Sulfanilamide supplier | CasNO.63-74-1

Name
Sulfanilamide
EINECS 200-563-4
CAS No. 63-74-1
Article Data103
CAS DataBase
Density 1.427 g/cm³
Solubility 7.5 g/L at 25 °C
Melting Point 164-167 °C
Formula C₆H₈N₂O₂S
Boiling Point 400.5 °C at 760 mmHg
Molecular Weight 172.208
Flash Point 196 °C
Transport Information
Appearance White to almost white crystalline powder
Safety 24/25-36-22
Risk Codes 40
Molecular Structure
Hazard Symbols Xn
Synonyms Sulfanilamide (SN);Sulfanilamide(8CI);(4-(Aminosulfonyl)phenyl)amine;4-(Aminosulfonyl)aniline;4-Aminobenzenesulfonamide;4-Aminophenylsulfonamide;A-349;Albosal;Ambeside;Antistrept;Astreptine;Bactesid;Deseptyl;Dipron;Ergaseptine;Erysipan;Fourneau 1162;Gombardol;Infepan;NSC 7618;Neococcyl;Orgaseptine;PABS;Prontosil white;PronzinAlbum;Proseptine;Proseptol;Pysococcine;Ro 1-3354;Rubiazol A;Sanamid;Septamide Album;Septanilam;Septinal;Septoplex;Septoplix;Stramid;Strepamide;Strepsan;Streptasol;Streptocid;Streptocid album;Streptocide (white);Streptoclase;Strepton;Streptopan;Streptosil;Sulfamidyl;Sulfana;Sulfanalone;Sulfanidyl;Sulfanil;Sulfanilamide Vaginal Cream;Sulfonamide;Sulfonylamide;Sulphanilamide;Tolder;Whitestreptocide;p-Aminophenylsulfonamide;p-Anilinesulfonamide;p-Sulfamoylaniline;Sulfanilamide;
PSA 94.56000
LogP 2.27850

Synthetic route

: 6325-93-5
p-nitrobenzenesulfonamide

: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
With hydrogen In methanol; ethyl acetate under 760.051 Torr; for 4h; Heating; Flow reactor; Green chemistry;	99%
With maghemite-palladium nanocomposite; hydrogen In ethanol; ethyl acetate at 30℃; for 0.0125h;	98%
With sodium tetrahydroborate In water at 20℃; for 0.5h; Green chemistry;	98%

: 36326-86-0
4-azidobenzenesulfonamide

: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
With D-glucose; potassium hydroxide In water at 85℃; for 0.0833333h; Green chemistry; chemoselective reaction;	99%

: 14860-69-6
(p-aminobenzene)sulfonyl azide

: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
With C24H21CuN3O3; sodium L-ascorbate In water; tert-butyl alcohol at 80℃; for 6h; Inert atmosphere;	98%
With C27H34ClN2ORu(1+)*Cl(1-); sodium formate In aq. phosphate buffer at 37℃; for 24h; pH=7.4;

: 108-90-7
chlorobenzene

: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
Stage #1: chlorobenzene With chlorosulfonic acid; ammonium chloride In 1,2-dichloro-ethane at 55℃; for 4h; Stage #2: With ammonia In water; 1,2-dichloro-ethane at 15 - 40℃; for 2h; Stage #3: With copper(l) iodide In water; 1,2-dichloro-ethane at 160℃; for 12h; Reagent/catalyst; Temperature;	97.5%

: 57-67-0
1-amino-4-({[amino(imino)methyl]amino}sulfonyl)benzene

A: 722-27-0
bis(4-aminophenyl)disulfide

B: 63-74-1
sulfanilamide

C: 62-53-3
aniline

D: 121-57-3
4-aminobenzene sulfonic acid

Conditions

Conditions	Yield
In methanol for 76h; Product distribution; Mechanism; Irradiation; λ=254 nm;	A n/a B 4.4% C 95.1% D 2.7%

...Expand

: 352542-64-4
tert-butyl (4-sulfamoylphenyl)carbamate

: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
With H-β zeolite In dichloromethane for 10h; Heating;	91%

