Product Name

  • Name

    HIPPURIC ACID SODIUM SALT

  • EINECS 208-548-4
  • CAS No. 532-94-5
  • Article Data1
  • CAS DataBase
  • Density g/cm3
  • Solubility H2O: 0.5 M at 20 °C, clear, colorless
  • Melting Point 240～244℃
  • Formula C9H9 N O3 . Na
  • Boiling Point 464.1 °C at 760 mmHg
  • Molecular Weight 201.157
  • Flash Point 234.5 °C
  • Transport Information
  • Appearance white to off-white powder
  • Safety Mildly toxic by intravenous route. When heated to decomposition it emits toxic fumes of NOx and Na2O.
  • Risk Codes 22-36/37/38
  • Molecular Structure Molecular Structure of 532-94-5 (HIPPURIC ACID SODIUM SALT)
  • Hazard Symbols Xn
  • Synonyms Glycine,N-benzoyl-, monosodium salt (9CI); Hippuric acid, monosodium salt (8CI);Hippuric acid sodium salt; N-Benzoylglycine sodium salt; Sodium hippurate
  • PSA 69.23000
  • LogP -0.44280

Synthetic route

benzoyl chloride
98-88-4

benzoyl chloride

glycine
56-40-6

glycine

sodium hippurate
532-94-5

sodium hippurate

Conditions
ConditionsYield
With sodium hydroxide
sodium hippurate
532-94-5

sodium hippurate

benzaldehyde
100-52-7

benzaldehyde

4-benzylidene-2-phenyloxazole-5(4H)-one
842-74-0

4-benzylidene-2-phenyloxazole-5(4H)-one

Conditions
ConditionsYield
With sodium acetate; acetic anhydride; triethylamine sulfate In neat (no solvent) at 90℃; Solvent; Temperature; Green chemistry;99%
sodium hippurate
532-94-5

sodium hippurate

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

4-(4-methoxybenzylidene)-2-phenyl-5(4H)-oxazolone
5429-22-1

4-(4-methoxybenzylidene)-2-phenyl-5(4H)-oxazolone

Conditions
ConditionsYield
With sodium acetate; acetic anhydride; triethylamine sulfate In neat (no solvent) at 90℃; Green chemistry;98%
sodium hippurate
532-94-5

sodium hippurate

4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

4-(4-methylbenzylidene)-2-phenyloxazol-5-one
82309-33-9

4-(4-methylbenzylidene)-2-phenyloxazol-5-one

Conditions
ConditionsYield
With sodium acetate; acetic anhydride; triethylamine sulfate In neat (no solvent) at 90℃; Green chemistry;97%
sodium hippurate
532-94-5

sodium hippurate

3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

4-(3'-nitrobenzylidene)-2-phenyl-4-oxazolone
15601-45-3, 66949-11-9, 123990-32-9

4-(3'-nitrobenzylidene)-2-phenyl-4-oxazolone

Conditions
ConditionsYield
With sodium acetate; acetic anhydride; triethylamine sulfate In neat (no solvent) at 90℃; Green chemistry;96%
sodium hippurate
532-94-5

sodium hippurate

terephthalaldehyde,
623-27-8

terephthalaldehyde,

4-(4-formylbenzylidene)-2-phenyloxazol-5(4H)-one

4-(4-formylbenzylidene)-2-phenyloxazol-5(4H)-one

Conditions
ConditionsYield
With sodium acetate; acetic anhydride; triethylamine sulfate In neat (no solvent) at 90℃; Green chemistry;96%
4-hydroxy-3-ethoxybenzaldehyde
121-32-4

