SODIUM FORMALDEHYDE BISULFITE supplier

Name
Sodium formaldehyde bisulfite
EINECS 212-800-9
CAS No. 870-72-4
Article Data7
CAS DataBase
Density
Solubility 800 g/L (20 °C) in water
Melting Point 200 °C (dec.)(lit.)
Formula CH₃NaO₄S
Boiling Point 184 °C
Molecular Weight 134.088
Flash Point 184 °C
Transport Information
Appearance white to almost white powder
Safety 24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols
Synonyms Methanesulfonicacid, hydroxy-, monosodium salt (8CI,9CI);Methanesulfonic acid, hydroxy-,sodium salt (6CI);Hydroxymethanesulfonic acid sodium salt;Monosodiumhydroxymethanesulfonate;Sodium formaldehyde bisulfite;Sodiumhydroxymethanesulfonate;Sodium hydroxymethylsulfonate;
PSA 85.81000
LogP -0.43780

Synthetic route

: 50-00-0
formaldehyd

: 870-72-4
sodium formaldehyde bisulfite

Conditions

Conditions	Yield
With sodium sulfite In water at 45℃; for 0.333333h;
With sodium hydrogensulfite In water for 0.5h;
With sodium hydrogensulfite In aq. buffer pH=3.5 - 5.5;

: Dimethylamino-methanesulfonic acid anion

A: 870-72-4
sodium formaldehyde bisulfite

B: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
With water at 20.8℃; Equilibrium constant;

: 56638-52-9
p-methylanilinomethanesulfonate

A: 870-72-4
sodium formaldehyde bisulfite

B: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With water Equilibrium constant; Rate constant; Thermodynamic data; Ambient temperature; also formation constants;

: 56638-59-6
p-chloroanilinomethanesulfonate

A: 870-72-4
sodium formaldehyde bisulfite

B: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With water Equilibrium constant; Rate constant; Thermodynamic data; Ambient temperature; also formation constants;

: 91598-30-0
p-methoxyanilinomethanesulfonate

A: 870-72-4
sodium formaldehyde bisulfite

B: 104-94-9
4-methoxy-aniline

Conditions

Conditions	Yield
With water Equilibrium constant; Rate constant; Thermodynamic data; Ambient temperature; also formation constants;

: 56638-53-0
anilinomethanesulfonate

A: 870-72-4
sodium formaldehyde bisulfite

B: 62-53-3
aniline

Conditions

Conditions	Yield
With water Equilibrium constant; Rate constant; Thermodynamic data; Ambient temperature; also formation constants;

: 56638-54-1
m-methylanilinomethanesulfonate

A: 870-72-4
sodium formaldehyde bisulfite

B: 108-44-1
1-amino-3-methylbenzene

Conditions

Conditions	Yield
With water Equilibrium constant; Rate constant; Thermodynamic data; Ambient temperature; also formation constants;

: 56638-60-9
m-chloroanilinomethanesulfonate

A: 870-72-4
sodium formaldehyde bisulfite

B: 108-42-9
3-chloro-aniline

Conditions

Conditions	Yield
With water Equilibrium constant; Rate constant; Thermodynamic data; Ambient temperature; also formation constants;

: 26021-90-9
sodium anilinomethanesulfonate

A: 870-72-4
sodium formaldehyde bisulfite

B: 62-53-3
aniline

Conditions

Conditions	Yield
With water at 25℃; Kinetics; Equilibrium constant; Hydrolysis;

: 870-72-4
sodium formaldehyde bisulfite

: 78668-34-5
3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(14),11(15),12-triene

: 3,9-bis(sodium methylenesulfonato)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene

Conditions

Conditions	Yield
Stage #1: 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(14),11(15),12-triene With hydrogenchloride In water pH=5; Stage #2: sodium formaldehyde bisulfite With potassium hydroxide In water pH=8.5;	100%

