Tetracycline hydrochloride supplier

Name
Tetracycline hydrochloride
EINECS 200-593-8
CAS No. 64-75-5
Article Data4
CAS DataBase
Density
Solubility 50 g/L in water
Melting Point 220-223 °C(lit.)
Formula C₂₂H₂₄N₂O₈^.HCl
Boiling Point 799.4 °C at 760 mmHg
Molecular Weight 480.902
Flash Point 437.3 °C
Transport Information
Appearance Yellow crystalline powder
Safety 26-36
Risk Codes 36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xi, Xn
Synonyms Neocycline B;Paltet;Panmycin hydrochloride;Partrex;Polyotic ointment;Purocyclina;Remicyclin;Riocyclin;Robitet;Subamycin;Supramycin;Tefilin;Tet-Cy;Tetrabakat;Tetrabid;Tetrabon;Tetrachel;Tetracompren;Tetracycline hydrochloride;Tetracyn;Tetralution;Tetrosol;Triphacyclin;Unicin;Vetquamycin 324;2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride (8CI);Achro;Achromycin hydrochloride;Ala-Tet;Ambracyn;Bristacycline;Cancycline-250;Criseociclina;Dumocyclin;Helvecyclin;Hostacycline;Medamycin;Tetracycline HCL;
PSA 181.62000
LogP 1.28790

Synthetic route

: 60-54-8
TETRACYCLINE

: 64-75-5
tetracycline hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water

: 32359-20-9
(1S,2R)-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylic acid

: 64-75-5
tetracycline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 13 steps 1.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 10.5 h / 23 °C / Inert atmosphere 2.1: methanol; hexane; benzene / 0.08 h / 23 °C / Inert atmosphere 2.2: 0.5 h 3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 3.2: 1 h / -78 °C / Inert atmosphere 4.1: lithium trifluoromethanesulfonate / toluene / 3 h / 23 - 60 °C / Inert atmosphere 4.2: 18 h / 23 °C / Inert atmosphere 5.1: diethylazodicarboxylate; triphenylphosphine / toluene / 1.5 h / 0 °C / Inert atmosphere 5.2: 23 h / 0 - 23 °C / Inert atmosphere 6.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 5.5 h / 0 - 23 °C / Inert atmosphere 7.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 36 h / 23 °C / Inert atmosphere 8.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere 8.2: 0.42 h / 0 °C / Inert atmosphere 9.1: 48 h / 85 °C / Inert atmosphere 10.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere 11.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere 12.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere 12.2: air 13.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr 13.2: Inert atmosphere View Scheme

Yield

Multi-step reaction with 13 steps
1.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 10.5 h / 23 °C / Inert atmosphere
2.1: methanol; hexane; benzene / 0.08 h / 23 °C / Inert atmosphere
2.2: 0.5 h
3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
3.2: 1 h / -78 °C / Inert atmosphere
4.1: lithium trifluoromethanesulfonate / toluene / 3 h / 23 - 60 °C / Inert atmosphere
4.2: 18 h / 23 °C / Inert atmosphere
5.1: diethylazodicarboxylate; triphenylphosphine / toluene / 1.5 h / 0 °C / Inert atmosphere
5.2: 23 h / 0 - 23 °C / Inert atmosphere
6.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 5.5 h / 0 - 23 °C / Inert atmosphere
7.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 36 h / 23 °C / Inert atmosphere
8.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere
8.2: 0.42 h / 0 °C / Inert atmosphere
9.1: 48 h / 85 °C / Inert atmosphere
10.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere
11.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere
12.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere
12.2: air
13.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr
13.2: Inert atmosphere
View Scheme

: 367954-24-3
(1S,2R,3S,6R)-2,3-Dihydroxy-7-oxa-bicyclo[4.1.0]hept-4-ene-3-carboxylic acid

