Sulfathiazole sodium supplier

Name
Sulfathiazole sodium
EINECS 205-638-5
CAS No. 144-74-1
Article Data1
CAS DataBase
Density
Solubility
Melting Point 175oC (form a); 202oC (form b)
Formula C₉H₈N₃NaO₂S₂
Boiling Point 479.5 °C at 760 mmHg
Molecular Weight 277.303
Flash Point 243.8 °C
Transport Information
Appearance
Safety 26-36-24/25-23
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Benzenesulfonamide,4-amino-N-2-thiazolyl-, monosodium salt (9CI);Sodium norsulfazole;Sodium sulfathiazolate;Norsulfazole soluble;Sodium sulfathiazole;Soluble norsulfazole;Solublesulfathiazole;Soluthiazomide;Sulfathiazole sodium salt;Sulphathiazole sodium;2-(p-Amino-N-sodiobenzenesulfonamide)thiazole;2-(p-Aminobenzenesulfonamido)thiazole sodium salt;2-Sulfanilamidothiazolesodium salt;Norsulfazol sodium;Sodium 2-sulfanilamidothiazole;Norsulfazole sodium;Norsulfazole sodium salt;
PSA 112.91000
LogP 3.04690

Synthetic route

: iron(III) chloride

: 144-74-1
sulfathiazole sodium

: C27H24FeN9O6S6

Conditions

Conditions	Yield
at 20℃;	97%

: copper (II)-fluoride

: 144-74-1
sulfathiazole sodium

: 72446-92-5
Cu2(sulfathiazolato)4

Conditions

Conditions	Yield
In methanol pptn. on addn. of Cu-salt to warm soln. of 2 equiv. ligand (stirring); collection (filtration), drying; elem. anal.;	90%

: cobalt(II) chloride hexahydrate

: 144-74-1
sulfathiazole sodium

A: Co(II)(sulfathiazolate)2(H2O)4

B: Co(II)(sulfathiazolate)2(H2O)3

Conditions

Conditions	Yield
In water aq. soln. of CoCl2 was added to 2.2 equiv. of S-compd. in H2O, stirring at room temp.; standing for 4 d, solid was centrifuged off, washed with H2O several times, dried (vac., away from light), elem. anal.; liq. was stood for 7-12 d, crystals were centrifuged off, washed with H2O several times, dried (vac., away from light), elem. anal.;	A 88.6% B 88%

...Expand

: 144-74-1
sulfathiazole sodium

: 39757-35-2
methyl 4-(4-chlorophenyl)-2,4-dioxobutanoate

: (2Z)-2-hydroxy-4-oxo-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-4-(4-chlorophenyl)but-2-eneamide

Conditions

Conditions	Yield
In acetic acid for 0.333333h; Reflux;	78%

: cadmium(II) perchlorate hydrate

: 7732-18-5
water

: 144-74-1
sulfathiazole sodium

: C18H24CdN6O8S4

Conditions

Conditions	Yield
In methanol for 4h; Reflux;	60%

...Expand

: 34446-64-5, 42996-84-9
(E)-3-(4-methoxyphenyl)propenoyl chloride

: 144-74-1
sulfathiazole sodium

: p-methoxycinnamoyl sulfathiazole

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran for 25.5h; Cooling with ice;	55%

: 85-44-9
phthalic anhydride

: 144-74-1
sulfathiazole sodium

: 85-73-4
Cremothalidine

Conditions

Conditions	Yield
at 85 - 150℃; Kinetics;

: 144-74-1
sulfathiazole sodium

: 594-42-3
chlorothio-trichloro-methane

: 103501-32-2
4-amino-N-thiazol-2-yl-N-trichloromethylsulfanyl-benzenesulfonamide

Conditions

Conditions	Yield
In benzene Heating;

: 67-56-1
methanol

: 144-74-1
sulfathiazole sodium

: 50-81-7
ascorbic acid

compound C15H15N3O7S2: compound C15H15N3O7S2

...Expand

: 144-74-1
sulfathiazole sodium

: 77-78-1
dimethyl sulfate

aqueous NaOH: aqueous NaOH

sulfanilic acid-<3-methyl-3H-thiazol-2-ylidenamide>: sulfanilic acid-<3-methyl-3H-thiazol-2-ylidenamide>

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: 60-29-7
diethyl ether

: 144-74-1
sulfathiazole sodium

A: 51203-19-1
4-amino-N-methyl-N-(thiazol-2-yl)benzenesulfonamide

B sulfanilic acid-<3-methyl-3H-thiazol-2-ylidenamide>: sulfanilic acid-<3-methyl-3H-thiazol-2-ylidenamide>

...Expand

: 144-74-1
sulfathiazole sodium

: copper(II) nitrate

: 72446-92-5
Cu2(sulfathiazolato)4

Conditions

Conditions	Yield
In not given

: 144-74-1
sulfathiazole sodium

: copper(II) perchlorate

: 72446-92-5
Cu2(sulfathiazolato)4

Conditions

Conditions	Yield
In not given

: 144-74-1
sulfathiazole sodium

: copper dichloride

: 72446-92-5
Cu2(sulfathiazolato)4

Conditions

Conditions	Yield
In not given

: 144-74-1
sulfathiazole sodium

: 10108-64-2
cadmium(II) chloride

: 156187-43-8, 146597-11-7
Cd(H2NC6H4SO2N(C3H2NS))2

Conditions

Conditions	Yield
In water dropwise addn. of metal chloride soln. to 10 % stoich. excess of ligand salt at 90°C (pptn.), heating for 1 h on water bath; filtration, washing (H2O, alcohol), drying (110-115°C); elem. anal.;

