Pyridinium,3-(aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)-, inner salt supplier

: 23111-00-4
3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium (β-D-nicotinamide riboside)

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
With trimethyl phosphite; trichlorophosphate at 0℃; for 12h; Inert atmosphere;	88.27%
Stage #1: 3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium (β-D-nicotinamide riboside) With Sodium trimetaphosphate; sodium hydroxide In water at 30℃; for 4h; pH=9; Stage #2: With hydrogenchloride In water at 10℃; Reagent/catalyst;	68%
With nitromethane; water; trichlorophosphate

: 78687-39-5
3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium bromide

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
With trimethyl phosphite; trichlorophosphate at -5 - 0℃; for 7h;	80%
With trimethyl phosphite; trichlorophosphate at 0℃; for 4h;	64%

: (3,4-dihydroxy-5-(3-(ethoxycarbonyl)pyridin-1-ium-1-yl)tetrahydrofuran-2-yl)methyl hydrogen phosphate

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
With ammonia In acetonitrile at -5 - 5℃; for 1h;	80%

: 53-84-9
NAD

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
With ethylenediaminetetraacetic acid; ammonium acetate; zirconium(IV) chloride In ethanol at 50℃; for 0.5h; pH 5;	70%
With water; zirconium(IV) chloride at 80℃; for 0.5h; Reagent/catalyst;

: C23H24N2O8P(1+)*Cl(1-)

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
With platinum(IV) oxide; hydrogen In deuteromethanol for 12h; Reagent/catalyst;	64%

: 1341-23-7
1-(β-D-ribofuranosyl)-nicotinamide

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
With trichlorophosphate In tetrahydrofuran at 0 - 20℃; for 12h;	56%

: 53406-00-1
3-carbamoyl-1-(2,4-dinitrophenyl)pyridinium chloride

: 87763-86-8
ribose 5-phosphate bis(cyclohexylammonium) salt

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
With ammonia 1.) -60 deg C, 36 h; r.t., 1 h; 2.) methanol, ethylene glycol (1:1), 4 deg C, 11 h;	35%

: 98-92-0
nicotinamide

: 97-55-2, 7540-64-9, 99945-37-6, 130384-52-0
5-phosphoribosyl-1-pyrophosphate

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
Enzym aus Erythrocyten;

: 53406-00-1
3-carbamoyl-1-(2,4-dinitrophenyl)pyridinium chloride

: 14050-66-9
phosphoribosylamine

A: 1094-61-7
nicotinamide mononucleotide

B: 7298-94-4
α-nicotinamide mononucleotide

C: 97-02-9
2,4-Dinitroanilin

Conditions

Conditions	Yield
In methanol at 5℃; for 14h; Yield given;
In methanol at 5℃; for 14h;

...Expand

β-NAD: β-NAD

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
enzymatische Spaltung;

: 18784-01-5
N1-(2,3,5-Tri-O-benzoyl-β-D-ribofuranosyl)-3-aminocarbonylpyridinium bromide

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NH3 / methanol 2: 80 percent / POCl3, PO(OMe)3 / 7 h / -5 - 0 °C View Scheme
Multi-step reaction with 2 steps 1: 55 percent / NH3 / methanol / 72 h / -18 °C 2: 64 percent / Phosphoryl chloride, trimethyl phosphate / 4 h / 0 °C View Scheme

: 78687-38-4
N1-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-3-aminocarbonylpyridinium bromide

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 80 percent / NH3 / methanol / 20 h / -5 - -3 °C 2: 80 percent / POCl3, PO(OMe)3 / 7 h / -5 - 0 °C View Scheme

: 47287-36-5, 119923-66-9
adenosine 5'-monophosphate

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 91 percent / 1.) H(+), H2O / 1.) 100 deg C, 6 min; 2.) 0 deg C 2: 35 percent / NH3 / 1.) -60 deg C, 36 h; r.t., 1 h; 2.) methanol, ethylene glycol (1:1), 4 deg C, 11 h View Scheme

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: HBr / CH2Cl2 / 3 h / -20 °C 2: liquid sulphur dioxide 3: 55 percent / NH3 / methanol / 72 h / -18 °C 4: 64 percent / Phosphoryl chloride, trimethyl phosphate / 4 h / 0 °C View Scheme
Multi-step reaction with 4 steps 1: hydrogen chloride; diethyl ether 2: acetonitrile 3: NH3; methanol 4: POCl3; nitromethane; H2O View Scheme

