1. Introduction of Sunitinib
Sunitinib, with the IUPAC Name of N-(2-Diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, is one kind of yellow solid. And this chemical belongs to the Product Categories which include Active Pharmaceutical Ingredients; Sunitinib; Molecular Targeted Antineoplastic; Heterocyclic Compounds; anti-neoplastic;Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; Tyrosine Kinase Inhibitors; Pharmaceutical intermediate. In addition, it has the following Classification Code which include Angiogenesis Inhibitors; Angiogenesis Modulating Agents; Antineoplastic Agents; Growth Inhibitors; Growth Substances; Protein kinase inhibitors.
2. Properties of Sunitinib
Sunitinib has the following properties: (1)Index of Refraction: 1.611; (2)Molar Refractivity: 112.52 cm3; (3)Molar Volume: 324 cm3; (4)Polarizability: 44.6×10-24 cm3; (5)Surface Tension: 51.3 dyne/cm; (6)Density: 1.229 g/cm3; (7)Flash Point: 299.8 °C; (8)Enthalpy of Vaporization: 85.77 kJ/mol; (9)Boiling Point: 572.1 °C at 760 mmHg; (10)Melting Point: 189-191 °C; (11)Vapour Pressure: 4.24E-13 mmHg at 25 °C.
3. Structure Descriptors of Sunitinib
You could convert the following datas into the molecular structure:
(1).SMILES: c1c(F)cc2\C(C(Nc2c1)=O)=C\c1[nH]c(c(C(NCCN(CC)CC)=O)c1C)C
(2).InChI: InChI=1/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
4. Use of Sunitinib
Sunitinib (CAS NO.557795-19-4) is a multi-kinase inhibitor targeting several receptor tyrosine kinases (RTK).It is an antineoplastic agent.
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