Product Name

  • Name

    Thiazole-2-carboxylic acid

  • EINECS
  • CAS No. 14190-59-1
  • Article Data24
  • CAS DataBase
  • Density 1.525 g/cm3
  • Solubility Slightly soluble in water.
  • Melting Point 91.6-93 °C
  • Formula C4H3NO2S
  • Boiling Point 310.6 °C at 760 mmHg
  • Molecular Weight 129.139
  • Flash Point 141.6 °C
  • Transport Information
  • Appearance
  • Safety 26-36/37/39
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 14190-59-1 (Thiazole-2-carboxylic acid)
  • Hazard Symbols R36/37/38:;
  • Synonyms 1,3-Thiazole-2-carboxylicacid;2-Carboxythiazole;2-Thiazolecarboxylic acid,thiazole-2-carboxylic acid;
  • PSA 78.43000
  • LogP 0.84130

Synthetic route

2-bromo-1,3-thiazole
3034-53-5

2-bromo-1,3-thiazole

carbon dioxide
124-38-9

carbon dioxide

1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: 2-bromo-1,3-thiazole With n-butyllithium In tetrahydrofuran
Stage #2: carbon dioxide		73%
Stage #1: 2-bromo-1,3-thiazole With n-butyllithium In diethyl ether; hexane at -78℃; for 0.166667h;
Stage #2: carbon dioxide In diethyl ether; hexane at -78℃; for 1.16667h;		64%
1,3-thiazole
288-47-1

1,3-thiazole

carbon dioxide
124-38-9

carbon dioxide

A

thiazole-5-carboxylic acid
14527-41-4

thiazole-5-carboxylic acid

B

1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: carbon dioxide With AuOH(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene); potassium hydroxide In tetrahydrofuran at 20℃; under 1125.11 Torr; for 0.25h;
Stage #2: 1,3-thiazole In tetrahydrofuran at 20℃; under 1125.11 Torr; for 12h;
Stage #3: With hydrogenchloride In tetrahydrofuran; water regioselective reaction;		A 27%
B 61%
...Expand
2-bromo-1,3-thiazole
3034-53-5

2-bromo-1,3-thiazole

water
7732-18-5

water

A

1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

B

ETHYL 2-[N-(1'-AMINOCITRACONAMIDO)]-4-(2'-THIAZOLYL)PYRIMIDINE-5-CARBOXYLATE

ETHYL 2-[N-(1'-AMINOCITRACONAMIDO)]-4-(2'-THIAZOLYL)PYRIMIDINE-5-CARBOXYLATE

Conditions
ConditionsYield
With n-butyllithium; carbon dioxideA 57%
B n/a
...Expand
thiazole-2-carboxylic acid ethyl ester
14527-42-5

thiazole-2-carboxylic acid ethyl ester

1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: thiazole-2-carboxylic acid ethyl ester With potassium hydroxide; ethanol; water at 20℃; for 2h;
Stage #2: With hydrogenchloride; water In ethanol		25%
With potassium hydroxide
Stage #1: thiazole-2-carboxylic acid ethyl ester With potassium hydroxide; ethanol at 120℃; for 0.5h;
Stage #2: With hydrogenchloride; water In ethanol pH=4.0;
Stage #1: thiazole-2-carboxylic acid ethyl ester With potassium hydroxide; ethanol at 120℃; for 0.5h;
Stage #2: With hydrogenchloride In ethanol; water pH=4.0;
Stage #1: thiazole-2-carboxylic acid ethyl ester With potassium hydroxide; ethanol; water at 20℃; for 2h;
Stage #2: With hydrogenchloride; water
1,3-thiazole
288-47-1

1,3-thiazole

1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

Conditions
ConditionsYield
With diethyl ether; phenyllithium anschliessend Behandeln mit CO2;
2-bromo-1,3-thiazole
3034-53-5

2-bromo-1,3-thiazole

1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

Conditions
ConditionsYield
With n-butyllithium; diethyl ether anschliessend mit CO2;
thiocarboxamide
115-08-2

thiocarboxamide

formylchloroacetic acid ethyl ester

formylchloroacetic acid ethyl ester

1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

Conditions
ConditionsYield
beim anschliessenden Verseifen; reagirt analog mit 2-Chlor-acetessigsaeure-aethylester, 3-Chlor-laevulinsaeure-aethylester,;
C4H2NO2S(1-)*Li(1+)
1192365-76-6

C4H2NO2S(1-)*Li(1+)

1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

Conditions
ConditionsYield
With sulfuric acid; water
1,3-thiazole
288-47-1

1,3-thiazole

carbon dioxide
124-38-9

carbon dioxide

1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: 1,3-thiazole With n-butyllithium In tetrahydrofuran at -60℃; for 0.166667h;
Stage #2: carbon dioxide In tetrahydrofuran
Stage #1: 1,3-thiazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere;
Stage #2: carbon dioxide In tetrahydrofuran; hexane at -78 - 20℃; for 2h; Inert atmosphere;		12 g
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

