ampicillin
1-chlorocarbonyl-2-oxo-3-methylcarbonyl-imidazolidine
penicillin G
Conditions | Yield |
---|---|
With triethylamine In methanol; aqueous tetrahydrofurane; water; ethyl acetate | 95% |
With triethylamine In methanol; aqueous tetrahydrofurane; water; ethyl acetate | 95% |
With triethylamine In methanol; aqueous tetrahydrofurane; water; ethyl acetate | 95% |
Conditions | Yield |
---|---|
With triethylamine | A 94% B n/a |
Conditions | Yield |
---|---|
With triethylamine | A 88% B n/a |
Conditions | Yield |
---|---|
With hydrogenchloride; triethylamine In tetrahydrofuran; aqueous tetrahydrofurane | 85% |
Conditions | Yield |
---|---|
With triethylamine | A 81% B n/a |
Conditions | Yield |
---|---|
With triethylamine | A 80% B n/a |
Conditions | Yield |
---|---|
With triethylamine | A 78.5% B n/a |
phosgene
ampicillin trihydrate
B
penicillin G
Conditions | Yield |
---|---|
With triethylamine | A 78% B n/a |
Conditions | Yield |
---|---|
With triethylamine | A 77% B n/a |
phosgene
ampicillin trihydrate
B
penicillin G
Conditions | Yield |
---|---|
With triethylamine | A 77% B n/a |
Conditions | Yield |
---|---|
With triethylamine | A 76% B n/a |
Conditions | Yield |
---|---|
With triethylamine | A 75% B n/a |
Conditions | Yield |
---|---|
With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere; | 100% |
Conditions | Yield |
---|---|
With potassium carbonate In acetic acid butyl ester; water; butan-1-ol at 45 - 48℃; Product distribution / selectivity; | 94.5% |
With potassium carbonate In acetic acid butyl ester; water; butan-1-ol at 50 - 60℃; Product distribution / selectivity; | 91% |
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In ethyl acetate for 24h; Ambient temperature; | 89.5% |
penicillin G
A
(5S,6S,3S)-benzyl-D-penicilloic acid
B
(5R,6S,3S)-benzyl-D-penicilloic acid
Conditions | Yield |
---|---|
With Zn(II) cyclen; water at 15 - 35℃; Rate constant; Kinetics; Thermodynamic data; | A 88% B 12% |
With Zn(II) cyclen-OH-; water at 15 - 35℃; Rate constant; Kinetics; Thermodynamic data; | A 88% B 12% |
penicillin G
[(chlorosulfonyl)oxy]methyl sulfurochloridate
bis-(6β-phenylacetamido-penicillanoyloxy)-methane
Conditions | Yield |
---|---|
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In dichloromethane 1.) 20-22 deg C, 2.) 30 min; | 80% |
EPA Genetic Toxicology Program.
The 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)-, with the CAS registry number 61-33-6, is also known as Benzyl-6-aminopenicillinic acid. Its EINECS number is 200-506-3. This chemical's molecular formula is C16H18N2O4S and molecular weight is 334.42. What's more, its systematic name is (5R,6R)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid. Its classification codes are: (1)Anti-Bacterial Agents; (2)Anti-Infective Agents; (3)Drug / Therapeutic Agent; (4)Human Data; (5)Mutation data; (6)Natural Product; (7)Tumor data. It is a penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci.
Physical properties of 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)- are: (1)ACD/LogP: 1.67; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.31; (4)ACD/LogD (pH 7.4): -2.06; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 6; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 92.22 Å2; (13)Index of Refraction: 1.655; (14)Molar Refractivity: 86.34 cm3; (15)Molar Volume: 235.1 cm3; (16)Polarizability: 34.22×10-24cm3; (17)Surface Tension: 67.8 dyne/cm; (18)Density: 1.42 g/cm3; (19)Flash Point: 355 °C; (20)Enthalpy of Vaporization: 102.51 kJ/mol; (21)Boiling Point: 663.3 °C at 760 mmHg; (22)Vapour Pressure: 1.69E-18 mmHg at 25°C.
When you are using this chemical, please be cautious about it as the following:
It may cause sensitisation by inhalation and skin contact. When using it, you should wear suitable protective clothing and gloves.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)C2N3C(=O)[C@@H](NC(=O)Cc1ccccc1)[C@H]3SC2(C)C
(2)Std. InChI: InChI=1S/C16H18N2O4S/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12?,14-/m1/s1
(3)Std. InChIKey: JGSARLDLIJGVTE-YXHCSQSYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | TDLo | parenteral | 15000units/kg (15000units/kg) | SENSE ORGANS AND SPECIAL SENSES: CHANGES IN COCHLEAR STRUCTURE OR FUNCTION: EAR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Lancet. Vol. 1, Pg. 394, 1986. |
dog | LD50 | intracrebral | 1118ug/kg (1.118mg/kg) | BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES | Journal of Laboratory and Clinical Medicine. Vol. 34, Pg. 126, 1949. |
dog | LD50 | unreported | 4940ug/kg (4.94mg/kg) | BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES | Journal of Laboratory and Clinical Medicine. Vol. 34, Pg. 126, 1949. |
guinea pig | LD50 | unreported | 38mg/kg (38mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(9), Pg. 10, 1977. | |
hamster | LD50 | oral | 24mg/kg (24mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: FOOD INTAKE (ANIMAL) | Toxicology and Applied Pharmacology. Vol. 14, Pg. 510, 1969. |
hamster | LD50 | subcutaneous | 96mg/kg (96mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Toxicology and Applied Pharmacology. Vol. 14, Pg. 510, 1969. |
mouse | LD50 | intracrebral | 5700ug/kg (5.7mg/kg) | BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES | Journal of Laboratory and Clinical Medicine. Vol. 34, Pg. 126, 1949. |
mouse | LD50 | intraperitoneal | 3500mg/kg (3500mg/kg) | Antimicrobial Agents and Chemotherapy Vol. -, Pg. 619, 1967. | |
mouse | LD50 | intravenous | 329mg/kg (329mg/kg) | Biochemical Pharmacology. Vol. 16, Pg. 1365, 1967. | |
mouse | LD50 | oral | > 5gm/kg (5000mg/kg) | Antimicrobial Agents and Chemotherapy Vol. -, Pg. 619, 1967. | |
mouse | LD50 | unreported | 7800mg/kg (7800mg/kg) | Antibiotiki. Vol. 23, Pg. 317, 1978. | |
rabbit | LD50 | intracrebral | 653ug/kg (0.653mg/kg) | BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES | Journal of Laboratory and Clinical Medicine. Vol. 34, Pg. 126, 1949. |
rat | LD50 | oral | 8gm/kg (8000mg/kg) | Antibiotics and Chemotherapy Vol. 12, Pg. 249, 1962. | |
rat | LD50 | unreported | 9gm/kg (9000mg/kg) | Antibiotiki. Vol. 23, Pg. 317, 1978. |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View