• Name

  TACROLIMUS

• EINECS
• CAS No. 109581-93-3
• Density
• Solubility
• Melting Point
• Formula C₄₄H₆₉NO₁₂^.H₂O
• Boiling Point 871.7 °C at 760 mmHg
• Molecular Weight 822.16
• Flash Point 481 °C
• Transport Information UN 2811 6.1/PG 3
• Appearance
• Safety 45
• Risk Codes 25
• Molecular Structure
• Hazard Symbols T
• Synonyms 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,monohydrate, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)- (9CI);15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,monohydrate,[3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-;Tsukubaenolide hydrate;
• PSA 187.59000
• LogP 4.51260

Tacrolimus monohydrate Specification

1. Introduction of Tacrolimus monohydrate

Tacrolimus monohydrate, with its cas register number of 109581-93-3, is also called Prograf; Fk-506; Tacrolimus. Tacrolimus monohydrate (CAS NO.109581-93-3) reduces myasthenic symptoms due to its immunosuppressive properties. We studied its therapeutic effects and noted improvement in 7 of 13 myasthenic patients on the clinical muscle test. Two other patients with relapsing ocular symptoms improved. We also examined patient sensitivity to FK506, but could not predict such sensitivity before it treatment in the present study.

2. Properties of Tacrolimus monohydrate

Tacrolimus monohydrate has the following properties: (1)Flash Point: 481 °C; (2)Storage tempreture: -20 °C; (3)Enthalpy of Vaporization: 143.95 kJ/mol; (4)Boiling Point: 871.7 °C at 760 mmHg; (5)Vapour Pressure: 1.73E-35 mmHg at 25 °C.

3. Toxicity of Tacrolimus monohydrate

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD50	intravenous	23600ug/kg (23.6mg/kg)		Drugs in Japan Vol. -, Pg. 720, 1995.
rat	LD50	oral	134mg/kg (134mg/kg)		Drugs in Japan Vol. -, Pg. 720, 1995.

4. Safety Information of Tacrolimus monohydrate
Hazard Codes of Tacrolimus monohydrate (CAS NO.109581-93-3): T
Risk Statements: 25
R25 :Toxic if swallowed.
Safety Statements: 45
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)