: 103-84-4
Acetanilid

: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
Stage #1: Acetanilid With chlorosulfonic acid; thionyl chloride; phosphorus pentoxide In tetrachloromethane at 60 - 90℃; Stage #2: With ammonia In tetrachloromethane at 50℃; for 3h;	86.98%
Multi-step reaction with 3 steps 1.1: chlorosulfonic acid / 55 h / 40 °C 1.2: 3 h / 65 °C 2.1: ammonium hydroxide / 1,2-dichloro-ethane / 2.5 h / 15 - 40 °C / Large scale 3.1: sodium hydroxide / 3 h / 90 °C / Large scale View Scheme

: 98-10-2
benzenesulfonamide

: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
With ammonia; dihydrogen peroxide In water; tert-butyl alcohol at 75℃; for 2h; Reagent/catalyst; Temperature; Molecular sieve;	82.3%

: 2858-20-0
5-chloro-2,6-dimethyl-pyrimidin-4-ylamine

: 121-60-8
p-acetylaminobenzenesulfonyl chloride

A: 54951-54-1
N-[4-(dimethylamino-4-ylsulfonyl)phenyl]acetamide

B: 63-74-1
sulfanilamide

C: 4015-18-3
Sulfaclomid

D: 84729-42-0
C22H22ClN5O6S2

E: 4049-04-1
4-(4'-Acetylaminobenzensulfonyl)amino-5-chlor-2,6-dimethylpyrimidin

Conditions

Conditions	Yield
With trimethylamine In dichloromethane at 33 - 40℃; for 10h; Mechanism; Product distribution; further amines;	A n/a B n/a C n/a D 70% E n/a

...Expand

: 121-61-9
p-acetylaminobenzenesulfonamide

: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
With hydrogenchloride; water In ethanol for 1h; Reflux;	68%
With hydrogenchloride
With sodium hydroxide

: 2158-14-7
4-acetamidobenzenesulfonyl azide

: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
With hydrogenchloride In water at 5℃; for 0.583333h; Reflux;	60%

: 144-83-2
sulphapyridine

A: 504-29-0
2-aminopyridine

B: 722-27-0
bis(4-aminophenyl)disulfide

C: 6325-93-5
p-nitrobenzenesulfonamide

D: 63-74-1
sulfanilamide

E: 62-53-3
aniline

F: 121-57-3
4-aminobenzene sulfonic acid

Conditions

Conditions	Yield
In methanol for 48h; Product distribution; Mechanism; Irradiation; λ=254 nm;	A 15.6% B n/a C n/a D 6.1% E 29.1% F 20.1%

...Expand

: 98-64-6
4-Chlorobenzenesulfonamide

: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
With ammonium hydroxide; copper; copper(II) sulfate at 150℃; under 44130.5 Torr;
With copper(I) oxide; ammonium hydroxide at 160℃;
With ammonium chloride; copper at 160℃;

: 34894-11-6
N-formyl-sulfanilyl chloride

: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
With ammonium hydroxide
Multi-step reaction with 2 steps 1: aqueous ammonia 2: aq. NaOH solution View Scheme

: 1773-43-9
4,4'-(carbonylbis(azanediyl))dibenzenesulfonamide

: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
With sulfuric acid at 150℃;
With sodium hydroxide at 100℃;

: 829-72-1
N-formyl-sulfanilic acid amide

: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
With water
With ammonium hydroxide
With sulfuric acid
With sodium hydroxide
Multi-step reaction with 2 steps 2: ethanolic NaOH-solution View Scheme

: 781-00-0
N-formyl-sulfanilic acid acetylamide

A: 63-74-1
sulfanilamide

B: 144-80-9
sulphaacetamide

Conditions

Conditions	Yield
With sodium hydroxide

: 6306-24-7
4-amidobenzylsulfonamide

: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
With alkaline aqueous sodium hypochlorite

: 102840-86-8
(E)-4-(phenyldiazenyl)benzenesulfonamide

: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
With hydrogenchloride; tin

: 102840-86-8
(E)-4-(phenyldiazenyl)benzenesulfonamide

A: 521972-91-8
4-(N'-phenyl-hydrazino)-benzenesulfonic acid amide

B: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
With sodium hydroxide; sodium dithionite

