PHOSPHORIC ACID, TRIS(TRIMETHYLSILYL) ESTER supplier

Name
TRIS(TRIMETHYLSILYL) PHOSPHATE
EINECS 234-028-1
CAS No. 10497-05-9
Article Data40
CAS DataBase
Density 0.945 g/mL at 25 °C(lit.)
Solubility 935.5μg/L at 20℃
Melting Point 3-4 °C(lit.)
Formula C9H27 O4 P Si3
Boiling Point 228-229 °C720 mm Hg(lit.)
Molecular Weight 314.541
Flash Point 76 °F
Transport Information UN 1993 3
Appearance
Safety Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of PO_x. See also ESTERS.
Risk Codes 11-36/37/38
Molecular Structure
Hazard Symbols FXi
Synonyms Silanol,trimethyl-, phosphate (3:1) (8CI,9CI); Tris(trimethylsiloxy)phosphine oxide;Tris(trimethylsilyl) phosphate
PSA 54.57000
LogP 4.64900

Synthetic route

: 3385-94-2
hexamethyldisilathiane

A: 10497-05-9
Tris(trimethylsilyl) phosphate

B: 20152-28-7
O,O,O-tris(trimethylsilyl) phosphorothioate

Conditions

Conditions	Yield
With phosphorus pentoxide at 170 - 180℃; for 10h;	A 85% B 98%

: potassium dihydrogenphosphate

: 75-77-4
chloro-trimethyl-silane

: 10497-05-9
Tris(trimethylsilyl) phosphate

Conditions

Conditions	Yield
In formamide for 1h; Inert atmosphere; Schlenk technique;	98%

: 107-46-0
Hexamethyldisiloxane

: N-trimethylsilyldihydropyrrole

: 10497-05-9
Tris(trimethylsilyl) phosphate

Conditions

Conditions	Yield
Stage #1: Hexamethyldisiloxane With phosphoric acid at 160 - 170℃; under 4500.45 - 6000.6 Torr; for 5h; Autoclave; Reflux; Stage #2: N-trimethylsilyldihydropyrrole at 100℃; under 760.051 Torr;	96.52%

: 75-77-4
chloro-trimethyl-silane

: 10497-05-9
Tris(trimethylsilyl) phosphate

Conditions

Conditions	Yield
With potassium dihydrogenphosphate In hexane Reflux;	96%
With ammonium dihydrogen phosphate at 78℃; for 3h; Temperature; Reagent/catalyst; Time;	89.6%
With phosphoric acid
With phosphoric acid Schlenk technique; Inert atmosphere;
With phosphoric acid Inert atmosphere;

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

H3PO4: H3PO4

: 10497-05-9
Tris(trimethylsilyl) phosphate

Conditions

Conditions	Yield
With saccharin In acetonitrile for 1h; Heating;	93%

: 14468-90-7
N-trimethylsilyl-pyrrolidin-2-one

: 10497-05-9
Tris(trimethylsilyl) phosphate

Conditions

Conditions	Yield
With lithium dihydrogenphosphate at 20℃; for 1h;	86%

: 53380-41-9
tetrakis(trimethylsiloxy)phosphonium iodide

A: 16029-98-4
trimethylsilyl iodide

B: 10497-05-9
Tris(trimethylsilyl) phosphate

Conditions

Conditions	Yield
In benzene Heating; during 5 h the solvent was distilled off, the temp. rose to 110 deg C;	A n/a B 85%

: 1416767-26-4
C22H50O10P2SSi5

A: 10497-05-9
Tris(trimethylsilyl) phosphate

B: 1416767-27-5
bis(trimethylsilyl) (1,1-dioxido-3Н-2,1-benzoxathiol-3-yl)phosphonate

Conditions

Conditions	Yield
at 90 - 110℃; under 1 Torr;	A n/a B 52%

: 10416-59-8
N,O-bis-(trimethylsilyl)-acetamide

: 10497-05-9
Tris(trimethylsilyl) phosphate

Conditions

Conditions	Yield
With trichlorophosphate at 120℃; for 1h;	26%

: 1795-31-9
tris(trimethylsilyl) phosphite

: 10497-05-9
Tris(trimethylsilyl) phosphate

Conditions

Conditions	Yield
With trityl-glycidol at 130 - 150℃;	24%
With styrene oxide at 130 - 150℃;