: 870-72-4
sodium formaldehyde bisulfite

: 55101-47-8, 55101-58-1, 141032-06-6
aminomethylphosphonic acid disodium salt

: 129574-80-7
N-Phosphonylmethyl-aminomethylsulfonic acid trisodium salt

Conditions

Conditions	Yield
In water at 20℃; for 4h;	99.1%

: 870-72-4
sodium formaldehyde bisulfite

: 34494-03-6, 40465-64-3, 40465-65-4, 70393-85-0, 102413-71-8
tri-sodium salt of N-phosphonomethylglycine

: 129574-82-9
N-Phosphonylmethyl-N-hydroxysulfonylmethyl-glycine tetrasodium salt

Conditions

Conditions	Yield
In water at 20℃; for 4h;	98.68%

: 870-72-4
sodium formaldehyde bisulfite

: 124-40-3
dimethyl amine

: dimethylamino-methanesulfonic acid ; sodium salt

Conditions

Conditions	Yield
In water at 20℃;	97%
With water

: 870-72-4
sodium formaldehyde bisulfite

: 387859-83-8
5-benzyl-4-isobutyl-1,1-dioxo-1λ6-[1,2,5]thiadiazolidin-3-one

: 300553-85-9
5-benzyl-2-chloromethyl-4-isobutyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide

Conditions

Conditions	Yield
With thionyl chloride Heating;	97%

: 870-72-4
sodium formaldehyde bisulfite

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1257064-34-8
sodium (R)-(1-phenylethylamino)methanesulfonate

Conditions

Conditions	Yield
In water for 15h; Reflux;	95%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 870-72-4
sodium formaldehyde bisulfite

: 1135028-09-9
N-(2-hydroxyethyl)piperazine-N'-methanesulfonic acid sodium salt

Conditions

Conditions	Yield
In water at 60℃; for 48h;	93%

: 870-72-4
sodium formaldehyde bisulfite

: 5-butyl-1,1-dioxo-4-propyl-1λ6-[1,2,5]thiadiazolidin-3-one

: 5-butyl-2-chloromethyl-1,1-dioxo-4-propyl-1λ6-[1,2,5]thiadiazolidin-3-one

Conditions

Conditions	Yield
With thionyl chloride Heating;	91%

: 870-72-4
sodium formaldehyde bisulfite

: 2217-41-6
1-amino-5,6,7,8-tetrahydronaphthalene

: C11H14NO3S(1-)*Na(1+)

Conditions

Conditions	Yield
In tetrahydrofuran; water at 70℃; for 4h;	91%

: 123-75-1
pyrrolidine

: 870-72-4
sodium formaldehyde bisulfite

: N-pyrrolidinylmethanesulfonate

Conditions

Conditions	Yield
In water for 3h; Ambient temperature;	90%

: (S)-(-)-2-amino-5,7-difluoro-1,2,3,4-tetrahydronaphthalene hydrochloride

: 870-72-4
sodium formaldehyde bisulfite

: potassium cyanide

: (S)-(-)-(5,7-difluoro-1,2,3,4-tetrahydronaphth-2-yl)(cyanomethyl)amine

Conditions

Conditions	Yield
Stage #1: (S)-(-)-2-amino-5,7-difluoro-1,2,3,4-tetrahydronaphthalene hydrochloride With sodium hydroxide In water Stage #2: sodium formaldehyde bisulfite In water at 50℃; for 0.5h; Stage #3: potassium cyanide In water at 80℃; for 1h;	87.5%

...Expand

: 870-72-4
sodium formaldehyde bisulfite

: 17261-34-6
(iminobismethylene)bisphosphonic acid

: sodium salt of nitrilo sulfo methane bis-methane phosphonic acid

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water	87%

: 870-72-4
sodium formaldehyde bisulfite

: 108-91-8
cyclohexylamine

: cyclohexylaminomethanesulfonic acid sodium salt

Conditions

Conditions	Yield
In water at 60℃; for 48h;	84%

: 110-91-8
morpholine

: 870-72-4
sodium formaldehyde bisulfite

: N-morpholinomethanesulfonic acid sodium salt

Conditions

Conditions	Yield
In water at 60℃; for 48h;	82%
In water for 3h; Ambient temperature;

