Propanalol supplier | CasNO.525-66-6

Name
1-Isopropylamino-3-(naphthalen-1-yloxy)-propan-2-ol
EINECS 208-378-0
CAS No. 525-66-6
Article Data126
CAS DataBase
Density 1.093 g/cm³
Solubility Sol of 1 in 20 of water or alcohol; sltly sol in chloroform; practically insol in ether.
Melting Point 163-164 °C
Formula C16H21 N O2
Boiling Point 434.9 °C at 760 mmHg
Molecular Weight 259.348
Flash Point 216.8 °C
Transport Information
Appearance White, odorless crystalline powder.
Safety A deadly human poison by ingestion and intravenous routes. Poison experimentally by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: cardiac arrhythmias, hallucinations, hypoglycemia, convulsions, and thyroid malfunction. Human reproductive and teratogenic effects by ingestion: extra embryonic structures, abnormal Apgar score in newborn, and abnormal growth statistics. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. See also INDERAL HYDROCHLORIDE.
Risk Codes
Molecular Structure
Hazard Symbols Highly toxic.
Synonyms 2-Propanol,1-(isopropylamino)-3-(1-naphthyloxy)- (7CI,8CI); (?à)-Propranolol; 1-(1-Naphthyloxy)-3-(isopropylamino)-2-propanol;1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol;3-(Naphth-1-yloxy)-1-(isopropylamino)propan-2-ol; AY 64043; Betalong;DL-Propranolol; Euprovasin; Innopran XL; Propranolol; Proprasylyt; Racemicpropranolol; Reducor; dl-Propranolol; b-Propranolol
PSA 41.49000
LogP 2.96840

Synthetic route

: 91740-63-5
3-isopropyl-5-<(nphthyloxy)methyl>oxazolidin-2-one

: 525-66-6
propranolol

Conditions

Conditions	Yield
With potassium hydroxide In benzene for 24h; Heating;	100%

: 2461-42-9
3-(1-naphthyloxy)-1,2-epoxypropane

: 75-31-0
isopropylamine

: 525-66-6
propranolol

Conditions

Conditions	Yield
With acetic acid In water at 20℃; for 8h;	99%
In water	94%
Stage #1: 3-(1-naphthyloxy)-1,2-epoxypropane With calcium chloride In acetonitrile Stage #2: isopropylamine In acetonitrile Further stages.;	93%

: 2461-42-9
3-(1-naphthyloxy)-1,2-epoxypropane

: 79-46-9
2-nitropropane

: 525-66-6
propranolol

Conditions

Conditions	Yield
With sodium tetrahydroborate; nickel(II) chloride hexahydrate In water at 20℃; for 24h; Inert atmosphere; Green chemistry;	94%

: 90-15-3
α-naphthol

: 75-31-0
isopropylamine

: 106-89-8
epichlorohydrin

: 525-66-6
propranolol

Conditions

Conditions	Yield
With tetrabutylammomium bromide; sodium hydroxide In water at 0 - 100℃; for 5h; Reagent/catalyst; Solvent;	90%
Stage #1: α-naphthol; epichlorohydrin With potassium tert-butylate In dimethyl sulfoxide at 70℃; for 0.333333h; Williamson Ether Synthesis; Flow reactor; Stage #2: isopropylamine In dimethyl sulfoxide at 140℃; under 5250.53 Torr; for 0.333333h; Flow reactor;	47 %Chromat.

...Expand

: 2007-16-1
(RS)-1-bromo-3-(1-naphthyloxy)-2-propanol

: 75-31-0
isopropylamine

: 525-66-6
propranolol

Conditions

Conditions	Yield
In 5,5-dimethyl-1,3-cyclohexadiene at 40℃; for 4h; Solvent; Temperature;	88.9%