6-aminohexanoic acid phenylamide
115012-25-4

6-aminohexanoic acid phenylamide

thiazole-2-carboxylic acid (5-phenylcarbamoyl-pentyl)-amide

thiazole-2-carboxylic acid (5-phenylcarbamoyl-pentyl)-amide

Conditions
ConditionsYield
With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;94%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

2-amino-phenol
95-55-6

2-amino-phenol

2-(thiazol-2-yl)benzo[d]oxazole

2-(thiazol-2-yl)benzo[d]oxazole

Conditions
ConditionsYield
With PS-PPh3; trichloroacetonitrile In acetonitrile at 150℃; for 0.25h; microwave irradiation;94%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

1-(3-amino-2,6-difluoro-phenyl)-ethanone
99724-35-3

1-(3-amino-2,6-difluoro-phenyl)-ethanone

thiazole-2-carboxylic acid (3-acetyl-2,4-difluoro-phenyl)-amide
746630-05-7

thiazole-2-carboxylic acid (3-acetyl-2,4-difluoro-phenyl)-amide

Conditions
ConditionsYield
With triethylamine; HATU In tetrahydrofuran92%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

3-(8-nitroquinolin-4-yl)benzenamine

3-(8-nitroquinolin-4-yl)benzenamine

N-(3-(8-nitroquinolin-4-yl)phenyl)thiazole-2-carboxamide

N-(3-(8-nitroquinolin-4-yl)phenyl)thiazole-2-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃;92%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

ethyl potassium malonate
6148-64-7

ethyl potassium malonate

3-oxo-3-thiazol-2-yl-propionic acid ethyl ester
212621-63-1

3-oxo-3-thiazol-2-yl-propionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: 1,3-thiazole-2-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 0 - 20℃; for 4h;
Stage #2: ethyl potassium malonate With magnesium chloride In tetrahydrofuran at 50 - 75℃; for 20h;		91%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

2-[5-amino-2-[(1r,4r)-4-(hydroxymethyl)cyclohexyl]indazol-6-yl]propan-2-ol

2-[5-amino-2-[(1r,4r)-4-(hydroxymethyl)cyclohexyl]indazol-6-yl]propan-2-ol

N-(2-((1r,4r)-4-(hydroxymethyl)cyclohexyl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)thiazole-2-carboxamide

N-(2-((1r,4r)-4-(hydroxymethyl)cyclohexyl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)thiazole-2-carboxamide

Conditions
ConditionsYield
With 2-chloro-1-methyl-pyridinium iodide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 0.5h; Inert atmosphere;91%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

1-(1-benzhydrylazetidin-3-yl)piperazine
930782-73-3

1-(1-benzhydrylazetidin-3-yl)piperazine

(4-(1-benzhydrylazetidin-3-yl)piperazin-1-yl)(thiazol-2-yl)methanone
1252779-95-5

(4-(1-benzhydrylazetidin-3-yl)piperazin-1-yl)(thiazol-2-yl)methanone

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane for 48h;90%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane for 48h; Inert atmosphere;90%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In water; N,N-dimethyl-formamide at 20℃; for 16h;78%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

2-Fluoroaniline
348-54-9

2-Fluoroaniline

N-(2-fluorophenyl)thiazole-2-carboxamide

N-(2-fluorophenyl)thiazole-2-carboxamide

Conditions
ConditionsYield
With pyridine; trichlorophosphate In dichloromethane at 20℃; Cooling with ice;79%
With pyridine; trichlorophosphate In dichloromethane at 20℃; Cooling with ice;79%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

4-chlorobenzoic acid hydrazide
536-40-3

4-chlorobenzoic acid hydrazide

N'-(4-chlorobenzoyl)thiazole-2-carbohydrazide

N'-(4-chlorobenzoyl)thiazole-2-carbohydrazide

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide at 20℃;73%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

1-(4-phenoxyphenyl)-4-(piperazin-1-yl)pyrrolidin-2-one hydrochloride

1-(4-phenoxyphenyl)-4-(piperazin-1-yl)pyrrolidin-2-one hydrochloride

1-(4-phenoxyphenyl)-4-(4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl)pyrrolidin-2-one

1-(4-phenoxyphenyl)-4-(4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl)pyrrolidin-2-one

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;71%
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 10 - 35℃;170 mg
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

thiazole-2-carboxylic acid methoxy-methyl-amide
885278-18-2

thiazole-2-carboxylic acid methoxy-methyl-amide

Conditions
ConditionsYield
Stage #1: 1,3-thiazole-2-carboxylic acid With 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In tetrahydrofuran at 0℃; for 0.25h;
Stage #2: With 4-methyl-morpholine In tetrahydrofuran at 20℃; for 1.5h;
Stage #3: N,O-dimethylhydroxylamine*hydrochloride In tetrahydrofuran at 0 - 20℃;		70%
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

