Product Name

  • Name

    Ribostamycin sulfate

  • EINECS 258-783-1
  • CAS No. 53797-35-6
  • Density 1.6g/cm3
  • Solubility Soluble in water
  • Melting Point 175-180oC
  • Formula C17H34N4O10.H2SO4
  • Boiling Point 907.6 °C at 760 mmHg
  • Molecular Weight 552.55
  • Flash Point 502.7 °C
  • Transport Information
  • Appearance COA
  • Safety 53-22-36/37/39-45-26
  • Risk Codes 61-20/21/22-36/38
  • Molecular Structure Molecular Structure of 53797-35-6 (Ribostamycin sulfate)
  • Hazard Symbols ToxicT,IrritantXi
  • Synonyms Streptamine, O-2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4)-O-(beta-D-ribofuranosyl-(1-5))-2-deoxy-, sulfate;(2R,3R,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol; sulfuric acid;Vistamycin (TN);Ribomycine;5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[(2S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol; sulfuric acid;SF 733 antibioic sulfate;Ribostamin;(2R,3R,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol sulfate;Ribostamycin sulfate salt;Prestwick_190;Ribostamycin sulfate (JP14);Ribostamycin sulphate;Riboflavine sulfate;Landamycine;GA4+7;
  • PSA 345.36000
  • LogP -3.42310

Ribostamycin sulfate Chemical Properties

Molecular Formula: C17H34N4O10.H2SO4
Molar mass: 552.55 g/mol
EINECS: 258-783-1
Flash Point: 502.7 °C
Boiling Point: 907.6 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
Melting point: 175-180°C
Storage temp: 2-8°C
Product categories of Ribostamycin sulfate (53797-35-6): Antibacterial;Interferes with Protein SynthesisSpectrum of Activity;Antibiotics by Application;Antibiotics N-SAntibiotics;Chemical Structure Class;Mechanism of Action
Structure of Ribostamycin sulfate (53797-35-6):

H-Bond Donor: 12
H-Bond Acceptor: 18
Systematic Name: (2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-[(1R,2R,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-3-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol; sulfuric acid 
SMILES: OS(O)(=O)=O.O[C@@H]3[C@H](O)[C@@H](CO)O[C@H]3O[C@H]2[C@H](O[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1N)[C@@H](N)C[C@@H](N)C2O 
InChI: InChI=1/C17H34N4O10.H2O4S/c18-2-6-10(24)12(26)8(21)16(28-6)30-14-5(20)1-4(19)9(23)15(14)31-17-13(27)11(25)7(3-22)29-17;1-5(2,3)4/h4-17,22-27H,1-3,18-21H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8-,9?,10-,11-,12-,13-,14-,15-,16-,17+;/m1./s1 
InChIKey: RTCDDYYZMGGHOE-BJRDGYLYBV 
Std. InChI: InChI=1S/C17H34N4O10.H2O4S/c18-2-6-10(24)12(26)8(21)16(28-6)30-14-5(20)1-4(19)9(23)15(14)31-17-13(27)11(25)7(3-22)29-17;1-5(2,3)4/h4-17,22-27H,1-3,18-21H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8-,9?,10-,11-,12-,13-,14-,15-,16-,17+;/m1./s1 
Std. InChIKey: RTCDDYYZMGGHOE-BJRDGYLYSA-N

Ribostamycin sulfate Uses

 Ribostamycin sulfate (53797-35-6) can be  used for  bronchitis, pneumonia, pleurisy, lymphadenitis, cholecystitis, Boil, osteomyelitis, urinary tract infection treatment caused by the susceptible strains.

Ribostamycin sulfate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 1561mg/kg (1561mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.
mouse LD50 intraperitoneal 1981mg/kg (1981mg/kg)   Japan Medical Gazette. Vol. 10(2), Pg. 5, 1973.
mouse LD50 intravenous 210mg/kg (210mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.
mouse LD50 oral > 7gm/kg (7000mg/kg)   Drugs in Japan Vol. 6, Pg. 885, 1982.
mouse LD50 subcutaneous 2345mg/kg (2345mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.
rat LD50 intramuscular 2030mg/kg (2030mg/kg)   Drugs in Japan Vol. 6, Pg. 885, 1982.
rat LD50 intraperitoneal 3080mg/kg (3080mg/kg)   Japan Medical Gazette. Vol. 10(2), Pg. 5, 1973.
rat LD50 intravenous 375mg/kg (375mg/kg)   Japan Medical Gazette. Vol. 10(2), Pg. 5, 1973.
rat LD50 oral > 7gm/kg (7000mg/kg)   Drugs in Japan Vol. 6, Pg. 885, 1982.
rat LD50 subcutaneous 5600mg/kg (5600mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.

Ribostamycin sulfate Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal, intramuscular, and subcutaneous routes. Used as an antibiotic. When heated to decomposition it emits very toxic fumes of NOx and SOx.
 

Hazard Codes: T,Xi
Risk Statements:
20:  Harmful by inhalation
21:  Harmful in contact with skin
22:  Harmful if swallowed 
36:  Irritating to the eyes
38:  Irritating to the skin
61:  May cause harm to the unborn child 
Safety Statements:
22:  Do not breathe dust
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing 
37:  Wear suitable gloves
39:  Wear eye/face protection
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
53:  Avoid exposure - obtain special instruction before use

Ribostamycin sulfate Specification

 Ribostamycin sulfate (53797-35-6) also can be called Ribostamycin ; Ribostamin and Landamycine .

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