4-hydroxy-3-ethoxybenzaldehyde

sodium hippurate
532-94-5

sodium hippurate

4-(3-ethoxy-4-hydroxybenzylidene)-2-phenyloxazol-5(4H)-one

4-(3-ethoxy-4-hydroxybenzylidene)-2-phenyloxazol-5(4H)-one

Conditions
ConditionsYield
With sodium acetate; acetic anhydride; triethylamine sulfate In neat (no solvent) at 90℃; Green chemistry;96%
sodium hippurate
532-94-5

sodium hippurate

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

4-(4-bromobenzylidene)-2-phenyl-5(4H)oxazolone
20345-16-8

4-(4-bromobenzylidene)-2-phenyl-5(4H)oxazolone

Conditions
ConditionsYield
With sodium acetate; acetic anhydride; triethylamine sulfate In neat (no solvent) at 90℃; Green chemistry;95%
sodium hippurate
532-94-5

sodium hippurate

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

4-(4-nitrobenzylidene)-2-phenyl-5(4H) oxazolone
7152-75-2, 57427-80-2, 57427-96-0

4-(4-nitrobenzylidene)-2-phenyl-5(4H) oxazolone

Conditions
ConditionsYield
With sodium acetate; acetic anhydride; triethylamine sulfate In neat (no solvent) at 90℃; Green chemistry;95%
sodium hippurate
532-94-5

sodium hippurate

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

(Z/E)-4-(4-chlorobenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one
15601-44-2

(Z/E)-4-(4-chlorobenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one

Conditions
ConditionsYield
With sodium acetate; acetic anhydride; triethylamine sulfate In neat (no solvent) at 90℃; Green chemistry;94%
pyridine-4-carbaldehyde
872-85-5

pyridine-4-carbaldehyde

sodium hippurate
532-94-5

sodium hippurate

2-phenyl-4-(pyridin-4-ylmethylene)oxazol-5(4H)-one
5027-85-0

2-phenyl-4-(pyridin-4-ylmethylene)oxazol-5(4H)-one

Conditions
ConditionsYield
With sodium acetate; acetic anhydride; triethylamine sulfate In neat (no solvent) at 90℃; Green chemistry;93%
sodium hippurate
532-94-5

sodium hippurate

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

4-(4-fluorobenzylidene)-2-phenyloxazol-5(4H)-one
449-81-0

4-(4-fluorobenzylidene)-2-phenyloxazol-5(4H)-one

Conditions
ConditionsYield
With sodium acetate; acetic anhydride; triethylamine sulfate In neat (no solvent) at 90℃; Green chemistry;91%
sodium hippurate
532-94-5

sodium hippurate

4-dimethylamino-benzaldehyde
100-10-7

4-dimethylamino-benzaldehyde

4-(4'-N,N-dimethylaminobenzylidene)-2-phenyloxazole-5(4H)-one
66949-12-0, 1564-29-0

4-(4'-N,N-dimethylaminobenzylidene)-2-phenyloxazole-5(4H)-one

Conditions
ConditionsYield
With sodium acetate; acetic anhydride; triethylamine sulfate In neat (no solvent) at 90℃; Green chemistry;91%
trichlorotritetrahydrofuran chromium(III)

trichlorotritetrahydrofuran chromium(III)

sodium hippurate
532-94-5

sodium hippurate

tris(N-benzoylglycinato)chromium(III)
97824-06-1

tris(N-benzoylglycinato)chromium(III)

Conditions
ConditionsYield
In methanol byproducts: NaCl, THF; addn. of sodium hippurate in MeOH to CrCl3*3THF in methanol, pptn. of NaCl, refluxing for 2 h; filtration of NaCl, crystn. of Cr(C6H5CONHCH2COO)3, drying under vac. (120°C, 2mm), elem. anal.;90%
sodium hippurate
532-94-5

sodium hippurate

2-nitro-benzaldehyde
552-89-6

2-nitro-benzaldehyde

4-(2-nitrobenzylidene)-2-phenyl-5(4H)oxazolone
7621-81-0

4-(2-nitrobenzylidene)-2-phenyl-5(4H)oxazolone

Conditions
ConditionsYield
With sodium acetate; acetic anhydride; triethylamine sulfate In neat (no solvent) at 90℃; Green chemistry;90%
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

sodium hippurate
532-94-5

sodium hippurate

2-phenyl-4-(thiophen-2-ylmethylidene)-1,3-oxazol-5(4 H)-one
68100-05-0

2-phenyl-4-(thiophen-2-ylmethylidene)-1,3-oxazol-5(4 H)-one

Conditions
ConditionsYield
With sodium acetate; acetic anhydride; triethylamine sulfate In neat (no solvent) at 90℃; Green chemistry;90%
sodium hippurate
532-94-5

