Palmitoyl chloride supplier

Name
Palmitoyl chloride
EINECS 203-996-7
CAS No. 112-67-4
Article Data21
CAS DataBase
Density 0.913 g/cm³
Solubility decompose in water
Melting Point 11-13 °C(lit.)
Formula C₁₆H₃₁ClO
Boiling Point 323.492 °C at 760 mmHg
Molecular Weight 274.875
Flash Point 155.505 °C
Transport Information UN 3265 8/PG 2
Appearance clear liquid
Safety 26-36/37/39-43-45-8
Risk Codes 14-34-29
Molecular Structure
Hazard Symbols C
Synonyms Palmitoylchloride (6CI,7CI,8CI);Hexadecanoic acid chloride;NSC 9854;Palmitic acidchloride;Palmityl acid chloride;
PSA 17.07000
LogP 6.23310

Synthetic route

: 57-10-3
1-hexadecylcarboxylic acid

: 112-67-4
n-hexadecanoyl chloride

Conditions

Conditions	Yield
With thionyl chloride Reflux;	100%
With thionyl chloride In N,N-dimethyl-formamide for 3h; Reflux;	97%
With thionyl chloride; N,N-dimethyl-formamide for 3h; Reflux;	97%

: 112-39-0
hexadecanoic acid methyl ester

A: 74-87-3
methylene chloride

B: 112-67-4
n-hexadecanoyl chloride

C WOCl4: WOCl4

Conditions

Conditions	Yield
With tungsten(VI) chloride In benzene at 20℃; for 90h; Product distribution;

...Expand

: 408-35-5
sodium palmitate

: 112-67-4
n-hexadecanoyl chloride

Conditions

Conditions	Yield
With thionyl chloride at 20℃;

: 79-37-8
oxalyl dichloride

: 57-10-3
1-hexadecylcarboxylic acid

: 112-67-4
n-hexadecanoyl chloride

Conditions

Conditions	Yield
With N,N-dimethyl-formamide In dichloromethane at 20℃; for 1h;
In dichloromethane for 12h; Inert atmosphere;

: 130277-53-1, 130324-58-2
DL-3,4,5,6-Tetra-O-benzyl-3,5/4,6-tetrahydroxycyclohex-1-ene-1-methanol

: 112-67-4
n-hexadecanoyl chloride

: 130277-54-2, 130324-59-3
methyl Hexadecanoate

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane for 2h; Ambient temperature;	100%

: 88110-81-0
9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-2-{[(4-methoxyphenyl)diphenylmethyl]amino}-6,9-dihydro-1H-purin-6-one

: 112-67-4
n-hexadecanoyl chloride

: 88110-83-2
Hexadecanoic acid 3-hexadecanoyloxy-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propyl ester

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane for 20h; Ambient temperature;	100%

: 190505-04-5
1-(2',3',4',6'-tetra-O-benzyl-β-D-glucopyranosyl)-2-hydroxymethyl-3-propanol

: 112-67-4
n-hexadecanoyl chloride

: 190505-07-8
Hexadecanoic acid 2-hexadecanoyloxymethyl-3-((2S,3S,4R,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-propyl ester

Conditions

Conditions	Yield
With dmap In pyridine for 2h; Heating;	100%

: 7,11,15,28-tetrakis(4-aminophenyl)-1,21,23,25-tetraundecyl 2,20:3,19-dimetheno-1H,21H,23H,25H-bis[1,3]dioxocino[5,4-i:5',4'-i']benzo[1,2-d:5,4-d']bis[1,3]benzodioxin

: 112-67-4
n-hexadecanoyl chloride

: 7,11,15,28-tetrakis(4-palmitoylamidophenyl)-1,21,23,25-tetraundecyl 2,20:3,19-dimetheno-1H,21H,23H,25H-bis[1,3]dioxocino[5,4-i:5',4'-i']benzo[1,2-d:5,4-d']bis[1,3]benzodioxin

Conditions

Conditions	Yield
With potassium carbonate In water; ethyl acetate for 2h; Ambient temperature;	100%

: 177898-40-7
N-octyl-2,3:4,6-di-O-isopropylidene-5a-carba-β-D-xylo-hex-5(5a)-enopyranosylamine

: 112-67-4
n-hexadecanoyl chloride

: 218924-27-7
Hexadecanoic acid octyl-((3aS,4R,9aR,9bS)-2,2,8,8-tetramethyl-4,6,9a,9b-tetrahydro-3aH-[1,3]dioxolo[4',5':3,4]benzo[1,2-d][1,3]dioxin-4-yl)-amide

