IUPAC Name: 2-Phenylindene-1,3-dione
Synonyms:1H-Indene-1,3(2H)-dione, 2-phenyl- ; 2-Phenyl-1,3-indanedione ; 2-Phenyl-1H-indene-1,3(2H)-dione ; 2-Phenylindan-1,3-dione ; 2-Phenylindane-1,3-dione
Product Categories: Indane/Indanone and Derivatives
CAS NO:83-12-5
Molecular Formula of Phenylindione (CAS NO.83-12-5) :C15H10O2
Molecular Weight of Phenylindione (CAS NO.83-12-5) :222.24
Molecular Structure of Phenylindione (CAS NO.83-12-5):
Index of Refraction: 1.637
Surface Tension: 53.2 dyne/cm
Density: 1.264 g/cm3
Flash Point: 153.4 °C
Enthalpy of Vaporization: 66.2 kJ/mol
Boiling Point: 409.8 °C at 760 mmHg
Vapour Pressure: 6.33E-07 mmHg at 25°C
Melting point: 144-148 °C(lit.)
Appearance:light yellow fluffy fine flakes
Phenylindione has actions similar to warfarin.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | LDLo | oral | 48mg/kg/27D-I (48mg/kg) | BLOOD: OTHER CHANGES | New Zealand Medical Journal. Vol. 57, Pg. 283, 1958. |
man | LDLo | unreported | 1683mg/kg/31D (1683mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Lancet. Vol. 1, Pg. 920, 1963. |
man | TDLo | oral | 42500ug/kg/17 (42.5mg/kg) | KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED | British Medical Journal. Vol. 1, Pg. 1655, 1963. |
man | TDLo | unreported | 22mg/kg/17D-I (22mg/kg) | LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Annals of Internal Medicine. Vol. 52, Pg. 706, 1960. |
man | TDLo | unreported | 90mg/kg/27D-I (90mg/kg) | LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" | Canadian Medical Association Journal. Vol. 77, Pg. 1028, 1957. |
mouse | LD50 | intraperitoneal | 150mg/kg (150mg/kg) | Pharmazie. Vol. 27, Pg. 520, 1972. | |
mouse | LD50 | intravenous | 130mg/kg (130mg/kg) | BEHAVIORAL: REGIDITY BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Therapie. Vol. 16, Pg. 34, 1961. |
mouse | LD50 | oral | 175mg/kg (175mg/kg) | Schweizerische Medizinische Wochenschrift. Vol. 90, Pg. 213, 1960. | |
mouse | LD50 | subcutaneous | 140mg/kg (140mg/kg) | Dissertationes Pharmaceuticae. Vol. 8, Pg. 289, 1956. | |
rat | LD50 | intraperitoneal | 190mg/kg (190mg/kg) | BEHAVIORAL: REGIDITY BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Therapie. Vol. 16, Pg. 34, 1961. |
rat | LD50 | oral | 163mg/kg (163mg/kg) | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 9, Pg. 519, 1974. |
A human poison by ingestion. Poison experimentally by ingestion and intraperitoneal routes. Moderately toxic to humans by an unspecified route. Human systemic effects by: blood effects, fever, hepatitis, hepatocellular necrosis, dermatitis, allergic effects, other skin effects, nausea or vomiting, tubule changes, urine volume decrease, interstitial nephritis. When heated to decomposition it emits acrid smoke and irritating fumes. Used to treat angina pectoris.
Hazard Codes T
Risk Statements 25
R25 :Toxic if swallowed.
Safety Statements 36/37/39-45
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS NK6125000
HazardClass 6.1(b)
PackingGroup III
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