: 64-75-5
tetracycline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 12 steps 1.1: methanol; hexane; benzene / 0.08 h / 23 °C / Inert atmosphere 1.2: 0.5 h 2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 2.2: 1 h / -78 °C / Inert atmosphere 3.1: lithium trifluoromethanesulfonate / toluene / 3 h / 23 - 60 °C / Inert atmosphere 3.2: 18 h / 23 °C / Inert atmosphere 4.1: diethylazodicarboxylate; triphenylphosphine / toluene / 1.5 h / 0 °C / Inert atmosphere 4.2: 23 h / 0 - 23 °C / Inert atmosphere 5.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 5.5 h / 0 - 23 °C / Inert atmosphere 6.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 36 h / 23 °C / Inert atmosphere 7.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere 7.2: 0.42 h / 0 °C / Inert atmosphere 8.1: 48 h / 85 °C / Inert atmosphere 9.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere 10.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere 11.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere 11.2: air 12.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr 12.2: Inert atmosphere View Scheme

Yield

Multi-step reaction with 12 steps
1.1: methanol; hexane; benzene / 0.08 h / 23 °C / Inert atmosphere
1.2: 0.5 h
2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.2: 1 h / -78 °C / Inert atmosphere
3.1: lithium trifluoromethanesulfonate / toluene / 3 h / 23 - 60 °C / Inert atmosphere
3.2: 18 h / 23 °C / Inert atmosphere
4.1: diethylazodicarboxylate; triphenylphosphine / toluene / 1.5 h / 0 °C / Inert atmosphere
4.2: 23 h / 0 - 23 °C / Inert atmosphere
5.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 5.5 h / 0 - 23 °C / Inert atmosphere
6.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 36 h / 23 °C / Inert atmosphere
7.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere
7.2: 0.42 h / 0 °C / Inert atmosphere
8.1: 48 h / 85 °C / Inert atmosphere
9.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere
10.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere
11.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere
11.2: air
12.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr
12.2: Inert atmosphere
View Scheme

: 367954-37-8
(1S,2R,3R,6S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-7-oxa-bicyclo[4.1.0]hept-4-ene-1-carboxylic acid methyl ester

: 64-75-5
tetracycline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 11 steps 1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 1.2: 1 h / -78 °C / Inert atmosphere 2.1: lithium trifluoromethanesulfonate / toluene / 3 h / 23 - 60 °C / Inert atmosphere 2.2: 18 h / 23 °C / Inert atmosphere 3.1: diethylazodicarboxylate; triphenylphosphine / toluene / 1.5 h / 0 °C / Inert atmosphere 3.2: 23 h / 0 - 23 °C / Inert atmosphere 4.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 5.5 h / 0 - 23 °C / Inert atmosphere 5.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 36 h / 23 °C / Inert atmosphere 6.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere 6.2: 0.42 h / 0 °C / Inert atmosphere 7.1: 48 h / 85 °C / Inert atmosphere 8.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere 9.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere 10.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere 10.2: air 11.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr 11.2: Inert atmosphere View Scheme

Yield

Multi-step reaction with 11 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 1 h / -78 °C / Inert atmosphere
2.1: lithium trifluoromethanesulfonate / toluene / 3 h / 23 - 60 °C / Inert atmosphere
2.2: 18 h / 23 °C / Inert atmosphere
3.1: diethylazodicarboxylate; triphenylphosphine / toluene / 1.5 h / 0 °C / Inert atmosphere
3.2: 23 h / 0 - 23 °C / Inert atmosphere
4.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 5.5 h / 0 - 23 °C / Inert atmosphere
5.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 36 h / 23 °C / Inert atmosphere
6.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere
6.2: 0.42 h / 0 °C / Inert atmosphere
7.1: 48 h / 85 °C / Inert atmosphere
8.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere
9.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere
10.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere
10.2: air
11.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr
11.2: Inert atmosphere
View Scheme

