Product Name

  • Name

    ESERINE SULFATE

  • EINECS
  • CAS No. 64-47-1
  • Density 1.0911 (rough estimate)
  • Solubility
  • Melting Point 140° (after drying at 100°)
  • Formula C30H42N6O4S
  • Boiling Point 557.5°C at 760 mmHg
  • Molecular Weight 646.84
  • Flash Point 291°C
  • Transport Information
  • Appearance
  • Safety Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Human systemic effects by subcutaneous route: hallucinations or distorted perceptions; nausea or vomiting, and other gastrointestinal changes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx. See also PHYSOSTIGMINE.
  • Risk Codes R26/28
  • Molecular Structure Molecular Structure of 64-47-1 (ESERINE SULFATE)
  • Hazard Symbols T+
  • Synonyms (3as-cis)-amate(estersulfate(2:1)(salt);(3as-cis)-ylcarbamate(estersulfate(2:1);3-b)indole,1,2,3,3a,8,8a-hexahydro-5-hydroxy-1,3a,8-trimethyl-pyrrolo(meth;eserinesulphate;physostigmineso4;physostigminesulphate;ESERINE SULFATE;ESERINE HEMISULFATE
  • PSA 172.60000
  • LogP 4.76340

Physostigmine sulfate Chemical Properties

Empirical Formula: C30H44N6O8S
Molecular Weight: 648.7708 g/mol
EINECS: 200-585-4 
Flash Point: 191.8 °C
Boiling Point: 393.5 °C at 760 mmHg
Vapour Pressure: 2.12E-06 mmHg at 25 °C 
Storage tempreture: 2-8 °C
Structure of Physostigmine sulfate (CAS NO.64-47-1):
           
IUPAC Name: [(3aR,8bS)-3,4,8b-Trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl]N-methylcarbamate; sulfuric acid
Product Categories of Physostigmine sulfate (CAS NO.64-47-1): Acetylcholine receptor
 

Physostigmine sulfate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo subcutaneous 1250ug/kg (1.25mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Pharmacology and Experimental Therapeutics. Vol. 44, Pg. 95, 1932.
frog LDLo parenteral 325mg/kg (325mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 44, Pg. 95, 1932.
frog LDLo subcutaneous 1gm/kg (1000mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 207, Pg. 547, 1949.
man TDLo subcutaneous 191ng/kg (0.000191mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
GASTROINTESTINAL: NAUSEA OR VOMITING
GASTROINTESTINAL: OTHER CHANGES		 Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 53, Pg. 313, 1905.
mouse LD50 intraperitoneal 510ug/kg (0.51mg/kg)   Archiv fuer Toxikologie. Vol. 29, Pg. 39, 1972.
mouse LD50 intravenous 178ug/kg (0.178mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03167,
mouse LD50 oral 1680ug/kg (1.68mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 137, 1972.
mouse LD50 subcutaneous 700ug/kg (0.7mg/kg)   Annales Pharmaceutiques Francaises. Vol. 11, Pg. 286, 1953.
rabbit LDLo subcutaneous 1500ug/kg (1.5mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Pharmacology and Experimental Therapeutics. Vol. 44, Pg. 95, 1932.
rat LD50 intraperitoneal 1621ug/kg (1.621mg/kg)   Fundamental and Applied Toxicology. Vol. 4, Pg. S195, 1984.
rat LD50 intravenous 450ug/kg (0.45mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 259, Pg. 153, 1982.
rat LD50 oral 4mg/kg (4mg/kg)   Annales Pharmaceutiques Francaises. Vol. 11, Pg. 286, 1953.
 

Physostigmine sulfate Consensus Reports

EPA Genetic Toxicology Program.

Physostigmine sulfate Safety Profile

Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Human systemic effects by subcutaneous route: hallucinations or distorted perceptions; nausea or vomiting, and other gastrointestinal changes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx. See also PHYSOSTIGMINE.
Hazard Codes of Physostigmine sulfate (CAS NO.64-47-1): VeryT+
Risk Statements: 26/28 
R26/28:Very toxic by inhalation and if swallowed.
Safety Statements: 25-45 
S25:Avoid contact with eyes. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Physostigmine sulfate Specification

 Physostigmine sulfate ,its cas register number is 64-47-1. It also can be called Sulfuric acid compd. with physostigmine (1:2) ; (3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol Methylcarbamate (Ester) Sulfate (2:1) ; and Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS,8aR)-, sulfate (2:1) (salt) .

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View