: 2461-42-9
3-(1-naphthyloxy)-1,2-epoxypropane

: 75-31-0
isopropylamine

A: 83314-78-7
N-Isopropyl-N,N-di-<3-(1-naphthoxy)-2-hydroxypropyl>amin

B: 525-66-6
propranolol

Conditions

Conditions	Yield
In toluene for 4h;	A 60% B n/a

...Expand

: 82616-68-0
1-(3,4-Dihydro-naphthalen-1-yloxy)-3-isopropylamino-propan-2-ol

: 525-66-6
propranolol

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone	59%

: 75-31-0
isopropylamine

: 2,2-Dichloro-3-(naphthalen-1-yloxymethyl)-oxirane

A: C24H20O2

B: C24H20O2

C: 525-66-6
propranolol

Conditions

Conditions	Yield
In tetrahydrofuran	A n/a B n/a C 35%

...Expand

: 20133-93-1
1-chloro-3-(1-naphthoxy)-2-propanol

: 75-31-0
isopropylamine

: 525-66-6
propranolol

: 129459-75-2
1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-yl acetate

: 525-66-6
propranolol

Conditions

Conditions	Yield
at 37℃; Rate constant; plasma intestine and liver of rats;

: 129207-75-6
N'-tert-Butyl-N-[2-hydroxy-3-(naphthalen-1-yloxy)-propyl]-N-isopropyl-formamidine

: 525-66-6
propranolol

Conditions

Conditions	Yield
With potassium hydroxide; water In methanol at 60℃; for 12h; Yield given;

: 94769-42-3
O-pivaloyl-1-(1-naphthyloxy)-3-isopropylaminopropan-2-ol hydrochloride

: 525-66-6
propranolol

Conditions

Conditions	Yield
With phosphate buffer (μ = 0.15) In dimethyl sulfoxide at 37℃; Rate constant; var. pH; hydrolysis in buffers and enzymatic hydrolysis in blood plasma and liver homogenate, both taken from beagle dogs;

: 4290-58-8
O-acetylpropranolol hydrochloride

: 525-66-6
propranolol

Conditions

Conditions	Yield
With phosphate buffer (μ = 0.15) In dimethyl sulfoxide at 37℃; Rate constant; var. pH; hydrolysis in buffers and enzymatic hydrolysis in blood plasma and liver homogenate, both taken from beagle dogs;

: O-propionylpropranolol hydrochloride

: 525-66-6
propranolol

Conditions

Conditions	Yield
With phosphate buffer (μ = 0.15) In dimethyl sulfoxide at 37℃; Rate constant; var. pH; hydrolysis in buffers and enzymatic hydrolysis in blood plasma and liver homogenate, both taken from beagle dogs;

: O-Butyryl propranolol hydrochloride

: 525-66-6
propranolol

Conditions

Conditions	Yield
With phosphate buffer (μ = 0.15) In dimethyl sulfoxide at 37℃; Rate constant; var. pH; hydrolysis in buffers and enzymatic hydrolysis in blood plasma and liver homogenate, both taken from beagle dogs;

: O-isobutyrylpropranolol hydrochloride

: 525-66-6
propranolol

Conditions

Conditions	Yield
With phosphate buffer (μ = 0.15) In dimethyl sulfoxide at 37℃; Rate constant; var. pH; hydrolysis in buffers and enzymatic hydrolysis in blood plasma and liver homogenate, both taken from beagle dogs;

: O-isovalerylpropranolol hydrochloride

: 525-66-6
propranolol

Conditions

Conditions	Yield
With phosphate buffer (μ = 0.15) In dimethyl sulfoxide at 37℃; Rate constant; var. pH; hydrolysis in buffers and enzymatic hydrolysis in blood plasma and liver homogenate, both taken from beagle dogs;

: O-valerylpropranolol hydrochloride

: 525-66-6
propranolol

Conditions

Conditions	Yield
With phosphate buffer (μ = 0.15) In dimethyl sulfoxide at 37℃; Rate constant; var. pH; hydrolysis in buffers and enzymatic hydrolysis in blood plasma and liver homogenate, both taken from beagle dogs;

: O-cyclopropanoylpropranolol hydrochloride

: 525-66-6
propranolol

Conditions

Conditions	Yield
With phosphate buffer (μ = 0.15) In dimethyl sulfoxide at 37℃; Rate constant; var. pH; hydrolysis in buffers and enzymatic hydrolysis in blood plasma and liver homogenate, both taken from beagle dogs;

: Cyclobutanecarboxylic acid 1-(isopropylamino-methyl)-2-(naphthalen-1-yloxy)-ethyl ester; hydrochloride

