Propionyl chloride supplier

Name
Propionyl chloride
EINECS 201-170-0
CAS No. 79-03-8
Article Data140
CAS DataBase
Density 1.068 g/cm³
Solubility reacts with water
Melting Point -94 °C
Formula C₃H₅ClO
Boiling Point 75.5 °C at 760 mmHg
Molecular Weight 92.5251
Flash Point 11.7 °C
Transport Information UN 1815 3/PG 2
Appearance colorless liquid with a pungent odor
Safety 9-16-26-45
Risk Codes 11-14-34
Molecular Structure
Hazard Symbols F, C
Synonyms Propionylchloride (6CI,8CI);Chloro ethyl ketone;NSC 83547;Propionic acid chloride;
PSA 17.07000
LogP 1.16180

Synthetic route

: 802294-64-0
propionic acid

: 79-03-8
propionyl chloride

Conditions

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide at 70 - 75℃;	97%
With N,N-dimethyl-formamide; trichlorophosphate at 100℃;	93.7%
Stage #1: propionic acid With chloroform; oxygen; N,N-dimethyl-formamide at 30℃; for 3h; Irradiation; Stage #2: at 30℃; for 2h;	86%

: 802294-64-0
propionic acid

A: 79-03-8
propionyl chloride

B: 123-62-6
propionic acid anhydride

Conditions

Conditions	Yield
With phosphorus trichloride at 40 - 50℃; 4-5h;	A 57.9% B n/a
With phosphorus trichloride at 40 - 50℃; 4-5h;	A 46.4% B 18%

: 16844-98-7
trimethylsilyl propionate

: 4353-77-9
chlorosulfonate de trimethylsilyle

A: 79-03-8
propionyl chloride

B: 86521-60-0
trimethylsilyl 1-<(trimethylsiloxy)carbonyl>ethanesulfonate

Conditions

Conditions	Yield
In 1,2-dichloro-ethane for 12h; Mechanism; Heating; course is discussed; further trimethylsilyl carboxylates, aldehydes and ketones;	A n/a B 41%
In 1,2-dichloro-ethane for 12h; Heating;	A n/a B 41%

...Expand

: 98-88-4
benzoyl chloride

: 802294-64-0
propionic acid

: 79-03-8
propionyl chloride

: 51430-68-3
3,4-dichloro-(E)-3-hexene

A: 79-03-8
propionyl chloride

B: 100220-04-0
1,1-Dichlorpropylhydroperoxid

Conditions

Conditions	Yield
With hydrogenchloride; ozone; formic acid ethyl ester at -10 - 0℃;

: 802294-64-0
propionic acid

: 7719-12-2, 52843-90-0
phosphorus trichloride

: 79-03-8
propionyl chloride

Conditions

Conditions	Yield
at 20℃;

: 56-23-5
tetrachloromethane

: 7782-50-5
chlorine

: 123-62-6
propionic acid anhydride

A: 79-03-8
propionyl chloride

B propionyl hypochlorite: propionyl hypochlorite

Conditions

Conditions	Yield
at -15 - -5℃; unter Lichtausschluss;

...Expand

: 2570-00-5
3,3-dichloro-1,2-diphenylcyclopropene

: 802294-64-0
propionic acid

A: 79-03-8
propionyl chloride

B: 886-38-4
diphenylcyclopropenone

Conditions

Conditions	Yield
In chloroform-d1 for 0.25h; Inert atmosphere;

...Expand

: 96-22-0
pentan-3-one

A: 17042-21-6
2-chloro-3-pentanone

B: 32830-97-0
1-chloro-3-pentanone

C: 600-14-6
2,3-Pentanedione

D: 79-03-8
propionyl chloride

E: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
With oxygen; chlorine at 23.84℃; under 830 - 980 Torr; UV-irradiation;