: 144-74-1
sulfathiazole sodium

: 7646-79-9
cobalt(II) chloride

: 67077-81-0
Co(H2NC6H4SO2N(C3H2NS))2

Conditions

Conditions	Yield
In water dropwise addn. of metal chloride soln. to 10 % stoich. excess of ligand salt at 90°C (pptn.), heating for 1 h on water bath; filtration, washing (H2O, alcohol), drying (110-115°C); elem. anal.;

: 144-74-1
sulfathiazole sodium

: palladium dichloride

: 156187-42-7
Pd(H2NC6H4SO2N(C3H2NS))2

Conditions

Conditions	Yield
In water dropwise addn. of metal chloride soln. to 10 % stoich. excess of ligand salt at 90°C (pptn.), heating for 1 h on water bath; filtration, washing (H2O, alcohol), drying (110-115°C); elem. anal.;

: 123-03-5
cetylpyridinium chloride

: 144-74-1
sulfathiazole sodium

: cetylpyridinium sulfathiazole

Conditions

Conditions	Yield
With methanol at 20℃; for 3h;

: 70475-59-1
3,4,5-triacetoxybenzoyl chloride

: 144-74-1
sulfathiazole sodium

: N-(sulfathiazole)-3,4,5-triacetoxybenzamide

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran Cooling with ice;

: 7732-18-5
water

: 6018-89-9
nickel(II) acetate tetrahydrate

: 144-74-1
sulfathiazole sodium

: 4C9H8N3O2S2(1-)*2Ni(2+)*3H2O

Conditions

Conditions	Yield
for 2h;

...Expand

: 7732-18-5
water

: 6147-53-1
cobalt(II) diacetate tetrahydrate

: 144-74-1
sulfathiazole sodium

: Co(II)(sulfathiazolate)2(H2O)3

Conditions

Conditions	Yield
for 72h; Sealed tube;

...Expand

: 7732-18-5
water

: 6147-53-1
cobalt(II) diacetate tetrahydrate

: 144-74-1
sulfathiazole sodium

: 4C9H8N3O2S2(1-)*Co(2+)*10H2O*2Na(1+)

Conditions

Conditions	Yield
at 40℃; Sealed tube;

...Expand

Sulfathiazole sodium Consensus Reports

Reported in EPA TSCA Inventory.

Sulfathiazole sodium Specification

The Sulfathiazole sodium, with the CAS registry number 144-74-1, is also known as Benzenesulfonamide, 4-amino-N-2-thiazolyl-, sodium salt (1:1). It belongs to the classification code of Drug / Therapeutic Agent. Its EINECS registry number is 205-638-5. This chemical's molecular formula is C₉H₈N₃NaO₂S₂ and molecular weight is 277.30. What's more, both its IUPAC name and systematic name are the same which is called Sodium (4-aminophenyl)sulfonyl-(1,3-thiazol-2-yl)azanide. It is a sulfonamide for the treatment of infection in susceptible strains.

Physical properties about Sulfathiazole sodium are: (1)ACD/LogP: 0.05; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.04; (4)ACD/LogD (pH 7.4): -0.26; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 24.92; (8)ACD/KOC (pH 7.4): 12.59; (9)#H bond acceptors: 5; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 98.92 Å²; (13)Flash Point: 243.8 °C; (14)Enthalpy of Vaporization: 74.38 kJ/mol; (15)Boiling Point: 479.5 °C at 760 mmHg; (16)Vapour Pressure: 2.35E-09 mmHg at 25 °C.

When you are dealing with this chemical, you should be very careful. This chemical is inflammation to the skin, eyes and respiratory system or other mucous membranes. Therefore, you should wear suitable protective clothing. You can not breathe the gas/fumes/vapour/spray and you should avoid contacting with skin and eyes. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: [Na+].O=S(=O)([N-]c1nccs1)c2ccc(N)cc2
(2) InChI: InChI=1S/C9H8N3O2S2.Na/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9;/h1-6H,10H2;/q-1;+1
(3) InChIKey: GWIJGCIVKLITQK-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	1320mg/kg (1320mg/kg)	Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 284, 1944.
mouse	LD50	intravenous	708mg/kg (708mg/kg)	Journal of the Indiana State Medical Association. Vol. 33, Pg. 503, 1940.
mouse	LD50	oral	3800mg/kg (3800mg/kg)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 94, Pg. 338, 1953.
mouse	LD50	parenteral	1950mg/kg (1950mg/kg)	Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 328, 1940.
mouse	LD50	subcutaneous	1434mg/kg (1434mg/kg)	Journal of Pharmacology and Experimental Therapeutics. Vol. 71, Pg. 138, 1941.
rat	LDLo	intraperitoneal	750mg/kg (750mg/kg)	Proceedings of the Society for Experimental Biology and Medicine. Vol. 45, Pg. 15, 1940.

Product Name

Sulfathiazole sodium

Synthetic route

Sulfathiazole sodium Consensus Reports

Sulfathiazole sodium Specification

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