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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine

Cas:1550-50-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Factory supply N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine CAS 1550-50-1 with fast delivery Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its int

Factory supply N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine CAS 1550-50-1 with fast delivery

Cas:1550-50-1

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

1,1,2,2-Tetrafluoro-N,N-dimethylethylamine

Cas:1550-50-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine Basic information Product Name: N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine Synonyms: N,N-DIMETHYL-1,1,2,2-TETRAFLUOROETHYLAMINE;TFEDMA;N,N-Dime

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine

Cas:1550-50-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine CAS 1550-50-1

Cas:1550-50-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 1550-50-1 with fast shipping

Cas:1550-50-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine CAS 1550-50-1

Cas:1550-50-1

Min.Order:1 Metric Ton

FOB Price: $56.0 / 76.0

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine CAS: 1550-50-1 MF: C4H7F4N MW: 145.1 EINECS: Product Categories: Mol File: 1550-50-1.mol N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine Structure N,N-Dimethyl-1,1,2,2-tetraf

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine

Cas:1550-50-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Ethanamine,1,1,2,2-tetrafluoro-N,N-dimethyl-

Cas:1550-50-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ethanamine,1,1,2,2-tetrafluoro-N,N-dimethyl-

Cas:1550-50-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Ethanamine,1,1,2,2-tetrafluoro-N,N-dimethyl-

Cas:1550-50-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine

Cas:1550-50-1

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine

Cas:1550-50-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Ethanamine,1,1,2,2-tetrafluoro-N,N-dimethyl-

Cas:1550-50-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

N,N-DiMethyltetrafluoroethylaMine

Cas:1550-50-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine

Cas:1550-50-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

1550-50-1 CAS NO.1550-50-1

Cas:1550-50-1

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application: Used in organic synthesis Transpor

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine

Cas:1550-50-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine

Cas:1550-50-1

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine

Cas:1550-50-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine

Cas:1550-50-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine

Cas:1550-50-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine

Cas:1550-50-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

factory?direct?sale Application:Fine chemical intermediates, used as the main raw material for the synthesis of various pesticides, medicines, surfactants, polymer monomers, and antifungal agents

Ethanamine,1,1,2,2-tetrafluoro-N,N-dimethyl-

Cas:1550-50-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine CAS No.1550-50-1

Cas:1550-50-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

SAGECHEM LIMITED

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine 1550-50-1 Application:N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine 1550-50-1

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine

Cas:1550-50-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

best seller Application:API

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine

Cas:1550-50-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

1550-50-1

Cas:1550-50-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine cas 1550-50-1Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine cas 1550-50-1

Cas:1550-50-1

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine

Cas:1550-50-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

polytetrafluoroethylene
116-14-3

polytetrafluoroethylene

dimethyl amine
124-40-3

dimethyl amine

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

Conditions
ConditionsYield
at 20℃; for 12h;98%
at -70℃;
Difluoroacetic acid N,N-dimethylamide
667-50-5

Difluoroacetic acid N,N-dimethylamide

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

Conditions
ConditionsYield
With Carbonyl fluoride at 20 - 25℃; for 16h; Neat (no solvent);85%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

ethyl 3-(dimethylamino)acrylate
924-99-2, 1117-37-9, 114894-59-6

ethyl 3-(dimethylamino)acrylate

N-[(2E)-1-(difluoromethyl)-3-(dimethylamino)-2-(ethoxycarbonyl)prop-2-en-1-ylidene]-N-methylmethanaminium tetrafluoroborate
1009318-76-6

N-[(2E)-1-(difluoromethyl)-3-(dimethylamino)-2-(ethoxycarbonyl)prop-2-en-1-ylidene]-N-methylmethanaminium tetrafluoroborate

