-
Name
NETROPSIN
- EINECS 634-294-2
- CAS No. 1438-30-8
- Density 1.52g/cm3
- Solubility
- Melting Point 171-173℃
- Formula C18H26 N10 O3
- Boiling Point °Cat760mmHg
- Molecular Weight 430.47
- Flash Point °C
- Transport Information
- Appearance
- Safety A poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
- Risk Codes 22
-
Molecular Structure
-
Hazard Symbols
- Synonyms 1H-Pyrrole-2-carboxamide,4-[[[(aminoiminomethyl)amino]acetyl]amino]-N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-1-methyl-(9CI);Congocidine (6CI);N,4'-Bi[pyrrole-2-carboxamide],N'-(2-amidinoethyl)-4-(2-guanidinoacetamido)-1,1'-dimethyl- (7CI,8CI);Congocidin;IA 887;NCI 3067;NSC 3067;Netropsin;Sinanomycin;T 1384;
- PSA 208.93000
- LogP 1.62120
Netropsin Chemical Properties
Product Name: Netropsin
CAS: 1438-30-8
The Molecular formula of Netropsin (CAS NO.1438-30-8): C18H26N10O3
The Molecular Weight of Netropsin (CAS NO.1438-30-8): 430.46
The Molecular Structure of Netropsin (CAS NO.1438-30-8):
Density: 1.52 g/cm3
Index of Refraction: 1.709
Molar Refractivity: 110.37 cm3
Molar Volume: 282.7 cm3
Polarizability: 43.75×10-24cm3
Surface Tension: 69.9 dyne/cm
Appearance: Faint yellow powder
Water Solubility: 1.158e+005 (mg/L) at 25°C
Netropsin Toxicity Data With Reference
| 1. | dnd-omi 200 µmol | EJBCAI European Journal of Biochemistry. 26 (1972),81. | ||
| 2. | dnd-omi 200 µmol | EJBCAI European Journal of Biochemistry. 26 (1972),81. | ||
| 3. | orl-mus LD50: 300 mg/kg | 85ERAY Antibiotics: Origin, Nature, and Properties. 2 (1978),1180. | ||
| 4. | ipr-mus LDLo:50 mg/kg | JAJAAA Journal of Antibiotics, Series A. 9 (1956),102. | ||
| 5. | scu-mus LD50: 70 mg/kg | 85ERAY Antibiotics: Origin, Nature, and Properties. 2 (1978),1180. | ||
| 6. | ivn-mus LD50: 17 mg/kg | 85ERAY Antibiotics: Origin, Nature, and Properties. 2 (1978),1180. |
Netropsin Safety Profile
A poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Safety Information about Netropsin (CAS NO.1438-30-8):
Hazard Codes:
Xn: 
Risk Statements about Netropsin (CAS NO.1438-30-8):
R22: Harmful if swallowed.
Safety Statements about Netropsin (CAS NO.1438-30-8):
S36: Wear suitable protective clothing.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: DW2973000
Netropsin Specification
Netropsin with CAS number of 1438-30-8 is also known as 2814-A ; 4-22-00-06712 (Beilstein Handbook Reference) ; Antibiotic 1142 ; Antibiotic T-1384 ; BRN 0376913 ; CH-777-A ; Congocidin ; Congocidine ; Netropsin ; Sinanomycin .It shoud be storaged at −20°C. Netropsin binds to the minor groove of AT-rich sequences of double stranded DNA . In contrast, Netropsin does not bind single stranded DNA or double stranded RNA. Crystallographic structures of DNA-bound Netropsin have been obtained and elucidate details of how the drug binds in the minor groove . In the bound structure, the drug makes hydrogen bonding interactions with four subsequent base pairs of the DNA duplex, locally displacing the water molecules of the spine of hydration. It has been shown that Netropsin is active both against Gram-positive bacteria and Gram-negative bacteria.
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