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

A: 10497-05-9
Tris(trimethylsilyl) phosphate

B: 18395-45-4
Tetrakis(trimethylsilyl) pyrophosphate

C: 32284-31-4
1,1,3,5,7,7-hexakis(trimethylsilyl) pyrophosphate

D: 1,1,3,5,5-pentakis(trimethylsilyl) pyrophosphate

Conditions

Conditions	Yield
With phosphorus pentoxide at 100 - 140℃; for 2h; Further byproducts given;	A 21% B 6% C 3% D 3%

...Expand

: 1825-61-2
Methoxytrimethylsilane

: 10497-05-9
Tris(trimethylsilyl) phosphate

Conditions

Conditions	Yield
With phosphonic Acid; air

: 107-46-0
Hexamethyldisiloxane

: 10497-05-9
Tris(trimethylsilyl) phosphate

Conditions

Conditions	Yield
With phosphorus pentoxide
With phosphorus pentoxide durch langsame Destillation;
With phosphorus pentoxide In neat (no solvent) very slow distn. of (CH3)3SiOSi(CH3)3 over P2O5;;
With P4O10 In neat (no solvent) very slow distn. of (CH3)3SiOSi(CH3)3 over P2O5;;

: 18291-81-1
phosphoric acid, bis(trimethylsilyl)monomethyl ester

: 4551-15-9
phenylthiotrimethylsilane

: 10497-05-9
Tris(trimethylsilyl) phosphate

Conditions

Conditions	Yield
With perhydrodibenzo-18-crown-6; potassium thiophenolate In benzene

: 17882-98-3
phosphoric acid ethyl ester-bis-trimethylsilanyl ester

: 4551-15-9
phenylthiotrimethylsilane

: 10497-05-9
Tris(trimethylsilyl) phosphate

Conditions

Conditions	Yield
With perhydrodibenzo-18-crown-6; potassium thiophenolate In benzene

: 4551-15-9
phenylthiotrimethylsilane

: Bis-(trimethylsilyl)-n-propyl-phosphat

: 10497-05-9
Tris(trimethylsilyl) phosphate

Conditions

Conditions	Yield
With perhydrodibenzo-18-crown-6; potassium thiophenolate In benzene

: 2754-27-0
trimethylsilyl acetate

: 10497-05-9
Tris(trimethylsilyl) phosphate

Conditions

Conditions	Yield
With phosphorus(V) oxybromide at 90℃; for 3h;

: 107-46-0
Hexamethyldisiloxane

P2O5: P2O5

: 10497-05-9
Tris(trimethylsilyl) phosphate

Conditions

Conditions	Yield
durch langsame Destillation;

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 10497-05-9
Tris(trimethylsilyl) phosphate

Conditions

Conditions	Yield
With ammonium hypophosphite

: 30148-50-6
bis(trimethylsilyl)phosphonite

: 762-72-1
allyl-trimethyl-silane

A: 3663-52-3
bis(trimethylsilyl) phosphonate

B: 10497-05-9
Tris(trimethylsilyl) phosphate

C: 1219077-76-5
trimethylsilyl [3-(trimethylsilyl)propyl]phosphinate

D: 1219077-75-4
bis(trimethylsilyl) [3-(trimethylsilyl)propyl]phosphonate

E: 38049-93-3
trimethylsilylhypophosphite

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); water for 7h; Reflux;	A n/a B 0.1 g C 0.45 g D 0.12 g E n/a

