Conditions | Yield |
---|---|
With phosphorus trichloride In chlorobenzene at 100 - 130℃; for 0.75h; Microwave irradiation; | 71% |
With phosphorus trichloride 1) xylene, 80 deg C, 10 min; 2) xylene, reflux, 2 h; Multistep reaction; | |
Acylation; |
Conditions | Yield |
---|---|
at 220℃; |
Conditions | Yield |
---|---|
With sodium acetate In N,N-dimethyl-formamide; chlorobenzene at 5 - 50℃; |
naphthol AS-E
Conditions | Yield |
---|---|
With water at 37℃; for 29.2h; Kinetics; |
Conditions | Yield |
---|---|
Stage #1: 1-(p-sulphophenyl)-3-methyl-4-amino-5-pyrazolone With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 1h; Stage #2: naphthol AS-E With sodium carbonate; sodium hydroxide In water at 0 - 5℃; for 4.5h; pH=8 - 9; | 80.72% |
N-tert-butoxycarbonyl-3-aminopropanol
naphthol AS-E
tert-butyl (3-((3-((4-Chlorophenyl)carbamoyl)naphthalen-2-yl)oxy)propyl)carbamate
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; | 78% |
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; | 77% |
naphthol AS-E
11-amino-3-bromo-13H-acenaphtho[1,2-e]pyridazino[3,2-b]quinazoline-13-one
Conditions | Yield |
---|---|
Stage #1: 11-amino-3-bromo-13H-acenaphtho[1,2-e]pyridazino[3,2-b]quinazoline-13-one With hydrogenchloride; sodium nitrite at 0 - 5℃; Stage #2: naphthol AS-E In alkaline aq. solution at 0 - 5℃; | 70% |
oxalyl dichloride
naphthol AS-E
3-(4-chlorophenyl)-2H-naphtho[2,3-e][1,3]oxazine-2,4-(3H)-dione
Conditions | Yield |
---|---|
In para-xylene at 120℃; | 52% |
naphthol AS-E
tert-butyl N-tosyloxycarbamate
3-{[(tert-butoxycarbonyl)amino]oxy}-2-naphthoic acid
Conditions | Yield |
---|---|
Stage #1: naphthol AS-E With potassium hexamethylsilazane In tetrahydrofuran at 0℃; for 0.25h; Stage #2: tert-butyl N-tosyloxycarbamate With n-butyllithium In tetrahydrofuran at -78 - 0℃; | 31% |
2,3-Dichloro-1,4-naphthoquinone
naphthol AS-E
8,13-dioxo-8,13-dihydro-dinaphtho[2,1-b;2',3'-d]furan-6-carboxylic acid-(4-chloro-anilide)
Conditions | Yield |
---|---|
With pyridine |
naphthol AS-E
chloroformic acid ethyl ester
3-(4-chlorophenyl)-2H-naphtho[2,3-e][1,3]oxazine-2,4-(3H)-dione
Conditions | Yield |
---|---|
In pyridine |
naphthol AS-E
Conditions | Yield |
---|---|
With phosphorus pentachloride In 1,4-dioxane at 50℃; for 1h; |
naphthol AS-E
Conditions | Yield |
---|---|
Stage #1: 1,5-diaminoanthraquinone With hydrogenchloride; sodium nitrite Diazotization; Stage #2: naphthol AS-E With sodium acetate Substitution; |
Conditions | Yield |
---|---|
With sodium hydroxide In methanol |
naphthol AS-E
3-{[(tert-butoxycarbonyl)amino]oxy}-2-naphthoic methanesulfonic anhydride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / 0 °C 1.2: -78 - 0 °C 2.1: triethylamine / tetrahydrofuran / 4 h / 0 - 20 °C View Scheme |
naphthol AS-E
tert-butyl {3-[(4-chlorophenyl)carbamoyl]naphthalen-2-yl}oxycarbamate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / 0 °C 1.2: -78 - 0 °C 2.1: triethylamine / tetrahydrofuran / 4 h / 0 - 20 °C 3.1: dmap / toluene / 140 °C / Sealed tube View Scheme |
naphthol AS-E
3-[(tert-butylamino)oxy]-N-(4-chlorophenyl)-2-naphthamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / 0 °C 1.2: -78 - 0 °C 2.1: triethylamine / tetrahydrofuran / 4 h / 0 - 20 °C 3.1: dmap / toluene / 140 °C / Sealed tube 4.1: hydrogenchloride / methanol; diethyl ether; chloroform / 20 °C View Scheme |
naphthol AS-E
3-(3-aminopropoxy)-N-(4-chlorophenyl)-2-naphthamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C 2: hydrogenchloride / diethyl ether; chloroform; methanol / 20 °C View Scheme |
naphthol AS-E
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C 2: hydrogenchloride / diethyl ether; chloroform; methanol / 20 °C 3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
Stage #1: 2-methyl-5-nitroaniline With hydrogenchloride In water at 70℃; for 1h; Stage #2: With sodium nitrite In water for 1.5h; Stage #3: naphthol AS-E Further stages; |
naphthol AS-E
3-(3-aminopropoxy)-N-(4-chlorophenyl)-2-naphthamide hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 2: hydrogenchloride / tetrahydrofuran; water / 20 °C View Scheme |
Product Name: 2-Naphthalenecarboxamide,N-(4-chlorophenyl)-3-hydroxy- (CAS NO.92-78-4)
Molecular Formula: C17H12ClNO2
Molecular Weight: 297.74g/mol
Mol File: 92-78-4.mol
EINECS: 202-189-7
Melting Point: 255°C
Boiling point: 416.5 °C at 760 mmHg
Flash Point: 205.7 °C
Density: 1.399 g/cm3
Surface Tension: 63.8 dyne/cm
Enthalpy of Vaporization: 69.57 kJ/mol
Vapour Pressure: 1.57E-07 mmHg at 25°C
XLogP3-AA: 4.8
H-Bond Donor: 2
H-Bond Acceptor: 2
Structure Descriptors of 2-Naphthalenecarboxamide,N-(4-chlorophenyl)-3-hydroxy- (CAS NO.92-78-4):
IUPAC Name: N-(4-chlorophenyl)-3-hydroxynaphthalene-2-carboxamide
Canonical SMILES: C1=CC=C2C=C(C(=CC2=C1)C(=O)NC3=CC=C(C=C3)Cl)O
InChI: InChI=1S/C17H12ClNO2/c18-13-5-7-14(8-6-13)19-17(21)15-9-11-3-1-2-4-12(11)10-16(15)20/h1-10,20H,(H,19,21)
InChIKey: OHAXNCGNVGGWSO-UHFFFAOYSA-N
Product Categories: Intermediates of Dyes and Pigments; Substrates
2-Naphthalenecarboxamide,N-(4-chlorophenyl)-3-hydroxy- , its CAS NO. is 92-78-4, the synonyms are Acna Naphthol PC ; Amanil Naphthol AS-E ; Azoic Coupling Component 10 ; C.I. 37510 ; C.I. Azoic Coupling Component 10 ; Cibanaphthol RC ; Daito Grounder E ; Hiltonaphthol AS-E ; Naphtanilide E ; Sanatol E ; Tulathol AS-E ; 2-Naphthanilide, 4'-chloro-3-hydroxy- (8CI) ; 4'-Chloro-3-hydroxy-2-naphthanilide .
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