Conditions

Conditions	Yield
In pyridine for 1h; Ambient temperature;	100%

: 123-75-1
pyrrolidine

: 112-67-4
n-hexadecanoyl chloride

: 70974-48-0
1-(pyrrolidin-1-yl)hexadecan-1-one

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	100%
With pyridine at 20℃; for 3h; Acylation;	4.5 g
With triethylamine In dichloromethane at 20℃; for 4h; Inert atmosphere;

: 345287-87-8
(+)-1-O-[12-N-(benzyloxycarbonyl)aminododecanoyl]-3-O-(4-methoxybenzyl)-sn-glycerol

: 112-67-4
n-hexadecanoyl chloride

: 345287-88-9
(+)-1-O-[12-N-(benzyloxycarbonyl)aminododecanoyl]-2-O-hexadecanoyl-3-O-(4-methoxybenzyl)-sn-glycerol

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at 0 - 20℃;	100%
With pyridine; dmap In dichloromethane at 0 - 20℃; Inert atmosphere;	100%
With pyridine; dmap In dichloromethane	90%
Stage #1: (+)-1-O-[12-N-(benzyloxycarbonyl)aminododecanoyl]-3-O-(4-methoxybenzyl)-sn-glycerol With pyridine; dmap In dichloromethane at 0℃; for 0.5h; Stage #2: n-hexadecanoyl chloride In dichloromethane at 20℃; Further stages.;	70%

: 1-O-hexanoyl-3-pmethoxybenzyl-sn-glycerol

: 112-67-4
n-hexadecanoyl chloride

: 1-O-hexanoyl-2-O-palmitoyl-3-O-p-methoxybenzyl-sn-glycerol

Conditions

Conditions	Yield
With dmap In pyridine at 20℃; for 20h;	100%

3-[4-(3α-hydroxynortropanylazo)phenoxy]propyloxymethylpolystyrene: 3-[4-(3α-hydroxynortropanylazo)phenoxy]propyloxymethylpolystyrene

: 112-67-4
n-hexadecanoyl chloride

: 3-palmitoylnortropine

Conditions

Conditions	Yield
Stage #1: 3-[4-(3α-hydroxynortropanylazo)phenoxy]propyloxymethylpolystyrene; n-hexadecanoyl chloride With dmap; triethylamine In dichloromethane at 20℃; for 12h; Stage #2: With trifluoroacetic acid In dichloromethane at 0℃; Further stages.;	100%

3-[3-(4-hydroxypiperidinylazo)phenoxy]propyloxymethylpolystyrene: 3-[3-(4-hydroxypiperidinylazo)phenoxy]propyloxymethylpolystyrene

: 112-67-4
n-hexadecanoyl chloride

: 4-palmitoyloxypiperidine

Conditions

Conditions	Yield
Stage #1: 3-[3-(4-hydroxypiperidinylazo)phenoxy]propyloxymethylpolystyrene; n-hexadecanoyl chloride With dmap; triethylamine In dichloromethane at 20℃; for 12h; Stage #2: With trifluoroacetic acid In dichloromethane at 0℃; Further stages.;	100%

: 104-78-9
diethylaminopropylamine

: 112-67-4
n-hexadecanoyl chloride

: N,N-diethyl-N'-hexadecanoyl-1,3-propanediamine

Conditions

Conditions	Yield
In methanol; sodium hydroxide; dichloromethane; chloroform	100%

: 929-06-6
2-(2-Aminoethoxy)ethanol

: 112-67-4
n-hexadecanoyl chloride

: 20138-27-6
N-(ω-hydroxyethoxyethyl)hexadecanamide

Conditions

Conditions	Yield
Stage #1: 2-(2-Aminoethoxy)ethanol With magnesium oxide In tetrahydrofuran; water at 5℃; for 0.5h; Stage #2: n-hexadecanoyl chloride In tetrahydrofuran; water at 5 - 10℃; for 2h;	100%
With triethylamine In dichloromethane at 0℃; for 4h;	92%
With magnesium oxide In tetrahydrofuran; water

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 112-67-4
n-hexadecanoyl chloride

: 14464-31-4
palmitic acid N-succinimide ester

Conditions

Conditions	Yield
With triethylamine In chloroform at 20℃; for 8h; Cooling with ice;	100%
With triethylamine In chloroform at 20℃; for 8h; Cooling with ice;	100%