: 852821-12-6
3-benzyloxy-5-dimethylaminomethylisoxazole

: 64-75-5
tetracycline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 11 steps 1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 1.2: 1 h / -78 °C / Inert atmosphere 2.1: lithium trifluoromethanesulfonate / toluene / 3 h / 23 - 60 °C / Inert atmosphere 2.2: 18 h / 23 °C / Inert atmosphere 3.1: diethylazodicarboxylate; triphenylphosphine / toluene / 1.5 h / 0 °C / Inert atmosphere 3.2: 23 h / 0 - 23 °C / Inert atmosphere 4.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 5.5 h / 0 - 23 °C / Inert atmosphere 5.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 36 h / 23 °C / Inert atmosphere 6.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere 6.2: 0.42 h / 0 °C / Inert atmosphere 7.1: 48 h / 85 °C / Inert atmosphere 8.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere 9.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere 10.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere 10.2: air 11.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr 11.2: Inert atmosphere View Scheme

Yield

: 90109-84-5
C6H9BrN2O

: 64-75-5
tetracycline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 12 steps 1.1: sodium / 32 h / 23 °C / Inert atmosphere 1.2: 20 h / 23 - 120 °C / Inert atmosphere 2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 2.2: 1 h / -78 °C / Inert atmosphere 3.1: lithium trifluoromethanesulfonate / toluene / 3 h / 23 - 60 °C / Inert atmosphere 3.2: 18 h / 23 °C / Inert atmosphere 4.1: diethylazodicarboxylate; triphenylphosphine / toluene / 1.5 h / 0 °C / Inert atmosphere 4.2: 23 h / 0 - 23 °C / Inert atmosphere 5.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 5.5 h / 0 - 23 °C / Inert atmosphere 6.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 36 h / 23 °C / Inert atmosphere 7.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere 7.2: 0.42 h / 0 °C / Inert atmosphere 8.1: 48 h / 85 °C / Inert atmosphere 9.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere 10.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere 11.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere 11.2: air 12.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr 12.2: Inert atmosphere View Scheme

Yield

Multi-step reaction with 12 steps
1.1: sodium / 32 h / 23 °C / Inert atmosphere
1.2: 20 h / 23 - 120 °C / Inert atmosphere
2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.2: 1 h / -78 °C / Inert atmosphere
3.1: lithium trifluoromethanesulfonate / toluene / 3 h / 23 - 60 °C / Inert atmosphere
3.2: 18 h / 23 °C / Inert atmosphere
4.1: diethylazodicarboxylate; triphenylphosphine / toluene / 1.5 h / 0 °C / Inert atmosphere
4.2: 23 h / 0 - 23 °C / Inert atmosphere
5.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 5.5 h / 0 - 23 °C / Inert atmosphere
6.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 36 h / 23 °C / Inert atmosphere
7.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere
7.2: 0.42 h / 0 °C / Inert atmosphere
8.1: 48 h / 85 °C / Inert atmosphere
9.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere
10.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere
11.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere
11.2: air
12.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr
12.2: Inert atmosphere
View Scheme

: C32H50N2O6Si2

: 64-75-5
tetracycline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 10 steps 1.1: lithium trifluoromethanesulfonate / toluene / 3 h / 23 - 60 °C / Inert atmosphere 1.2: 18 h / 23 °C / Inert atmosphere 2.1: diethylazodicarboxylate; triphenylphosphine / toluene / 1.5 h / 0 °C / Inert atmosphere 2.2: 23 h / 0 - 23 °C / Inert atmosphere 3.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 5.5 h / 0 - 23 °C / Inert atmosphere 4.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 36 h / 23 °C / Inert atmosphere 5.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere 5.2: 0.42 h / 0 °C / Inert atmosphere 6.1: 48 h / 85 °C / Inert atmosphere 7.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere 8.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere 9.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere 9.2: air 10.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr 10.2: Inert atmosphere View Scheme

Yield

Multi-step reaction with 10 steps
1.1: lithium trifluoromethanesulfonate / toluene / 3 h / 23 - 60 °C / Inert atmosphere
1.2: 18 h / 23 °C / Inert atmosphere
2.1: diethylazodicarboxylate; triphenylphosphine / toluene / 1.5 h / 0 °C / Inert atmosphere
2.2: 23 h / 0 - 23 °C / Inert atmosphere
3.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 5.5 h / 0 - 23 °C / Inert atmosphere
4.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 36 h / 23 °C / Inert atmosphere
5.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere
5.2: 0.42 h / 0 °C / Inert atmosphere
6.1: 48 h / 85 °C / Inert atmosphere
7.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere
8.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere
9.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere
9.2: air
10.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr
10.2: Inert atmosphere
View Scheme

