Sodium sulfadiazine supplier

Name
Sodium sulfadiazine
EINECS 208-919-0
CAS No. 547-32-0
Article Data4
CAS DataBase
Density 1.496g/cm3
Solubility
Melting Point
Formula C₁₀H₉N₄NaO₂S
Boiling Point 512.6oC at 760 mmHg
Molecular Weight 273.271
Flash Point 263.8oC
Transport Information UN 3249
Appearance white to off-white crystalline powder
Safety 22-26-36/37-45
Risk Codes 22-36/37/38-42/43
Molecular Structure
Hazard Symbols Xn
Synonyms Benzenesulfonamide,4-amino-N-2-pyrimidinyl-, monosodium salt (9CI);Sodium, (N1-2-pyrimidinylsulfanilamido)-(7CI);Sulfadiazine, sodium deriv. (6CI);Sulfanilamide, N1-2-pyrimidinyl-,monosodium salt (8CI);2-Sulfanilamidopyrimidine sodium salt;Monosodium2-sulfanilamidopyrimidine;Sodium 2-sulfanilamidopyrimidine;Sodium sulfapyrimidine;Sulfadiazine sodium;Sulfapyrimidine sodium;
PSA 97.56000
LogP 2.38040

Synthetic route

: 68-35-9
sulfadiazine

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water Heating;

: 12080-32-9
dichloro(1,5-cyclooctadiene)platinum(ll)

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: 39234-21-4
sodium N-methyl-N-phenyldithiocarbamate

: [Pt(SD)(me-DTC)]

Conditions

Conditions	Yield
Stage #1: dichloro(1,5-cyclooctadiene)platinum(ll); poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)] In water for 1h; Reflux; Stage #2: sodium N-methyl-N-phenyldithiocarbamate In water for 3h; Reflux;	97%

...Expand

: 7440-22-4
silver

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: 22199-08-2
silver sulfadiazine

Conditions

Conditions	Yield
With sodium nitrate; nitric acid In water for 0.1h; Electrochemical reaction; Green chemistry;	97%

: 12080-32-9
dichloro(1,5-cyclooctadiene)platinum(ll)

: 13074-29-8
(N-ethyl-N'-phenyl-dithiocarbamato) sodium

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: [Pt(SD)(et-DTC)]

Conditions

Conditions	Yield
Stage #1: dichloro(1,5-cyclooctadiene)platinum(ll); poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)] In water for 1h; Reflux; Stage #2: (N-ethyl-N'-phenyl-dithiocarbamato) sodium In water for 3h; Reflux;	92%

...Expand

: 5263-87-6
6-methoxy quinoline

: cobalt(II) sulphate heptahydrate

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: Co(sulfadiazine)2(6-methoxyquinoline)2

Conditions

Conditions	Yield
In methanol for 4h; Reflux;	89.1%

...Expand

: 298-96-4
triphenyltetrazolium chloride

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: C19H15N4(1+)*C10H9N4O2S(1-)

Conditions

Conditions	Yield
In methanol; water at 20℃; for 2h;	88%

: zinc(II) chloride hexahydrate

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: 1096051-46-5
Zn(sulfadiazine)2(H2O)2

Conditions

Conditions	Yield
In water aq. Zn salt added to aq. Na salt of sulfadiazine; soln. stirred at 40°C for 3 h; cooled to room temp.; filtered under vac., washed with water; dried over CaCl2; elem. anal.;	87%

: zinc(II) acetate tetrahydrate

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: 1096051-46-5
Zn(sulfadiazine)2(H2O)2

Conditions

Conditions	Yield
In water aq. Zn salt added to aq. Na salt of sulfadiazine; soln. stirred at 40°C for 3 h; cooled to room temp.; filtered under vac., washed with water; dried over CaCl2;	87%

: 21264-30-2, 90243-59-7, 14592-56-4
dichloro bis(acetonitrile) palladium(II)

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: 39234-21-4
sodium N-methyl-N-phenyldithiocarbamate

: [Pd(SD)(me-DTC)]

Conditions

Conditions	Yield
Stage #1: dichloro bis(acetonitrile) palladium(II); poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)] In water for 1h; Reflux; Stage #2: sodium N-methyl-N-phenyldithiocarbamate In water for 3h; Reflux;	85%

...Expand

: [Fe(N-(2-hydroxybenzyl)-N-(2-pyridylmethyl)(3-chloro)(2-hydroxy)propylamine)Cl2]*H2O

