Chemistry. 9 (1973),1.
5.	ipr-rat LD50:220 mg/kg	TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. 29 (1982),400.
6.	scu-rat LD50:230 mg/kg	TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. 29 (1982),400.
7.	orl-mus LDLo:1000 mg/kg	85GDA2 CRC Handbook of Antibiotic Compounds, Volumes 1-9. 5 (1981),445.
8.	ipr-mus LD50:505 mg/kg	TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. 29 (1982),400.
9.	ivn-mus LDLo:500 mg/kg	85ERAY Antibiotics: Origin, Nature, and Properties. 3 (1978),1740.

Mycophenolic acid Consensus Reports

EPA Genetic Toxicology Program.

Mycophenolic acid Safety Profile

A poison by ingestion and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Information of Mycophenolic acid (CAS NO.24280-93-1):
Hazard Codes: Harmful Xn
Risk Statements: 22-61-40
R22:Harmful if swallowed.
R61:May cause harm to the unborn child.
R40:Limited evidence of a carcinogenic effect.
Safety Statements: 53-45-36/37
S53:Avoid exposure - obtain special instructions before use.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37:Wear suitable protective clothing and gloves.
RIDADR: 2811
WGK Germany: 3
RTECS: MP8050000
F: 10
HazardClass: 6.1(b)
PackingGroup: III

Mycophenolic acid Specification

Mycophenolic acid , with CAS number of 24280-93-1, can be called 6-(1,3-Dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxoisobenzofuran-6-yl)-4-methyl-4-hexanoic acid ; 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid . It is a white to off-white powder. Mycophenolic acid (CAS NO.24280-93-1) is an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleot.

Product Name

Mycophenolic acid

Synthetic route

Mycophenolic acid Chemical Properties

Mycophenolic acid Toxicity Data With Reference

Mycophenolic acid Consensus Reports

Mycophenolic acid Safety Profile

Mycophenolic acid Specification

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