...Expand

: 96-22-0
pentan-3-one

A: 17042-21-6
2-chloro-3-pentanone

B: 32830-97-0
1-chloro-3-pentanone

C: 1629-58-9
4-penten-3-one

D: 79-03-8
propionyl chloride

E: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
With oxygen; chlorine at 236.84℃; under 700 - 950 Torr; UV-irradiation;

...Expand

: 96-22-0
pentan-3-one

A: 17042-21-6
2-chloro-3-pentanone

B: 32830-97-0
1-chloro-3-pentanone

C: 79-03-8
propionyl chloride

D: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
With chlorine at 23.84℃; under 830 - 980 Torr; UV-irradiation;

...Expand

: 123-38-6
propionaldehyde

: 79-03-8
propionyl chloride

Conditions

Conditions	Yield
With trichloroisocyanuric acid In dichloromethane at 20℃; Inert atmosphere;
With trichloroisocyanuric acid In dichloromethane at 20℃; Inert atmosphere;

: 188290-36-0
thiophene

: 79-03-8
propionyl chloride

: 13679-75-9
1-thiophen-2-yl-propan-1-one

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 0℃; for 1.5h; Inert atmosphere;	100%
With aluminum (III) chloride In dichloromethane at 0℃; for 1.5h; Inert atmosphere;	100%
With zinc trifluoromethanesulfonate In nitromethane at 20℃; for 4h; Friedel-Crafts acylation;	89%

: 97-67-6
(S)-Malic acid

: 79-03-8
propionyl chloride

: 2,5-dioxotetrahydrofuran-3-yl propionate

Conditions

Conditions	Yield
for 8h; Inert atmosphere; Reflux;	100%

: 79-03-8
propionyl chloride

: 100-66-3
methoxybenzene

: 121-97-1
4-Methoxypropiophenone

Conditions

Conditions	Yield
With Noccaea caerulescens extract supported in montmorillonite K10 at 60℃; for 6h; Friedel Crafts acylation; Inert atmosphere; regioselective reaction;	100%
With aluminum (III) chloride In dichloromethane at 5 - 20℃; for 2.5h;	98%
With benzyltributylammonium tetrachloroferrate at 50℃; for 0.1h; Friedel-Crafts reaction;	93%

: 79-03-8
propionyl chloride

: 135-19-3
β-naphthol

: 13080-43-8
2-naphthyl propionate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	100%

: 420-04-2
CYANAMID

: 79-03-8
propionyl chloride

: 5634-64-0
propionylcyanamide

Conditions

Conditions	Yield
With sodium hydroxide In acetone	100%
With triethylamine In benzene

: 3597-45-3
cortienic acid

: 79-03-8
propionyl chloride

: 37933-23-6
11β-hydroxy-17α-propanoyloxy-3-oxo-androst-4-ene-17β-carboxylic acid

Conditions

Conditions	Yield
With triethylamine In dichloromethane	100%
(i), (ii) Et2NH, acetone; Multistep reaction;

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 79-03-8
propionyl chloride

: Propionic acid 9,10-dioxo-8-propionyloxy-9,10-dihydro-anthracen-1-yl ester

Conditions

Conditions	Yield
In pyridine for 3h; Ambient temperature;	100%

: 552-79-4
(-)-N-methylephedrine

: 79-03-8
propionyl chloride

: 53135-04-9
(1R,2S)-(2-Dimethylamino-1-phenyl)propyl propanoate

Conditions

Conditions	Yield
In dichloromethane	100%
In dichloromethane for 4h; Ambient temperature;	99%
In dichloromethane for 3h; Ambient temperature;	99%
In dichloromethane Yield given;

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 79-03-8
propionyl chloride

: 131685-53-5, 101711-78-8
(S)-4-benzyl-3-propionyl-2-oxazolidinone

Conditions

Conditions	Yield
Stage #1: (S)-4-Benzyl-2-oxazolidinone With sodium hydride In tetrahydrofuran at 0℃; for 1.16667h; Stage #2: propionyl chloride In tetrahydrofuran at 0 - 20℃;	100%
With n-butyllithium In tetrahydrofuran	100%
With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃;	99%