: 870-72-4
sodium formaldehyde bisulfite

: 111182-08-2
N,N'-Bis-(4-phenylbutyl)-benzol-1,3-dimethanamin

: N,N'-Bis-(4-phenylbutyl)-N,N'-m-xylen-di-aminomethansulfonsaeure-dinatriumsalz

Conditions

Conditions	Yield
In ethanol at 70℃; for 3h;	80%

: 870-72-4
sodium formaldehyde bisulfite

: 62-53-3
aniline

: 26021-90-9
sodium anilinomethanesulfonate

Conditions

Conditions	Yield
In water at 40 - 50℃;	80%
In ethanol; water at 20 - 25℃; for 1h;

: 870-72-4
sodium formaldehyde bisulfite

: 106-47-8
4-chloro-aniline

: 28141-44-8
p-Cl-Anilinium-methansulfonat

Conditions

Conditions	Yield
In water at 60℃; for 1h;	76%

: 870-72-4
sodium formaldehyde bisulfite

: 773837-37-9
sodium cyanide

: 78668-34-5
3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(14),11(15),12-triene

A: 160981-97-5
3,9-bis(methylenenitrile)-3,6,9,15-teraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene

B: pyclen-3,6-bis(methylenenitrile)

Conditions

Conditions	Yield
Stage #1: sodium formaldehyde bisulfite; 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(14),11(15),12-triene With hydrogenchloride In water at 60℃; for 3h; pH=8.7; Stage #2: sodium cyanide With sodium hydroxide at 20℃; for 3h;	A 76% B n/a

...Expand

: 870-72-4
sodium formaldehyde bisulfite

: 108-42-9
3-chloro-aniline

: 28141-45-9
sodium 3-chloroanilinomethanesulphonate

Conditions

Conditions	Yield
In water at 60℃; for 1h;	75%

: 870-72-4
sodium formaldehyde bisulfite

: (2-benzyl-1,1,4-trioxo-1λ6-[1,2,5]thiadiazolidin-3-yl)-acetic acid benzyl ester

: (2-benzyl-5-chloromethyl-1,1,4-trioxo-1λ6-[1,2,5]thiadiazolidin-3-yl)-acetic acid benzyl ester

Conditions

Conditions	Yield
With thionyl chloride Heating;	74%

: 870-72-4
sodium formaldehyde bisulfite

: 81-07-2
saccharin

: 13947-21-2
N-chloromethylsaccharin

Conditions

Conditions	Yield
With thionyl chloride Heating;	73%

: 870-72-4
sodium formaldehyde bisulfite

: 108-44-1
1-amino-3-methylbenzene

: 6274-20-0
sodium m-tolylamino-N-methanesulfonate

Conditions

Conditions	Yield
In ethanol; water at 20 - 100℃; for 5h;	72.8%

: 870-72-4
sodium formaldehyde bisulfite

: 124-40-3
dimethyl amine

: 68507-34-6
dimethylaminomethylsulfonic acid

Conditions

Conditions	Yield
In water at 0℃;	70%
In water

: 110-85-0
piperazine

: 870-72-4
sodium formaldehyde bisulfite

: piperazine-N,N'-bis(methanesulfonic acid) disodium salt

Conditions

Conditions	Yield
In water at 60℃; for 48h;	66%

: 870-72-4
sodium formaldehyde bisulfite

: 112169-14-9
N,N',N''-Tris-(4-phenylbutyl)-benzol-1,3,5-trimethanamin

: N,N',N''-Tris-(4-phenylbutyl)-N,N',N''-mesitylen-tri-aminomethansulfonsaeure-trinatriumsalz

