Product Name

Synthetic route

3-Benzyloxy-pyridine-2-carboxylic acid {(5R,6S,9S,10S,11R)-10-hydroxy-5,11-dimethyl-2-[1-methyl-prop-(Z)-ylidene]-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-amide
128829-10-7

3-Benzyloxy-pyridine-2-carboxylic acid {(5R,6S,9S,10S,11R)-10-hydroxy-5,11-dimethyl-2-[1-methyl-prop-(Z)-ylidene]-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-amide

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
With hydrogen; palladium In methanol95%
((S)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methanol

((S)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methanol

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
Multi-step reaction with 15 steps
1: NaIO4, RuCl3 / CCl4; acetonitrile; H2O / 1 h / Ambient temperature
2: 83 percent / DCC,DMAP / ethyl acetate / 2 h / Ambient temperature
3: aq. TFA / 1 h / Ambient temperature
4: ethyl acetate; petroleum ether / 2.5 h / Ambient temperature
5: DCC, DMAP / ethyl acetate / 2.5 h / Ambient temperature
6: 1.) aq. HCl 2.) aq. TFA / 1 ) dioxane, 35 deg C, 12 h 2 ) rt., 20 min.
7: H2 / Raney-Ni W-4 / methanol / 0.67 h / 35 °C
8: DCC, HOBt / dimethylformamide / 68 h / 2 °C
9: 95 percent / SOCl2 / pyridine / 1 h / -30 °C
10: 84 percent / O3/O2 / CH2Cl2 / 0 h / -78 °C
11: 1)NaH / 1)THF, 0 deg C, 15 min., 2)0 deg C, 1 h
12: 25 percent / tetrahydrofuran / 3 h / -70 - -30 °C
13: H2 / Pd-black / methanol / 0.5 h / Ambient temperature
15: 95 percent / H2 / Pd-black / methanol
View Scheme
(R)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid
128829-04-9

(R)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
Multi-step reaction with 14 steps
1: 83 percent / DCC,DMAP / ethyl acetate / 2 h / Ambient temperature
2: aq. TFA / 1 h / Ambient temperature
3: ethyl acetate; petroleum ether / 2.5 h / Ambient temperature
4: DCC, DMAP / ethyl acetate / 2.5 h / Ambient temperature
5: 1.) aq. HCl 2.) aq. TFA / 1 ) dioxane, 35 deg C, 12 h 2 ) rt., 20 min.
6: H2 / Raney-Ni W-4 / methanol / 0.67 h / 35 °C
7: DCC, HOBt / dimethylformamide / 68 h / 2 °C
8: 95 percent / SOCl2 / pyridine / 1 h / -30 °C
9: 84 percent / O3/O2 / CH2Cl2 / 0 h / -78 °C
10: 1)NaH / 1)THF, 0 deg C, 15 min., 2)0 deg C, 1 h
11: 25 percent / tetrahydrofuran / 3 h / -70 - -30 °C
12: H2 / Pd-black / methanol / 0.5 h / Ambient temperature
14: 95 percent / H2 / Pd-black / methanol
View Scheme
(S)-1-Benzyloxy-3-ethyl-pentane-2,3-diol

(S)-1-Benzyloxy-3-ethyl-pentane-2,3-diol

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
Multi-step reaction with 17 steps
1: DMP, H2SO4 / 2 h / Ambient temperature
2: H2 / Pd(OH)2 / methanol / 1 h / Ambient temperature
3: NaIO4, RuCl3 / CCl4; acetonitrile; H2O / 1 h / Ambient temperature
4: 83 percent / DCC,DMAP / ethyl acetate / 2 h / Ambient temperature
5: aq. TFA / 1 h / Ambient temperature
6: ethyl acetate; petroleum ether / 2.5 h / Ambient temperature
7: DCC, DMAP / ethyl acetate / 2.5 h / Ambient temperature
8: 1.) aq. HCl 2.) aq. TFA / 1 ) dioxane, 35 deg C, 12 h 2 ) rt., 20 min.
9: H2 / Raney-Ni W-4 / methanol / 0.67 h / 35 °C
10: DCC, HOBt / dimethylformamide / 68 h / 2 °C
11: 95 percent / SOCl2 / pyridine / 1 h / -30 °C
12: 84 percent / O3/O2 / CH2Cl2 / 0 h / -78 °C
13: 1)NaH / 1)THF, 0 deg C, 15 min., 2)0 deg C, 1 h
14: 25 percent / tetrahydrofuran / 3 h / -70 - -30 °C
15: H2 / Pd-black / methanol / 0.5 h / Ambient temperature
17: 95 percent / H2 / Pd-black / methanol
View Scheme
(S)-5-Benzyloxymethyl-4,4-diethyl-2,2-dimethyl-[1,3]dioxolane

