Product Name

  • Name

    N-Methyl-N-(trimethylsilyl)trifluoroacetamide

  • EINECS 246-331-6
  • CAS No. 24589-78-4
  • Density 1.082 g/cm3
  • Solubility reacts with water
  • Melting Point 98-100 °C
  • Formula C6H12F3NOSi
  • Boiling Point 131 °C at 760 mmHg
  • Molecular Weight 199.248
  • Flash Point 28 °C
  • Transport Information UN 1993 3/PG 3
  • Appearance Clear colorless to light yellow liquid
  • Safety 26-36-37/39-16
  • Risk Codes 10-36/37/38
  • Molecular Structure Molecular Structure of 24589-78-4 (N-Methyl-N-(trimethylsilyl)trifluoroacetamide)
  • Hazard Symbols IrritantXi, FlammableF
  • Synonyms 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide;MSTFA;N-Methyl-N-trimethylsilyltrifluoracetamide;NSC 339701;
  • PSA 20.31000
  • LogP 1.84200

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Chemical Properties

The Molecular formula of N-METHYL-N-TRIMETHYLSILYLTRIFLUORO-ACETAMIDE (24589-78-4):C6H12F3NOSi   
The Molecular Weight of N-METHYL-N-TRIMETHYLSILYLTRIFLUORO-ACETAMIDE (24589-78-4):199.25 
The Molecular Structure of N-METHYL-N-TRIMETHYLSILYLTRIFLUORO-ACETAMIDE (24589-78-4) is:
Density:1.082 g/cm3  
Melting point:98-100°
Boiling point:131 °C at 760 mmHg 
Flash point:28 °C    
Solubility in water:reacts
Sensitive:Moisture Sensitive
BRN:1941550
Index of Refraction:1.381 
Molar Refractivity:42.77 cm3 
Molar Volume:184 cm3
Polarizability:16.95 10-24cm3
Surface Tension:19dyne/cm
Enthalpy of Vaporization:36.86 kJ/mol
Vapour Pressure: 9.47 mmHg at 25°C    
Appearance:clear colorless to light yellow liquid
IUPAC Name: 2,2,2-trifluoro-N-methyl-N-trimethylsilylacetamide
Synonyms: N-METHYL-N-TMS-TRIFLUOROACETAMIDE ; N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAMIDE ; N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAMIDE ACTIVATED I ; N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAMIDE ACTIVATED II ; N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAMIDE ACTIVATED III ; N-METHYL-N-(TRIMETHYLSILYL)-2,2,2-TRIFLUOROACETAMIDE ; N-METHYLTRIMETHYLSILYLTRIFLUORACETAMIDE ; 2,2,2-TRIFLUORO-N-METHYL-N-(TRIMETHYLSILYL)-ACETAMIDE
 

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Toxicity Data With Reference

1.    

ipr-mus LDLo:1000 mg/kg

    StoGD#    Personal Communication to NIOSH from Fr. Gary D. Stoner, Dept. of Community Medicine, School of Medicine, University of California, La Jolla, CA 92037, May 25, 1975 27May75 .

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Consensus Reports

Reported in EPA TSCA Inventory.

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Safety Profile

Moderately toxic by intraperitoneal route. When heated to decomposition it emits very toxic fumes of F and NOx.
Hazard Codes:Xi:IrritantF:Highly Flammable
Risk Statements
R10:Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection .
S16:Keep away from sources of ignition - No smoking .
RIDADR:UN 1993 3/PG 3
WGK Germany:3
RTECS:AC9800000
F:10-21
Hazard Note:Flammable
TSCA:T
HazardClass:3
PackingGroup:III

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Specification

Chemical Stability: Moisture sensitive. 
Incompatibilities with Other Materials Strong oxidizing agents, strong oxidizing agents, acids, bases, alcohols, peroxides, alkalies. 
Conditions to Avoid: Incompatible materials, ignition sources, exposure to moist air or water, temperatures above 75°C (167°F).  
Hazardous Decomposition Products Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen fluoride gas, silicon dioxide. 
Hazardous Polymerization Will not occur.  
 

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