sodium hippurate

acetic anhydride
108-24-7

acetic anhydride

benzamidoacetone
50996-03-7

benzamidoacetone

Conditions
ConditionsYield
Stage #1: sodium hippurate; acetic anhydride With pyridine
Stage #2: With water Heating;		80%
sodium hippurate
532-94-5

sodium hippurate

tricyclohexyltin(IV) chloride
3091-32-5

tricyclohexyltin(IV) chloride

tricyclohexyltin N-benzoylglycinate
129296-27-1

tricyclohexyltin N-benzoylglycinate

Conditions
ConditionsYield
In ethanol; benzene byproducts: NaCl; refluxing (6-8 h), cooling, filtration (vac.), addn. of benzene, 2-3x refluxing and filtration; solvent removal (distn., reduced pressure), recrystn. (EtOH); elem. anal.;63%
trimethyltin(IV)chloride
1066-45-1

trimethyltin(IV)chloride

sodium hippurate
532-94-5

sodium hippurate

trimethyltin N-benzoylglycinate
84706-02-5

trimethyltin N-benzoylglycinate

Conditions
ConditionsYield
In ethanol; benzene byproducts: NaCl; refluxing (6-8 h), cooling, filtration (vac.), addn. of benzene, 2-3x refluxing and filtration; solvent removal (distn., reduced pressure); elem. anal.;62%
sodium hippurate
532-94-5

sodium hippurate

tripropyltin chloride
2279-76-7

tripropyltin chloride

tri(n-propyl)tin N-benzoylglycinate
129382-94-1

tri(n-propyl)tin N-benzoylglycinate

Conditions
ConditionsYield
In ethanol; benzene byproducts: NaCl; refluxing (6-8 h), cooling, filtration (vac.), addn. of benzene, 2-3x refluxing and filtration; solvent removal (distn., reduced pressure); elem. anal.;60%
sodium hippurate
532-94-5

sodium hippurate

triphenyltin chloride
639-58-7

triphenyltin chloride

triphenyltin N-benzoylglycinate
84706-03-6

triphenyltin N-benzoylglycinate

Conditions
ConditionsYield
In ethanol; benzene byproducts: NaCl; refluxing (6-8 h), cooling, filtration (vac.), addn. of benzene, 2-3x refluxing and filtration; solvent removal (distn., reduced pressure); elem. anal.;58%
tributyltin chloride
1461-22-9

tributyltin chloride

sodium hippurate
532-94-5

sodium hippurate

tri(n-butyl)tin N-benzoylglycinate
3262-53-1

tri(n-butyl)tin N-benzoylglycinate

Conditions
ConditionsYield
In ethanol; benzene byproducts: NaCl; refluxing (6-8 h), cooling, filtration (vac.), addn. of benzene, 2-3x refluxing and filtration; solvent removal (distn., reduced pressure); elem. anal.;55%
14-iodo-N-(trifluoroacetyl)daunorubicin
26295-55-6

14-iodo-N-(trifluoroacetyl)daunorubicin

sodium hippurate
532-94-5

sodium hippurate

N-(trifluoroacetyl)-14-O-(N-benzoylglycyl)adriamycin
101980-55-6

N-(trifluoroacetyl)-14-O-(N-benzoylglycyl)adriamycin

Conditions
ConditionsYield
In ethylene glycol; N,N-dimethyl-formamide at 45℃; for 1h;38%
butanoic acid anhydride
106-31-0

butanoic acid anhydride

sodium hippurate
532-94-5

sodium hippurate

2-phenyl-4-butyryl-5-oxazolinone
90127-56-3

2-phenyl-4-butyryl-5-oxazolinone

piperonal
120-57-0

piperonal

sodium hippurate
532-94-5

sodium hippurate

(Z)-2-phenyl-4-piperonylidene-2-oxazoline-5(4H)-one
6412-89-1, 82301-51-7, 82301-54-0