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 0.5h; Inert atmosphere;
Stage #2: ethyl 3-(dimethylamino)acrylate In dichloromethane at 20℃; for 2h; Product distribution / selectivity; Inert atmosphere;
100%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

methyl 3-methoxyprop-2-enoate
34846-90-7

methyl 3-methoxyprop-2-enoate

N-[(2E)-1-(difluoromethyl)-3-methoxy-2-(methoxycarbonyl)prop-2-en-1-ylidene]-N-methyl-methanaminium tetrafluoroborate
1009318-81-3

N-[(2E)-1-(difluoromethyl)-3-methoxy-2-(methoxycarbonyl)prop-2-en-1-ylidene]-N-methyl-methanaminium tetrafluoroborate

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 0.5h; Inert atmosphere;
Stage #2: methyl 3-methoxyprop-2-enoate In dichloromethane at 20℃; for 2h; Inert atmosphere;
100%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

difluoromethyl lactate

difluoromethyl lactate

A

Difluoroacetic acid N,N-dimethylamide
667-50-5

Difluoroacetic acid N,N-dimethylamide

B

difluoromethyl 2-fluoropropionate

difluoromethyl 2-fluoropropionate

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; difluoromethyl lactate at 10 - 80℃; for 2h;
Stage #2: With N-pyrazolyl-N-cyclohexyl-N-ethylamine at 0℃;
A n/a
B 98.95%
methyl lactate
547-64-8

methyl lactate

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

A

methyl 2-fluoropropanoate
2366-56-5

methyl 2-fluoropropanoate

B

Difluoroacetic acid N,N-dimethylamide
667-50-5

Difluoroacetic acid N,N-dimethylamide

Conditions
ConditionsYield
Stage #1: methyl lactate; 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine at 10 - 40℃; for 5h;
Stage #2: With triethylamine at 0℃;
A 98.92%
B n/a
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

trifluoroethyl lactate

trifluoroethyl lactate

A

Difluoroacetic acid N,N-dimethylamide
667-50-5

Difluoroacetic acid N,N-dimethylamide

B

2-trifluoroethyl fluoropropionate

2-trifluoroethyl fluoropropionate

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; trifluoroethyl lactate at 10 - 100℃; for 1h;
Stage #2: With N-piperidin-1-yl-N-pyrid-1-yl-N-ethylamine at 0℃;
A n/a
B 98.85%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

trifluoropropyl lactate

trifluoropropyl lactate

A

Difluoroacetic acid N,N-dimethylamide
667-50-5

Difluoroacetic acid N,N-dimethylamide

B

trifluoropropyl 2-fluoropropionate

trifluoropropyl 2-fluoropropionate

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; trifluoropropyl lactate at 10 - 60℃; for 3h;
Stage #2: With N-cyclohexyl-N-cyclopentyl-N-ethylamine at 0℃;
A n/a
B 97.52%
ethyl 2-hydroxypropionate
97-64-3, 2676-33-7

ethyl 2-hydroxypropionate

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

A

ethyl 2-fluoropropionate
349-43-9

ethyl 2-fluoropropionate

B

Difluoroacetic acid N,N-dimethylamide
667-50-5

Difluoroacetic acid N,N-dimethylamide

Conditions
ConditionsYield
Stage #1: ethyl 2-hydroxypropionate; 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine at 10 - 50℃; for 4h;
Stage #2: With dmap at 0℃;
A 96.62%
B n/a
2-Methyl-2-<β-dimethylamino-vinyl>-1,3-dioxolan
118800-67-2

2-Methyl-2-<β-dimethylamino-vinyl>-1,3-dioxolan

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

methylhydrazine
60-34-4

methylhydrazine

3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxolan-2-yl)-1H-pyrazole

3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxolan-2-yl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 2-Methyl-2-<β-dimethylamino-vinyl>-1,3-dioxolan; 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride In tetrahydrofuran at 0 - 20℃; for 2.5h;
Stage #2: methylhydrazine In tetrahydrofuran at 5 - 20℃; for 2.5h;
93.6%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