: 525-66-6
propranolol

Conditions

Conditions	Yield
With phosphate buffer (μ = 0.15) In dimethyl sulfoxide at 37℃; Rate constant; var. pH; hydrolysis in buffers and enzymatic hydrolysis in blood plasma and liver homogenate, both taken from beagle dogs;

: Cyclopentanecarboxylic acid 1-(isopropylamino-methyl)-2-(naphthalen-1-yloxy)-ethyl ester; hydrochloride

: 525-66-6
propranolol

Conditions

Conditions	Yield
With phosphate buffer (μ = 0.15) In dimethyl sulfoxide at 37℃; Rate constant; var. pH; hydrolysis in buffers and enzymatic hydrolysis in blood plasma and liver homogenate, both taken from beagle dogs;

: O-cyclohexanoylpropranolol hydrochloride

: 525-66-6
propranolol

Conditions

Conditions	Yield
With phosphate buffer (μ = 0.15) In dimethyl sulfoxide at 37℃; Rate constant; var. pH; hydrolysis in buffers and enzymatic hydrolysis in blood plasma and liver homogenate, both taken from beagle dogs;

: Malonic acid 1-(isopropylamino-methyl)-2-(naphthalen-1-yloxy)-ethyl ester methyl ester; hydrochloride

: 525-66-6
propranolol

Conditions

Conditions	Yield
With phosphate buffer (μ = 0.15) In dimethyl sulfoxide at 37℃; Rate constant; var. pH; hydrolysis in buffers and enzymatic hydrolysis in blood plasma and liver homogenate, both taken from beagle dogs;

: Malonic acid ethyl ester 1-(isopropylamino-methyl)-2-(naphthalen-1-yloxy)-ethyl ester; hydrochloride

: 525-66-6
propranolol

Conditions

Conditions	Yield
With phosphate buffer (μ = 0.15) In dimethyl sulfoxide at 37℃; Rate constant; var. pH; hydrolysis in buffers and enzymatic hydrolysis in blood plasma and liver homogenate, both taken from beagle dogs;

: Succinic acid 1-(isopropylamino-methyl)-2-(naphthalen-1-yloxy)-ethyl ester methyl ester; hydrochloride

: 525-66-6
propranolol

Conditions

Conditions	Yield
With phosphate buffer (μ = 0.15) In dimethyl sulfoxide at 37℃; Rate constant; var. pH; hydrolysis in buffers and enzymatic hydrolysis in blood plasma and liver homogenate, both taken from beagle dogs;

: Pentanedioic acid 1-(isopropylamino-methyl)-2-(naphthalen-1-yloxy)-ethyl ester methyl ester; hydrochloride

: 525-66-6
propranolol

Conditions

Conditions	Yield
With phosphate buffer (μ = 0.15) In dimethyl sulfoxide at 37℃; Rate constant; var. pH; hydrolysis in buffers and enzymatic hydrolysis in blood plasma and liver homogenate, both taken from beagle dogs;

: 99106-37-3
1--N-isopropylamino>-3-(1-naphthyloxy)-2-propanol

A: 124-38-9
carbon dioxide

B: 75-07-0
acetaldehyde

C: 64-19-7
acetic acid

D: 525-66-6
propranolol

Conditions

Conditions	Yield
With phosphate buffer; water at 37℃; Product distribution; pH 7.4, further reagent, half-lives;

...Expand

: 129459-75-2
1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-yl acetate

A: 2007-11-6
N-[2-hydroxy-3-(1-naphthalenyloxy)propyl]-N-(1-methylethyl)acetamide

B: 525-66-6
propranolol

Conditions

Conditions	Yield
With potassium hydroxide In water; acetone at 25℃; Rate constant;

: 27827-17-4
1-isopropyl-2-naphthalen-1-yloxymethyl-aziridine

: 525-66-6
propranolol

Conditions

Conditions	Yield
With sulfuric acid

: 24424-99-5
di-tert-butyl dicarbonate

: 525-66-6
propranolol

: 122835-05-6
rac-N-tert-Butoxycarbonyl-N-isopropyl-N-[2-hydroxy-3-(1-naphthyloxy)propyl]amine