: 79-03-8
propionyl chloride

: 622-24-2
2-phenylethyl chloride

: 117922-95-9
4-(2-chloroethyl)propiophenone

Conditions

Conditions	Yield
With aluminium trichloride In 1,2-dichloro-ethane for 0.416667h; Ambient temperature;	100%
aluminium trichloride In 1,2-dichloro-ethane
aluminium trichloride In 1,2-dichloro-ethane

: 79-03-8
propionyl chloride

: 24560-29-0
lithium 2,6-dimethylphenolate dimer

: 51233-80-8
2,6-dimethylphenyl propionate

Conditions

Conditions	Yield
In tetrahydrofuran at -78℃;	100%

: 79-03-8
propionyl chloride

: 135928-55-1
1-[(2R,3S,4R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-4-phenylselanyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

: 134100-05-3
Propionic acid (2R,3S,4S,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-phenylselanyl-tetrahydro-furan-3-yl ester

Conditions

Conditions	Yield
	100%

: 79-03-8
propionyl chloride

: 83651-44-9
(2S*,3S*)-1-<(tert-butyldimethylsilyl)oxy>-2-methyl-4-penten-3-ol

: 83651-45-0
(2S*,3S*)-1-<(tert-butyldimethylsilyl)oxy>-2-methyl-4-penten-3-yl propanoate

Conditions

Conditions	Yield
With pyridine In dichloromethane for 2h; Ambient temperature;	100%
In dichloromethane	73%

: 79-03-8
propionyl chloride

: 90069-21-9
2-(4-{2-[8-Fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-ethyl}-piperazin-1-yl)-ethanol

: 77796-16-8
Propionic acid 2-(4-{2-[8-fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-ethyl}-piperazin-1-yl)-ethyl ester

Conditions

Conditions	Yield
In chloroform for 1h; Heating;	100%

: 79-03-8
propionyl chloride

: 77796-03-3
1-[8-Fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-2-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-ethanone

: 90069-22-0
Propionic acid 2-(4-{2-[8-fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-2-oxo-ethyl}-piperazin-1-yl)-ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In chloroform for 1h; Heating;	100%

: 79-03-8
propionyl chloride

: 78095-35-9
(S)-8-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride

: 136655-73-7
(2S)-8-methoxy-2-(N-propylpropionamido)-1,2,3,4-tetrahydronaphthaline

Conditions

Conditions	Yield
With triethylamine In diethyl ether Ambient temperature;	100%

: 79-03-8
propionyl chloride

: 46864-14-6
(1S,2R)-N,N-dimethyl-2-hydroxy-1,2-diphenyl-ethylamine

: (1R,2S)-N-methylephedrine-O-propionate

Conditions

Conditions	Yield
In dichloromethane	100%

: 79-03-8
propionyl chloride

: 93503-09-4
(S)-(-)-(7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride

: 93503-15-2
(S)-N-propionyl-7-methoxy-2-(propylamine)tetralin

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane for 0.5h;	100%

: 79-03-8
propionyl chloride

: 23978-55-4
1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

: 105399-97-1
N,N'-dipropanoyl-4,13-diaza-18-crown-6

Conditions

Conditions	Yield
With sodium carbonate In benzene for 12h; Ambient temperature;	100%

: 79-03-8
propionyl chloride

: 149250-83-9
cis-(1S,2S)-2-(3-methoxyphenyl)-N-propylcyclohexylamine

: 149191-75-3
N-[(1S,2S)-2-(3-Methoxy-phenyl)-cyclohexyl]-N-propyl-propionamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 1.5h; Ambient temperature;	100%

: 79-03-8
propionyl chloride

: 149250-84-0
cis-(1R,2R)-2-(3-methoxyphenyl)-N-propylcyclohexylamine

: N-[(1R,2R)-2-(3-Methoxy-phenyl)-cyclohexyl]-N-propyl-propionamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 1.5h; Ambient temperature;	100%

