Pentadecafluorooctanoyl chloride supplier

Name
Pentadecafluorooctanoyl chloride
EINECS 206-394-2
CAS No. 335-64-8
Article Data26
CAS DataBase
Density 1.722 g/cm³
Solubility Reacts with water.
Melting Point 74-75 °C(Solv: benzene (71-43-2))
Formula C₈ClF₁₅O
Boiling Point 134.6 °C at 760 mmHg
Molecular Weight 432.516
Flash Point 35.2 °C
Transport Information
Appearance COLORLESS LIQUID
Safety 26-36/37/39-45
Risk Codes 34
Molecular Structure
Hazard Symbols C
Synonyms Octanoylchloride, pentadecafluoro- (7CI,8CI,9CI);2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluorooctanoic acid chloride;2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluorooctanoyl chloride;Pentadecafluorooctanoyl chloride;Perfluorocaprylic chloride;Perfluorooctanoicacid chloride;Perfluorooctanoic chloride;Perfluorooctanoyl chloride;n-Perfluorooctanoyl chloride;
PSA 17.07000
LogP 5.12590

Synthetic route

: 335-67-1
Perfluorooctanoic acid

: 335-64-8
pentadecafluorooctanoyl chloride

Conditions

Conditions	Yield
With pyridine; thionyl chloride at 80℃; for 4h; Reflux;	97%
With thionyl chloride; N,N-dimethyl-formamide for 4h; Heating;	90%
With benzoyl chloride Heating;	77%

: 376-27-2
methyl perfluorooctanoate

: 335-64-8
pentadecafluorooctanoyl chloride

Conditions

Conditions	Yield
With chlorine Irradiation;

: 335-95-5
sodium perfluorooctanoate

: 335-64-8
pentadecafluorooctanoyl chloride

Conditions

Conditions	Yield
With Phthaloyl dichloride

: 307-35-7
perfluorooctyl sulfofluorure

A: 307-34-6
Perfluorooctane

B: 307-33-5
1-Chloroperfluorooctane

C: 335-64-8
pentadecafluorooctanoyl chloride

D: 423-60-9
perfluorooctanesulphonyl chloride

Conditions

Conditions	Yield
With aluminium trichloride at 100 - 110℃; for 5h; Title compound not separated from byproducts;

...Expand

: 335-64-8
pentadecafluorooctanoyl chloride

: 17154-34-6
(trimethylsilyl)diphenylphosphine

: 548459-25-2
diphenyl-perfluoro-octanoylphosphine

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; for 1h;	100%

: 335-64-8
pentadecafluorooctanoyl chloride

: 829-85-6
diphenylphosphane

: 548459-25-2
diphenyl-perfluoro-octanoylphosphine

Conditions

Conditions	Yield
With triethylamine	100%

: 335-64-8
pentadecafluorooctanoyl chloride

: 335-67-1
Perfluorooctanoic acid

Conditions

Conditions	Yield
With water	99.6%

: 335-64-8
pentadecafluorooctanoyl chloride

: 6306-52-1
L-valine methylester hydrochloride

: 170980-91-3
(S)-N-pentadecafluorooctanoylvalinemethylester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 3.5h;	99%

: 1121-30-8
1-hydroxy-2(1H)-pyridinethione

: 356-42-3
2,2,3,3,3-pentafluoropropanoic anhydride

: 335-64-8
pentadecafluorooctanoyl chloride

: 407-25-0
trifluoroacetic anhydride

: 336-59-4
heptafluorobutyric anhydride

A: 57830-49-6
2-((trifluoromethyl)thio)pyridine

B: 107146-03-2
2-pyridyl pentafluoroethyl sulfide

C: 107146-04-3
2-(perfluoro-n-buthylthio)-pyridine

D: 107146-05-4
2-(perfluoroheptylthio)-pyridine

Conditions

Conditions	Yield
Product distribution; Irradiation; further reactions inpresence of perfluorobutyric anhydride with different alkenes;	A 98% B 94% C 95% D 60%

...Expand

: 904684-59-9
N-Boc-N'-(pyren-1-ylmethyl)-3,6-dioxaoctane-1,8-diamine

: 335-64-8
pentadecafluorooctanoyl chloride

: 904684-62-4
N'-2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctanoyl-N-Boc-N'-(pyren-1-ylmethyl)-3,6-dioxaoctane-1,8-diamide

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at 20℃; for 3h;	97%

: 335-64-8
pentadecafluorooctanoyl chloride

: 1228010-31-8
2,3,4,6-tetra-O-pivaloyl-d-galactopyranosylamine

: 1228010-32-9
C34H44F15NO10

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 22℃; for 19.75h;	96%

: 335-64-8
pentadecafluorooctanoyl chloride

: 83585-56-2
2-aminomethyl-15-crown-5

: 1228010-22-7
N-(1,4,7,10,13-pentaoxacyclopentadecan-2-ylmethyl)-2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctanamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 22℃; for 19.75h;	96%