C7H13NO2

C7H13NO2

methylhydrazine
60-34-4

methylhydrazine

3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxetan-2-yl)-1H-pyrazole

3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxetan-2-yl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; C7H13NO2 With boron trifluoride In acetonitrile at 20℃; for 2.5h;
Stage #2: methylhydrazine In acetonitrile at 5 - 20℃; for 2.5h; Temperature;
93.3%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

methylhydrazine
60-34-4

methylhydrazine

3-dimethylaminoacrolein
927-63-9

3-dimethylaminoacrolein

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde
1094484-55-5

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; 3-dimethylaminoacrolein With boron trifluoride In acetonitrile for 2.5h;
Stage #2: methylhydrazine In acetonitrile at 5 - 20℃; for 2.5h;
92.8%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

C9H17NO2

C9H17NO2

methylhydrazine
60-34-4

methylhydrazine

3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxan-2-yl)-1H-pyrazole

3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxan-2-yl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; C9H17NO2 With boron trifluoride In acetonitrile at 0 - 30℃; for 2.5h;
Stage #2: methylhydrazine In acetonitrile at 5 - 30℃; for 2.5h;
91.9%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

C7H13NO2

C7H13NO2

methylhydrazine
60-34-4

methylhydrazine

3-(difluoromethyl)-1-methyl-4-(1,3-dioxolan-2-yl)-1H-pyrazole

3-(difluoromethyl)-1-methyl-4-(1,3-dioxolan-2-yl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; C7H13NO2 With boron trifluoride In tetrahydrofuran at 0 - 20℃; for 2.5h;
Stage #2: methylhydrazine In tetrahydrofuran at 5 - 20℃; for 2.5h; Temperature; Solvent;
91.6%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

4-dimethylamino-3-buten-2-one
1190-91-6

4-dimethylamino-3-buten-2-one

methylhydrazine
60-34-4

methylhydrazine

1-(3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)ethan-1-one

1-(3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)ethan-1-one

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; 4-dimethylamino-3-buten-2-one With boron trifluoride In acetonitrile for 2.5h;
Stage #2: methylhydrazine In acetonitrile at 5 - 20℃; for 2.5h;
90.3%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

methyl 3-methoxyprop-2-enoate
34846-90-7

methyl 3-methoxyprop-2-enoate

1-benzylidene-2-methylhydrazine
13466-29-0

1-benzylidene-2-methylhydrazine

methyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

methyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; methyl 3-methoxyprop-2-enoate With boron trifluoride diethyl etherate In acetonitrile at 25 - 70℃; Inert atmosphere;
Stage #2: 1-benzylidene-2-methylhydrazine In toluene; acetonitrile at 25℃; for 0.75h;
Stage #3: With hydrogenchloride In water; toluene; acetonitrile for 3h; Reflux;
89%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

ethyleneglycoldi(3-N,N-dimethylaminopropyl)acrylate

ethyleneglycoldi(3-N,N-dimethylaminopropyl)acrylate

methylhydrazine
60-34-4

methylhydrazine

ethylene glycol bis((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carboxylate)

ethylene glycol bis((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carboxylate)

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; ethyleneglycoldi(3-N,N-dimethylaminopropyl)acrylate With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 2h;
Stage #2: methylhydrazine In acetonitrile at 20℃; for 2h; Reagent/catalyst; Solvent; Temperature;
89%
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 0.5h;
Stage #2: ethyleneglycoldi(3-N,N-dimethylaminopropyl)acrylate In dichloromethane at 20℃; for 2h;
Stage #3: methylhydrazine In acetonitrile at 20℃; for 2h;
89%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

ethyl 4,4-difluoro-3-(phenylamino)but-2-enoate

ethyl 4,4-difluoro-3-(phenylamino)but-2-enoate

ethyl 2,4-bis(difluoromethyl)quinoline-3-carboxylate

ethyl 2,4-bis(difluoromethyl)quinoline-3-carboxylate

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In acetonitrile for 0.25h; Inert atmosphere;
Stage #2: ethyl 4,4-difluoro-3-(phenylamino)but-2-enoate In acetonitrile at 20 - 50℃; for 19.25h; Inert atmosphere;
89%
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In acetonitrile for 0.25h; Inert atmosphere;
Stage #2: ethyl 4,4-difluoro-3-(phenylamino)but-2-enoate In acetonitrile at 20 - 50℃; for 19.25h;
89%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