: 623-11-0
1-methyl-4-nitrosobenzene

: 57-67-0
1-amino-4-({[amino(imino)methyl]amino}sulfonyl)benzene

: 63-74-1
sulfanilamide

: 4392-55-6
hidrazobenzene-4,4'-disulfonamide

A: 63-74-1
sulfanilamide

B: C6H7N2O2S(1-)

Conditions

Conditions	Yield
With Britton-Robinson buffer Rate constant; controlled potential electrolysis;

: 16588-39-9
p-<(8-hydroxy-5-quinolyl)azo>benzenesulphonamide

A: 13207-66-4
5-amino-8-hydroxyquinoline

B: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
In water; N,N-dimethyl-formamide for 1.5h; electrolysis at dropping mercury electrode;

: 140648-35-7
4-(2,4-dihydroxy-phenylazo)-benzenesulfonic acid amide

A: 13066-95-0
4-aminoresorcinol

B: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Rate constant; Thermodynamic data; electrochemical reduction (HMDE electrode), various pHs (from 2.25 to 10.12);

: 140648-38-0
4-(5-bromo-2-hydroxy-phenylazo)-benzenesulfonic acid amide

A: 40925-68-6
2-amino-4-bromo-phenol

B: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Rate constant; Thermodynamic data; electrochemical reduction (HMDE electrode), various pHs (from 3.22 to 10.00);

: 140648-40-4
4-(5-Formyl-2-hydroxy-phenylazo)-benzenesulfonamide

A: 63-74-1
sulfanilamide

B: 163036-58-6
3-amino-4-hydroxybenzaldehyde

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Rate constant; Thermodynamic data; electrochemical reduction (HMDE electrode), various pHs (from 3.10 to 10.34);

: 140648-36-8
4-(2-Hydroxy-5-methoxy-phenylazo)-benzenesulfonamide

A: 20734-76-3
2-amino-4-methoxyphenol

B: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Rate constant; Thermodynamic data; electrochemical reduction (HMDE electrode), various pHs (from 2.03 to 10.00);

: 140648-37-9
4-(4-Dimethylamino-2-hydroxy-phenylazo)-benzenesulfonamide

A: 15103-39-6
2-amino-5-(dimethylamino)phenol

B: 63-74-1
sulfanilamide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Rate constant; Thermodynamic data; electrochemical reduction (HMDE electrode), various pHs (from 2.03 to 10.00);

: 108-24-7
acetic anhydride

: 63-74-1
sulfanilamide

: 121-61-9
p-acetylaminobenzenesulfonamide

Conditions

Conditions	Yield
at 20℃; for 1h;	100%
In ethanol at 20 - 70℃; for 0.0166667h; other time tested;

: 63-74-1
sulfanilamide

: 36326-86-0
4-azidobenzenesulfonamide

Conditions

Conditions	Yield
With hydrogenchloride; sodium azide; sodium nitrite In water at 0 - 5℃; for 1h;	100%
With hydrogenchloride; sodium azide; sodium nitrite In tetrahydrofuran; N,N-dimethyl-formamide at 0 - 25℃;	93%
Stage #1: sulfanilamide With hydrogenchloride; sodium nitrite In tetrahydrofuran; water; N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere; Stage #2: With sodium azide In tetrahydrofuran; water; N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;	90.6%

: 500-22-1
3-pyridinecarboxaldehyde

: 63-74-1
sulfanilamide

: 74028-05-0
N4-(3-pyridylidene) sulfanilamide

Conditions

Conditions	Yield
at 150 - 155℃; for 0.0833333h;	100%
In ethanol for 3h; Heating;

: 334-99-6
trifluoronitrosomethane

: 63-74-1
sulfanilamide

: 4-(Trifluoromethyl-azo)-benzenesulfonamide

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	100%

: 63-74-1
sulfanilamide

: 407-25-0
trifluoroacetic anhydride

: 2,2,2-trifluoro-N-(4-sulfamoylphenyl)acetamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 0.5h;	100%
In 1,4-dioxane	100%
In 1,4-dioxane	97%