: 22860-91-9
2,3,5-tri-O-benzoyl-D-ribofuranosyl bromide

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: liquid sulphur dioxide 2: 55 percent / NH3 / methanol / 72 h / -18 °C 3: 64 percent / Phosphoryl chloride, trimethyl phosphate / 4 h / 0 °C View Scheme

: 105499-44-3
2,3,5-tri-O-acetyl-α-D-ribofuranosyl chloride

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: acetonitrile 2: NH3; methanol 3: POCl3; nitromethane; H2O View Scheme

: 98-92-0
nicotinamide

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: acetonitrile 2: NH3; methanol 3: POCl3; nitromethane; H2O View Scheme
Multi-step reaction with 3 steps 1: trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 12 h / 0 - 20 °C 2: sodium ethanolate / ethanol / 1 h / -5 - 5 °C 3: trichlorophosphate / tetrahydrofuran / 12 h / 0 - 20 °C View Scheme
Multi-step reaction with 4 steps 1.1: ammonium sulfate / 8 h / 125 °C 2.1: tin(IV) chloride / dichloromethane / 1.5 h / 55 °C 2.2: 0.75 h / 0 °C 3.1: methanol; propylamine / 22 h / -5 °C 4.1: trimethyl phosphite; trichlorophosphate / 12 h / 0 °C / Inert atmosphere View Scheme

: 109527-15-3
5’,3‘,2’-tri-O-acetyl-1-β-D-ribofuranosylnicotinamide chloride

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NH3; methanol 2: POCl3; nitromethane; H2O View Scheme
Multi-step reaction with 2 steps 1: hydrogenchloride / methanol / 12 h / Sealed tube 2: trichlorophosphate View Scheme

: 122620-02-4
3-carbamoyl-1-(tri-O-benzoyl-β-D-ribofuranosyl)-pyridinium; chloride

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NH3; methanol 2: POCl3; nitromethane; H2O View Scheme

: 5991-01-5
2,3,5-(tri-O-benzoyl)-D-ribofuranosyl chloride

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: acetonitrile 2: NH3; methanol 3: POCl3; nitromethane; H2O View Scheme

: 3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium trifluoromethanesulfonate

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
With trimethyl phosphite; trichlorophosphate at -5 - 0℃; for 12h; Inert atmosphere;

: pentasodium 5-phosphoribosyl 1-pyrophosphate

: 98-92-0
nicotinamide

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
With nicotinamide phosphoribosyltransferase; tris hydrochloride; ATP; magnesium chloride; D,L-dithiothreitol; bovine serum albumin In water at 37℃; Kinetics; Enzymatic reaction;

: 53-84-9
NAD

A: 1094-61-7
nicotinamide mononucleotide

B: 58-64-0
adenosine 5'-diphosphate

C: 58-61-7
adenosine

Conditions

Conditions	Yield
With water; zirconium(IV) oxide at 80℃; for 48h;

...Expand

: 40554-98-1
[(2R,3R,4R)-3,4-diacetoxy-5-chlorotetrahydrofuran-2-yl]methyl acetate

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: acetonitrile / 0.33 h / 70 °C 2: hydrogenchloride / methanol / 12 h / Sealed tube 3: trichlorophosphate View Scheme
Multi-step reaction with 3 steps 1: acetonitrile / 50 °C 2: hydrogenchloride / methanol / 12 h / Sealed tube 3: trichlorophosphate View Scheme

: 3-carbamoyl-1-((2R,3R,4R,5R)-3,4-diacetoxy-5-(acetoxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium trifluoromethanesulfonate

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: ammonia / methanol / 24 h / -9 - -8 °C 2: hydrogenchloride / methanol / 8 h / -8 - 0 °C 3: trimethyl phosphite; trichlorophosphate / 24 h / -10 - -7 °C View Scheme

: 76961-04-1
nicotinamide adenine dinucleotide

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
With zirconium(IV) chloride In water at 50℃; for 1h;

: 98-92-0
nicotinamide

: 5-phospho-α-D-ribosyl 1-pyrophosphate

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
With tris(3-hydroxypropyl)phosphine; nicotinamide phosphoribosyltransferase; tris hydrochloride; ATP; magnesium chloride In water at 37℃; pH=7.5; Kinetics; Reagent/catalyst; Enzymatic reaction;

