Tetrahydropapaverine hydrochloride supplier

Name
Tetrahydropapaverine hydrochloride
EINECS 229-213-9
CAS No. 6429-04-5
Article Data4
CAS DataBase
Density 1.12g/cm3
Solubility Soluble in water
Melting Point 213°C～215°C
Formula C₂₀H₂₅NO₄.HCl
Boiling Point 475.8 °C at 760 mmHg
Molecular Weight 379.884
Flash Point 202.7 °C
Transport Information
Appearance White crystal powder
Safety 36
Risk Codes 22
Molecular Structure
Hazard Symbols
Synonyms Isoquinoline,1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratryl-, hydrochloride (6CI,7CI,8CI);(?à)-Norlaudanosine hydrochloride;(?à)-Tetrahydropapaverine hydrochloride;1,2,3,4-Tetrahydropapaverine hydrochloride;NSC 118072;NZ 54;Tetrahydropapaverine hydrochloride;
PSA 48.95000
LogP 4.28130

Synthetic route

: 5884-22-0
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

Conditions

Conditions	Yield
With methanol; sodium tetrahydroborate at 0 - 20℃; for 0.166667h; Inert atmosphere;	89%

: 6957-27-3
3,4-dihydropapaverine

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

Conditions

Conditions	Yield
With sodium (S)-prolinate-borane In tetrahydrofuran for 240h; Ambient temperature;	78%
With sodium tetrahydroborate for 19h; Ambient temperature;	71%

: 13074-31-2
Tetrahydropapaverine

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol	66%

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 92 percent / 2 h / 190 - 210 °C 2: phosphoryl chloride / toluene / 3 h / Heating 3: 71 percent / sodium borohydride / 19 h / Ambient temperature View Scheme
Multi-step reaction with 3 steps 1: 1 h / 180 °C 2: trichlorophosphate / acetonitrile / 1 h / Reflux; Inert atmosphere 3: sodium tetrahydroborate; methanol / 0.17 h / 0 - 20 °C / Inert atmosphere View Scheme

: 139-76-4
N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: phosphoryl chloride / toluene / 3 h / Heating 2: 71 percent / sodium borohydride / 19 h / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: trichlorophosphate / acetonitrile / 1 h / Reflux; Inert atmosphere 2: sodium tetrahydroborate; methanol / 0.17 h / 0 - 20 °C / Inert atmosphere View Scheme

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

palladium/barium sulfate: palladium/barium sulfate

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 92 percent / 2 h / 190 - 210 °C 2: phosphoryl chloride / toluene / 3 h / Heating 3: 71 percent / sodium borohydride / 19 h / Ambient temperature View Scheme

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1 h / 180 °C 2: trichlorophosphate / acetonitrile / 1 h / Reflux; Inert atmosphere 3: sodium tetrahydroborate; methanol / 0.17 h / 0 - 20 °C / Inert atmosphere View Scheme

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 16659-88-4
(+/-)-Tetrahydropapaveroline hydrobromide

Conditions

Conditions	Yield
With hydrogen bromide for 2.5h; Reflux;	95.1%

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 109-94-4
formic acid ethyl ester

: 50722-30-0
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbaldehyde

Conditions

Conditions	Yield
With potassium carbonate In ethanol for 40h; Bischler-Napieralski Reaction; Reflux;	94%

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 1-(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-2-(3,4-dimethoxyphenyl)ethanone

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 17h;	89%

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 54417-53-7
(R)-tetrahydropapaverine hydrochloride

Conditions

Conditions	Yield
With N-acetyl-D-leucine; (R)-N-acetylphenylalanin In water; toluene; acetonitrile at 4 - 70℃; for 24.92h; Reagent/catalyst;	83.25%

: 50-00-0
formaldehyd

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 523-02-4, 4216-86-8, 6872-27-1, 13407-95-9
2,3,10,11-tetramethoxy-5,6,7,8,13,13a-hexahydroisoquinolino[3,2-a]isoquinoline