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 63-74-1
sulfanilamide

: 4-Amino-N-dimethylaminomethylenebenzenesulfonamide

Conditions

Conditions	Yield
In dichloromethane for 0.5h; Heating;	100%

: 953039-79-7
methyl 2-chloroquinazoline-7-carboxylate

: 63-74-1
sulfanilamide

: methyl 2-(4-sulfamoyl-phenylamino)quinazoline-7-carboxylate

Conditions

Conditions	Yield
In isopropyl alcohol at 90℃; for 2h;	100%

: 1036755-96-0
methyl 2-chloroquinazolin-6-carboxylate

: 63-74-1
sulfanilamide

: 1036743-15-3
Methyl 2-(4-sulfamoylphenylamino)quinazolin-6-carboxylate

Conditions

Conditions	Yield
at 90℃; for 2h;	100%

: 24424-99-5
di-tert-butyl dicarbonate

: 63-74-1
sulfanilamide

: 352542-64-4
tert-butyl (4-sulfamoylphenyl)carbamate

Conditions

Conditions	Yield
In 1,4-dioxane Reflux;	100%
With potassium hydroxide In tetrahydrofuran; water

: 7476-79-1
4-nitrosobenzoic acid ethyl ester

: 63-74-1
sulfanilamide

: (E)-ethyl 4-((4-sulfamoylphenyl)diazenyl)benzoate

Conditions

Conditions	Yield
With acetic acid In dichloromethane	100%

: 108-45-2
m-phenylenediamine

: 63-74-1
sulfanilamide

: 103-12-8
(E)-4-(2-(4-sulfonamido)diazenyl)benzene-1,3-diamine

Conditions

Conditions	Yield
Stage #1: sulfanilamide With hydrogenchloride; sodium nitrite In water at 0℃; for 0.666667h; Stage #2: m-phenylenediamine With hydrogenchloride In water at 0℃; for 0.5h;	100%

: 141-30-0
3,6-dichlorpyridazine

: 63-74-1
sulfanilamide

: sulfachloropyridazine sodium

Conditions

Conditions	Yield
Stage #1: 3,6-dichlorpyridazine; sulfanilamide In dimethyl sulfoxide at 100℃; under 2250.23 Torr; for 10h; Stage #2: With sodium In water at 60℃; for 8h; Solvent; Reagent/catalyst;	99.5%

: 110-13-4
2,5-hexanedione

: 63-74-1
sulfanilamide

: 26165-69-5
4-(2,5-dimethyl-1H-pyrrol-1-yl)benzenesulfonamide

Conditions

Conditions	Yield
With iodine at 20℃; for 2h; Paal-Knorr Pyrrole Synthesis;	99%
With acetic acid at 120℃; for 3h;	86%
at 180℃; for 0.25h; Paal-Knorr pyrrole synthesis; Microwave irradiation;	75%
With ethanol; acetic acid

: 63-74-1
sulfanilamide

: 103-80-0
phenylacetyl chloride

: N-[4-(aminosulfonyl)phenyl]-2-phenylacetamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 15h;	99%
With triethylamine In acetonitrile at 0 - 5℃;	35%
With pyridine

: N,N'-bis(triethylgermyl)sulfanilamide

: 63-74-1
sulfanilamide

: 566174-01-4
N-triethylgermylsulfanilamide

Conditions

Conditions	Yield
In chloroform-d1 org. compd. addn. to Ge-compd. soln. in NMR tube; complete conversion after 24 h at 20°C ((1)H-NMR monitoring);	99%

: 24801-88-5
3-(triethoxypropyl) isocyanate

: 63-74-1
sulfanilamide

: 1311165-68-0
C26H50N4O10SSi2

Conditions

Conditions	Yield
In acetonitrile for 24h; Inert atmosphere; Reflux;	99%

: 100-52-7
benzaldehyde

: 63-74-1
sulfanilamide

: 104-22-3
benzylsulfamide

Conditions

Conditions	Yield
With (2,6-dichlorophenyl)bis(2,3,5,6-tetrafluorophenyl)borane; hydrogen In tetrahydrofuran at 100℃; under 15201 Torr; for 6h; Sealed tube; Molecular sieve; Autoclave; Green chemistry;	99%
With triethylsilane; palladium on carbon; TPGS-750-M In water at 45℃; for 12h;	78%
Multi-step reaction with 2 steps 1: chloroform; methanol / 18 h / Reflux 2: sodium tetrahydroborate / methanol / 4 h View Scheme
Multi-step reaction with 2 steps 1: formic acid / methanol / Reflux 2: sodium tetrahydroborate / methanol / 25 h / 0 - 25 °C View Scheme