N-(1,1-difluoropropan-2-ylidene)propan-2-amine

N-(1,1-difluoropropan-2-ylidene)propan-2-amine

3,5-bis(difluoromethyl)-1H-pyrazole
77614-79-0

3,5-bis(difluoromethyl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride In acetonitrile at 10 - 20℃; for 1h;
Stage #2: N-(1,1-difluoropropan-2-ylidene)propan-2-amine In acetonitrile at 40℃; for 13h;
Stage #3: With hydrogenchloride; hydrazine hydrate In water; acetonitrile at 40 - 60℃; for 5h; Reagent/catalyst;
87%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

hexane-1,6-diol bis(3-(N,N-dimethylamino)acrylate)

hexane-1,6-diol bis(3-(N,N-dimethylamino)acrylate)

methylhydrazine
60-34-4

methylhydrazine

hexylene glycol bis((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carboxylate)

hexylene glycol bis((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carboxylate)

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; hexylene glycol bis(3-(N,N-dimethylamino)acrylate) With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 2h;
Stage #2: methylhydrazine In acetonitrile at 20℃; for 2h;
86%
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 0.5h;
Stage #2: hexylene glycol bis(3-(N,N-dimethylamino)acrylate) In dichloromethane at 20℃; for 2h;
Stage #3: methylhydrazine In acetonitrile at 20℃; for 2h;
86%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

1-(1,1-difluoropropan-2-ylidene)-2-(diphenylmethylene)hydrazine

1-(1,1-difluoropropan-2-ylidene)-2-(diphenylmethylene)hydrazine

3,5-bis(difluoromethyl)-1H-pyrazole
77614-79-0

3,5-bis(difluoromethyl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With aluminum (III) chloride In acetonitrile at 10 - 20℃; for 1h;
Stage #2: 1-(1,1-difluoropropan-2-ylidene)-2-(diphenylmethylene)hydrazine In acetonitrile at 20℃;
Stage #3: With water In acetonitrile at 20 - 40℃; for 1h; Reagent/catalyst; Solvent; Temperature;
85%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

N-(2,2,2-trifluoro-1-methylethylidene)propan-2-amine
723294-90-4

N-(2,2,2-trifluoro-1-methylethylidene)propan-2-amine

3-(difluoromethyl)-5-(trifluoromethyl)-1H-pyrazole
1015780-64-9

3-(difluoromethyl)-5-(trifluoromethyl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In acetonitrile at 10 - 20℃; for 1h;
Stage #2: N-(2,2,2-trifluoro-1-methylethylidene)propan-2-amine In acetonitrile at 40℃; for 13h;
Stage #3: With hydrogenchloride; hydrazine hydrate In water; acetonitrile at 40 - 60℃; for 5h;
85%
(S)-Methyl lactate
27871-49-4

(S)-Methyl lactate

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

A

Difluoroacetic acid N,N-dimethylamide
667-50-5

Difluoroacetic acid N,N-dimethylamide

B

(R)-2-fluoropropionic acid methyl ester
146805-74-5

(R)-2-fluoropropionic acid methyl ester

Conditions
ConditionsYield
at 20 - 30℃; for 12h;A n/a
B 83%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