...Expand

: 1795-31-9
tris(trimethylsilyl) phosphite

A: 3663-52-3
bis(trimethylsilyl) phosphonate

B: 10497-05-9
Tris(trimethylsilyl) phosphate

C: 18395-45-4
Tetrakis(trimethylsilyl) pyrophosphate

D: 4414-25-9
Trimethylsilyldifluorophosphat

E: 5668-94-0
bis(trimethylsilyl) phosphorofluoridate

Conditions

Conditions	Yield
With [1,3]-dioxolan-2-one; lithium hexafluorophosphate; water; Diethyl carbonate In [D3]acetonitrile at 20℃; Glovebox; Inert atmosphere;

...Expand

: 1795-31-9
tris(trimethylsilyl) phosphite

A: 3663-52-3
bis(trimethylsilyl) phosphonate

B: 10497-05-9
Tris(trimethylsilyl) phosphate

Conditions

Conditions	Yield
With nickel(II) chloride hexahydrate at 160℃; for 42h; Schlenk technique; Inert atmosphere;

: trimethylgallium

: 10497-05-9
Tris(trimethylsilyl) phosphate

: Me3Ga*OP(OSiMe3)3

Conditions

Conditions	Yield
In hexane N2-atmosphere; addn. of soln. of GaMe3 (10% excess) to phosphate ester soln.; concn., crystd. on cooling (-24°C), collection (filtration), drying (vac.); elem. anal.;	95%

: 10497-05-9
Tris(trimethylsilyl) phosphate

: 420-56-4
trimethylsilyl fluoride

Conditions

Conditions	Yield
With sodium fluoride 150 to 200 deg C;	91.5%

: 10497-05-9
Tris(trimethylsilyl) phosphate

: 942422-03-9
(fluoro)bis(cyclopentadienyl)vanadium

: 1109-15-5
tris(pentafluorophenyl)borate

: C41H29BF15O4PSiV2

Conditions

Conditions	Yield
Stage #1: Tris(trimethylsilyl) phosphate; tris(pentafluorophenyl)borate In dichloromethane at 20℃; for 1h; Inert atmosphere; Glovebox; Stage #2: (fluoro)bis(cyclopentadienyl)vanadium In dichloromethane at 20℃; for 24h; Inert atmosphere; Glovebox;	90%

...Expand

: 10497-05-9
Tris(trimethylsilyl) phosphate

: 4648-54-8
trimethylsilylazide

Conditions

Conditions	Yield
With sodium azide at 150℃; for 0.166667h;	87%

: 10497-05-9
Tris(trimethylsilyl) phosphate

A: 4648-54-8
trimethylsilylazide

B Na3PO4: Na3PO4

Conditions

Conditions	Yield
With sodium azide at 150℃; for 0.166667h; other substrates, other reagents;	A 87% B n/a

: hexaethyldialuminum

: 10497-05-9
Tris(trimethylsilyl) phosphate

: Et3Al*OP(OSiMe3)3

Conditions

Conditions	Yield
In hexane N2-atmosphere; addn. of soln. of AlMe3 (10% excess) to phosphate ester soln. at cooling, warming to room temp.; evapn. (vac.); elem. anal.;	87%

: 3663-52-3
bis(trimethylsilyl) phosphonate

: 10497-05-9
Tris(trimethylsilyl) phosphate

: 6780-49-0
ethyl N-phenylformimidate

: 1227665-11-3
O,O',O'',O'''-tetra(trimethylsilyl) N-anilinomethylenebisphosphonate

Conditions

Conditions	Yield
With zinc(II) chloride at 150 - 160℃; for 1h; Reflux;	86%

...Expand

: 17455-13-9
18-crown-6 ether

: 10497-05-9
Tris(trimethylsilyl) phosphate

: 865-47-4
potassium tert-butylate

: C12H24KO6(1+)*C6H18O4PSi2(1-)

Conditions

Conditions	Yield
In 1,2-dimethoxyethane for 0.166667h;	85%

...Expand

: 10497-05-9
Tris(trimethylsilyl) phosphate

: 1331770-02-5
trimethylsilane adduct of trimethylsilylium tetrakis(pentafluorophenyl)borate