: 82945-59-3
2-amino-5,10,15,20-tetraphenylporphyrin

: 112-67-4
n-hexadecanoyl chloride

: C60H61N5O

Conditions

Conditions	Yield
Stage #1: 2-amino-5,10,15,20-tetraphenylporphyrin With triethylamine In dichloromethane at 20℃; for 0.25h; Stage #2: n-hexadecanoyl chloride In dichloromethane at 20℃; for 3h;	100%

: 87357-65-1
(3R)-3-hydroxytetradecanoic acid phenacyl ester

: 112-67-4
n-hexadecanoyl chloride

: 339316-64-2
Hexadecanoic acid (R)-1-(2-oxo-2-phenyl-ethoxycarbonylmethyl)-dodecyl ester

Conditions

Conditions	Yield
With dmap In pyridine; dichloromethane Ambient temperature;	99.4%

: 74-89-5
methylamine

: 112-67-4
n-hexadecanoyl chloride

: 7388-58-1
N-methylhexadecanamide

Conditions

Conditions	Yield
In dichloromethane; water at 20℃; for 12h;	99%
In dichloromethane; water at 20℃; for 24h;	92%
With water

: 112-67-4
n-hexadecanoyl chloride

: 39633-51-7
pentadecanyl isocyanate

Conditions

Conditions	Yield
With sodium azide In para-xylene for 2h; Heating;	99%
With sodium azide; benzene
With sodium azide In toluene for 5h; Reflux; Inert atmosphere;

: 134469-06-0
thiazolidine-2-thione

: 112-67-4
n-hexadecanoyl chloride

: 74058-64-3
1-(2-Thioxo-thiazolidin-3-yl)-hexadecan-1-one

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 50℃; for 0.5h;	99%
With triethylamine In dichloromethane at 0 - 5℃; for 3h;	75%

: 89861-45-0
N-hydroxy-N-methylbenzenecarbothioamide

: 112-67-4
n-hexadecanoyl chloride

: 89861-46-1
N-methyl-N-palmitoyloxythiobenzamide

Conditions

Conditions	Yield
With pyridine In diethyl ether for 0.5h; Ambient temperature;	99%

: 130277-63-3, 130324-67-3
DL-(1,2,4/3,5,6)-2,5,6-Tri-O-benzyl-2,3,4,5,6-pentahydroxy-3,4-bis-O-(4-methoxybenzyl)cyclohexane-1-methanol, DL-(1,2,3,5/4,6)-2,3,6-Tri-O-benzyl-2,3,4,5,6-pentahydroxy-4,5-bis-O-(4-methoxybenzyl)cyclohexane-1-methanol

: 112-67-4
n-hexadecanoyl chloride

: 130277-66-6, 130324-68-4
methyl Hexadecanoate, methyl Hexadecanoate

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at 25℃; for 1h;	99%

: 103475-80-5
rac-1-O-hexadecyl-3-O-benzylglycerol

: 112-67-4
n-hexadecanoyl chloride

: 95895-49-1
Hexadecanoic acid 2-benzyloxy-1-hexadecyloxymethyl-ethyl ester

Conditions

Conditions	Yield
With pyridine In benzene at 70℃;	99%

: 68-26-8
RETINOL

: 112-67-4
n-hexadecanoyl chloride

: 79-81-2
retinyl palmitate

Conditions

Conditions	Yield
In toluene at 35℃; for 1h;	99%
With pyridine In 1,2-dichloro-ethane

: 167768-03-8
6,7dihydroxy-3methyl-4-thiaheptanoic acid t-butyl ester

: 112-67-4
n-hexadecanoyl chloride

: 167768-04-9
6,7-bis(palmitoyloxy)-3-methyl-4-thiaheptanoic acid t-butyl ester

Conditions

Conditions	Yield
With dmap In dichloromethane for 1h; Ambient temperature;	99%
With 2-(Dimethylamino)pyridine; sodium bicarbonate; triethylamine; citric acid In chloroform; water	99%

: 204583-04-0
(S)-2-(4-{[3-(3-Hexadecanoylamino-2-hydroxy-propylsulfanyl)-propionylamino]-methyl}-benzoylamino)-pentanedioic acid di-tert-butyl ester

: 112-67-4
n-hexadecanoyl chloride

: 204583-05-1
(S)-2-(4-{[3-(3-Hexadecanoylamino-2-hexadecanoyloxy-propylsulfanyl)-propionylamino]-methyl}-benzoylamino)-pentanedioic acid di-tert-butyl ester