Conditions

Conditions	Yield
With triethylamine In dichloromethane	98.7%

: 109-94-4
formic acid ethyl ester

: 525-66-6
propranolol

: 1-<(1-methylethyl)-amino>-3-(1-naphthalenyloxy)-2-propanol formate

Conditions

Conditions	Yield
for 48h; Ambient temperature;	95%

: 525-66-6
propranolol

: (±)-propranolol hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In ethanol at 0 - 10℃; for 3h; Temperature; Solvent;	93.5%

: 525-66-6
propranolol

: 4199-09-1
(S)-1-isopropylamino-3-(1-naphthyloxy)-2-propanol

Conditions

Conditions	Yield
Stage #1: propranolol With L-Tartaric acid In ethanol for 10h; Reflux; Stage #2: With sodium hydrogencarbonate In toluene at 25℃; for 0.333333h; Cooling with ice;	88%

: 106-94-5
propyl bromide

: 525-66-6
propranolol

: 1-isopropylamino-3-(1-naphthyloxy)-2-n-propoxypropane

Conditions

Conditions	Yield
Stage #1: propranolol With sodium hydride In N,N-dimethyl-formamide at 35 - 40℃; for 0.5h; Stage #2: propyl bromide In N,N-dimethyl-formamide at 20℃; for 1h;	86%

: 74-88-4
methyl iodide

: 525-66-6
propranolol

: isopropyl-[2-methoxy-3-(naphthalen-1-yloxy)-propyl]-amine

Conditions

Conditions	Yield
Stage #1: propranolol With sodium hydride In N,N-dimethyl-formamide at 35 - 40℃; for 0.5h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 1h;	86%

: 525-66-6
propranolol

: 318-98-9
Inderal

Conditions

Conditions	Yield
Stage #1: propranolol With pyrographite In ethanol for 0.5h; Reflux; Stage #2: With hydrogenchloride at 4℃; pH=2;	85.1%
With hydrogenchloride In ethanol; water	79.7%

: C28H26O5

: 525-66-6
propranolol

A: C30H33NO4

B: C30H33NO4

Conditions

Conditions	Yield
In acetonitrile at 30℃; for 0.5h; pH=9.5; Temperature;	A 85.08% B 83.14%

...Expand

: 77124-20-0
(E)-3-(3-phenoxyphenyl)acrylic acid

: 525-66-6
propranolol

: (E)-N-(2-hydroxy-3-(naphthalen-1-yloxy)propyl)-N-isopropyl-3-(3-phenoxyphenyl)acrylamide

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In dichloromethane at 20℃; for 24h;	79%

: C33H52NS2(1+)*FO3S(1-)

: 525-66-6
propranolol

: 136912-10-2
1-{[(3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ylsulfanyl]-isopropyl-amino}-3-(naphthalen-1-yloxy)-propan-2-ol

Conditions

Conditions	Yield
In N,N-dimethyl-formamide	76%

: 109-94-4
formic acid ethyl ester

: 525-66-6
propranolol

: 77252-87-0
1-<<(1-methylethyl)-formyl>amino>-3-(1-naphthalenyloxy)-2-propanol

Conditions

Conditions	Yield
for 48h; Heating;	75%

: 4525-33-1
dimethyl dicarbonate

: 525-66-6
propranolol

: 135984-69-9
N,O-dimethoxycarbonyl propranolol

Conditions

Conditions	Yield
With dmap at 60℃; for 12h;	75%
With dmap

methanol-benzene: methanol-benzene

: 51263-39-9
(Z)-ethyl 2-bromobut-2-enoate

: 525-66-6
propranolol

: N-carbethoxypropenyl propranolol

Conditions

Conditions	Yield
In tetrahydrofuran; water	75%

...Expand

: 3911-55-5
N-benzoyl-carbonimidic acid dichloride

: 525-66-6
propranolol

: N-[3-Isopropyl-5-(naphthalen-1-yloxymethyl)-oxazolidin-(2E)-ylidene]-benzamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 0.5h;	72%

: 107-13-1
acrylonitrile

: 525-66-6
propranolol

A: 1606176-73-1
3-((1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-yl)oxy)propanenitrile

