Product Name

  • Name

    OXACILLIN

  • EINECS 200-635-5
  • CAS No. 66-79-5
  • Article Data6
  • CAS DataBase
  • Density 1.49±0.1 g/cm3(Predicted)
  • Solubility Soluble
  • Melting Point 188oC
  • Formula C19H19 N3 O5 S
  • Boiling Point 686.8±55.0 °C(Predicted)
  • Molecular Weight 401.443
  • Flash Point
  • Transport Information
  • Appearance white to off white free flowing crystalline powder
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 66-79-5 (OXACILLIN)
  • Hazard Symbols UN NO.
  • Synonyms 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-6-(5-methyl-3-phenyl-4-isoxazolecarboxamido)-7-oxo- (8CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-, [2S-(2a,5a,6b)]-; 5-Methyl-3-phenyl-4-isooxazolylpenicillin;5-Methyl-3-phenyl-4-isoxazolylpenicillin;6-(5-Methyl-3-phenyl-4-isoxazolyl)aminopenicillanic acid; MPI-penicillin;MPi-PC; Oxacillin; Oxazocillin; Oxazocilline; Penicillin,(5-methyl-3-phenyl-4-isoxazolyl)-; Prostaphlyn
  • PSA 138.04000
  • LogP 2.22410

Oxacillin Chemical Properties

Chemistry informtion about Oxacillin (CAS NO.66-79-5) is:
IUPAC Name: (2S,5R,6R)-3,3-Dimethyl-6-[(5-Methyl-3-Phenyl-1,2-Oxazole-4-Carbonyl)Amino]-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid
Synonyms: Oxacillin ; [2s-(2,5,6)]-3,3-Dimethyl-6-(Methyl-3-Phenylisoxaz-4-Ole-Carboxamide-7-Oxy-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid ; (2s,5r,6r)-3,3-Dimethyl-6-[(5-Methyl-3-Phenylisoxazol-4-Yl)Carbonylamino]-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid ; Bactocil ; Oxazina ; Penstapho
MF: C19H19N3O5S
MW: 401.44
EINECS: 200-635-5 
Density: 1.49 g/cm3
Flash Point: 369.2 °C 
Boiling Point: 686.8 °C at 760 mmHg
Vapour Pressure: 8.32E-20 mmHg at 25°C 
Enthalpy of Vaporization: 105.76 kJ/mol
Following is the molecular structure of Oxacillin (CAS NO.66-79-5) is:

Oxacillin Uses

Oxacillin (CAS NO.66-79-5) is effective against penicillinase enzymes.Also, it is widely used clinically in the US, but in the UK is only used for laboratory identification of resistant organisms.

Oxacillin Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo intravenous 2550mg/kg/17D (2550mg/kg) blood: agranulocytosis Journal of Pediatrics. Vol. 90, Pg. 668, 1977.
guinea pig LD50 unreported 120mg/kg (120mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(9), Pg. 10, 1977.
infant TDLo intravenous 3800mg/kg/19D (3800mg/kg) blood: agranulocytosis Journal of Pediatrics. Vol. 89, Pg. 769, 1976.
man TDLo intravenous 3800mg/kg/19D (3800mg/kg) blood: agranulocytosis Journal of Pediatrics. Vol. 89, Pg. 769, 1976.
mouse LD50 intravenous 1490mg/kg (1490mg/kg)   Pharmaceutical Chemistry Journal Vol. 1, Pg. 245, 1967.
mouse LD50 oral 6500mg/kg (6500mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 95, 1982.
mouse LD50 unreported 28gm/kg (28000mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(9), Pg. 10, 1977.
rat LD50 unreported 10gm/kg (10000mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(9), Pg. 10, 1977.
women TDLo intravenous 40mg/kg/7H-I (40mg/kg) skin and appendages (skin): "dermatitis, other: after systemic exposure" Annals of Pharmacotherpy. Vol. 33, Pg. 1060, 1999.
women TDLo intravenous 5560mg/kg/20D (5560mg/kg) blood: agranulocytosis Southern Medical Journal. Vol. 70, Pg. 1245, 1977.
women TDLo oral 200mg/kg/10D- (200mg/kg) gastrointestinal: other changes Southern Medical Journal. Vol. 77, Pg. 532, 1984.

Oxacillin Safety Profile

Poison by an unspecified route. Moderately toxic by ingestion and intravenous routes. Human systemic effects: angranulocytosis. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also PENICILLIN; PENICILLIN compounded with CHOLINE CHLORIDE; PENICILLIN G BENETHAMINE; PENICILLIN G EPHEDRINE SALT; PENICILLIN G PROCAINE.

Oxacillin Specification

Oxacillin (CAS NO.66-79-5) is a narrow spectrum beta-lactam antibiotic of the penicillin class.

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