Conditions

Conditions	Yield
In ethanol; water at 20℃; for 8h;	80%
With acetic acid at 100℃; for 0.5h; Pictet-Spengler Synthesis;	73%
In water Cyclization; Heating;
In water for 30h; Heating;	8.2 g

: 5884-22-0
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

Conditions

Conditions	Yield
With methanol; sodium tetrahydroborate at 0 - 20℃; for 0.166667h; Inert atmosphere;	89%

: 6957-27-3
3,4-dihydropapaverine

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

Conditions

Conditions	Yield
With sodium (S)-prolinate-borane In tetrahydrofuran for 240h; Ambient temperature;	78%
With sodium tetrahydroborate for 19h; Ambient temperature;	71%

: 13074-31-2
Tetrahydropapaverine

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol	66%

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 92 percent / 2 h / 190 - 210 °C 2: phosphoryl chloride / toluene / 3 h / Heating 3: 71 percent / sodium borohydride / 19 h / Ambient temperature View Scheme
Multi-step reaction with 3 steps 1: 1 h / 180 °C 2: trichlorophosphate / acetonitrile / 1 h / Reflux; Inert atmosphere 3: sodium tetrahydroborate; methanol / 0.17 h / 0 - 20 °C / Inert atmosphere View Scheme

: 139-76-4
N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: phosphoryl chloride / toluene / 3 h / Heating 2: 71 percent / sodium borohydride / 19 h / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: trichlorophosphate / acetonitrile / 1 h / Reflux; Inert atmosphere 2: sodium tetrahydroborate; methanol / 0.17 h / 0 - 20 °C / Inert atmosphere View Scheme

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

palladium/barium sulfate: palladium/barium sulfate

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 92 percent / 2 h / 190 - 210 °C 2: phosphoryl chloride / toluene / 3 h / Heating 3: 71 percent / sodium borohydride / 19 h / Ambient temperature View Scheme

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1 h / 180 °C 2: trichlorophosphate / acetonitrile / 1 h / Reflux; Inert atmosphere 3: sodium tetrahydroborate; methanol / 0.17 h / 0 - 20 °C / Inert atmosphere View Scheme

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 16659-88-4
(+/-)-Tetrahydropapaveroline hydrobromide

Conditions

Conditions	Yield
With hydrogen bromide for 2.5h; Reflux;	95.1%

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 109-94-4
formic acid ethyl ester

: 50722-30-0
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbaldehyde

Conditions

Conditions	Yield
With potassium carbonate In ethanol for 40h; Bischler-Napieralski Reaction; Reflux;	94%

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 1-(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-2-(3,4-dimethoxyphenyl)ethanone

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 17h;	89%

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 54417-53-7
(R)-tetrahydropapaverine hydrochloride

Conditions

Conditions	Yield
With N-acetyl-D-leucine; (R)-N-acetylphenylalanin In water; toluene; acetonitrile at 4 - 70℃; for 24.92h; Reagent/catalyst;	83.25%

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 938-18-1
mesitylene-2-carboxylic acid chloride

: (1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(mesityl)methanone

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere;	83%

: 50-00-0
formaldehyd

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 523-02-4, 4216-86-8, 6872-27-1, 13407-95-9
2,3,10,11-tetramethoxy-5,6,7,8,13,13a-hexahydroisoquinolino[3,2-a]isoquinoline

Conditions

Conditions	Yield
In ethanol; water at 20℃; for 8h;	80%
With acetic acid at 100℃; for 0.5h; Pictet-Spengler Synthesis;	73%
In water Cyclization; Heating;
In water for 30h; Heating;	8.2 g

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 298-12-4
Glyoxilic acid

: 2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-8-carboxylic acid

Conditions

Conditions	Yield
for 1h; Heating;	80%

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 61804-12-4
1,7-heptanediol dipropenoate