B: 1606176-74-2
3-((2-hydroxy-3-((naphthalen-1-yloxy)propyl)isopropyl)amino)propanenitrile

Conditions

Conditions	Yield
With n-butyllithium; copper(I) 2-hydroxy-3-methylbenzoate; 1,2-bis-(diphenylphosphino)ethane In hexane; N,N-dimethyl-formamide at 20℃; for 3h; Michael Addition; Inert atmosphere; chemoselective reaction;	A 63% B n/a

...Expand

: 74-88-4
methyl iodide

: 525-66-6
propranolol

: 38726-81-7, 113571-33-8, 113571-35-0
1-(N-Isopropyl-N,N-dimethylamino)-3-(α-naphthoxy)propan-2-ol iodide

Conditions

Conditions	Yield
With sodium hydroxide In isopropyl alcohol	62%

: potassium cyanide

: 525-66-6
propranolol

: 77252-87-0
1-<<(1-methylethyl)-formyl>amino>-3-(1-naphthalenyloxy)-2-propanol

Conditions

Conditions	Yield
With water; malonic acid dimethyl ester In methanol at 45℃; for 52h; Reflux;	62%

: 14737-89-4
3,4-dimethoxy-trans-cinnamic acid

: 525-66-6
propranolol

: (E)-3-(3,4-dimethoxyphenyl)-N-(2-hydroxy-3-(naphthalen-1-yloxy)propyl)-N-isopropylacrylamide

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In dichloromethane at 20℃; for 24h;	62%

: 140-10-3
(E)-3-phenylacrylic acid

: 525-66-6
propranolol

: (E)-N-(2-hydroxy-3-(naphthalen-1-yloxy)propyl)-N-isopropylcinnamamide

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In dichloromethane at 20℃; for 24h;	60%

: phenyl (4-methoxybenzoyl)oxycarbamate

: 525-66-6
propranolol

: 1-(2-hydroxy-3-(naphthalen-1-yloxy)propyl)-1-isopropyl-3-((4-methoxybenzoyl)oxy)urea

Conditions

Conditions	Yield
With 1H-imidazole In tetrahydrofuran at 100℃; for 2h; Microwave irradiation; Sealed tube;	60%

: 81282-38-4
N-diphenoxymethylene benzamide

: 525-66-6
propranolol

: N-[3-Isopropyl-5-(naphthalen-1-yloxymethyl)-oxazolidin-(2E)-ylidene]-benzamide

Conditions

Conditions	Yield
In dichloromethane for 5h; Ambient temperature;	58%

: 108-24-7
acetic anhydride

: 525-66-6
propranolol

: 70153-33-2
N-[2-acetyloxy-3-(1-naphthalenyloxy)propyl]-N-(1-methylethyl)acetamide

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃; for 4h;	54%

Propanalol Chemical Properties

Molecular Structure of Inderal (CAS NO.525-66-6):

Molecular Formula: C₁₆H₂₁NO₂
Molecular Weight: 259.34344
IUPAC Name: 1-(Isopropylamino)-3-(1-naphthyloxy)propan-2-ol
CAS: 525-66-6
EINECS: 208-378-0
SMILES: OC(CNC(C)C)COc2cccc1ccccc12
InChI: InChI=1/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
InChIKey: AQHHHDLHHXJYJD-UHFFFAOYAS
Std.InChI: InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
Std.InChIKey: AQHHHDLHHXJYJD-UHFFFAOYSA-N
Melting Point: 163-164℃
Boiling Point: 434.9℃ at 760mmHg
Flash Point: 216.8℃
Molar Volume: 237.1cm³
Density: 1.093g/cm³
Index of Refraction: 1.58
Molar Refractivity: 78.98cm³
Surface Tension: 42.6dyne/cm
Polarizability: 31.31 10^-24cm³
Enthalpy of Vaporization: 72.84kJ/mol
Vapour Pressure: 2.48E-08mmHg at 25℃

Propanalol Uses

Inderal (CAS NO.525-66-6) can be used for medication (vet).

