Oxomemazine supplier | CasNO.3689-50-7

Name
Oxomemazine
EINECS 222-996-8
CAS No. 3689-50-7
Density 1.202 g/cm³
Solubility
Melting Point 115°
Formula C₁₈H₂₂N₂O₂S
Boiling Point 492.4 °C at 760 mmHg
Molecular Weight 330.451
Flash Point 251.6 °C
Transport Information
Appearance White crystals powder
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 10-(3-(Dimethylamino)-2-methylpropyl)phenothiazine-5,5-dioxide;10H-Phenothiazine-10-propanamine, N,N,beta-trimethyl-, 5,5-dioxide;3-(5,5-Dioxido-10H-phenothiazin-10-yl)-N,N,2-trimethyl-1-propanamine;Alimemazine S,S-dioxide;
PSA 49.00000
LogP 4.31440

Synthetic route

(+-)-dimethyl-<γ-phenothiazin-10-yl-isobutyl>-amine: (+-)-dimethyl-<γ-phenothiazin-10-yl-isobutyl>-amine

: 3689-50-7
oxomemazine

Conditions

Conditions	Yield
With dihydrogen peroxide

Oxomemazine Specification

Oxomemazine, with the CAS NO.3689-50-7, has the synonyms of 10-(3-(Dimethylamino)-2-methylpropyl)phenothiazine-5,5-dioxide; 10H-Phenothiazine-10-propanamine, N,N,beta-trimethyl-, 5,5-dioxide; 3-(5,5-Dioxido-10H-phenothiazin-10-yl)-N,N,2-trimethyl-1-propanamine; 6487 RP; 6847 R.P.; Alimemazine S,S-dioxide. Oxomemazine is an antihistamine and anticholinergic of the phenothiazine chemical class used for the treatment of cough.

Physical properties about Oxomemazine are: (1)ACD/LogP: 3.977; (2)ACD/LogD (pH 5.5): 0.96; (3)ACD/LogD (pH 7.4): 2.09; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 8.09; (6)ACD/KOC (pH 5.5): 3.30; (7)ACD/KOC (pH 7.4): 45.26; (8)#H bond acceptors: 4; (9)#Freely Rotating Bonds: 4; (10)Index of Refraction: 1.598 ; (11)Molar Refractivity: 93.748 cm³; (12)Molar Volume: 274.936 cm³; (13)Polarizability: 37.165 10-24cm³; (14)Surface Tension: 45.7599983215332 dyne/cm; (15)Density: 1.202 g/cm³; (16)Flash Point: 251.616 °C; (17)Enthalpy of Vaporization: 75.937 kJ/mol; (18)Boiling Point: 492.436 °C at 760 mmHg

You can still convert the following datas into molecular structure:
(1)InChI=1S/C18H22N2O2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)23(21,22)18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3;
(2)InChIKey=QTQPVLDZQVPLGV-UHFFFAOYSA-N;
(3)SmilesCC(CN1c2ccccc2S(=O)(=O)c3c1cccc3)CN(C)C

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	185mg/kg (185mg/kg)	BEHAVIORAL: IRRITABILITY BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 57, Pg. 460, 1961.
mouse	LD50	intravenous	35mg/kg (35mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 135, Pg. 364, 1962.
mouse	LD50	oral	140mg/kg (140mg/kg)		Therapie. Vol. 26, Pg. 1203, 1971.
mouse	LD50	subcutaneous	260mg/kg (260mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 135, Pg. 364, 1962.

Product Name

Oxomemazine

Synthetic route

Oxomemazine Specification

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