: 852821-14-8
C26H36N2O6Si

: 64-75-5
tetracycline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 9 steps 1.1: diethylazodicarboxylate; triphenylphosphine / toluene / 1.5 h / 0 °C / Inert atmosphere 1.2: 23 h / 0 - 23 °C / Inert atmosphere 2.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 5.5 h / 0 - 23 °C / Inert atmosphere 3.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 36 h / 23 °C / Inert atmosphere 4.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere 4.2: 0.42 h / 0 °C / Inert atmosphere 5.1: 48 h / 85 °C / Inert atmosphere 6.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere 7.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere 8.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere 8.2: air 9.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr 9.2: Inert atmosphere View Scheme

Yield

Multi-step reaction with 9 steps
1.1: diethylazodicarboxylate; triphenylphosphine / toluene / 1.5 h / 0 °C / Inert atmosphere
1.2: 23 h / 0 - 23 °C / Inert atmosphere
2.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 5.5 h / 0 - 23 °C / Inert atmosphere
3.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 36 h / 23 °C / Inert atmosphere
4.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere
4.2: 0.42 h / 0 °C / Inert atmosphere
5.1: 48 h / 85 °C / Inert atmosphere
6.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere
7.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere
8.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere
8.2: air
9.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr
9.2: Inert atmosphere
View Scheme

: 852821-15-9
C26H36N2O5Si

: 64-75-5
tetracycline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 5.5 h / 0 - 23 °C / Inert atmosphere 2.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 36 h / 23 °C / Inert atmosphere 3.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere 3.2: 0.42 h / 0 °C / Inert atmosphere 4.1: 48 h / 85 °C / Inert atmosphere 5.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere 6.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere 7.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere 7.2: air 8.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr 8.2: Inert atmosphere View Scheme

Yield

Multi-step reaction with 8 steps
1.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 5.5 h / 0 - 23 °C / Inert atmosphere
2.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 36 h / 23 °C / Inert atmosphere
3.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere
3.2: 0.42 h / 0 °C / Inert atmosphere
4.1: 48 h / 85 °C / Inert atmosphere
5.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere
6.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere
7.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere
7.2: air
8.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr
8.2: Inert atmosphere
View Scheme

: 870288-27-0
C20H22N2O5

: 64-75-5
tetracycline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 36 h / 23 °C / Inert atmosphere 2.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere 2.2: 0.42 h / 0 °C / Inert atmosphere 3.1: 48 h / 85 °C / Inert atmosphere 4.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere 5.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere 6.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere 6.2: air 7.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr 7.2: Inert atmosphere View Scheme

Yield

Multi-step reaction with 7 steps
1.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 36 h / 23 °C / Inert atmosphere
2.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere
2.2: 0.42 h / 0 °C / Inert atmosphere
3.1: 48 h / 85 °C / Inert atmosphere
4.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere
5.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere
6.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere
6.2: air
7.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr
7.2: Inert atmosphere
View Scheme

: 856906-36-0
C20H20N2O5

: 64-75-5
tetracycline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere 1.2: 0.42 h / 0 °C / Inert atmosphere 2.1: 48 h / 85 °C / Inert atmosphere 3.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere 4.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere 5.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere 5.2: air 6.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr 6.2: Inert atmosphere View Scheme

Yield

Multi-step reaction with 6 steps
1.1: pyridinium hydrobromide perbromide / dichloromethane / 17 h / 23 °C / Inert atmosphere
1.2: 0.42 h / 0 °C / Inert atmosphere
2.1: 48 h / 85 °C / Inert atmosphere
3.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere
4.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere
5.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere
5.2: air
6.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr
6.2: Inert atmosphere
View Scheme

: 856906-37-1
C26H24N2O5S

: 64-75-5
tetracycline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: 48 h / 85 °C / Inert atmosphere 2.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere 3.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere 4.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere 4.2: air 5.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr 5.2: Inert atmosphere View Scheme