Conditions

Conditions	Yield
In ethanol at 70℃; for 3h;	65%

: 870-72-4
sodium formaldehyde bisulfite

: 4-benzylisothiazolidin-3-one 1,1-dioxide

: 170918-76-0
4-benzyl-2-chloromethyl-isothiazolidin-3-one 1,1-dioxide

Conditions

Conditions	Yield
With thionyl chloride Heating;	64%

: 870-72-4
sodium formaldehyde bisulfite

: 91-00-9
Benzhydrylamine

: sodium methylenesulfonate benzhydrylamine

Conditions

Conditions	Yield
In water at 70℃; for 2h;	62%

: 870-72-4
sodium formaldehyde bisulfite

: 108-95-2
phenol

: 55116-32-0
sodium (2-hydroxyphenyl)methanesulfonate

Conditions

Conditions	Yield
With sodium hydroxide In water at 130℃; under 3878.6 Torr; for 3h; Product distribution; pH=8.5, Parr 4541 pressure reactor; different substituted phenols;	61%
With sodium hydroxide In water at 130℃; under 3878.6 Torr; for 3h; pH=8.5, Parr 4541 pressure reactor;	61%

: 870-72-4
sodium formaldehyde bisulfite

: 100-61-8
N-methylaniline

: 28141-38-0
sodium N-methylphenylaminomethanesulfonate

Conditions

Conditions	Yield
In water at 40 - 50℃;	60%

: 870-72-4
sodium formaldehyde bisulfite

: 106-44-5
p-cresol

: 110830-60-9
Sodium; (2-hydroxy-5-methyl-phenyl)-methanesulfonate

Conditions

Conditions	Yield
With sodium hydroxide In water at 130℃; under 3878.6 Torr; for 3h; pH=8.5, Parr 4541 pressure reactor;	59%

SODIUM FORMALDEHYDE BISULFITE Chemical Properties

Molecular Formula: CH₃NaO₄S

Formula Weight: 134.09
mp of SODIUM FORMALDEHYDE BISULFITE (870-72-4): 200 ^°C (dec.)(lit.)
Fp of SODIUM FORMALDEHYDE BISULFITE (870-72-4): 184 ^°C
Solubility: Easily soluble in methanol. Soluble in cold water.
Water Solubility : 800 g/L (20 ^°C )
Sensitive : Hygroscopic
Appearance: SODIUM FORMALDEHYDE BISULFITE (870-72-4) is a White solid

SODIUM FORMALDEHYDE BISULFITE Uses

SODIUM FORMALDEHYDE BISULFITE (870-72-4) is used for the production of the medicine cancer enemy-M, neosalvarsan and methaniazide.

SODIUM FORMALDEHYDE BISULFITE Production

Put distilled water and formaldehyde solution into the reaction vessel and cool it to 15^° C. After mixing, batch adding sodium bisulfite at the temperature 60-65 ^° C and reacting for 20min. Control it approximately at pH 9 by using sodium hydroxide solution. Then adding HCl to make pH up to 3. Use active carbon in order to decolor, filtering and after cooling filtrate, add ethanol to separate out solid, then place it to the next day. Again filtering and washing by ethanol, after drying we can obtain SODIUM FORMALDEHYDE BISULFITE (870-72-4).

SODIUM FORMALDEHYDE BISULFITE Toxicity Data With Reference

1.		orl-rat LDLo:3200 mg/kg		KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650).
2.		ipr-rat LDLo:3200 mg/kg		KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650).

SODIUM FORMALDEHYDE BISULFITE Consensus Reports

Reported in EPA TSCA Inventory.

SODIUM FORMALDEHYDE BISULFITE Safety Profile

Safety: WARNING: Irritates lungs, eyes, skin
Risk Statements : 36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements : 24/25: Avoid contact with skin and eyes
WGK Germany : 1
RTECS : PB2200000
Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SO_x and Na₂O. See also FORMALDEHYDE and SULFITES.

SODIUM FORMALDEHYDE BISULFITE Specification

Storage: Keep container in a cool, well-ventilated area. Keep container tightly closed.

Product Name

Sodium formaldehyde bisulfite

Synthetic route

SODIUM FORMALDEHYDE BISULFITE Chemical Properties

SODIUM FORMALDEHYDE BISULFITE Uses

SODIUM FORMALDEHYDE BISULFITE Production

SODIUM FORMALDEHYDE BISULFITE Toxicity Data With Reference

SODIUM FORMALDEHYDE BISULFITE Consensus Reports

SODIUM FORMALDEHYDE BISULFITE Safety Profile

SODIUM FORMALDEHYDE BISULFITE Specification

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