Rufloxacin hydrochloride supplier

Name
Rufloxacin hydrochloride
EINECS
CAS No. 106017-08-7
Article Data6
CAS DataBase
Density
Solubility
Melting Point 322-324 °C
Formula C₁₇H₁₈FN₃O₃S^.HCl
Boiling Point 574.6 °C at 760 mmHg
Molecular Weight 399.874
Flash Point 301.3 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 7H-Pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylicacid, 9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-,monohydrochloride (9CI);ISF 09334;Monos;Qari;Rufloxacin hydrochloride;Tebraxin;
PSA 91.08000
LogP 2.50120

Rufloxacin hydrochloride Specification

The Rufloxacin hydrochloride, with the CAS register number 106017-08-7, has the systematic name of 9-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride (1:1). Besides, it has other names as rufloxacin hcl; rufloxacin hydrochloride; 7h-pyrido(1,2,3-de)(1,4)benzothiazine-6-carboxylicacid,2,3-dihydro-9-fluoro-1; mf 934; rufloxacinhydrochloride(subjecttopatentfree); 2,3-dihydro-9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-7h-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride.

The physical characteristics could be summarized as: (1)ACD/LogP: 1.48; (2)ACD/LogD(pH5.5): -0.13; (3)ACD/LogD(pH7.4): -0.69; (4)ACD/BCF(pH5.5): 1; (5)ACD/BCF(pH7.4): 1; (6)ACD/KOC(pH5.5): 3.7; (7)ACD/KOC(pH7.4): 1.03; (8)#Hbondacceptors: 6; (9)#Hbonddonors: 1; (10)#FreelyRotatingBonds: 2; (11)PolarSurfaceArea: 78.39; (12)FlashPoint: 301.3°C; (13)EnthalpyofVaporization: 90.56kJ/mol; (14)BoilingPoint: 574.6°Cat760mmHg; (15)VapourPressure: 4.81E-14mmHgat25°C.

As for its usage, it is usually used for the drug / therapeutic agent, such as for curing the infection of the escherichia coli, shigella dysenteriae and Bacillus influenzae. Besides, its preparation products belong to the category of rufloxacin.

In addition, you could refer to the following data information to get the molecular structure:
SMILES:Cl.Fc4cc1c2N(/C=C(\C1=O)C(=O)O)CCSc2c4N3CCN(C)CC3
InChI:InChI=1/C17H18FN3O3S.ClH/c1-19-2-4-20(5-3-19)14-12(18)8-10-13-16(14)25-7-6-21(13)9-11(15(10)22)17(23)24;/h8-9H,2-7H2,1H3,(H,23,24);1H
InChIKey:LPQOADBMXVRBNX-UHFFFAOYAF

Below are the toxicity information of this chemical:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intravenous	224mg/kg (224mg/kg)	Journal of Medicinal Chemistry. Vol. 30, Pg. 465, 1987.
rabbit	LD50	oral	660mg/kg (660mg/kg)	Journal of Medicinal Chemistry. Vol. 30, Pg. 465, 1987.
rat	LD50	intravenous	285mg/kg (285mg/kg)	Journal of Medicinal Chemistry. Vol. 30, Pg. 465, 1987.
rat	LD50	oral	501mg/kg (501mg/kg)	Journal of Medicinal Chemistry. Vol. 30, Pg. 465, 1987.

Product Name

Rufloxacin hydrochloride

Rufloxacin hydrochloride Specification

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