• Name

  Piperaquine phosphate

• EINECS 202-303-5
• CAS No. 4085-31-8
• Article Data5
• CAS DataBase
• Density 1.292 g/cm³
• Solubility
• Melting Point 198-200 °C
• Formula C₂₉H₃₂Cl₂N₆
• Boiling Point 721.1 °C at 760 mmHg
• Molecular Weight 535.519
• Flash Point 389.9 °C
• Transport Information
• Appearance Almost wite powder
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Quinoline,4,4'-(trimethylenedi-4,1-piperazinediyl)bis[7-chloro- (7CI,8CI);Piperaquinoline;Piperaquine;
• PSA 38.74000
• LogP 5.42990

Synthetic route

109-64-8

1,3-dibromo-propane

837-52-5

7-chloro-4-piperazinylquinoline

4085-31-8

1,3-bis[1-(7-chloroquinolin-4-yl)piperazin-4-yl]propane

Conditions

Conditions	Yield
With sodium carbonate In water at 100℃; for 15h;
With triethylamine In methanol Product distribution / selectivity; Heating; Reflux;

86-98-6

4,7-dichloroquinoline

4085-31-8

1,3-bis[1-(7-chloroquinolin-4-yl)piperazin-4-yl]propane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium iodide / isopropyl alcohol / 10 h / Reflux; Heating 2: triethylamine / methanol / Heating; Reflux View Scheme

4085-31-8

1,3-bis[1-(7-chloroquinolin-4-yl)piperazin-4-yl]propane

Piperaquine tetraphosphate

Conditions

Conditions	Yield
With phosphoric acid; water In methanol; dichloromethane for 1 - 2h; Product distribution / selectivity;	99.9%

4085-31-8

1,3-bis[1-(7-chloroquinolin-4-yl)piperazin-4-yl]propane

1,3-bis[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propanephosphate

Conditions

Conditions	Yield
With phosphoric acid; water at 5 - 15℃; for 4 - 5h;