: 79-03-8
propionyl chloride

: 149250-84-0
cis-(1R,2R)-2-(3-methoxyphenyl)-N-propylcyclohexylamine

: cis-(1R,2R)-2-(3-hydroxyphenyl)-N,N-dipropylcyclohexylamine hydrobromide

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 1.5h; Ambient temperature;	100%

: 79-03-8
propionyl chloride

: 136905-97-0
2-n-Propylamino-8-chloro-1,2,3,4-tetrahydronaphthalene

: 136905-98-1
8-chloro-2-(N-n-propyl-N-propionyl-amino)-1,2,3,4-tetrahydronaphthalene

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 0.166667h; Ambient temperature;	100%

: 79-03-8
propionyl chloride

: 598-40-3
ethyl iodoacetate

Conditions

Conditions	Yield
With diiodosilane; iodine In chloroform-d1 at 25℃; for 0.166667h;	100%
With trimethylsilyl iodide	93%
With sodium iodide In acetonitrile for 1h; Ambient temperature;	53%
With sodium iodide at 20℃; for 0.166667h;

: 700-12-9
pentamethylbenzene,

: 79-03-8
propionyl chloride

: 2040-17-7
1-(2,3,4,5,6-pentamethylphenyl)propan-1-one

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 0℃; for 0.583333h;	100%
aluminium trichloride In dichloromethane at 0℃; for 4h;	92.1%

: 79-03-8
propionyl chloride

: 159142-00-4
(R)-N-(1S,2R)-<3-<2-<<(1,1-dimethylethyl)amino>carbonyl>phenyl>-2-hydroxy-1-(phenylmethyl)propyl>-2-amino-4-oxo-4-(benzyloxy)butanamide

: (R)-N-(1S,2R)-<3-<2-<<(1,1-dimethylethyl)amino>carbonyl>phenyl>-2-hydroxy-1-(phenylmethyl)propyl>-2-<(ethylcarbonyl)amino>-4-oxo-4-(benzyloxy)butanamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 0.5h; Ambient temperature;	100%

: 16251-45-9, 17097-67-5, 28044-22-6, 28044-23-7, 39663-75-7, 54418-69-8, 77943-39-6, 125133-96-2, 149055-02-7
(4S,5R)-4-methyl-5-phenyl-oxazolidin-2-one

: 79-03-8
propionyl chloride

: 77877-20-4, 116382-72-0, 143654-01-7
(4S,5R)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one

Conditions

Conditions	Yield
Stage #1: (4S,5R)-4-methyl-5-phenyl-oxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Metallation; Stage #2: propionyl chloride In tetrahydrofuran; hexane at -78 - 0℃; for 1.5h; Acylation;	100%
Stage #1: (4S,5R)-4-methyl-5-phenyl-oxazolidin-2-one With n-butyllithium In tetrahydrofuran at -78℃; for 2h; Stage #2: propionyl chloride In tetrahydrofuran at -78℃; for 2h;	99.5%
Stage #1: (4S,5R)-4-methyl-5-phenyl-oxazolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; Stage #2: propionyl chloride In tetrahydrofuran; hexane at -78 - 20℃;	97%

: 40217-17-2, 90719-32-7, 120574-96-1, 102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: 79-03-8
propionyl chloride

: 101711-78-8, 131685-53-5
(3R)-3-propionyl-4-benzyloxazolidin-2-one

Conditions

Conditions	Yield
Stage #1: (R)-4-(phenylmethyl)-2-oxazolidinone With n-butyllithium In tetrahydrofuran; hexane at -78 - -68℃; for 1h; Cooling with acetone-dry ice; Stage #2: propionyl chloride In tetrahydrofuran; hexane at -68 - 20℃; for 2.25h;	100%
Stage #1: (R)-4-(phenylmethyl)-2-oxazolidinone With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.75h; Inert atmosphere; Stage #2: propionyl chloride In tetrahydrofuran; hexane at -78 - 0℃; Inert atmosphere;	99%
Stage #1: (R)-4-(phenylmethyl)-2-oxazolidinone With n-butyllithium In tetrahydrofuran at -78℃; for 0.333333h; Inert atmosphere; Stage #2: propionyl chloride In tetrahydrofuran at -78 - 20℃; Inert atmosphere;	99%