: tetrakis(trimethylsiloxy)phosphonium tetrakis(pentafluorophenyl)borate

Conditions

Conditions	Yield
In toluene for 1h; Sonication;	83%

: 2,2,4,4-tetraethyl-1,3-dichlora(II)-2,4-dialumina(IV)cyclobutane

: 10497-05-9
Tris(trimethylsilyl) phosphate

: [Et2Al(μ-O)2P(OSiMe3)2]2

Conditions

Conditions	Yield
In tetrahydrofuran N2-atmosphere; refluxing for 5 h; elem. anal.;	82%

: dimethylaluminum chloride dimer

: 10497-05-9
Tris(trimethylsilyl) phosphate

: [Me2Al(μ-O)2P(OSiMe3)2]2

Conditions

Conditions	Yield
In tetrahydrofuran N2-atmosphere; refluxing for 5 h; evapn., recrystn. (hexane); elem. anal.;	81%

: trimethylaluminium dimer

: 10497-05-9
Tris(trimethylsilyl) phosphate

: Me3Al*OP(OSiMe3)3

Conditions

Conditions	Yield
In hexane N2-atmosphere; addn. of soln. of AlMe3 (10% excess) to phosphate ester soln. at cooling, warming to room temp.; concn., crystd. on cooling (-24°C), collection (filtration), drying (vac.); elem. anal.;	74%

: bis(bis(trimethylsilyl)amido)zinc(II)

: 10497-05-9
Tris(trimethylsilyl) phosphate

: [Zn{N(SiMe3)2}2OP(OSiMe3)3]

Conditions

Conditions	Yield
In toluene at 20℃; Schlenk technique; Inert atmosphere;	69%

: 10497-05-9
Tris(trimethylsilyl) phosphate

: 7550-45-0
titanium tetrachloride

: Ti2Cl7(O2P(OSi(CH3)3)2)(OP(OSi(CH3)3)3)

Conditions

Conditions	Yield
In further solvent(s) boiling gently soln. of OP(OSi(CH3)3)3 (0.51 mmol) and TiCl4 (0.50 mmol) in ClSi(CH3)3; allowing to cool;; pptn.;;	66%
In benzene-d6 byproducts: ClSi(CH3)3; briefly heating to boiling in benzene-d6;; not isolated, detected by 1H- and 31P-NMR;;

: VOCl3*CH3CN

: 10497-05-9
Tris(trimethylsilyl) phosphate

: (VO)6(O3POSi(CH3)3)8(1+)*Cl(1-)=(VO)6(O3POSi(CH3)3)8Cl

Conditions

Conditions	Yield
In acetonitrile inert atmosphere; crystn. (40-50°C, 4 h, room temp., 2 d); elem. anal.;	59%

: 10497-05-9
Tris(trimethylsilyl) phosphate

: 50307-34-1
tert-butylaluminium dichloride

: [((t)Bu)Al(μ2-O)3P(OSiMe3)]4

Conditions

Conditions	Yield
In tetrahydrofuran dropwise addn. of 1 equiv. P-compd. to Al-compd. (stirring), refluxing for 2 h; vol. reduction (vac.), crystn. (-20°C, overnight); elem. anal.;	56%

: 10497-05-9
Tris(trimethylsilyl) phosphate

: 22086-73-3
bis(tert-butyl)aluminium chloride

: [((t)Bu)2Al(μ2-O)2P(OSiMe3)2]2

Conditions

Conditions	Yield
In tetrahydrofuran dropwise addn. of 1 equiv. P-compd. to Al-compd. (stirring), refluxing for 2 h; vol. reduction (vac.), crystn. (-20°C, overnight); elem. anal.;	56%

: 10497-05-9
Tris(trimethylsilyl) phosphate

: 127-09-3
sodium acetate

: 2754-27-0
trimethylsilyl acetate

Conditions

Conditions	Yield
150 to 200 deg C;	45.5%

: 10497-05-9
Tris(trimethylsilyl) phosphate

: 942422-03-9
(fluoro)bis(cyclopentadienyl)vanadium

: 1109-15-5
tris(pentafluorophenyl)borate

: C48H30BF15O4PV3

Conditions

Conditions	Yield
Stage #1: Tris(trimethylsilyl) phosphate; tris(pentafluorophenyl)borate In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Glovebox; Stage #2: (fluoro)bis(cyclopentadienyl)vanadium In tetrahydrofuran at 20℃; for 48h; Inert atmosphere; Glovebox;	43.2%

