Terlipressin supplier | CasNO.14636-12-5

Name
N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin
EINECS 238-680-8
CAS No. 14636-12-5
Density 1.46 g/cm³
Solubility
Melting Point
Formula C₅₂H₇₄N₁₆O₁₅S₂
Boiling Point 1824 °C at 760 mmHg
Molecular Weight 1227.39
Flash Point 1056.9 °C
Transport Information
Appearance White powder
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms (2S)-1-[(4R,7S,10S,13S,16S,19R)-19-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(1S)-5-amino-1-(carbamoylmethylcarbamoyl)pentyl]pyrrolidine-2-carboxamide;N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin;Glypressin;Terlipressin Acetate;Remestyp;Thymosin α1 Acetate;Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (disulfide bridge 4:9);Glycylpressin;
PSA 563.45000
LogP 0.05740

Synthetic route

: 14636-12-5
terlipressin

A: 63-91-2
L-phenylalanine

B: 60-18-4
L-tyrosine

C: 56-40-6
glycine

Conditions

Conditions	Yield
With blood serum of pregnant women In water at 37℃; for 1h; Kinetics; other pH;

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Terlipressin Analytical Methods

Terlipressin is a synthetic analog of vasopressin and is used as a vasoactive drug in the management of hypotension. It is a prodrug, which is converted to (Lys8)- vasopressin after removal of the N-terminal triglycine in vivo. Terlipressin has a longer duration of action and a better safety profile than the parent compound.

Terlipressin Specification

1. Introduction of Terlipressin

Terlipressin, with the IUPAC Name of (2S)-1-[(1R,4S,7S,10S,13S,16R)-16-[[2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]acetyl]amino]-
4-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-10-benzyl-13-[(4-hydroxyphenyl)methyl]-3,6,9,12,15-pentaoxo-18,19-
dithia-2,5,8,11,14-pentazacycloicosane-1-carbonyl]-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-
2-yl]pyrrolidine-2-carboxamide, is one kind of white powder. This chemical belongs to the Product Categories which include Amino Acid Derivatives; Peptide.

2. Properties of Terlipressin

Terlipressin has the following datas: (1)H bond acceptors: 31; (2)H bond donors: 21; (3)Freely Rotating Bonds: 28; (4)Polar Surface Area: 350.65; (5)Index of Refraction: 1.664; (6)Molar Refractivity: 310.14 cm³; (7)Molar Volume: 835.7 cm³; (8)Surface Tension: 87.3 dyne/cm; (9)Density: 1.46 g/cm³; (10)Flash Point: 1056.9 °C; (11)Enthalpy of Vaporization: 306.02 kJ/mol; (12)Boiling Point: 1824 °C at 760 mmHg; (13)Vapour Pressure: 0 mmHg at 25°C.

3. Use and Preparation of Terlipressin

Terlipressin (CAS NO.14636-12-5) is used as a vasoactive drug in the management of hypotension. In addition, it is also used in bleeding esophageal varices.

Product Name

N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin

Synthetic route

Terlipressin Analytical Methods

Terlipressin Specification

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