: 335-64-8
pentadecafluorooctanoyl chloride

: 109-55-7
1-amino-3-(dimethylamino)propane

: 376-23-8
2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctanoic acid [3-(dimethylamino)propyl]amide

Conditions

Conditions	Yield
In tetrahydrofuran at -5 - 20℃; for 5h;	95.9%

: 118-48-9
isatoic anhydride

: 335-64-8
pentadecafluorooctanoyl chloride

: 16062-72-9
2-pentadecafluoroheptyl-benzo[d][1,3]oxazin-4-one

Conditions

Conditions	Yield
With pyridine at 75℃; for 2h;	95%

: 335-64-8
pentadecafluorooctanoyl chloride

: 2835-98-5
2-Hydroxy-4-methylanilin

: 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluoro-octanoic acid (2-hydroxy-4-methyl-phenyl)-amide

Conditions

Conditions	Yield
In pyridine at 40℃; for 0.5h;	95%

: 335-64-8
pentadecafluorooctanoyl chloride

: 423-54-1
perfluorooctanoyl ammonia

Conditions

Conditions	Yield
With ammonia; calcium oxide In ethanol at 15℃; for 4h;	94%
With ammonia In diethyl ether
With ammonia; calcium oxide In ethanol for 4h; Inert atmosphere;

: 335-64-8
pentadecafluorooctanoyl chloride

: 20439-47-8
(1R,2R)-1,2-diaminocyclohexane

: R,R-N,N'-diperfluorooctanoyl-1,2-diaminocyclohexane

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	94%
With triethylamine In tetrahydrofuran at 0 - 20℃;	88%
With triethylamine In tetrahydrofuran at 0℃; for 1h;

: 335-64-8
pentadecafluorooctanoyl chloride

: Bis(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-Heptadecafluoro-undecyl)amine

: N,N-bis[3-(perfluorooctyl)propyl]perfluorooctanamide

Conditions

Conditions	Yield
With triethylamine In diethyl ether at 20℃; for 1h;	94%

: 335-64-8
pentadecafluorooctanoyl chloride

: 66943-05-3
1,4,7,10-tetraoxa-15-azacyclopentadecane

: N-perfluorooctanoyl aza-15-crown-5

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 0 - 20℃; Acylation;	92%

: 335-64-8
pentadecafluorooctanoyl chloride

: 241490-98-2
sym-(amino)dibenzo-16-crown-5

: N-(sym-dibenzo-16-crown-5)-perfluorooctanoyl amide

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 20℃; for 12h;	92%

: 335-64-8
pentadecafluorooctanoyl chloride

: 423-54-1
perfluorooctanoyl ammonia

: N,N-bis(perfluorooctyl)imine

Conditions

Conditions	Yield
With pyridine In ethanol at 5℃; for 8h;	92%
With triethylamine In ethanol at 5℃; for 6h;

: 335-64-8
pentadecafluorooctanoyl chloride

: 2576-47-8
2-bromoethylamine hydrobromide

: 110388-00-6
N-(2-bromoethyl)perfluoroctanamide

Conditions

Conditions	Yield
With zinc(II) oxide In acetonitrile Heating;	91%

: 335-64-8
pentadecafluorooctanoyl chloride

: 76019-94-8
4-(4-chlorophenyl)butan-2-ol

: 1-(4-chlorophenyl)but-3-yl perfluorooctanoate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;	91%

: 335-64-8
pentadecafluorooctanoyl chloride

: 1020-33-3
4-amino-6-methyl-benzene-1,3-disulfonic acid diamide

: 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluoro-octanoic acid (5-methyl-2,4-disulfamoyl-phenyl)-amide

Conditions

Conditions	Yield
In 1,4-dioxane Heating;	90%

: 335-64-8
pentadecafluorooctanoyl chloride

: 84195-43-7
Tributyl-[fluoro-(tributyl-λ5-phosphanylidene)-methyl]-phosphonium; chloride

: C21H27F16OP

Conditions

Conditions	Yield
at 0 - 20℃; for 1h;	90%

: 7677-24-9
trimethylsilyl cyanide

: 335-64-8
pentadecafluorooctanoyl chloride

: 2-Pentadecafluoroheptyl-2-trimethylsilanyloxy-malononitrile

Conditions

Conditions	Yield
tetra-n-butylammonium cyanide for 3h; Ambient temperature;	90%

: 111-88-6
Octanethiol

: 335-64-8
pentadecafluorooctanoyl chloride

: n-octyl pentadecafluorothiooctanoate

Conditions

Conditions	Yield
With dmap In dichloromethane at 0 - 40℃;	90%

: 335-64-8
pentadecafluorooctanoyl chloride

: 220968-09-2
2-(sym-dibenzo-16-crown-5-oxo)ethylamine

: N-[(2-sym-dibenzo-16-crown-5-oxy)ethyl] perfluorooctanoyl amide

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 20℃; for 12h;	90%

: 335-64-8
pentadecafluorooctanoyl chloride

: 599171-69-4
2-(sym-dicyclohexano-16-crown-5-oxy)ethylamine

: 599171-76-3
N-[(2-sym-dicyclohexano-16-crown-5-oxy)ethyl] perfluorooctanoyl amide