(S)-5-Benzyloxymethyl-4,4-diethyl-2,2-dimethyl-[1,3]dioxolane

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
Multi-step reaction with 16 steps
1: H2 / Pd(OH)2 / methanol / 1 h / Ambient temperature
2: NaIO4, RuCl3 / CCl4; acetonitrile; H2O / 1 h / Ambient temperature
3: 83 percent / DCC,DMAP / ethyl acetate / 2 h / Ambient temperature
4: aq. TFA / 1 h / Ambient temperature
5: ethyl acetate; petroleum ether / 2.5 h / Ambient temperature
6: DCC, DMAP / ethyl acetate / 2.5 h / Ambient temperature
7: 1.) aq. HCl 2.) aq. TFA / 1 ) dioxane, 35 deg C, 12 h 2 ) rt., 20 min.
8: H2 / Raney-Ni W-4 / methanol / 0.67 h / 35 °C
9: DCC, HOBt / dimethylformamide / 68 h / 2 °C
10: 95 percent / SOCl2 / pyridine / 1 h / -30 °C
11: 84 percent / O3/O2 / CH2Cl2 / 0 h / -78 °C
12: 1)NaH / 1)THF, 0 deg C, 15 min., 2)0 deg C, 1 h
13: 25 percent / tetrahydrofuran / 3 h / -70 - -30 °C
14: H2 / Pd-black / methanol / 0.5 h / Ambient temperature
16: 95 percent / H2 / Pd-black / methanol
View Scheme
(S)-1-Benzyloxy-3-ethyl-2-methoxymethoxy-pentan-3-ol
128829-03-8

(S)-1-Benzyloxy-3-ethyl-2-methoxymethoxy-pentan-3-ol

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
Multi-step reaction with 18 steps
1: aq. HCl / dioxane / 3 h / 50 °C
2: DMP, H2SO4 / 2 h / Ambient temperature
3: H2 / Pd(OH)2 / methanol / 1 h / Ambient temperature
4: NaIO4, RuCl3 / CCl4; acetonitrile; H2O / 1 h / Ambient temperature
5: 83 percent / DCC,DMAP / ethyl acetate / 2 h / Ambient temperature
6: aq. TFA / 1 h / Ambient temperature
7: ethyl acetate; petroleum ether / 2.5 h / Ambient temperature
8: DCC, DMAP / ethyl acetate / 2.5 h / Ambient temperature
9: 1.) aq. HCl 2.) aq. TFA / 1 ) dioxane, 35 deg C, 12 h 2 ) rt., 20 min.
10: H2 / Raney-Ni W-4 / methanol / 0.67 h / 35 °C
11: DCC, HOBt / dimethylformamide / 68 h / 2 °C
12: 95 percent / SOCl2 / pyridine / 1 h / -30 °C
13: 84 percent / O3/O2 / CH2Cl2 / 0 h / -78 °C
14: 1)NaH / 1)THF, 0 deg C, 15 min., 2)0 deg C, 1 h
15: 25 percent / tetrahydrofuran / 3 h / -70 - -30 °C
16: H2 / Pd-black / methanol / 0.5 h / Ambient temperature
18: 95 percent / H2 / Pd-black / methanol
View Scheme
(R)-3-Ethyl-2,3-dihydroxy-pentanoic acid (1R,2S)-2-benzyloxycarbonylamino-2-carboxy-1-methyl-ethyl ester

(R)-3-Ethyl-2,3-dihydroxy-pentanoic acid (1R,2S)-2-benzyloxycarbonylamino-2-carboxy-1-methyl-ethyl ester

