Rivastigmine supplier | CasNO.123441-03-2

Name
Rivastigmine
EINECS 602-936-0
CAS No. 123441-03-2
Article Data49
CAS DataBase
Density 1.038 g/cm³
Solubility
Melting Point
Formula C₁₄H₂₂N₂O₂
Boiling Point 316.2 °C at 760 mmHg
Molecular Weight 400.429
Flash Point 145 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Carbamicacid, ethylmethyl-, 3-[1-(dimethylamino)ethyl]phenyl ester, (S)-;ENA 713 free base;Exelon;S-Rivastigmine;SDZ 212-713;
PSA 147.84000
LogP 0.63710

Rivastigmine History

It was developed by Novartis.
In 2006, it became the first product approved globally for the treatment of mild to moderate dementia associated with Parkinson's Disease. Rivastigmine has been available in capsule and liquid formulations since 1997.In 2007 the rivastigmine transdermal patch became the first patch treatment for dementia.

Rivastigmine Specification

The Rivastigmine is an organic compound with the formula C₁₄H₂₂N₂O₂. The IUPAC name of this chemical is [3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate. With the CAS registry number 123441-03-2, it is also named as Ethyl-methyl-carbamic acid 3-(1-dimethylamino-ethyl)-phenyl ester. Besides, it is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.

Physical properties about Rivastigmine are: (1)ACD/LogP: 2.14; (2)ACD/LogD (pH 5.5): -0.65; (3)ACD/LogD (pH 7.4): 0.93; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1.55; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 21.64; (8)#H bond acceptors: 4; (9)#Freely Rotating Bonds: 5; (10)Polar Surface Area: 32.78 Å²; (11)Index of Refraction: 1.518; (12)Molar Refractivity: 73.12 cm³; (13)Molar Volume: 241.1 cm³; (14)Polarizability: 28.98×10^-24cm³; (15)Surface Tension: 36.9 dyne/cm; (16)Density: 1.038 g/cm³; (17)Flash Point: 145 °C; (18)Enthalpy of Vaporization: 55.75 kJ/mol; (19)Boiling Point: 316.2 °C at 760 mmHg; (20)Vapour Pressure: 0.000416 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(Oc1cc(ccc1)C(N(C)C)C)N(CC)C
(2)InChI: InChI=1/C14H22N2O2/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4/h7-11H,6H2,1-5H3
(3)InChIKey: XSVMFMHYUFZWBK-UHFFFAOYAM
(4)Std. InChI: InChI=1S/C14H22N2O2/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4/h7-11H,6H2,1-5H3
(5)Std. InChIKey: XSVMFMHYUFZWBK-UHFFFAOYSA-N

Product Name

Rivastigmine

Rivastigmine History

Rivastigmine Specification

Related Products

Hot Products