• Name

  Pramiracetam

• EINECS 806-175-7
• CAS No. 68497-62-1
• Article Data7
• CAS DataBase
• Density 1.036 g/cm³
• Solubility
• Melting Point 47-48°
• Formula C₁₄H₂₇N₃O₂
• Boiling Point 461 °C at 760 mmHg
• Molecular Weight 269.387
• Flash Point 232.6 °C
• Transport Information
• Appearance white crystalline powder
• Safety
• Risk Codes 22
• Molecular Structure
• Hazard Symbols Xn
• Synonyms Amacetam;Vinpotropil;
• PSA 52.65000
• LogP 1.17260

Synthetic route

616-45-5

2-pyrrolidinon

N-[2-(di(isopropyl)amino)ethyl]-2-chloroacetamide

68497-62-1

pramiracetam

Conditions

Conditions	Yield
Stage #1: 2-pyrrolidinon With sodium methylate In toluene at 105 - 108℃; for 3h; Stage #2: N-[2-(di(isopropyl)amino)ethyl]-2-chloroacetamide In toluene at 60 - 70℃;	89.49%

61516-73-2

2-(oxo-pyrrolidin-1-yl)-acetic acid ethyl ester

121-05-1

N',N'-diisopropyl-ethane-1,2-diamine

68497-62-1

pramiracetam

Conditions

Conditions	Yield
at 100℃; for 16h;	69%

121-05-1

N',N'-diisopropyl-ethane-1,2-diamine

N-(6-bromopyridin-2-yl)-2-(2-oxopyrrolidin-1-yl)acetamide

68497-62-1

pramiracetam

Conditions

Conditions	Yield
at 110℃; for 11h; Inert atmosphere;

121-05-1

N',N'-diisopropyl-ethane-1,2-diamine

68497-62-1

pramiracetam

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: tetrahydrofuran / 1.67 h / 0 - 15 °C 2.1: sodium methylate / toluene / 3 h / 105 - 108 °C 2.2: 60 - 70 °C View Scheme

68497-62-1

pramiracetam

pramiracetam monohydrate

Conditions

Conditions	Yield
With water In cyclohexane at 20 - 50℃; for 1.5h; Solvent;	90.92%

68497-62-1

pramiracetam

Pramiracetam sulfate

Conditions

Conditions	Yield
With sulfuric acid In acetonitrile at 0 - 5℃;	84.83%

Pramiracetam Chemical Properties