: 13035-61-5
1,2,3,5-tetraacetylribose

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 12 h / 0 - 20 °C 2.1: ammonia / 1 h / -5 - 5 °C 2.2: 1 h / -5 - 5 °C 3.1: trichlorophosphate / tetrahydrofuran / 12 h / 0 - 20 °C View Scheme
Multi-step reaction with 3 steps 1: trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 12 h / 0 - 20 °C 2: sodium ethanolate / ethanol / 1 h / -5 - 5 °C 3: trichlorophosphate / tetrahydrofuran / 12 h / 0 - 20 °C View Scheme

: 614-18-6
3-pyridinecarboxylic acid ethyl ester

: 1094-61-7
nicotinamide mononucleotide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 12 h / 0 - 20 °C 2.1: ammonia / 1 h / -5 - 5 °C 2.2: 1 h / -5 - 5 °C 3.1: trichlorophosphate / tetrahydrofuran / 12 h / 0 - 20 °C View Scheme

: 72-18-4
L-valine

: 1094-61-7
nicotinamide mononucleotide

: (S)-1-carboxy-2-methypropan-1-aminium ((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In water at 10℃; pH=Ca. 3.8 - 4;	100%

: 1094-61-7
nicotinamide mononucleotide

: 71-00-1
L-histidine

: (S)-1-carboxy-2-(1H-imidazol-4-yl)ethanaminium ((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In water at 10℃; pH=Ca. 6 - 6.2;	100%

: 72-19-5
L-threonine

: 1094-61-7
nicotinamide mononucleotide

: (1S,2R)-1-carboxy-2-hydropropan-1-aminium ((2R,3R,4S,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In water at 10℃; pH=Ca. 3.9 - 4.4;	100%

: 1094-61-7
nicotinamide mononucleotide

: 147-85-3
L-proline

: (S)-2-carboxypyrrolidin-1-ium ((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In water at 10℃; pH=Ca. 3.3 - 3.9;	100%

: 56-87-1
L-lysine

: 1094-61-7
nicotinamide mononucleotide

: (S)-5-amino-5-carboxypentan-1-aminium ((2R,3R,4S,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In water at 10℃; pH=Ca. 6 - 6.2;	100%

: 56-84-8
L-Aspartic acid

: 1094-61-7
nicotinamide mononucleotide

: (S)-1,2-dicarboxyethan-1-aminium-((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In water pH=2.99 - 3.39; Inert atmosphere; Cooling with ice;	100%

: 107-43-7
betaine

: 1094-61-7
nicotinamide mononucleotide

: 1-carboxy-N,N,N-trimethylmethanaminium ((2R,35,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In water at 10℃; for 0.166667h;	97%

: 63-91-2
L-phenylalanine

: 1094-61-7
nicotinamide mononucleotide

: (S)-1-carboxy-2-phenylethan-1-aminium-((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In water pH=3.43 - 4; Cooling with ice;	96%

: 52-90-4
L-Cysteine

: 1094-61-7
nicotinamide mononucleotide

: (R)-1-carboxy-2-mercaptoethan-1-aminium-((2R,3R,4S,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In water pH=3.38 - 3.86; Cooling with ice;	95%

: 70-47-3
L-asparagine

: 1094-61-7
nicotinamide mononucleotide

: (S)-3-amino-1-carboxy-3-oxopropan-1-aminium-((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In water pH=3.38 - 3.86; Cooling with ice;	95%

: 1094-61-7
nicotinamide mononucleotide

: 47287-36-5, 119923-66-9
adenosine 5'-monophosphate

: 606-67-7, 987-65-5, 4691-96-7, 15237-44-2, 20978-32-9, 71997-34-7, 71997-37-0, 71997-53-0, 71997-56-3
adenosine‐5'‐triphosphate disodium salt

: 76961-04-1
nicotinamide adenine dinucleotide

Conditions

Conditions	Yield
With 1,3-dimercaptopropanol; AdK on PAN gel; NAD pyrophosphorylase; PPiase; potassium acetate; magnesium chloride In water for 3h; Ambient temperature; pH: 7.0;	91%

...Expand

: 63-68-3
L-methionine

: 1094-61-7
nicotinamide mononucleotide

: (S)-1-carboxy-3-(methylthio)propan-1-aminium ((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In water at 10℃; pH=Ca. 4.4 - 4.6;	89%

