Product Name

  • Name

    Pancuronium bromide

  • EINECS 239-532-5
  • CAS No. 15500-66-0
  • Density ~1, mp: 0°C
  • Solubility
  • Melting Point 214 - 217oC
  • Formula C35H60Br2N2O4
  • Boiling Point ~100°C
  • Molecular Weight 732.68
  • Flash Point
  • Transport Information UN 2811 6.1/PG 3
  • Appearance White powder
  • Safety
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 15500-66-0 (Pancuronium bromide)
  • Hazard Symbols HarmfulXn
  • Synonyms 5a-Androstane-3a,17b-diol, 2b,16b-bis(1-methylpiperidinio)-,dibromide, diacetate (8CI);1,1'-(3a,17b-Dihydroxy-5a-androstan-2b,16b-ylene)bis[1-methylpiperidinium]dibromide diacetate;Mioblock;NA 97;NSC 293162;Org NA 97;Pancuronium;Pancuronium dibromide;Pavulon;
  • PSA 52.60000
  • LogP 0.03610

Pancuronium bromide Chemical Properties

The Molecular Structure of Pancuronium bromide (CAS NO.15500-66-0):

The Molecular formula of Pancuronium bromide (CAS NO.15500-66-0): C35H60Br2N2O4  
The Molecular Weight of Pancuronium bromide (CAS NO.15500-66-0): 732.67
IUPAC Name: [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-acetyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate dibromide   
Synonyms: 1,1’-(3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1-methylpiperidinium)dibro ; 1,1’-[3alpha,17beta-bis(acetyloxy)-5alpha-androstane-2beta,16beta-diyl]bis[1-m;16-diyl)bis(1-methyl-ostane-dibromide ; 2beta,16beta-dipiperidino-5alpha-androstane-3alpha,17beta-dioldiacetatedimetho ; 3-alpha,17-beta-diacetoxy-2-beta,16-beta-dipiperidino-5-alpha-androstanedime ; 3-alpha,17-beta-diacetoxy-2-beta,16-beta-dipiperidino-5-alpha-androstanedimeth ; 3alpha,17beta-diacetoxy-2beta,16beta-dipiperidino-5alpha androstanedimethobrom ; 1,1’-(3alpha,17beta-dihydroxy-5alpha-androstan-2beta,16beta-ylene)bis[1-methyl  

Pancuronium bromide Uses

 Pancuronium bromide (CAS NO.15500-66-0) is a chemical compound, used in medicine as the bromide salt pancuronium bromide. It has the brand name Pavulon (Organon International). It is a muscle relaxant with various purposes. It is one of the drugs administered during a lethal injection in the United States. It's non-depolarizing muscle relaxant drugs, fast onset of action, role-keung. It's used for surgery or anesthesia-assisted orthopedic surgery medication, to get the full effect of muscle relaxation can also used for tetanus and other convulsive diseases.

Pancuronium bromide Toxicity Data With Reference

1.    

ivn-man LDLo:143 µg/kg:BLD,PUL

     JATOD3    Journal of Analytical Toxicology. 4 (1980),275.
2.    

orl-rat LD50:202 mg/kg

     SKKNAJ    Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories 22 (1970),187.
3.    

ipr-rat LD50:479 µg/kg

     SKKNAJ    Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories 22 (1970),187.
4.    

scu-rat LD50:436 µg/kg

     SKKNAJ    Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories 22 (1970),187.
5.    

ivn-rat LD50:153 µg/kg

     DRUGAY    Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 6 (1982),353.
6.    

orl-mus LD50:21,200 µg/kg

     SKKNAJ    Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories 22 (1970),187.
7.    

ivn-rat LD50:153 µg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),353.
8.    

ipr-mus LD50:128 µg/kg

     OYYAA2    Oyo Yakuri. Pharmacometrics. 5 (1971),715.
9.    

scu-mus LD50:167 µg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),353.

Pancuronium bromide Consensus Reports

EPA Genetic Toxicology Program.

Pancuronium bromide Safety Profile

A human poison by intravenous route. Poison experimentally by intravenous, subcutaneous, and intraperitoneal routes. Human systemic effects by intravenous route: chronic pulmonary edema, hemorrhage. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and Br−.
Hazard Codes:Xn
Xn: Harmful
Risk Statements
R22: Harmful if swallowed.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: TN4930000
F: 10-21-33
HazardClass: 6.1(b)
PackingGroup: III

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