Product Name

  • Name

    rimazolium metilsulfate

  • EINECS
  • CAS No. 28610-84-6
  • Density g/cm3
  • Solubility
  • Melting Point 165-166°
  • Formula C13H19N2O3•CH3O4S
  • Boiling Point °Cat760mmHg
  • Molecular Weight 362.404
  • Flash Point °C
  • Transport Information
  • Appearance
  • Safety Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx and SOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 28610-84-6 (rimazolium metilsulfate)
  • Hazard Symbols
  • Synonyms rimazolium metilsulfate;Rimazolium
  • PSA 126.99000
  • LogP 0.92060

Probonal Chemical Properties

Product Name: Probonal (CAS NO.28610-84-6)


Molecular Formula: C13H19N2O3.CH3O4S
Molecular Weight: 362.44g/mol
Mol File: 28610-84-6.mol
Einecs: 249-103-4
H-Bond Donor: 0
H-Bond Acceptor: 7
Structure Descriptors of Probonal (CAS NO.28610-84-6):
  IUPAC Name: ethyl1,6-dimethyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-1-ium-3-carboxylate; methyl sulfate
  Canonical SMILES: CCOC(=O)C1=C[N+](=C2CCCC(N2C1=O)C)C.COS(=O)(=O)[O-]
  InChI: InChI=1S/C13H19N2O3.CH4O4S/c1-4-18-13(17)10-8-14(3)11-7-5-6-9(2)15(11)12(10)16;1-5-6(2,3)4/h8-9H,4-7H2,1-3H3;1H3,(H,2,3,4)/q+1;/p-1 
  InChIKey: SEISMQVOJUJKGE-UHFFFAOYSA-M

Probonal Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 150mg/kg (150mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
dog LD50 intravenous 230mg/kg (230mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
dog LD50 oral 500mg/kg (500mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
guinea pig LD50 intraperitoneal 500mg/kg (500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
guinea pig LD50 subcutaneous 420mg/kg (420mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
monkey LD50 oral > 1200mg/kg (1200mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
monkey LD50 subcutaneous > 900mg/kg (900mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
mouse LD50 intravenous 200mg/kg (200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
mouse LD50 oral 1100mg/kg (1100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
mouse LD50 subcutaneous 500mg/kg (500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
rabbit LD50 intravenous 200mg/kg (200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
rat LD50 intraperitoneal 720mg/kg (720mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
rat LD50 intravenous 217mg/kg (217mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 717, 1971.
rat LD50 oral 1500mg/kg (1500mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
rat LD50 subcutaneous 750mg/kg (750mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 727, 1971.

Probonal Safety Profile

Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx and SOx.

Probonal Specification

 Probonal ,its CAS NO. is 28610-84-6,the synonyms is 4H-Pyrido(1,2-a)pyrimidinium, 6,7,8,9-tetrahydro-3-carboxy-1,6-dimethyl-4-oxo-, ethyl ester, methyl sulfate ; 1,6-Dimethyl-3-carbethoxy-4-oxo-6,7,8,9-tetrahydrohomopyrimidazol methylsulphate ; 3-(Ethoxycarbonyl)-6,7,8,9-tetrahydro-1,6-dimethyl-4-oxo-4H-pyrido(1,2-a)pyrimidinium methyl sulfate ; Dolcuran ; EINECS 249-103-4 ; Metilsulfate de rimazolium ; Rimagina ; Rimazolii metilsulfas ; Rimazolium methyl sulfate ; Rimazolium metilsulfate ; Ro 11-780 ; UNII-99YI50276I .

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