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1: ethyl acetate; petroleum ether / 2.5 h / Ambient temperature
2: DCC, DMAP / ethyl acetate / 2.5 h / Ambient temperature
3: 1.) aq. HCl 2.) aq. TFA / 1 ) dioxane, 35 deg C, 12 h 2 ) rt., 20 min.
4: H2 / Raney-Ni W-4 / methanol / 0.67 h / 35 °C
5: DCC, HOBt / dimethylformamide / 68 h / 2 °C
6: 95 percent / SOCl2 / pyridine / 1 h / -30 °C
7: 84 percent / O3/O2 / CH2Cl2 / 0 h / -78 °C
8: 1)NaH / 1)THF, 0 deg C, 15 min., 2)0 deg C, 1 h
9: 25 percent / tetrahydrofuran / 3 h / -70 - -30 °C
10: H2 / Pd-black / methanol / 0.5 h / Ambient temperature
12: 95 percent / H2 / Pd-black / methanol
View Scheme
(5R,6S,9S,10S,11R)-6-Amino-10-hydroxy-5,11-dimethyl-2-[1-methyl-prop-(Z)-ylidene]-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododecane-3,7,12-trione

(5R,6S,9S,10S,11R)-6-Amino-10-hydroxy-5,11-dimethyl-2-[1-methyl-prop-(Z)-ylidene]-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododecane-3,7,12-trione

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: 95 percent / H2 / Pd-black / methanol
View Scheme
(R)-3-Ethyl-2,3-dihydroxy-pentanoic acid (1R,2S)-2-benzhydryloxycarbonyl-2-benzyloxycarbonylamino-1-methyl-ethyl ester
128849-60-5

(R)-3-Ethyl-2,3-dihydroxy-pentanoic acid (1R,2S)-2-benzhydryloxycarbonyl-2-benzyloxycarbonylamino-1-methyl-ethyl ester

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: DCC, DMAP / ethyl acetate / 2.5 h / Ambient temperature
2: 1.) aq. HCl 2.) aq. TFA / 1 ) dioxane, 35 deg C, 12 h 2 ) rt., 20 min.
3: H2 / Raney-Ni W-4 / methanol / 0.67 h / 35 °C
4: DCC, HOBt / dimethylformamide / 68 h / 2 °C
5: 95 percent / SOCl2 / pyridine / 1 h / -30 °C
6: 84 percent / O3/O2 / CH2Cl2 / 0 h / -78 °C
7: 1)NaH / 1)THF, 0 deg C, 15 min., 2)0 deg C, 1 h
8: 25 percent / tetrahydrofuran / 3 h / -70 - -30 °C
9: H2 / Pd-black / methanol / 0.5 h / Ambient temperature
11: 95 percent / H2 / Pd-black / methanol
View Scheme
(R)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (1R,2S)-2-benzhydryloxycarbonyl-2-benzyloxycarbonylamino-1-methyl-ethyl ester
128849-59-2

(R)-5,5-Diethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (1R,2S)-2-benzhydryloxycarbonyl-2-benzyloxycarbonylamino-1-methyl-ethyl ester

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1: aq. TFA / 1 h / Ambient temperature
2: ethyl acetate; petroleum ether / 2.5 h / Ambient temperature
3: DCC, DMAP / ethyl acetate / 2.5 h / Ambient temperature
4: 1.) aq. HCl 2.) aq. TFA / 1 ) dioxane, 35 deg C, 12 h 2 ) rt., 20 min.
5: H2 / Raney-Ni W-4 / methanol / 0.67 h / 35 °C
6: DCC, HOBt / dimethylformamide / 68 h / 2 °C
7: 95 percent / SOCl2 / pyridine / 1 h / -30 °C
8: 84 percent / O3/O2 / CH2Cl2 / 0 h / -78 °C
9: 1)NaH / 1)THF, 0 deg C, 15 min., 2)0 deg C, 1 h
10: 25 percent / tetrahydrofuran / 3 h / -70 - -30 °C
11: H2 / Pd-black / methanol / 0.5 h / Ambient temperature
13: 95 percent / H2 / Pd-black / methanol
View Scheme
[(2R,5R,6S,9S,10S,11R)-2-((E)-1-Ethyl-propenyl)-10-hydroxy-5,11-dimethyl-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl]-carbamic acid benzyl ester
128829-06-1

[(2R,5R,6S,9S,10S,11R)-2-((E)-1-Ethyl-propenyl)-10-hydroxy-5,11-dimethyl-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl]-carbamic acid benzyl ester