: morpholin-4-yl-phosphonic acid mono-5′-[6-(pyrrol-2-yl)-9-β-D-ribofuranosyl-purine]

: 1094-61-7
nicotinamide mononucleotide

: P1-[6-(pyrrol-2-yl)-purine-9-β-D-ribofuranos-5'-yl]-P2-[nicotinamide-1-β-D-ribofuranos-5′-yl]pyrophosphate

Conditions

Conditions	Yield
With magnesium sulfate; manganese(ll) chloride In formamide at 20℃; for 12h; Inert atmosphere;	87%

: 1094-61-7
nicotinamide mononucleotide

: 56-40-6
glycine

: carboxymethanaminium ((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methvl phosphate

Conditions

Conditions	Yield
In water pH=3.22 - 3.9; Inert atmosphere; Cooling with ice;	85%

: 56-45-1
L-serin

: 1094-61-7
nicotinamide mononucleotide

: (S)-1-carboxy-2-hydroxyethan-1-aminium ((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In water pH=3.22 - 3.8; Inert atmosphere; Cooling with ice;	83%

: ((2R,3R,4R,5R)-5-(4-aminothieno[3,4-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen triphosphate

: 1094-61-7
nicotinamide mononucleotide

: 1-((2R,3R,4R,5R)-5-((((((((2R,3R,4R,5R)-5-(4-aminothieno[3,4-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)- 3,4-dihydroxytetrahydrofuran-2-yl)-3-carbamoylpyridin-1-ium

Conditions

Conditions	Yield
With Saccharomyces cerevisiae inorganic pyrophosphatase; Homo sapiens recombinant nicotinamide mononucleotide adenylyl transferase 1; potassium chloride; sodium chloride; magnesium chloride In ethanol at 37℃; for 2.16667h; Enzymatic reaction;	81%

: 7-deaza-8-bromoadenosine 5'-monophosphate morpholidate triethylammonium salt

: 1094-61-7
nicotinamide mononucleotide

: 213894-71-4
7-deaza-8-bromo nicotinamide adenine dinucleotide triethylammonium salt

Conditions

Conditions	Yield
With magnesium sulfate; formamide; manganese(ll) chloride at 20℃; for 48h;	79%

: 56-41-7
L-alanin

: 1094-61-7
nicotinamide mononucleotide

: C11H15N2O8P*C3H7NO2

Conditions

Conditions	Yield
In water pH=3.22-3.8; Inert atmosphere; Cooling with ice;	79%

: 1278592-46-3
C14H23N6O10P

: 1094-61-7
nicotinamide mononucleotide

: 1278592-45-2
C25H36N8O17P2

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; magnesium chloride; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid at 37℃;	67%

: 1094-61-7
nicotinamide mononucleotide

: 541-15-1
L-carnitine

: (R)-3-carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium ((2R,35,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In water at 10℃; for 0.166667h;	67%

: 1094-61-7
nicotinamide mononucleotide

: 108-24-7
acetic anhydride

: 154591-45-4
2',3'-di-O-acetylnicotinamide mononucleotide

Conditions

Conditions	Yield
With pyridine In water at 0℃; for 3h;	65%
With pyridine In water at 0℃; for 48h;
With pyridine at 0 - 5℃; for 24h; Inert atmosphere;
With pyridine In water at -5 - 0℃; for 24h; Inert atmosphere;

: 6-N-methyladnenosine 5'-monophosphate morpholidated triethylammonium salt

: 1094-61-7
nicotinamide mononucleotide

: 6-N-methyl nicotinamide adenine dinucleotide triethylammonium salt

Conditions

Conditions	Yield
Stage #1: 6-N-methyladnenosine 5'-monophosphate morpholidated triethylammonium salt; nicotinamide mononucleotide With magnesium sulfate; manganese(ll) chloride In formamide at 20℃; for 48h; Inert atmosphere; Stage #2: With triethylamine carbonate In formamide; acetonitrile	64%

: 1352621-63-6
C26H36N7O9P

: 1094-61-7
nicotinamide mononucleotide

: 1352621-54-5
8-(3-(Boc-aminomethyl)phenyl) NAD

Conditions

Conditions	Yield
With magnesium sulfate; manganese(ll) chloride In formamide at 20℃; for 24h; Inert atmosphere;	61%

Product Name

BETA-NICOTINAMIDE MONONUCLEOTIDE

Synthetic route

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