: 79-03-8
propionyl chloride

: (3aS,6R,6aS)-6-Ethyl-3,3-dimethyl-5-(toluene-4-sulfonyl)-hexahydro-pyrrolo[3,4-c]isoxazole

: 1-[(3aS,6R,6aS)-6-Ethyl-3,3-dimethyl-5-(toluene-4-sulfonyl)-hexahydro-pyrrolo[3,4-c]isoxazol-1-yl]-propan-1-one

Conditions

Conditions	Yield
With triethylamine In dichloromethane	100%

: 79-03-8
propionyl chloride

: 190838-91-6
(3aR,6S,6aR)-6-Isopropyl-3,3-dimethyl-5-(toluene-4-sulfonyl)-hexahydro-pyrrolo[3,4-c]isoxazole

: 190838-95-0
1-[(3aR,6S,6aR)-6-Isopropyl-3,3-dimethyl-5-(toluene-4-sulfonyl)-hexahydro-pyrrolo[3,4-c]isoxazol-1-yl]-propan-1-one

Conditions

Conditions	Yield
With triethylamine In dichloromethane	100%

Propionyl chloride Consensus Reports

Reported in EPA TSCA Inventory.

Propionyl chloride Specification

1. Introduction of Propionyl chloride
Propionyl chloride, its Synonyms are Propionic acid chloride; Propionic chloride; Propanoyl chloride.

2. Properties of Propionyl chloride
XLogP3-AA: 1.2
H-Bond Donor: 0
H-Bond Acceptor: 1
Index of Refraction: 1.396
Molar Refractivity: 20.82 cm³
Molar Volume: 86.5 cm³
Surface Tension: 25.7 dyne/cm
Density: 1.068 g/cm³
Flash Point: 11.7 °C
Enthalpy of Vaporization: 31.67 kJ/mol
Boiling Point: 75.5 °C at 760 mmHg
Vapour Pressure: 105 mmHg at 25 °C
Appearance: colorless liquid with a pungent odor
Melting Point: -94 °C
storage temp.: Flammables area
Water Solubility: REACTS
FreezingPoint: -94 °C
Sensitive: Moisture Sensitive
Product Categories: Organics; Acid Halides; Carbonyl Compounds; Organic Building Blocks

3. Structure Descriptors of Propionyl chloride
Canonical SMILES: CCC(=O)Cl
InChI: InChI=1S/C3H5ClO/c1-2-3(4)5/h2H2,1H3
InChIKey: RZWZRACFZGVKFM-UHFFFAOYSA-N

4. Safety Information of Propionyl chloride
A corrosive irritant to skin, eyes, and mucous membranes. Dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. Reacts with water or steam to produce toxic and corrosive fumes. Exothermic reaction with diisopropyl ether produces much gas. The reaction may be dangerous if confined. To fight fire, use CO₂, dry chemical; do not use water. When heated to decomposition it emits highly toxic fumes of Cl⁻.
Hazard Codes: F,C
Risk Statements: 11-14-34
R11:Highly flammable.
R14 :Reacts violently with water.
R34:Causes burns.
Safety Statements: 9-16-26-45
S9:Keep container in a well-ventilated place.
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 1815 3/PG 2
WGK Germany: 1
HazardClass: 3
PackingGroup: II
RTECS: UG6657000

5. Use of Propionyl chloride
In the pharmaceutical industry, Propionyl chloride is used for the production of anti-epileptic drugs , anti-adrenaline drug,etc.

Product Name

Propionyl chloride

Synthetic route

Propionyl chloride Consensus Reports

Propionyl chloride Specification

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