N-(2'-chloro-5'-aminobenzoyl)-4-(p-fluorobenzy)-piperidine hydrochloride
944390-13-0

N-(2'-chloro-5'-aminobenzoyl)-4-(p-fluorobenzy)-piperidine hydrochloride

thiazole-2-carboxylic acid {4-chloro-3-[4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-phenyl}-amide

thiazole-2-carboxylic acid {4-chloro-3-[4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-phenyl}-amide

Conditions
ConditionsYield
Stage #1: 1,3-thiazole-2-carboxylic acid With N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate In acetonitrile for 0.25h;
Stage #2: N-(2'-chloro-5'-aminobenzoyl)-4-(p-fluorobenzy)-piperidine hydrochloride With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.25h;		69%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

potassium tert-butylate
865-47-4

potassium tert-butylate

tert-butyl thiazole-2-carboxylate

tert-butyl thiazole-2-carboxylate

Conditions
ConditionsYield
Stage #1: 1,3-thiazole-2-carboxylic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 23℃; for 5h;
Stage #2: potassium tert-butylate In dichloromethane; N,N-dimethyl-formamide at 23℃; for 1h; Temperature;		67%
Stage #1: 1,3-thiazole-2-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 23℃; for 5h;
Stage #2: potassium tert-butylate In dichloromethane at 23℃; for 1h;		67%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

Demethylmifepristone
104004-96-8

Demethylmifepristone

N-(4-((8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-3-oxo-17-(prop-1-yn-1-yl)-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-11-yl)phenyl)-N-methylthiazole-2-carboxamide

N-(4-((8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-3-oxo-17-(prop-1-yn-1-yl)-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-11-yl)phenyl)-N-methylthiazole-2-carboxamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 16h; Inert atmosphere;66%
N2-phenyl-5-amino-3-methyl-2,4-thiophenecarboxamide
331959-40-1

N2-phenyl-5-amino-3-methyl-2,4-thiophenecarboxamide

1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

3-methyl-N2-phenyl-5-(thiazole-2-carboxamido)thiophene-2,4-dicarboxamide

3-methyl-N2-phenyl-5-(thiazole-2-carboxamido)thiophene-2,4-dicarboxamide

Conditions
ConditionsYield
Stage #1: 1,3-thiazole-2-carboxylic acid With N-ethyl-N,N-diisopropylamine; ((3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: N2-phenyl-5-amino-3-methyl-2,4-thiophenecarboxamide In N,N-dimethyl-formamide at 20℃;		66%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

hex-5-ynyl methanesulphonate
79496-61-0

hex-5-ynyl methanesulphonate

C10H11NO2S

C10H11NO2S

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 90℃; for 0.5h; Microwave irradiation;61%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

cloridrato del 2-amino-2-isobutirrilacetacetato di etile

cloridrato del 2-amino-2-isobutirrilacetacetato di etile

ethyl 5-methyl-3-oxo-2-(thiazole-2-carboxamido)hexanoate
910476-37-8

ethyl 5-methyl-3-oxo-2-(thiazole-2-carboxamido)hexanoate

Conditions
ConditionsYield
With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; Molecular sieve;60%
With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; Molecular sieve;60%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

(S)-1-amino-N-(3-chloro-4-fluorophenyl)-7-fluoro-2,3-dihydro-1H-indene-4-carboxamide hydrochloride

(S)-1-amino-N-(3-chloro-4-fluorophenyl)-7-fluoro-2,3-dihydro-1H-indene-4-carboxamide hydrochloride

(S)-N-(4-((3-chloro-4-fluorophenyl)carbamoyl)-7-fluoro-2,3-dihydro-1H-inden-1-yl)thiazole-2-carboxamide

(S)-N-(4-((3-chloro-4-fluorophenyl)carbamoyl)-7-fluoro-2,3-dihydro-1H-inden-1-yl)thiazole-2-carboxamide

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In dichloromethane at 0 - 20℃; for 16h;60%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

4-methylthiosemicarbazide
6610-29-3

4-methylthiosemicarbazide

4-methyl-5-(1,3-thiazol-2-yl)-4H-1,2,4-triazole-3-thiol

4-methyl-5-(1,3-thiazol-2-yl)-4H-1,2,4-triazole-3-thiol

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate; N,N-dimethyl-formamide at 20℃; Cooling with ice;59%
Stage #1: 1,3-thiazole-2-carboxylic acid; 4-methylthiosemicarbazide With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate; N,N-dimethyl-formamide at 20℃; for 12h;
Stage #2: With sodium hydroxide for 0.666667h; Reflux;
Stage #1: 1,3-thiazole-2-carboxylic acid; 4-methylthiosemicarbazide With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate; N,N-dimethyl-formamide at 0 - 20℃;
Stage #2: With sodium hydroxide In ethyl acetate; N,N-dimethyl-formamide at 70℃;
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