Yield

Multi-step reaction with 5 steps
1.1: 48 h / 85 °C / Inert atmosphere
2.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere
3.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere
4.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere
4.2: air
5.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr
5.2: Inert atmosphere
View Scheme

: C48H54N2O7SSi

: 64-75-5
tetracycline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere 2.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere 3.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere 3.2: air 4.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr 4.2: Inert atmosphere View Scheme

Yield

Multi-step reaction with 4 steps
1.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere
2.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere
3.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere
3.2: air
4.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr
4.2: Inert atmosphere
View Scheme

: C42H40N2O7S

: 64-75-5
tetracycline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 18 h / 23 - 35 °C / Darkness; Inert atmosphere 2.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere 2.2: air 3.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr 3.2: Inert atmosphere View Scheme

: C42H38N2O7S

: 64-75-5
tetracycline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid / dichloromethane / 0.67 h / -78 - 0 °C / Inert atmosphere 1.2: air 2.1: palladium; hydrogen / 1,4-dioxane / 2 h / 23 °C / 760.05 Torr 2.2: Inert atmosphere View Scheme

: C36H32N2O9

: 64-75-5
tetracycline hydrochloride

Conditions

Conditions	Yield
Stage #1: C36H32N2O9 With hydrogen; palladium In 1,4-dioxane at 23℃; under 760.051 Torr; for 2h; Stage #2: With hydrogenchloride In methanol; water; acetonitrile Inert atmosphere;	16 mg

: 64-75-5
tetracycline hydrochloride

A: [6S-(2bα,6α,6aα,7aα)]-6-dimethylamino-1,2b,3,6,6a,7,7a,8-octahydro-2b,5,8,12-tetrahydroxy-8-methyl-3-oxo-1,2-diazacyclopenta[fg]naphthacene-4-carboxylic acid amide

B: [5S-(5α,5aα,6aα,12baα,12cα)]-5-dimethylamino-1,5,5a,6,6a,7,12,12a,12b,12c-decahydro-4,7,11,12b,12c-pentahydroxy-7-methyl-12-oxo-1,2-diazacyclopenta[de]naphthacene-3-carboxylic acid amide

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol for 3h; Heating;	A 68% B 6%

: 2981-10-4
1-(cyclohex-1-en-1-yl)piperidine

: 64-75-5
tetracycline hydrochloride

: (4S,4aS,5aS,6S,12aS)-4-Dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid cyclohex-1-enylamide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Ambient temperature;

: 1125-99-1
1-(1-Cyclohexen-1-yl)pyrrolidine

: 64-75-5
tetracycline hydrochloride

: (4S,4aS,5aS,6S,12aS)-4-Dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid cyclohex-1-enylamide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Ambient temperature;

: 670-80-4
4-cyclohexen-1-ylmorpholine

: 64-75-5
tetracycline hydrochloride

: (4S,4aS,5aS,6S,12aS)-4-Dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid cyclohex-1-enylamide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Ambient temperature;

: 19353-04-9
1-cyclohept-1-enyl-piperidine

: 64-75-5
tetracycline hydrochloride

: (4S,4aS,5aS,6S,12aS)-4-Dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid cyclohept-1-enylamide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Ambient temperature;
With N,N-dimethyl-formamide

: 101471-70-9
1-(1-cycloocten-1-yl)piperidine

: 64-75-5
tetracycline hydrochloride

: (4S,4aS,5aS,6S,12aS)-4-Dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid ((E)-cyclooct-1-enyl)amide

Conditions

Conditions	Yield
With N,N-dimethyl-formamide

: 24273-55-0
1-cyclooct-1-enyl-piperidine

: 64-75-5
tetracycline hydrochloride

: (4S,4aS,5aS,6S,12aS)-4-Dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid ((E)-cyclooct-1-enyl)amide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide Ambient temperature;