: 63-74-1
sulfanilamide

: 2-chloro-4-(p-hydroxyphenyl)pyrimidine

: 882875-01-6
4-{[4-(4-hydroxyphenyl)pyrimidin-2-yl]amino}benzenesulfonamide

Conditions

Conditions	Yield
With hydrogenchloride In ethanol at 160℃; for 2h; Microwave irradiation;	99%
With hydrogenchloride In ethanol Microwave irradiation;	99%

: 5413-85-4
5-amino-4,6-dichloropyridimine

: 63-74-1
sulfanilamide

: 4-((5-amino-6-chloropyrimidin-4-yl)amino)benzenesulfonamide

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In 1,4-dioxane; water Reflux;	99%

: 333-20-0
potassium thioacyanate

: 63-74-1
sulfanilamide

: 1694-29-7
3-chloropentane-2,4-dione

: 88323-93-7
5-Acetyl-4-methyl-2-<(p-sulphamylphenyl)amino>thiazole

Conditions

Conditions	Yield
With silica sulfuric acid In neat (no solvent) at 20℃; for 0.416667h; Milling; Green chemistry;	99%

...Expand

: 90-02-8
salicylaldehyde

: 63-74-1
sulfanilamide

: 2067-06-3
4-[(2-hydroxybenzylidene)amino]benzenesulfonamide

Conditions

Conditions	Yield
In ethanol for 0.333333h; Reflux;	98.57%
In ethanol at 60℃; Microwave irradiation;	88%
With formic acid In methanol Reflux;	85%

: 117-80-6
2,3-Dichloro-1,4-naphthoquinone

: 63-74-1
sulfanilamide

: 6949-34-4
4-((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide

Conditions

Conditions	Yield
In water for 3h; Reflux;	98%
In ethanol at 115℃; for 72h;	38.9%
With acetic acid; N,N-diethylaniline
In ethanol Reflux;

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 63-74-1
sulfanilamide

: 6912-49-8
4-amino-N-[(dimethylamino)methylidene]benzenesulfonamide

Conditions

Conditions	Yield
In neat (no solvent) at 20℃; under 760.051 Torr; for 0.25h; Green chemistry; chemoselective reaction;	98%

: 63-74-1
sulfanilamide

: 79-04-9
chloroacetyl chloride

: 14949-01-0
2-chloro-N-(4-sulfamoylphenyl)acetamide

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran at 0℃;	98%
With potassium carbonate In acetone at 0 - 20℃;	95%
In acetone at 20 - 95℃; for 1h;	89%

: 63-74-1
sulfanilamide

: 603-35-0
triphenylphosphine

: 95978-84-0
N-<(p-aminophenyl)sulfonyl>triphenylphospha-λ5-azene

Conditions

Conditions	Yield
With diethylazodicarboxylate In tetrahydrofuran at 0 - 25℃; for 12h;	98%
With diethylazodicarboxylate In tetrahydrofuran at 0℃;	79%

: 63-74-1
sulfanilamide

: 5231-87-8
3,4-diethoxy-3-cyclobuten-1,2-dione

: 4-(2-ethoxy-3,4-dioxo-cyclobut-1-enylamino)-benzenesulfonamide

Conditions

Conditions	Yield
In ethanol Substitution; Heating;	98%

: 117-08-8
tetrachlorophthalic anhydride

: 63-74-1
sulfanilamide

: 88062-88-8
4-(4,5,6,7-tetrachloro-1,3-dioxoisoindolin-2-yl)benzenesulfonamide

Conditions

Conditions	Yield
With acetic acid at 130℃; for 2h;	98%
With acetic acid for 24h; Reflux;

: 63-74-1
sulfanilamide

: 619-41-0
4-(bromoacetyl)toluene

: 1595285-57-6
4-((2-oxo-2-(p-tolyl)ethyl)amino)benzenesulfonamide

Conditions

Conditions	Yield
In methanol for 4h; Reflux;	98%

Sulfanilamide Consensus Reports

SULFANILAMIDE's reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Sulfanilamide Specification