Conditions

Conditions	Yield
With dmap In dichloromethane for 0.5h; Ambient temperature;	99%

: 4915-22-4
methyl furan-2-ylacetate

: 112-67-4
n-hexadecanoyl chloride

: 852152-07-9
(5-hexadecanoylfuran-2-yl)acetic acid methyl ester

Conditions

Conditions	Yield
With tin(IV) chloride In dichloromethane at -5℃; for 1h;	99%
With tin(IV) chloride In dichloromethane at -5℃; for 1h; Friedel-Crafts acylation;	98%
With tin(IV) chloride In dichloromethane at -5℃; for 1h; Substitution; Friedel-Crafts reaction;
With tin(IV) chloride In dichloromethane at -5℃; Friedel-Crafts acylation;

: 4145-51-1, 6236-22-2, 116947-35-4, 988-76-1
3-O-Benzyl-1-O-octadecanoyl-sn-glycerin

: 112-67-4
n-hexadecanoyl chloride

: 282532-76-7
3-O-benzyl-2-O-hexadecanoyl-1-O-octadecanoyl-sn-glycerol

Conditions

Conditions	Yield
With dmap In pyridine; dichloromethane at 0 - 20℃; Acylation;	99%

: 260785-43-1
(S)-3-Hydroxy-2-(2-tetradecanoylamino-acetylamino)-propionic acid benzyl ester

: 112-67-4
n-hexadecanoyl chloride

: Hexadecanoic acid (S)-2-benzyloxycarbonyl-2-(2-tetradecanoylamino-acetylamino)-ethyl ester

Conditions

Conditions	Yield
With triethylamine In chloroform at 20℃; for 6h; Acylation;	99%

: 94458-63-6
O-(5-Acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->3)-O-β-D-galactopyranosyl)-(1->4)-O-β-D-glucopyranosyl)-(1->1)-(2S,3R,4E)-2-amino-4-octadecene-1,3-diol

: 112-67-4
n-hexadecanoyl chloride

: (5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→3)-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl-(1→1)-(2S,3R,4E)-2-hexadecanamino-4-octadecene-1,3-diol

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran at 20℃; for 2h;	99%
With sodium acetate In tetrahydrofuran; water Acylation;

: 5680-79-5
glycine ethyl ester hydrochloride

: 112-67-4
n-hexadecanoyl chloride

: 214706-34-0
N-hexadecanoyl glycine methyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	99%
With sodium hydrogencarbonate In chloroform; water at 20℃; for 2h;
Stage #1: glycine ethyl ester hydrochloride With potassium carbonate In dichloromethane; water at 0℃; for 0.0833333h; Stage #2: n-hexadecanoyl chloride In dichloromethane; water at 20℃; for 16h;	1.48 g

Palmitoyl chloride Chemical Properties

IUPAC Name: Hexadecanoyl chloride
Synonyms of Palmitoyl chloride (CAS NO.112-67-4): AI3-52614 ; EINECS 203-996-7 ; HSDB 5573 ; Hexadecanoic acid, chloride ; NSC 9854 ; Palmitic acid chloride ; Palmityl chloride ; Hexadecanoyl chloride
CAS NO: 112-67-4
Molecular Formula of Palmitoyl chloride (CAS NO.112-67-4): C₁₆H₃₁ClO
Molecular Weight: 274.8697
Molecular Structure:

Melting Point: 11-13 °C
ProductCategories: ACID CHLORIDES
Polar Surface Area: 17.07 Å²
Index of Refraction: 1.45
Molar Refractivity: 81.05 cm³
Molar Volume: 301.1 cm³
Surface Tension: 31.2 dyne/cm
Density of Palmitoyl chloride (CAS NO.112-67-4): 0.912 g/cm³
Flash Point: 155.5 °C
Enthalpy of Vaporization: 56.54 kJ/mol
Boiling Point: 323.5 °C at 760 mmHg
Vapour Pressure: 0.000261 mmHg at 25°C

Palmitoyl chloride Uses

Palmitoyl chloride (CAS NO.112-67-4) is used as intermediates in organic synthesis.

Palmitoyl chloride Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 14-34-29
R14: Reacts violently with water.
R34: Causes burns.
R29: Contact with water liberates toxic gas.
Safety Statements: 26-36/37/39-43-45-8
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S43: In case of fire use ... (there follows the type of fire-fighting equipment to be used.)
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S8: Keep container dry.
RIDADR: UN 3265 8/PG 2
WGK Germany: 1
F: 9-21
HazardClass: 8
PackingGrou:p II

Product Name

Palmitoyl chloride

Synthetic route

Palmitoyl chloride Chemical Properties

Palmitoyl chloride Uses

Palmitoyl chloride Safety Profile

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