: 81165-43-7
3-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid 7-{3-[1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionyloxy}-heptyl ester; compound with oxalic acid

Conditions

Conditions	Yield
In benzene for 48h; Heating;	76%

: 13048-33-4
hexamethylene glycol diacrylate

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 81182-08-3
3-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid 6-{3-[1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionyloxy}-hexyl ester; compound with oxalic acid

Conditions

Conditions	Yield
In benzene for 48h; Heating;	67%

: 10526-04-2
1,6-hexanediol diacrylate

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 81165-44-8
3-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid 8-{3-[1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionyloxy}-octyl ester; compound with oxalic acid

Conditions

Conditions	Yield
In benzene for 48h; Heating;	60%

: 4074-88-8
diethyleneglycol(diacrylate)

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 81165-45-9
3-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid 2-(2-{3-[1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionyloxy}-ethoxy)-ethyl ester; compound with oxalic acid

Conditions

Conditions	Yield
In benzene for 48h; Heating;	57%

: 36840-85-4
pentamethylene 1,5-diacrylate

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 64228-78-0, 64493-10-3, 83285-74-9, 96687-52-4, 96687-53-5, 110817-20-4
pentamethylene bis(1-(3,4-dimethoxybenzyl)-3,4-dihydro-6,7-dimethoxy-1H-isoquinoline-2-propionate) dioxalate

Conditions

Conditions	Yield
In benzene for 48h; Heating;	51%

: 24493-53-6
2-propenoic acid 1,3-propanediyl ester

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 81165-42-6
3-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid 3-{3-[1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionyloxy}-propyl ester; compound with oxalic acid

Conditions

Conditions	Yield
In benzene for 48h; Heating;	50%

: 1070-70-8
1,4-Butanediol diacrylate

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 81182-07-2
3-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid 4-{3-[1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionyloxy}-butyl ester; compound with oxalic acid

Conditions

Conditions	Yield
In benzene for 48h; Heating;	48%

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 64194-22-5
3-methyl-1,5-pentanediol dipropenoate

: 81165-48-2
3-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid 5-{3-[1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionyloxy}-3-methyl-pentyl ester; compound with oxalic acid

Conditions

Conditions	Yield
In benzene for 48h; Heating;	38%

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 36431-64-8
Acrylic acid 2-[4-(2-acryloyloxy-ethyl)-phenyl]-ethyl ester

: 81165-47-1
3-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid 2-[4-(2-{3-[1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-propionyloxy}-ethyl)-phenyl]-ethyl ester; compound with oxalic acid

Conditions

Conditions	Yield
In benzene for 48h; Heating;	35%

: 7647-01-0
hydrogenchloride

: 105-57-7
diethyl acetal

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

A: 6899-65-6
(8R,13aR)-2,3,10,11-tetramethoxy-8-methyl-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline

B β-coralydine: β-coralydine

...Expand

: 7647-01-0
hydrogenchloride

: 109-87-5
Dimethoxymethane

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

norcoralydine: norcoralydine

...Expand

: 7647-01-0
hydrogenchloride

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

A: 74-87-3
methylene chloride

B Py-tetrahydro-papaveroline: Py-tetrahydro-papaveroline

Conditions

Conditions	Yield
at 170 - 175℃;

...Expand

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 52194-51-1, 52194-52-2, 52194-53-3, 52438-48-9, 57129-74-5, 62860-05-3, 62860-06-4, 65025-46-9, 120052-37-1
(+/-)-Xylopinin-trans-methiodid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 8.2 g / H2O / 30 h / Heating 2: 122 mg / acetone; CHCl3 / 1 h / 20 °C View Scheme

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: (+/-)-2,3,10,11-tetrademethylpseudotetrahydropalmatine hydrobromide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 8.2 g / H2O / 30 h / Heating 2: 1.85 g / HBr / 7 h / Heating View Scheme