The IUPAC name of Sulfanilamide is 4-aminobenzenesulfonamide. With the CAS registry number 63-74-1 and EINECS 200-563-4, it is also named as Benzenesulfonamide, p-amino-. The product's categories are Sulfonamides (Antibiotics for Research and Experimental Use); Antibiotics for Research and Experimental Use; Biochemistry. It is white to almost white crystalline powder which is alightly soluble in cold water, ethanol, methanol, ether and acetone, soluble in boiling water, glycerol, hydrochloric acid, potassium hydroxide and sodium hydroxide solution, insoluble in chloroform, ether, benzene or petroleum ether. As an antibiotic, this chemical functions by competitively inhibiting (ie, by acting as a substrate analogue) enzymatic reactions involving para-aminobenzoic acid (PABA). Additionally, it should be sealed in the container and stored in the cool and dry place.

The other characteristics of Sulfanilamide can be summarized as:
(1)ACD/LogP: -0.72; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.72; (4)ACD/LogD (pH 7.4): -0.72; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 9.66; (8)ACD/KOC (pH 7.4): 9.66; (9)#H bond acceptors: 4; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 49 Å²; (13)Index of Refraction: 1.627; (14)Molar Refractivity: 42.8 cm³; (15)Molar Volume: 120.6 cm³; (16)Surface Tension: 63.7 dyne/cm; (17)Enthalpy of Vaporization: 65.13 kJ/mol; (18)Vapour Pressure: 1.27E-06 mmHg at 25°C; (19)Rotatable Bond Count: 1; (20)Exact Mass: 172.030648; (21)MonoIsotopic Mass: 172.030648; (22)Topological Polar Surface Area: 94.6; (23)Heavy Atom Count: 11; (24)Complexity: 211.

Preparation of Sulfanilamide:
It can be obtained by chlorosulfonation, amination, hydrolysis and neutralization of acetanilide.

Uses of Sulfanilamide:
It is not only used as reagent in the determination of nitrite, but also used in the pharmaceutical industry. It is also the major raw material in the production of sulfonamides drug. What's more, it is used in organic synthesis. For example, it can react with furfural to get 4-(2-formyl-pyrrol-1-yl)-benzenesulfonic acid amide. This reaction needs reagent 2N-HCl and solvent ethanol by heating. The reaction time is 5 hours. The yield is 41%.

When you are using Sulfanilamide, please be cautious about it as the following:
It has limited evidence of a carcinogenic effect. So people should not breathe dust and avoid contact with skin and eyes. If you want to contact this product, you must wear suitable protective clothing.

People can use the following data to convert to the molecule structure.
1. SMILES:O=S(=O)(c1ccc(N)cc1)N
2. InChI:InChI=1/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)
3. InChIKey:FDDDEECHVMSUSB-UHFFFAOYAI

The following are the toxicity data of Sulfanilamide:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
dog	LD50	oral	2gm/kg (2000mg/kg)	Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 1079, 1966.
guinea pig	LD50	oral	3130mg/kg (3130mg/kg)	Journal of Pharmacology and Experimental Therapeutics. Vol. 82, Pg. 86, 1944.
mouse	LD50	intraperitoneal	5mg/kg (5mg/kg)	Antibiotics Annual. Vol. 5, Pg. 886, 1957/1958.
mouse	LD50	intravenous	500mg/kg (500mg/kg)	Antibiotics Annual. Vol. 5, Pg. 972, 1957/1958.
mouse	LD50	oral	3gm/kg (3000mg/kg)	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 48, Pg. 336, 1952.
mouse	LD50	subcutaneous	2900mg/kg (2900mg/kg)	Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955.
rabbit	LD50	oral	1300mg/kg (1300mg/kg)	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 31(3), Pg. 11, 1966.
rat	LD50	intravenous	1400mg/kg (1400mg/kg)	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 211, Pg. 367, 1950.
rat	LD50	oral	3900mg/kg (3900mg/kg)	"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1072, 1986.

Product Name

Sulfanilamide

Synthetic route

Sulfanilamide Consensus Reports

Sulfanilamide Specification

Related Products

Hot Products