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 84 percent / O3/O2 / CH2Cl2 / 0 h / -78 °C
2: 1)NaH / 1)THF, 0 deg C, 15 min., 2)0 deg C, 1 h
3: 25 percent / tetrahydrofuran / 3 h / -70 - -30 °C
4: H2 / Pd-black / methanol / 0.5 h / Ambient temperature
6: 95 percent / H2 / Pd-black / methanol
View Scheme
[(2R,5R,6S,9S,10S,11R)-2-(1-Ethyl-1-hydroxy-propyl)-10-hydroxy-5,11-dimethyl-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl]-carbamic acid benzyl ester

[(2R,5R,6S,9S,10S,11R)-2-(1-Ethyl-1-hydroxy-propyl)-10-hydroxy-5,11-dimethyl-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl]-carbamic acid benzyl ester

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 95 percent / SOCl2 / pyridine / 1 h / -30 °C
2: 84 percent / O3/O2 / CH2Cl2 / 0 h / -78 °C
3: 1)NaH / 1)THF, 0 deg C, 15 min., 2)0 deg C, 1 h
4: 25 percent / tetrahydrofuran / 3 h / -70 - -30 °C
5: H2 / Pd-black / methanol / 0.5 h / Ambient temperature
7: 95 percent / H2 / Pd-black / methanol
View Scheme
{(5R,6S,9S,10S,11R)-10-Hydroxy-5,11-dimethyl-2-[1-methyl-prop-(Z)-ylidene]-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-carbamic acid benzyl ester
128829-09-4

{(5R,6S,9S,10S,11R)-10-Hydroxy-5,11-dimethyl-2-[1-methyl-prop-(Z)-ylidene]-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-carbamic acid benzyl ester

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2 / Pd-black / methanol / 0.5 h / Ambient temperature
3: 95 percent / H2 / Pd-black / methanol
View Scheme
(2R,3S,4S)-4-Amino-3-hydroxy-2-methyl-5-pyridin-3-yl-pentanoic acid (R)-1-((1R,2S)-2-benzyloxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-ethyl-2-hydroxy-butyl ester

(2R,3S,4S)-4-Amino-3-hydroxy-2-methyl-5-pyridin-3-yl-pentanoic acid (R)-1-((1R,2S)-2-benzyloxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-ethyl-2-hydroxy-butyl ester

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: DCC, HOBt / dimethylformamide / 68 h / 2 °C
2: 95 percent / SOCl2 / pyridine / 1 h / -30 °C
3: 84 percent / O3/O2 / CH2Cl2 / 0 h / -78 °C
4: 1)NaH / 1)THF, 0 deg C, 15 min., 2)0 deg C, 1 h
5: 25 percent / tetrahydrofuran / 3 h / -70 - -30 °C
6: H2 / Pd-black / methanol / 0.5 h / Ambient temperature
8: 95 percent / H2 / Pd-black / methanol
View Scheme
((5R,6S,9S,10S,11R)-10-Hydroxy-5,11-dimethyl-3,7,12-trioxo-2-propionyl-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl)-carbamic acid benzyl ester
128829-07-2, 128829-11-8

((5R,6S,9S,10S,11R)-10-Hydroxy-5,11-dimethyl-3,7,12-trioxo-2-propionyl-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl)-carbamic acid benzyl ester

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1)NaH / 1)THF, 0 deg C, 15 min., 2)0 deg C, 1 h
2: 25 percent / tetrahydrofuran / 3 h / -70 - -30 °C
3: H2 / Pd-black / methanol / 0.5 h / Ambient temperature
5: 95 percent / H2 / Pd-black / methanol
View Scheme
(2R,3S,4S)-4-Azido-3-hydroxy-2-methyl-5-pyridin-3-yl-pentanoic acid (R)-1-((1R,2S)-2-benzyloxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-ethyl-2-hydroxy-butyl ester

(2R,3S,4S)-4-Azido-3-hydroxy-2-methyl-5-pyridin-3-yl-pentanoic acid (R)-1-((1R,2S)-2-benzyloxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-ethyl-2-hydroxy-butyl ester

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: H2 / Raney-Ni W-4 / methanol / 0.67 h / 35 °C
2: DCC, HOBt / dimethylformamide / 68 h / 2 °C
3: 95 percent / SOCl2 / pyridine / 1 h / -30 °C
4: 84 percent / O3/O2 / CH2Cl2 / 0 h / -78 °C
5: 1)NaH / 1)THF, 0 deg C, 15 min., 2)0 deg C, 1 h
6: 25 percent / tetrahydrofuran / 3 h / -70 - -30 °C
7: H2 / Pd-black / methanol / 0.5 h / Ambient temperature
9: 95 percent / H2 / Pd-black / methanol
View Scheme
{(5R,6S,9S,10S,11R)-2-[1-(Diethoxy-phosphoryloxy)-prop-(E)-ylidene]-10-hydroxy-5,11-dimethyl-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-carbamic acid benzyl ester