C9H17NO3*2ClH

C9H17NO3*2ClH

ethyl 5-methyl-3-oxo-2-(thiazole-2-carboxamido)hexanoate
910476-37-8

ethyl 5-methyl-3-oxo-2-(thiazole-2-carboxamido)hexanoate

Conditions
ConditionsYield
Stage #1: C9H17NO3*2ClH With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 0.166667h;
Stage #2: 1,3-thiazole-2-carboxylic acid With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;		59%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

C9H10Cl2N2

C9H10Cl2N2

C13H11Cl2N3OS

C13H11Cl2N3OS

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;57%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

(S)-3-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidine
851882-63-8

(S)-3-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidine

{(S)-3-[3-(4-fluoro-phenyl)-1,2,4-oxadiazol-5-yl]-piperidin-1-yl}-thiazol-2-yl-methanone

{(S)-3-[3-(4-fluoro-phenyl)-1,2,4-oxadiazol-5-yl]-piperidin-1-yl}-thiazol-2-yl-methanone

Conditions
ConditionsYield
With 1-hydroxy-7-aza-benzotriazole; PS-DCC; N-ethyl-N,N-diisopropylamine In dichloromethane55%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

water
7732-18-5

water

zinc(II) acetate dihydrate
5970-45-6

zinc(II) acetate dihydrate

bis(κ2-N,O-thiazole-2-carboxylate)diaquazinc(II)
1270159-28-8

bis(κ2-N,O-thiazole-2-carboxylate)diaquazinc(II)

Conditions
ConditionsYield
In water High Pressure; metal:thiazole=2:1 molar ratio, heated at 90°C for 24 h; slowly cooled overnight, crysts. washed (ethanol), dried (N2 stream, room temp.); elem. anal., single cryst. XRD, TGA;55%
...Expand
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

2-phenyl-1,3-benzothiazol-5-amine
43087-91-8

2-phenyl-1,3-benzothiazol-5-amine

N-(2-phenylbenzo[d]thiazol-5-yl)thiazole-2-carboxamide

N-(2-phenylbenzo[d]thiazol-5-yl)thiazole-2-carboxamide

Conditions
ConditionsYield
Stage #1: 1,3-thiazole-2-carboxylic acid With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran at 20℃; for 1.5h;
Stage #2: 2-phenyl-1,3-benzothiazol-5-amine In tetrahydrofuran		55%
Stage #1: 1,3-thiazole-2-carboxylic acid With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran at 20℃; for 1.5h;
Stage #2: 2-phenyl-1,3-benzothiazol-5-amine In tetrahydrofuran		55%
1,3-thiazole-2-carboxylic acid
14190-59-1

1,3-thiazole-2-carboxylic acid

N1-(1,2,3,4-tetrahydroacridin-9-yl)hexane-1,6-diamine
249290-17-3

N1-(1,2,3,4-tetrahydroacridin-9-yl)hexane-1,6-diamine

C23H28N4OS

C23H28N4OS

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 12h;55%

Thiazole-2-carboxylic acid Chemical Properties

IUPAC Name: 1,3-Thiazole-2-carboxylic acid
Synonyms of Thiazole-2-carboxylic acid (CAS NO.14190-59-1): 1,3-Thiazole-2-carboxylic acid ; 2-Thiazolecarboxylic acid,thiazole-2-carboxylic acid
CAS NO: 14190-59-1
Molecular Formula: C4H3NO2S
Molecular Weight: 129.1371
Molecular Structure:

Melting Point: 91.6-93°C
ProductCategories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts ; Thiazole series ; Carboxylic Acids ; Thiazoles, Isothiazoles &Benzothiazoles ; Carboxylic Acids ; Thiazoles, Isothiazoles & Benzothiazoles 
Polar Surface Area: 67.43 Å2
Index of Refraction: 1.617
Molar Refractivity: 29.65 cm3
Molar Volume: 84.6 cm3
Surface Tension: 72 dyne/cm
Density of Thiazole-2-carboxylic acid (CAS NO.14190-59-1): 1.525 g/cm3
Flash Point: 141.6 °C
Enthalpy of Vaporization: 58.22 kJ/mol
Boiling Point: 310.6 °C at 760 mmHg
Vapour Pressure: 0.000256 mmHg at 25°C

Thiazole-2-carboxylic acid Safety Profile

Risk Statements of Thiazole-2-carboxylic acid (CAS NO.14190-59-1): 36/37/38 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements 26-36/37/39 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
 

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