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: [(Cl)(sulfadiazine)Fe(III)(μ-N-(2-hydroxybenzyl)-N-(2-pyridylmethyl)(3-chloro)(2-hydroxy)propylamine)2Fe(III)(sulfadiazine)(Cl)]*2H2O

Conditions

Conditions	Yield
In methanol; water Reflux;	85%

: 21264-30-2, 90243-59-7, 14592-56-4
dichloro bis(acetonitrile) palladium(II)

: 13074-29-8
(N-ethyl-N'-phenyl-dithiocarbamato) sodium

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: [Pd(SD)(et-DTC)]

Conditions

Conditions	Yield
Stage #1: dichloro bis(acetonitrile) palladium(II); poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)] In water for 1h; Reflux; Stage #2: (N-ethyl-N'-phenyl-dithiocarbamato) sodium In water for 3h; Reflux;	84%

...Expand

: 52462-29-0
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: C30H32N8O4RuS2

Conditions

Conditions	Yield
In methanol for 3h;	84%

: 366-18-7
[2,2]bipyridinyl

: cobalt(II) chloride hexahydrate

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: Co(sulfadiazine)22,2′-bipyridine

Conditions

Conditions	Yield
In ethanol at 25℃; for 1h;	81.4%

...Expand

: copper(II) choride dihydrate

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: 1096051-43-2
Cu(sulfadiazine)2(H2O)2

Conditions

Conditions	Yield
In methanol to soln. of Na salt of sulfadiazine, Cu salt added dropwise; soln. stirred continuously at 40°C for 3 h; cooled to room temp.; filtered under vac.; washed with water or methanol; elem. anal.;	80%
In water to soln. of Na salt of sulfadiazine, Cu salt added dropwise; soln. stirred continuously at 40°C for 3 h; cooled to room temp.; filtered under vac.; washed with water or methanol;	80%

: copper(II) acetate dihydrate

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: 1096051-43-2
Cu(sulfadiazine)2(H2O)2

Conditions

Conditions	Yield
In methanol to soln. of Na salt of sulfadiazine, Cu salt added dropwise; soln. stirred continuously at 40°C for 3 h; cooled to room temp.; filtered under vac.; washed with water or methanol;	80%
In water to soln. of Na salt of sulfadiazine, Cu salt added dropwise; soln. stirred continuously at 40°C for 3 h; cooled to room temp.; filtered under vac.; washed with water or methanol;	80%

: copper(ll) sulfate pentahydrate

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: 1096051-43-2
Cu(sulfadiazine)2(H2O)2

Conditions

Conditions	Yield
In methanol to soln. of Na salt of sulfadiazine, Cu salt added dropwise; soln. stirred continuously at 40°C for 3 h; cooled to room temp.; filtered under vac.; washed with water or methanol;	80%
In water to soln. of Na salt of sulfadiazine, Cu salt added dropwise; soln. stirred continuously at 40°C for 3 h; cooled to room temp.; filtered under vac.; washed with water or methanol;	80%

: ammonium hydroxide

: 543-90-8
cadmium(II) acetate

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: Cd(sulfadiazinato)2*2(NH3)

Conditions

Conditions	Yield
In water Cd(II) acetate in distd. water added dropwise with stirring; stirred (18 h, room temp.); filtered off; air dried; crystd. (NH4OH-H2O, 1:1); elem. anal.;	80%

...Expand

: nickel(II) chloride hexahydrate

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: Ni(sulfadiazine)2(H2O)2*2H2O

Conditions

Conditions	Yield
In water to aq. NiCl2*6H2O, aq. Na salt of sulfadiazine added; stirred at 40°C for 3 h; filtered under vac., washed with water; dried over CaCl2; elem. anal.;	78%

: vanadyl(IV) sulphate pentahydrate

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: VO(sulfadiazine)2(H2O)*H2O

Conditions

Conditions	Yield
In water Pt compd. dissolved in water; then aq. soln. of Na salt of sulfadiazine added; mixt. stirred at 40°C for 3 h; filtered under vac., washed with water, dried over CaCl2; elem. anal.;	68%

: manganese(II) chloride tetrahydrate

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: 1096051-49-8
Mn(sulfadiazine)2(H2O)2

Conditions

Conditions	Yield
In water to aq. Na salt of sulfadiazine added aq. MnCl2*4H2O; mixt. stirred for 3h at 40°C; cooled to room temp.; filtered under vac.; washed with water; dried over CaCl2; elem. anal.;	64%