{(5R,6S,9S,10S,11R)-2-[1-(Diethoxy-phosphoryloxy)-prop-(E)-ylidene]-10-hydroxy-5,11-dimethyl-3,7,12-trioxo-9-pyridin-3-ylmethyl-1,4-dioxa-8-aza-cyclododec-6-yl}-carbamic acid benzyl ester

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 25 percent / tetrahydrofuran / 3 h / -70 - -30 °C
2: H2 / Pd-black / methanol / 0.5 h / Ambient temperature
4: 95 percent / H2 / Pd-black / methanol
View Scheme
(2R,3S,4S)-4-Azido-3-formyloxy-2-methyl-5-pyridin-3-yl-pentanoic acid (R)-1-((1R,2S)-2-benzhydryloxycarbonyl-2-benzyloxycarbonylamino-1-methyl-ethoxycarbonyl)-2-ethyl-2-hydroxy-butyl ester

(2R,3S,4S)-4-Azido-3-formyloxy-2-methyl-5-pyridin-3-yl-pentanoic acid (R)-1-((1R,2S)-2-benzhydryloxycarbonyl-2-benzyloxycarbonylamino-1-methyl-ethoxycarbonyl)-2-ethyl-2-hydroxy-butyl ester

pyridomicin
18791-21-4

pyridomicin

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 1.) aq. HCl 2.) aq. TFA / 1 ) dioxane, 35 deg C, 12 h 2 ) rt., 20 min.
2: H2 / Raney-Ni W-4 / methanol / 0.67 h / 35 °C
3: DCC, HOBt / dimethylformamide / 68 h / 2 °C
4: 95 percent / SOCl2 / pyridine / 1 h / -30 °C
5: 84 percent / O3/O2 / CH2Cl2 / 0 h / -78 °C
6: 1)NaH / 1)THF, 0 deg C, 15 min., 2)0 deg C, 1 h
7: 25 percent / tetrahydrofuran / 3 h / -70 - -30 °C
8: H2 / Pd-black / methanol / 0.5 h / Ambient temperature
10: 95 percent / H2 / Pd-black / methanol
View Scheme

Pyridomycin Chemical Properties

IUPAC Name: N-[(1S,4S,5R,6R,9Z,12R)-9-Butan-2-ylidene-5-hydroxy-6,12-dimethyl-2,7,10-trioxo-4-(pyridin-3-ylmethyl)-8,11-dioxa-3-azacyclododec-1-yl]-3-hydroxypyridine-2-carboxamide
Synonyms: [5R-(2Z,5R*,6S*,9S*,10S*,11R*)]-3-Hydroxy-N-[10-hydroxy-5,11-dimethyl-2-(1-methylpropylidene)-3,7,12-trioxo-9-(3-pyridinylmethyl)-1,4-dioxa-8-azacyclododec-6-yl]-2-pyridinecarboxamide ; Pyridomycin
CAS NO: 18791-21-4
Molecular Formula of Pyridomycin (CAS NO.18791-21-4) : C27H32N4O8
Molecular Weight of Pyridomycin (CAS NO.18791-21-4) : 540.565
Molecular Structure of Pyridomycin (CAS NO.18791-21-4) :
Index of Refraction: 1.606
Surface Tension: 67.3 dyne/cm
Density: 1.35 g/cm3
Flash Point: 529 °C
Enthalpy of Vaporization: 145.04 kJ/mol
Boiling Point: 951.1 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C

Pyridomycin Toxicity Data With Reference

1.    

orl-mus LD50:1000 mg/kg

     85GDA2    CRC Handbook of Antibiotic Compounds, Volumes 1-9. 4 (2)(1980),144.
2.    

ipr-mus LD50:1000 mg/kg

     85GDA2    CRC Handbook of Antibiotic Compounds, Volumes 1-9. 4 (2)(1980),144.
3.    

ivn-mus LD50:300 mg/kg

     85FZAT    Index of Antibiotics from Actinomycetes Umezawa, H., et al., eds.,Tokyo, Japan.: University of Tokyo Press,1967,541.

Pyridomycin Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.

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