Propanalol Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	LDLo	oral	800ug/kg/12H (0.8mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	British Medical Journal. Vol. 2, Pg. 254, 1978.
child	TDLo	oral	400mg/kg (400mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	Medical Journal of Australia. Vol. 1, Pg. 82, 1981.
dog	LDLo	intraperitoneal	40mg/kg (40mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Pharmazie. Vol. 31, Pg. 635, 1976.
dog	LDLo	oral	120mg/kg (120mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69(4), Pg. 262P, 1973.
guinea pig	LD50	intravenous	26mg/kg (26mg/kg)		Dissertationes Pharmaceuticae et Pharmacologicae. Vol. 24, Pg. 103, 1972.
human	LDLo	intravenous	71ug/kg (0.071mg/kg)		Lancet. Vol. 1, Pg. 165, 1967.
human	TDLo	oral	2300ug/kg/D (2.3mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	British Medical Journal. Vol. 1, Pg. 1182, 1978.
man	TDLo	oral	8343mg/kg/4Y- (8343mg/kg)	ENDOCRINE: EVIDENCE OF THYROID HYPERFUNCTION	Archives of Internal Medicine. Vol. 143, Pg. 2193, 1983.
man	TDLo	unreported	22857ug/kg/40 (22.857mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR	British Medical Journal. Vol. 289, Pg. 1490, 1984.
mouse	LD50	intraperitoneal	42mg/kg (42mg/kg)	AUTONOMIC NERVOUS SYSTEM: BETA ADRENERGIC BLOCKAGE	Ain Shams Medical Journal. Vol. 30, Pg. 23, 1979.
mouse	LD50	intravenous	24400ug/kg (24.4mg/kg)		United States Patent Document. Vol. #4013663,
mouse	LD50	oral	289mg/kg (289mg/kg)	AUTONOMIC NERVOUS SYSTEM: BETA ADRENERGIC BLOCKAGE	Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1831, 1980.
mouse	LD50	subcutaneous	150mg/kg (150mg/kg)		Farmakologiya i Toksikologiya Vol. 44, Pg. 342, 1981.
rat	LD50	intravenous	23mg/kg (23mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Pharmazie. Vol. 31, Pg. 635, 1976.
rat	LD50	oral	660mg/kg (660mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Pharmazie. Vol. 31, Pg. 635, 1976.
women	LDLo	oral	120mg/kg (120mg/kg)		Acta Pharmacologica et Toxicologica. Vol. 41, Pg. 190, 1977.
women	TDLo	oral	3200ug/kg/2D- (3.2mg/kg)	ENDOCRINE: HYPOGLYCEMIA	Israel Journal of Medical Sciences. Vol. 18, Pg. 725, 1982.
women	TDLo	oral	708mg/kg/39W- (708mg/kg)		Annals of Pharmacotherpy. Vol. 27, Pg. 512, 1993.

Propanalol Safety Profile

A deadly human poison by ingestion and intravenous routes. Poison experimentally by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: cardiac arrhythmias, hallucinations, hypoglycemia, convulsions, and thyroid malfunction. Human reproductive and teratogenic effects by ingestion: extra embryonic structures, abnormal Apgar score in newborn, and abnormal growth statistics. Mutation data reported.

Propanalol Specification

Inderal (CAS NO.525-66-6),which also can be called for 1-Isopropylamino-3-(1-naphthyloxy)propan-2-ol ; Propranolol Base ; 1-[Isopropylamino]-3-[1-naphthyloxy]-2-propanol ; 2-Propanol,1-(1-methylethyl)amino-3-(1-naphthalenyloxy)- ; 1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol ; 1-(1-Naphthyloxy)-3-(isopropylamino)-2-propanol ; 2-Propanol,1-(isopropylamino)-3-(1-naphthyloxy)- (7CI,8CI) ; 2-Propanol,1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)- (9CI) .When Inderal (525-66-6) was heated,it emits toxic fumes of NOx .This chemical is a crystals from Cyclohexane and it's slightly soluble in water.It is stable to heat, unstable to light.

Product Name

1-Isopropylamino-3-(naphthalen-1-yloxy)-propan-2-ol

Synthetic route

Propanalol Chemical Properties

Propanalol Uses

Propanalol Toxicity Data With Reference

Propanalol Safety Profile

Propanalol Specification

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