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 20℃; for 12h;	90%

poly(methyl methacrylate)-b-poly(2-hydroxyethyl methacrylate) block copolymer, block ratio: 26:5 kg/M, Mw = 24500, PDI = 1.05; monomer(s): methyl methacrylate; 2-[(trimethylsilyl)oxy]ethyl methacrylate; sec-butyl lithium; 1,1-diphenylethylene: poly(methyl methacrylate)-b-poly(2-hydroxyethyl methacrylate) block copolymer, block ratio: 26:5 kg/M, Mw = 24500, PDI = 1.05; monomer(s): methyl methacrylate; 2-[(trimethylsilyl)oxy]ethyl methacrylate; sec-butyl lithium; 1,1-diphenylethylene

: 335-64-8
pentadecafluorooctanoyl chloride

poly(methyl methacrylate)-b-poly(2-(perfluorooctanoyloxy)ethyl methacrylate) block copolymer, block ratio: 26:19.9 kg/mol, Mw = 29200, PDI = 1.05: poly(methyl methacrylate)-b-poly(2-(perfluorooctanoyloxy)ethyl methacrylate) block copolymer, block ratio: 26:19.9 kg/mol, Mw = 29200, PDI = 1.05

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran at 45℃;	90%

: 335-64-8
pentadecafluorooctanoyl chloride

: 80-97-7
Cholestanol

: 109481-61-0
5α-cholestan-3β-ol pentadecafluorooctanoate

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane for 2h; Ambient temperature;	89.2%

: 335-64-8
pentadecafluorooctanoyl chloride

: 154023-41-3
N-(pentafluorosulfanylperfluorobutyryl)hydrazine

: C12H2F26N2O2S

Conditions

Conditions	Yield
With pyridine In diethyl ether at 25℃; for 0.333333h;	89%

: 335-64-8
pentadecafluorooctanoyl chloride

: 67952-38-9
4-(4-methoxy-phenyl)-butan-2-ol

: 1-(4-methoxyphenyl)but-3-yl perfluorooctanoate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;	89%

Pentadecafluorooctanoyl chloride Specification

The Pentadecafluorooctanoyl chloride is an organic compound with the formula C₈ClF₁₅O. The systematic name of this chemical is pentadecafluorooctanoyl chloride. With the CAS registry number 335-64-8, it is also named as Octanoyl chloride, pentadecafluoro-. The product's categories are Rf-Tagged Building Blocks and Precursors; Fluorous Synthesis; Specialty Synthesis.

Physical properties about Pentadecafluorooctanoyl chloride are: (1)ACD/LogP: 8.49; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 8.49; (4)ACD/LogD (pH 7.4): 8.49; (5)ACD/BCF (pH 5.5): 1000000; (6)ACD/BCF (pH 7.4): 1000000; (7)ACD/KOC (pH 5.5): 991361.44; (8)ACD/KOC (pH 7.4): 991361.44; (9)#H bond acceptors: 1; (10)#Freely Rotating Bonds: 6; (11)Polar Surface Area: 17.07 Å²; (12)Index of Refraction: 1.294; (13)Molar Refractivity: 46.2 cm³; (14)Molar Volume: 251.1 cm³; (15)Polarizability: 18.31×10^-24cm³; (16)Surface Tension: 15.9 dyne/cm; (17)Density: 1.722 g/cm³; (18)Flash Point: 35.2 °C; (19)Enthalpy of Vaporization: 37.21 kJ/mol; (20)Boiling Point: 134.6 °C at 760 mmHg; (21)Vapour Pressure: 8.01 mmHg at 25°C.

Preparation: this chemical can be prepared by pentadecafluorooctanoic acid. This reaction will need reagent phosphorus (V)-chloride.

Uses of Pentadecafluorooctanoyl chloride: it can be used to produce 1H,1H-pentadecafluoro-octan-1-ol. It will need reagent lithium alanate, diethyl ether.

When you are using this chemical, please be cautious about it as the following:
This chemical can cause burns. When you are using it, wear suitable gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: FC(F)(C(F)(F)C(Cl)=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
(2)InChI: InChI=1/C8ClF15O/c9-1(25)2(10,11)3(12,13)4(14,15)5(16,17)6(18,19)7(20,21)8(22,23)24
(3)InChIKey: AQQBRCXWZZAFOK-UHFFFAOYAD
(4)Std. InChI: InChI=1S/C8ClF15O/c9-1(25)2(10,11)3(12,13)4(14,15)5(16,17)6(18,19)7(20,21)8(22,23)24
(5)Std. InChIKey: AQQBRCXWZZAFOK-UHFFFAOYSA-N

Product Name

Pentadecafluorooctanoyl chloride

Synthetic route

Pentadecafluorooctanoyl chloride Specification

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