Conditions | Yield |
---|---|
In d(4)-methanol; water-d2 Equilibrium constant; |
N-{{7-[bis(carboxymethyl)amino]coumarin-4-yl}methyloxycarbonyl}-L-norepinephrine
A
7-[bis(carboxymethyl)amino]-4-(hydroxymethyl)coumarin
B
carbon dioxide
C
norepinephrine hydrochloride
Conditions | Yield |
---|---|
With potassium hydroxide; HEPES buffer In acetonitrile pH=7.2; Quantum yield; UV-irradiation; |
norepinephrine hydrochloride
4-amino-3,6-disulfo-1,8-naphthaldehyde anhydride dipotassium salt
Conditions | Yield |
---|---|
In water Heating; pH 5, Li(1+)/H(1+) acetate buffer; |
L-Cysteine
norepinephrine hydrochloride
A
7-(1-Hydroxy-2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxylic acid
Conditions | Yield |
---|---|
With phosphate buffer for 0.5h; electro-oxidation reaction; Further byproducts given; |
L-Cysteine
norepinephrine hydrochloride
A
7-(1-Hydroxy-2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxylic acid
Conditions | Yield |
---|---|
With phosphate buffer for 0.5h; electro-oxidation reaction; Further byproducts given; |
L-Cysteine
norepinephrine hydrochloride
A
7-(1-Hydroxy-2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxylic acid
Conditions | Yield |
---|---|
With phosphate buffer for 0.5h; electro-oxidation reaction; Further byproducts given; |
norepinephrine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride for 0.5h; electrochemical oxidation; |
L-Cysteine
norepinephrine hydrochloride
C
(R)-7-[(R)-2-((R)-2-Amino-2-carboxy-ethyldisulfanyl)-1-carboxy-ethylamino]-10-((R)-2-amino-2-carboxy-ethylsulfanyl)-9-hydroxy-1,2,3,6-tetrahydro-4,5-dithia-1,8-diaza-phenanthrene-2-carboxylic acid
Conditions | Yield |
---|---|
pH 7.4; |
Conditions | Yield |
---|---|
In d(4)-methanol; water-d2 Equilibrium constant; Thermodynamic data; |
norepinephrine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 0.1M aq. HCl / 0.5 h / electrochemical oxidation 2: 0.1N HCl View Scheme |
norepinephrine hydrochloride
5-S-Cysteinylepinephrine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 0.1M aq. HCl / 0.5 h / electrochemical oxidation 2: 0.1N HCl View Scheme |
norepinephrine hydrochloride
Conditions | Yield |
---|---|
With triethylamine In chloroform; dimethyl sulfoxide | 110% |
C29H32N2O11
norepinephrine hydrochloride
N-{{7-[bis(tert-butoxycarbonylmethyl)amino]coumarin-4-yl}methyloxycarbonyl}-L-norepinephrine
Conditions | Yield |
---|---|
With dmap In N,N-dimethyl-formamide at 20℃; for 3.5h; | 70 mg |
Conditions | Yield |
---|---|
In water-d2 at 24.84℃; pH=7.1; aq. phosphate buffer; |
norepinephrine hydrochloride
Conditions | Yield |
---|---|
In methanol |
IUPAC Name: [2-(3,4-Dihydroxyphenyl)-2-hydroxyethyl]azanium chloride
Synonyms: 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]-, hydrochloride (1:1) ; 4-[(1R)-2-Amino-1-hydroxyethyl]benzene-1,2-diol hydrochloride (1:1) ; Aktamin hydrochloride ; Levophed hydrochloride
CAS NO:329-56-6
Molecular Formula of Norepinephrine hydrochloride (CAS NO.329-56-6) :C8H12ClNO3
Molecular Weight of Norepinephrine hydrochloride (CAS NO.329-56-6) :205.64
Molecular Structure of Norepinephrine hydrochloride (CAS NO.329-56-6) :
EINECS: 222-395-0
Flash Point: 221.5 °C
Enthalpy of Vaporization: 73.79 kJ/mol
Boiling Point: 442.6 °C at 760 mmHg
Vapour Pressure: 1.3E-08 mmHg at 25°C
Melting point: ~150 °C (dec.)
Storage temp: 2-8°C
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | 5mg/kg (5mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 45, 1950. | |
rat | LD50 | intraduodenal | 26mg/kg (26mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. | |
rat | LD50 | oral | 132mg/kg (132mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. | |
rat | LD50 | subcutaneous | 29mg/kg (29mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. |
Poison by ingestion, subcutaneous, and intraduodenal routes. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also l-NOREPINEPHRINE.
Hazard Codes T,C,F
Risk Statements 25-34-11
R11:Highly flammable.
R25 :Toxic if swallowed.
R34:Causes burns.
Safety Statements 45-36/37/39-26-16
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS DN6475000
F 3-8-10-23
HazardClass 6.1(b)
PackingGroup III
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