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 2,3,10,11-tetramethoxy-7-methyl-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinolinium; iodide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 8.2 g / H2O / 30 h / Heating 2: acetone; CHCl3 / 1 h / 20 °C View Scheme

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: C22H25(2)H3NO4(1+)*I(1-)

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 8.2 g / H2O / 30 h / Heating 2: 71 mg / acetone; CHCl3 / 2.5 h / 20 °C View Scheme

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: C22H25(2)H3NO4(1+)*I(1-)

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 8.2 g / H2O / 30 h / Heating 2: 290 mg / acetone; CHCl3 / 2.5 h / 20 °C View Scheme

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 19716-66-6
pseudopalmatine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: H2O / Heating 2.1: 55 percent / mCPBA / CHCl3 / 20 °C 3.1: TFAA / CH2Cl2 / -30 - 20 °C 3.2: NaOAc / CH2Cl2; H2O / 0.5 h / 20 °C View Scheme

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 6899-65-6, 7058-95-9, 57030-06-5, 58116-07-7, 58116-10-2, 58116-12-4, 79297-66-8
(+/-)-O-methylcorytenchirine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: H2O / Heating 2.1: 55 percent / mCPBA / CHCl3 / 20 °C 3.1: TFAA / CH2Cl2 / -30 - 20 °C 3.2: 49 percent / NaOAc / CH2Cl2; H2O / 0.5 h / 20 °C 4.1: 80 percent / methylmagnesium iodide / diethyl ether / 2 h / Heating View Scheme

: 6429-04-5
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 332951-52-7
7,14-dehydroxylopinine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: H2O / Heating 2: 55 percent / mCPBA / CHCl3 / 20 °C 3: 50 percent Spectr. / acetyl chloride / 2 h / 25 °C View Scheme

Tetrahydropapaverine hydrochloride Chemical Properties

Product Name: Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-,hydrochloride (1:1) (CAS NO.6429-04-5)

Molecular Formula: C₂₀H₂₅NO₄.HCl
Molecular Weight: 379.8814g/mol
Mol File: 6429-04-5.mol
EINECS: 229-213-9
Boiling point: 475.8 °C at 760 mmHg
Flash Point: 202.7 °C
Enthalpy of Vaporization: 73.93 kJ/mol
Vapour Pressure: 3.23E-09 mmHg at 25°C
H-Bond Donor: 2
H-Bond Acceptor: 5
Structure Descriptors of Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-,hydrochloride (1:1) (CAS NO.6429-04-5):
IUPAC Name: 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
Canonical SMILES: COC1=C(C=C(C=C1)CC2C3=CC(=C(C=C3CCN2)OC)OC)OC.Cl
InChI: InChI=1S/C20H25NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-6,10-12,16,21H,7-9H2,1-4H3;1H
InChIKey: VMPLLPIDRGXFTQ-UHFFFAOYSA-N
Classification Code: Drug / Therapeutic Agent

Tetrahydropapaverine hydrochloride Safety Profile

Safety Information of Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-,hydrochloride (1:1) (CAS NO.6429-04-5):
Hazard Codes: T Toxic

Tetrahydropapaverine hydrochloride Specification

Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-,hydrochloride (1:1) , its CAS NO. is 6429-04-5, the synonyms are 1,2,3,4-Tetrahydro-6,7-dimethoxy-1-veratryl-isoquinoline hydrochloride ; Papaverine, 1,2,3,4-tetrahydro-, hydrochloride ; Tetrahydropapaverine hydrochloride ; 1-(3,4-Dimethoxybenzyl)-1,2,3,4-tetrahydro-6,7-
dimethoxyisoquinolinium chloride ; Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratryl-, hydrochloride .

Product Name

Tetrahydropapaverine hydrochloride

Synthetic route

Tetrahydropapaverine hydrochloride Chemical Properties

Tetrahydropapaverine hydrochloride Safety Profile

Tetrahydropapaverine hydrochloride Specification

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