Product Name

  • Name

    RETRORSINE

  • EINECS
  • CAS No. 480-54-6
  • Article Data2
  • CAS DataBase
  • Density 1.32±0.1 g/cm3 (20 ºC 760 Torr)
  • Solubility
  • Melting Point 208-211oC(lit.)
  • Formula C18H25 N O6
  • Boiling Point 583.169°C at 760 mmHg
  • Molecular Weight 351.4
  • Flash Point 306.49°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion, intraperitoneal, and intravenous routes. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • Risk Codes R25
  • Molecular Structure Molecular Structure of 480-54-6 (RETRORSINE)
  • Hazard Symbols
  • Synonyms Retrorsine(6CI,7CI,8CI); Senecionan-11,16-dione, 12,18-dihydroxy-; NSC 107659; Retrorsin;[1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione,3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-(hydroxymethyl)-5-methyl-,[5R-(3Z,5R*,6S*,14aR*,14bR*)]-; b-Longilobine
  • PSA 96.30000
  • LogP 0.10310

RETRORSINE Chemical Properties

Molecular Formula:C18H25NO6
Molecular Weight:351.44
Mp:208-211 °C(lit.)
Merck:13,8253
Properties:Crystals from ethyl acetate.
Retrorsine's Synonyms: BETA-LONGILOBINE;12,18-DIHYDROXYSENECIONAN-11,16-DIONE;RETRORSIN;RETRORSINE;16-dione,12,18-dihydroxy-senecionan-1;5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-hydroxymethyl-5-3-ethylidene-4;cis-retronecicacidesterofretronecine;methyl(1,6)dioxacyclododeca(2,3,4-gh)pyrrolizidine-2,7-dione

RETRORSINE Toxicity Data With Reference

1.   

ctr-ham:kdy 25 µg/L

   CRNGDP    Carcinogenesis. 1 (1980),161.
2.   

sln-dmg-par 10 mmol/L

   JOGNAU    Journal of Genetics. 59 (1966),273.
3.   

orl-rat LDLo:30 mg/kg

   JPBAA7    Journal of Pathology and Bacteriology. 78 (1959),471.
4.   

ipr-rat LD50:34 mg/kg

   CBINA8    Chemico-Biological Interactions. 5 (1972),227.
5.   

ivn-rat LD50:38 mg/kg

   RETOAE    Research Today. 5 (1949),53.
6.   

ivn-mus LD50:59 mg/kg

   RETOAE    Research Today. 5 (1949),53.
7.   

orl-mam LDLo:33 mg/kg

   PAREAQ    Pharmacological Reviews. 22 (1970),429.

RETRORSINE Consensus Reports

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 ,1976,p. 303.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .

RETRORSINE Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Retrorsine's Safety Information
Hazard Codes  T
Risk Statements  25
Safety Statements  22-36/37/39-45
RIDADR  1544
RTECS  VH7525000
HazardClass  6.1(a)
PackingGroup  II

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