: 64-75-5
tetracycline hydrochloride

: 1-(6-Ethyl-3,4-dihydro-naphthalen-2-yl)-piperidine

: (4S,4aS,5aS,6S,12aS)-4-Dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid (6-ethyl-3,4-dihydro-naphthalen-2-yl)-amide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide
With N,N-dimethyl-formamide

: 64-75-5
tetracycline hydrochloride

4-epitetracycline, anhydrotetracycline, 4-epianhydrotetracycline: 4-epitetracycline, anhydrotetracycline, 4-epianhydrotetracycline

Conditions

Conditions	Yield
With iron(II) sulfate In methanol Product distribution; Irradiation; other salts, addition of EDTA; stability tested; microbiological activity;

: 64-75-5
tetracycline hydrochloride

A: (6S)-(2bα,6a,6aα,7aα)1-6-dimethylamino-1,2b,3,6,6a,7,7a,8-octahydro-2b,5,8,12-tetrahydroxy-8-methyl-3-oxo-1,2-diaza-cyclopenta[fg]naphthacene-4-carboxylic acid amide

B: [5S-(5α,5aα,6aα,12bα,12cα)]-5-dimethylamino-1,5,5a,6,6a,7,12,12a,12b,12c-decahydro-4,7,11,12b,12c-pentahydroxy-7-methyl-12-oxo-1,2-diaza-cyclopenta[de]-naphthacene-3-carboxylic acid amide

Conditions

Conditions	Yield
Stage #1: tetracycline hydrochloride With hydrazine In ethanol for 3h; Heating / reflux; Stage #2: With acetic acid In water Stage #3: With triethylamine In water

: 27384-95-8
1-((Z)-1-ethyl-propenyl)-piperidine

: 64-75-5
tetracycline hydrochloride

A N-(1-ethyl-1-propenyl)tetracycline: N-(1-ethyl-1-propenyl)tetracycline

B: 6091-44-7
piperidine hydrochloride

Conditions

Conditions	Yield
In N-methyl-acetamide
In N-methyl-acetamide

...Expand

: 64-75-5
tetracycline hydrochloride

: 60-54-8
TETRACYCLINE

Conditions

Conditions	Yield
In water pH=9; pH-value; Cooling;

: 79-41-4
poly(methacrylic acid)

: 64-75-5
tetracycline hydrochloride

: tetracycline methacrylate

Conditions

Conditions	Yield
With lipase at 45℃; for 10h;

: 64-75-5
tetracycline hydrochloride

: 124-38-9
carbon dioxide

Conditions

Conditions	Yield
With Ag2O/g-C3N4 for 3h; Kinetics; Reagent/catalyst; Irradiation;
With BiOCl/Bi2Ti2O7 nanocomposite In water for 1h; Mechanism; Kinetics; Reagent/catalyst; Irradiation;
With 10 wt% g-C3N4/BiOCl0.5Br0.5 heterojunction composite Reagent/catalyst; Irradiation;

: 137-08-6
calcium (R)-pantothenate

: 64-75-5
tetracycline hydrochloride

: tetracycline mono-pantothenate

Conditions

Conditions	Yield
In ethanol; water Solvent;

: 64-75-5
tetracycline hydrochloride

: C9H12O6

Conditions

Conditions	Yield
With sodium nitrite In water Kinetics; Reagent/catalyst; Irradiation;

: 64-75-5
tetracycline hydrochloride

A: 124-38-9
carbon dioxide

B: 7732-18-5
water

Conditions

Conditions	Yield
With 2D Ti3C2 electron harvester anchors on 2D graphitic carbon nitride for 2h; Kinetics; Reagent/catalyst; Wavelength; Irradiation;

: 64-75-5
tetracycline hydrochloride

A: C19H18O8

B: C19H16O6

C: C17H18O6

D: C14H14O5

Conditions

Conditions	Yield
With gallium oxide Catalytic behavior; Kinetics; Mechanism; Reagent/catalyst; UV-irradiation;

