• Name

  Sulfaclozine

• EINECS 203-044-0
• CAS No. 102-65-8
• Article Data3
• CAS DataBase
• Density 1.588 g/cm³
• Solubility soluble in water or methanol,slightly soluble in ethanol or acetone and not dissoluble in chloroform.
• Melting Point 234.8-235.4 °C
• Formula C₁₀H₉ClN₄O₂S
• Boiling Point 495.7 °C at 760 mmHg
• Molecular Weight 284.726
• Flash Point 253.6 °C
• Transport Information
• Appearance Slightly yellow crystal powder
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Benzenesulfonamide,4-amino-N-(6-chloropyrazinyl)- (9CI);Sulfanilamide, N1-(6-chloropyrazinyl)-(7CI,8CI);Esb3 (antibiotic);N1-(6-Chloropyrazinyl)sulfanilamide;Sulfachloropyrazine;Sulfatyf;
• PSA 106.35000
• LogP 3.24800

Synthetic route

N-(6-chloropyrazin-2-yl)-4-nitrobenzenesulfonamide

102-65-8

4-amino-N-(6-chloropyrazin-2-yl)benzenesulfonamide

Conditions

Conditions	Yield
With tin(II) chloride dihdyrate In ethanol at 80℃; for 0.5h;	81%

98-74-8

4-Nitrobenzenesulfonyl chloride

102-65-8

4-amino-N-(6-chloropyrazin-2-yl)benzenesulfonamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride; pyridine / acetone / 20 °C / Sealed tube 2: tin(II) chloride dihdyrate / ethanol / 0.5 h / 80 °C View Scheme

2555-29-5

8-acetyl-7-hydroxy-4-methyl-2H-chromen-2-one

102-65-8

4-amino-N-(6-chloropyrazin-2-yl)benzenesulfonamide

C22H17ClN4O5S

Conditions

Conditions	Yield
With acetic acid for 1h; Reflux;

102-65-8

4-amino-N-(6-chloropyrazin-2-yl)benzenesulfonamide

C21H19Cl2N5NiO8S

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: hydrogenchloride; sodium nitrite / water / Cooling with ice 1.2: 0.25 h / Cooling with ice 2.1: ammonium hydroxide / water; ethanol / Heating View Scheme

102-65-8

4-amino-N-(6-chloropyrazin-2-yl)benzenesulfonamide

C42H30Cl2N10O12S2Zn

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: hydrogenchloride; sodium nitrite / water / Cooling with ice 1.2: 0.25 h / Cooling with ice 2.1: ammonium hydroxide / ethanol / Heating View Scheme

102-65-8

4-amino-N-(6-chloropyrazin-2-yl)benzenesulfonamide

C21H15Cl2N5O6PdS

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: hydrogenchloride; sodium nitrite / water / Cooling with ice 1.2: 0.25 h / Cooling with ice 2.1: ammonium hydroxide / ethanol / Heating View Scheme

102-65-8

4-amino-N-(6-chloropyrazin-2-yl)benzenesulfonamide

86-48-6

1-hydroxy-2-naphthoic acid

C21H14ClN5O5S

Conditions

Conditions	Yield
Stage #1: 4-amino-N-(6-chloropyrazin-2-yl)benzenesulfonamide With hydrogenchloride; sodium nitrite In water Cooling with ice; Stage #2: 1-hydroxy-2-naphthoic acid With sodium hydroxide In water for 0.25h; Cooling with ice;

Sulfaclozine Chemical Properties

Sulfaclozine Uses