Product Name

  • Name

    Penbutolol

  • EINECS
  • CAS No. 38363-40-5
  • Article Data3
  • CAS DataBase
  • Density 1.03g/cm3
  • Solubility 7g/L(room temperature)
  • Melting Point 68-72°
  • Formula C18H29 N O2
  • Boiling Point 438.2°Cat760mmHg
  • Molecular Weight 291.434
  • Flash Point 218.8°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 38363-40-5 (Penbutolol)
  • Hazard Symbols
  • Synonyms 2-Propanol,1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-, (S)-; (-)-(S)-Penbutolol;(-)-Isopenbutolol; (-)-Penbutolol; (S)-Penbutolol; Betapressin; HOE 893; HOE893D; Levopenbutolol; Penbutolol; l-Penbutolol
  • PSA 41.49000
  • LogP 3.86290

Penbutolol Chemical Properties

IUPAC Name: 1-(tert-Butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol
Synonyms of Penbutolol (CAS NO.38363-40-5) : 1-(tert-Butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol ; 1-[(2-Cyclopentylphenyl)oxy]-3-[(1,1-dimethylethyl)amino]propan-2-ol ; 2-Propanol, 1-(2-cyclopentylphenoxy)-3-((1,1-dimethylethyl)amino)- ; 1-tert-Butylamino-3-(2-cyclopentyl-phenoxy)-propan-2-ol 
CAS NO: 38363-40-5
Molecular Formula:C18H29NO2       
Molecular Weight :291.42836            
Molecular Structure :
Index of Refraction:1.527    
Surface Tension: 38.9 dyne/cm 
Density: 1.03 g/cm3 
Flash Point: 218.8 °C 
Enthalpy of Vaporization: 73.25 kJ/mol 
Boiling Point: 438.2 °C at 760 mmHg 
Vapour Pressure: 1.87E-08 mmHg at 25°C 

Penbutolol Uses

 Penbutolol (CAS NO.38363-40-5) is used in the treatment of high blood pressure.

Penbutolol Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 20mg/kg (20mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 22, Pg. 1, 1981.
mouse LD50 intravenous 18mg/kg (18mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 22, Pg. 1, 1981.
mouse LD50 oral 1230mg/kg (1230mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 22, Pg. 1, 1981.
rabbit LD50 intravenous 17mg/kg (17mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 22, Pg. 1, 1981.
rabbit LD50 oral 300mg/kg (300mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 22, Pg. 1, 1981.
rat LD50 intravenous 22mg/kg (22mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 22, Pg. 1, 1981.
rat LD50 oral 1265mg/kg (1265mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 22, Pg. 1, 1981.

Penbutolol Safety Profile

Poison by ingestion and intravenous routes. Mutation data reported. When Penbutolol (CAS NO.38363-40-5) is heated to decomposition, it emits toxic fumes of NOx.

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