Chemistry informtion about Cefamandole Sodium (CAS NO.30034-03-8) is:
IUPAC Name: Sodium (6r,7r)-7-[[(2r)-2-Hydroxy-2-Phenylacetyl]Amino]-3-[(1-Methyltetrazol-5-Yl)Sulfanylmethyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate
Synonyms: Cefamandole Sodium ; Cefamandole Sodium Salt ; Sodium [6r-[6alpha,7beta(R*)]]-7-[[(Formyloxy)Phenylacetyl]Amino]-3-[[(1-Methyl-1h-Tetrazol-5-Yl)Thio]Methyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate ; Sodium (6r-(6alpha,7beta(R*)))-7-((Hydroxyphenylacetyl)Amino)-3-(((1-Methyl-1h-Tetrazol-5-Yl)Thio)Methyl)-8-Oxo-5-Thia-1-Azabicyclo(4.2.0)Oct-2-Ene-2-Carboxylate ; Sodium Cefamandole ; 5-Thia-1-Azabicyclo(4.2.0)Oct-2-Ene-2-Carboxylicacid,7-Mandelamido-3-(((1-Met ; Monosodiumsalt,D-Hyl-1h-Tetrazol-5-Yl)Thio)Methyl)-8-Oxo ; 5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid, 7-[(Hydroxyphenylacetyl)Amino]-3-[[(1-Methyl-1h-Tetrazol-5-Yl)Thio]Methyl]-8-Oxo-, Monosodium Salt, [6r-[6α,7β(R*)]]-
MF: C18H17N6NaO5S2
MW: 484.48
EINECS: 250-009-0
Melting Point: >175°C (dec.)
Storage temp.: Store at RT.
Following is the molecular structure of Cefamandole Sodium (CAS NO.30034-03-8) is:
Cefamandole Sodium (CAS NO.30034-03-8) can be used as broad-spectrum semi-synthetic cephalosporin antibiotic.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | 4460mg/kg (4460mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984. | |
mouse | LD50 | oral | > 19900mg/kg (19900mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984. | |
mouse | LD50 | subcutaneous | 10300mg/kg (10300mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984. | |
rabbit | LD | intravenous | > 2gm/kg (2000mg/kg) | behavioral: food intake (animal) kidney, ureter, and bladder: "changes in tubules (including acute renal failure, acute tubular necrosis)" kidney, ureter, and bladder: other changes in urine composition | Chemotherapy Vol. 27(Suppl, |
rat | LD50 | intravenous | 4410mg/kg (4410mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984. | |
rat | LD50 | oral | > 16600mg/kg (16600mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984. | |
rat | LD50 | subcutaneous | 12100mg/kg (12100mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 115, 1984. |
Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx, NOx, and Na2O.
Hazard Codes:
Xn
Risk Statements:
R36/37/38:Irritating to eyes, respiratory system and skin.
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 2
RTECS: XI0389000
Cefamandole Sodium (CAS NO.30034-03-8) is white solid.
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