...Expand

: 117960-70-0
tris[μ-[2,6-bis(1-methylethyl)benzenaminato]]trimethyltricycloaluminum

: 10497-05-9
Tris(trimethylsilyl) phosphate

: 482315-48-0
(MeAl)[2,6-(i-Pr)2C6H3N]3(Al[OP(OSiMe3)3])2(O3POSiMe3)

Conditions

Conditions	Yield
In toluene under N2 atm. OP(OSiMe3)3 was added dropwise to alumazene in toluene andrefluxed for 24 h; react. mixt. was cooled to room temp.; elem. anal.;	36%

PHOSPHORIC ACID, TRIS(TRIMETHYLSILYL) ESTER Chemical Properties

IUPAC Name: Tris(trimethylsilyl) phosphate
Synonyms: Phosphoric acid tris(trimethylsilyl) ester ; Timtec-bb sbb001292 ; Tris(trimethylsilyl) phosphate ; Ester ; Phosphoric acid, tms ; Phosphoric acid, tristrimethylsilyl ; Phosphoric acid, tritms ; Silanol, trimethyl-, phosphate (3:1)
Product Categories: Si (Classes of Silicon Compounds);Silicon Compounds (for Synthesis);Silyl Esters;Si-O Compounds;Synthetic Organic Chemistry
CAS NO: 10497-05-9
Molecular Formula of Phosphoric acid, tris(trimethylsilyl) ester (CAS NO.10497-05-9) : C₉H₂₇O₄PSi₃
Molecular Weight of Phosphoric acid, tris(trimethylsilyl) ester (CAS NO.10497-05-9) :314.54
Molecular Structure of Phosphoric acid, tris(trimethylsilyl) ester (CAS NO.10497-05-9) :
EINECS: 234-028-1
Mol File: 10497-05-9.mol
Index of Refraction: 1.414
Surface Tension: 20.7 dyne/cm
Density: 0.96 g/cm³
Flash Point: 110.8 °C
Enthalpy of Vaporization: 44.85 kJ/mol
Boiling Point: 230.8 °C at 760 mmHg
Vapour Pressure: 0.0977 mmHg at 25°C
Melting point: 3-4 °C(lit.)

PHOSPHORIC ACID, TRIS(TRIMETHYLSILYL) ESTER Toxicity Data With Reference

orl-rat LD50:3440 mg/kg

MarJV# Personal Communication from Josef V. Marhold, VUOS, 539-18, Pardubice, Czechoslovakia, to the Editor of RTECS, Cincinnati, OH, March 29, 1977 29MAR77 .

PHOSPHORIC ACID, TRIS(TRIMETHYLSILYL) ESTER Consensus Reports

Reported in EPA TSCA Inventory.

PHOSPHORIC ACID, TRIS(TRIMETHYLSILYL) ESTER Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of PO_x. See also ESTERS.
Hazard Codes F, Irritant Xi
Risk Statements 11-36/37/38
R11:Highly flammable.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 16-26-36
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RIDADR UN 1993 3/PG 2
WGK Germany 2
RTECS TC9700000
F 10-21
TSCA Yes
HazardClass 3.2
PackingGroup III

Product Name

TRIS(TRIMETHYLSILYL) PHOSPHATE

Synthetic route

PHOSPHORIC ACID, TRIS(TRIMETHYLSILYL) ESTER Chemical Properties

PHOSPHORIC ACID, TRIS(TRIMETHYLSILYL) ESTER Toxicity Data With Reference

PHOSPHORIC ACID, TRIS(TRIMETHYLSILYL) ESTER Consensus Reports

PHOSPHORIC ACID, TRIS(TRIMETHYLSILYL) ESTER Safety Profile

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