...Expand

Tetracycline hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

Tetracycline hydrochloride Specification

The Tetracycline hydrochloride is an organic compound with the formula C₂₂H₂₄N₂O₈^.HCl. The systematic name of this chemical is (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride (1:1). With the CAS registry number 64-75-5, it is also named as 2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-, hydrochloride (1:1). The product's categories are Active Pharmaceutical Ingredients; Antibiotics for Research and Experimental Use; Biochemistry; Others (Antibiotics for Research and Experimental Use); Antibiotic Explorer; TA - TEAntibiotics; Tetracyclines Antibiotics; Bacteriostatic Antibiotics; Chemical Structure; L - ZAlphabetic; Principle; TetracyclinesMore...Close...; Antibacterial; Antibiotics; Interferes with Protein Synthesis Spectrum of Activity;L - ZAntibiotics; Mechanism of Action; Antibiotics T-ZAntibiotics; Antibiotics Antibiotics; Antibiotics Research Essentials; Antibiotics A to; Antibiotics by Application; Cell Culture; Chemical Structure Class; Core Bioreagents; Genetic Marker Selection Antibiotics; Reagents and Supplements; Tetracyclines; Research Essentials. Besides, it is a yellow crystalline powder, which is a broad-spectrum polyketide antibiotic produced by the streptomyces genus of actinobacteria.

Physical properties about Tetracycline hydrochloride are:
(1)# of Rule of 5 Violations: 2; (2)ACD/LogD (pH 5.5): -4; (3)ACD/LogD (pH 7.4): -4; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 10; (9)#H bond donors: 7; (10)#Freely Rotating Bonds: 7; (11)Polar Surface Area: 181.62 Å²; (12)Flash Point: 437.3 °C; (13)Enthalpy of Vaporization: 121.9 kJ/mol; (14)Boiling Point: 799.4 °C at 760 mmHg; (15)Vapour Pressure: 5.82E-27 mmHg at 25°C.

Safety information of Tetracycline hydrochloride:
When you are using this chemical, please be cautious about it as the following:It is harmful by inhalation, in contact with skin and if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)SMILES: Cl.CN(C)[C@@H]2C(\O)=C(\C(N)=O)C(=O)[C@@]3(O)C(/O)=C4/C(=O)c1c(cccc1O)[C@@](C)(O)[C@H]4C[C@@H]23
(2)InChI: InChI=1/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1
(3)InChIKey: XMEVHPAGJVLHIG-FMZCEJRJBJ
(4)Std. InChI: InChI=1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1
(5)Std. InChIKey: XMEVHPAGJVLHIG-FMZCEJRJSA-N

The toxicity data of Tetracycline hydrochloride is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	200mg/kg/7D-I (200mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE	Clinical Pharmacy. Vol. 4, Pg. 455, 1985.
mouse	LD50	intraperitoneal	368mg/kg (368mg/kg)		Journal of Pharmacy and Pharmacology. Vol. 16, Pg. 33, 1964.
mouse	LD50	intravenous	157mg/kg (157mg/kg)		Farmaco, Edizione Scientifica. Vol. 10, Pg. 197, 1955.
mouse	LD50	oral	2759mg/kg (2759mg/kg)		Journal of Pharmacy and Pharmacology. Vol. 16, Pg. 33, 1964.
mouse	LD50	unreported	105mg/kg (105mg/kg)		"Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks In New Drugs, Proceedings of the Symposium on Toxicological Testing for Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague, Czechoslovakia, Univerzita Karlova, 1979Vol. -, Pg. 55, 1979.
rabbit	LDLo	intrapleural	35mg/kg (35mg/kg)	LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Lung. Vol. 174, Pg. 373, 1996.
rat	LD50	intraperitoneal	318mg/kg (318mg/kg)		Gendai no Rinsho. Vol. 2, Pg. 26, 1968.
rat	LD50	intravenous	128mg/kg (128mg/kg)		Farmaco, Edizione Scientifica. Vol. 10, Pg. 197, 1955.
rat	LD50	oral	6443mg/kg (6443mg/kg)		Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat	LD50	subcutaneous	700mg/kg (700mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Toxicology and Applied Pharmacology. Vol. 9, Pg. 445, 1966.

Product Name

Tetracycline hydrochloride

Synthetic route

Tetracycline hydrochloride Consensus Reports

Tetracycline hydrochloride Specification

Related Products

Hot Products