• Name

  ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate

• EINECS 1592732-453-0
• CAS No. 157115-85-0
• Article Data1
• CAS DataBase
• Density 1.202g/cm³
• Solubility
• Melting Point 94.0 to 98.0 °C
• Formula C₁₇H₂₂N₂O₄
• Boiling Point 547.3°Cat760mmHg
• Molecular Weight 318.373
• Flash Point 284.8°C
• Transport Information
• Appearance white powder
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Glycine,1-(phenylacetyl)-L-prolyl-, ethyl ester (9CI);Glycine,N-[1-(phenylacetyl)-L-prolyl]-, ethyl ester;GVS 111;Glycine,1-(2-phenylacetyl)-L-prolyl-, ethyl ester;SGS 111;Glycine, 1-(phenylacetyl)-L-prolyl-, ethyl ester;
• PSA 75.71000
• LogP 1.22820

Synthetic route

623-33-6

glycine ethyl ester hydrochloride

C18H23NO4

157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine In chloroform; N,N-dimethyl-formamide at -5 - 20℃; for 1.5h; Yield given;

2752-38-7

(S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid

157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N-methylmorpholine / CHCl3 / 0.03 h / -10 °C 2: N-methylmorpholine / CHCl3; dimethylformamide / 1.5 h / -5 - 20 °C View Scheme

103-80-0

phenylacetyl chloride

lead (II)-compound of ethanethiol

lead (II)-compound of ethanethiol

157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 86 percent / aq. NaOH / 0.25 h / 0 - 4 °C 2: N-methylmorpholine / CHCl3 / 0.03 h / -10 °C 3: N-methylmorpholine / CHCl3; dimethylformamide / 1.5 h / -5 - 20 °C View Scheme

147-85-3

L-proline

157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 86 percent / aq. NaOH / 0.25 h / 0 - 4 °C 2: N-methylmorpholine / CHCl3 / 0.03 h / -10 °C 3: N-methylmorpholine / CHCl3; dimethylformamide / 1.5 h / -5 - 20 °C View Scheme

74-89-5

methylamine

157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

N-phenylacetyl-L-prolylglycine methylamine

Conditions

Conditions	Yield
In methanol Ambient temperature;	99%

157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

N-phenylacetyl-L-prolylglycine amide

Conditions

Conditions	Yield
With ammonia In methanol Ambient temperature;	95%

157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

157115-95-2

N-phenylacetyl-L-prolylglycine

Conditions

Conditions	Yield
With sodium hydroxide for 3h;	89.9%

157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

N-phenylacetyl-L-prolylglycine dimethylamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 89.9 percent / 1 N aq. NaOH / 3 h 2: ethylmorpholine / dimethylformamide / 0.03 h / -10 °C 3: dimethylformamide / 0.5 h / -5 °C View Scheme

157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

C20H26N2O6

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 89.9 percent / 1 N aq. NaOH / 3 h 2: ethylmorpholine / dimethylformamide / 0.03 h / -10 °C View Scheme

N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester Chemical Properties

N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester Uses