(Z)-2-phenyl-4-piperonylidene-2-oxazoline-5(4H)-one

Conditions
ConditionsYield
With acetic anhydride
1,3-Dichloro-2-propanol
96-23-1

1,3-Dichloro-2-propanol

sodium hippurate
532-94-5

sodium hippurate

1,3-bis-hippuroyloxy-propan-2-ol

1,3-bis-hippuroyloxy-propan-2-ol

Conditions
ConditionsYield
at 185℃;
bis (2-chloroethyl) sulphide
505-60-2

bis (2-chloroethyl) sulphide

sodium hippurate
532-94-5

sodium hippurate

bis-(2-hippuroyloxy-ethyl)-sulfide

bis-(2-hippuroyloxy-ethyl)-sulfide

Conditions
ConditionsYield
With acetone
n-hexanoic anhydride
2051-49-2

n-hexanoic anhydride

sodium hippurate
532-94-5

sodium hippurate

2-phenyl-4-hexanoyl-5-oxazolinone
134279-72-4

2-phenyl-4-hexanoyl-5-oxazolinone

sodium hippurate
532-94-5

sodium hippurate

acetic anhydride
108-24-7

acetic anhydride

2-phenyl-4-acetyl-5-oxazolinone
37127-06-3

2-phenyl-4-acetyl-5-oxazolinone

sodium hippurate
532-94-5

sodium hippurate

propionic acid anhydride
123-62-6

propionic acid anhydride

2-phenyl-4-propionyl-5-oxazolinone
85094-77-5

2-phenyl-4-propionyl-5-oxazolinone

sodium hippurate
532-94-5

sodium hippurate

2-Bromo-4'-phenylacetophenone
135-73-9

2-Bromo-4'-phenylacetophenone

hippuric acid-(4-phenyl-phenacyl ester)
7497-81-6

hippuric acid-(4-phenyl-phenacyl ester)

Conditions
ConditionsYield
With ethanol

Sodium hippurate Chemical Properties

IUPAC Name: Sodium 2-benzamidoacetate
Synonyms: Glycine, N-benzoyl-, sodium salt (1:1) ; Sodium (benzoylamino)acetate ; Benzoylamino-acetate ; Glycine, N-benzoyl-, monosodium salt ; Hippuric acid sodium salt ; Hippuric acid, monosodium salt ; N-Benzoylglycine sodium salt  
CAS NO: 532-94-5
Molecular Formula of Sodium hippurate (CAS NO.532-94-5) : C9H8NNaO3
Molecular Weight of Sodium hippurate (CAS NO.532-94-5) : 201.15
Molecular Structure of Sodium hippurate (CAS NO.532-94-5) :
EINECS: 208-548-4
Mol File: 532-94-5.mol
Flash Point: 234.5 °C
Enthalpy of Vaporization: 76.44 kJ/mol
Boiling Point: 464.1 °C at 760 mmHg
Vapour Pressure: 2.06E-09 mmHg at 25°C
Storage temp. Store at RT.
Solubility H2O: 0.5 M at 20 °C, clear, colorless
Appearance:White crystalline powder

Sodium hippurate Uses

 Sodium hippurate (CAS NO.532-94-5) is used as intermediate in organic synthesis.

Sodium hippurate Production

Preparation products: 2-Phenyl-acetamidine-->N-Phenyl-1-naphthylamine hydrobromide, 98-->2-(4-Methoxy-phenyl)-acetamidine

Sodium hippurate Toxicity Data With Reference

1.    

ivn-mus LD50:4150 mg/kg

     JPETAB    Journal of Pharmacology and Experimental Therapeutics. 86 (1945),147.

Sodium hippurate Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Sodium hippurate Safety Profile

Mildly toxic by intravenous route. When heated to decomposition it emits toxic fumes of NOx and Na2O.
Hazard Codes HarmfulXn
Risk Statements 22-36/37/38
R22:Harmful if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 24/25-36/37-26-22
S22:Do not breathe dust. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S24/25:Avoid contact with skin and eyes. 
S36/37:Wear suitable protective clothing and gloves.
WGK Germany 3
RTECS MR8170000

Sodium hippurate Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: Use agent most appropriate to extinguish fire .
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Keep container closed when not in use.
 

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View