: 67-56-1
methanol

: 10025-98-6
potassium tetrachloropalladate(II)

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: 1096051-55-6
Pd(sulfadiazine)(CH3OH)Cl

Conditions

Conditions	Yield
In methanol; water Pd compd. dissolved in water; then MeOH soln. of Na salt of sulfadiazineadded; mixt. stirred at 40°C for 3 h; filtered under vac., washed with water, dried over CaCl2; elem. anal.;	56%

...Expand

: 10025-99-7
potassium tetrachloroplatinate(II)

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: 1096051-58-9
Pt(sulfadiazine)(H2O)Cl

Conditions

Conditions	Yield
In methanol; water Pt compd. dissolved in water; then MeOH soln. of Na salt of sulfadiazineadded; mixt. stirred at 40°C for 3 h; filtered under vac., washed with water, dried over CaCl2; elem. anal.;	53%

: [{(η5-C5Me5)RhCl(acetone)}2](CF3SO3)

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: C30H33N8O4RhS2

Conditions

Conditions	Yield
In methanol; dichloromethane at 55℃; for 4h;	44%

: 760147-40-8
[Zinc(II)(2-hydroxybenzyl-(2-pyridylmethyl)amine)Cl2]

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: C46H44N12O6S2Zn2*4H2O

Conditions

Conditions	Yield
In methanol; water	38%

: 7732-18-5
water

: 373-02-4, 14998-37-9, 33025-09-1, 94044-50-5, 98268-31-6
nickel diacetate

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: 1096252-90-2
C20H22N8NiO6S2

Conditions

Conditions	Yield
In methanol for 3h; Reflux;	35%

...Expand

: 5335-05-7
chloromethyl benzoate

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: 4-amino-N-benzoyloxymethyl-N-(2-pyrimidinyl)benzenesulfonamide

Conditions

Conditions	Yield
In tetrahydrofuran Substitution;	30%

: zinc(II) chloride dihydrate

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: C20H21ClN8O5S2Zn

Conditions

Conditions	Yield
In methanol; water	18%

: 1600-27-7
mercury(II) diacetate

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: [mercury(II)(sulfadiazine(-H))2(dimethylformamide)2]

Conditions

Conditions	Yield
With NH3 In methanol Na-salt of organic ligand dissolved in hot CH3OH; 2 equiv. of CH3OH soln. of Hg(CH3COO)2 added with constant stirring; stirred for 6 h; filtered; dried over silica gel in desiccator; dissolved in DMF; few drops of NH3 added; stirred for 30 min; filtered; left crystallized for a few days; elem. anal.;

...Expand

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: 24540-82-7
sulfadiazine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water at 20℃; for 72h;

: zinc(II) chloride hexahydrate

: 547-32-0
poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)]

: 107-15-3
ethylenediamine

: 2C10H9N4O2S(1-)*C6H24N6Zn(2+)*H2O

Conditions

Conditions	Yield
Stage #1: zinc(II) chloride hexahydrate; poly[{μ3-4-[(pyrimidin-2-ylazanidyl)sulfonyl]aniline}sodium(I)] In ethanol Stage #2: ethylenediamine In ethanol

...Expand

Sodium sulfadiazine Specification

This chemical is called Sulfadiazine Sodium, and its CAS registry number is 547-32-0. With the molecular formula of C₁₀H₉N₄NaO₂S, its classification codes are Antibacterial; Drug / Therapeutic Agent; Mutation data; Reproductive Effect. Additionally, it's used for cure sulfonamide, susceptible infections and it can also be used for T. gondii infection. However, it should be stored at 2-8°C.

Other characteristics of the Sulfadiazine Sodium can be summarised as followings: (1)#H bond acceptors: 6; (2)#H bond donors: 3; (3)#Freely Rotating Bonds: 2; (4)Polar Surface Area: 106.35 Å².

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. It may cause sensitization by inhalation and skin contacting. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	1747mg/kg (1747mg/kg)	Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 17, 1944.
mouse	LD50	intravenous	540mg/kg (540mg/kg)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 94, Pg. 338, 1953.
mouse	LD50	oral	1700mg/kg (1700mg/kg)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 94, Pg. 338, 1953.
mouse	LD50	subcutaneous	1408mg/kg (1408mg/kg)	Acta Medica Scandinavica, Supplement. Vol

Product Name

Sodium sulfadiazine

Synthetic route

Sodium sulfadiazine Specification

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