1-(diphenylmethylene)-2-(1,1,1-trifluoropropan-2-ylidene)hydrazine

1-(diphenylmethylene)-2-(1,1,1-trifluoropropan-2-ylidene)hydrazine

3-(difluoromethyl)-5-(trifluoromethyl)-1H-pyrazole
1015780-64-9

3-(difluoromethyl)-5-(trifluoromethyl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 0.25h; Inert atmosphere;
Stage #2: 1-(diphenylmethylene)-2-(1,1,1-trifluoropropan-2-ylidene)hydrazine In acetonitrile at 20 - 50℃; for 24h; Inert atmosphere;
Stage #3: With hydrogenchloride In water; acetonitrile at 20℃; for 1h; Inert atmosphere;
83%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

bis(1,1-difluoropropan-2-ylidene)hydrazine

bis(1,1-difluoropropan-2-ylidene)hydrazine

3,5-bis(difluoromethyl)-1H-pyrazole
77614-79-0

3,5-bis(difluoromethyl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In acetonitrile at 10 - 20℃; for 0.25h; Inert atmosphere;
Stage #2: bis(1,1-difluoropropan-2-ylidene)hydrazine In acetonitrile at 20℃; for 18h;
Stage #3: With hydrazine hydrochloride In water; acetonitrile at 40℃; for 4h;
81%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

phenylhydrazine
100-63-0

phenylhydrazine

sodium 3-ethoxy-1-(methylsulfonyl)-3-oxoprop-1-en-2-olate

sodium 3-ethoxy-1-(methylsulfonyl)-3-oxoprop-1-en-2-olate

ethyl 5-(difluoromethyl)-4-methylsulfonyl-2-phenylpyrazole-3-carboxylate

ethyl 5-(difluoromethyl)-4-methylsulfonyl-2-phenylpyrazole-3-carboxylate

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With acetonitrile boron trifluoride complex In acetonitrile at 20℃; for 0.25h; Inert atmosphere;
Stage #2: sodium 3-ethoxy-1-(methylsulfonyl)-3-oxoprop-1-en-2-olate With pyridine In acetonitrile at 10 - 20℃; for 10h;
Stage #3: phenylhydrazine In acetonitrile at -10 - 20℃; for 4h;
81%
3H-chromene-2,4-dione
4438-85-1

3H-chromene-2,4-dione

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

3-difluoroacetylchromene-2,4-dione

3-difluoroacetylchromene-2,4-dione

Conditions
ConditionsYield
In dichloromethane at 20℃; for 16h; Inert atmosphere;80%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

ethyl 4,4,4-trifluoro-3-(phenylamino)but-2-enoate
1700-88-5

ethyl 4,4,4-trifluoro-3-(phenylamino)but-2-enoate

ethyl 4-(difluoromethyl)-2-(trifluoromethyl)quinoline-3-carboxylate

ethyl 4-(difluoromethyl)-2-(trifluoromethyl)quinoline-3-carboxylate

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In acetonitrile for 0.25h; Inert atmosphere;
Stage #2: ethyl 4,4,4-trifluoro-3-(phenylamino)but-2-enoate With sulfuric acid In acetonitrile at 20 - 50℃; for 19.25h; Inert atmosphere;
80%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

ethyl 4,4,4-trifluoro-3-(phenylamino)but-2-enoate

ethyl 4,4,4-trifluoro-3-(phenylamino)but-2-enoate

ethyl 4-(difluoromethyl)-2-(trifluoromethyl)quinoline-3-carboxylate

ethyl 4-(difluoromethyl)-2-(trifluoromethyl)quinoline-3-carboxylate

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In acetonitrile for 0.25h; Inert atmosphere;
Stage #2: ethyl 4,4,4-trifluoro-3-(phenylamino)but-2-enoate In acetonitrile at 20 - 50℃; for 19.25h;
80%
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine
1550-50-1

1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

ethyl acetate
141-78-6

ethyl acetate

ethyl 4,4-difluoro-3-oxobutyrate
352-24-9

ethyl 4,4-difluoro-3-oxobutyrate

Conditions
ConditionsYield
Stage #1: ethyl acetate With sodium hydride In ethanol at 20℃; for 1h;
Stage #2: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine In ethanol at 30℃; for 2h; Product distribution / selectivity;
79%

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