Pentothal sodium (71-73-8) was discovered in the early 1930s by Ernest H. Volwiler and Donalee L. Tabern, working for Abbott Laboratories. It was first used in human beings on March 8, 1934, by Dr. Ralph M. Waters in an investigation of its properties, which were short-term anesthesia and surprisingly little analgesia. Three months later, Dr. John S. Lundy started a clinical trial of thiopental at the Mayo Clinic at the request of Abbott.
It is famously associated with a number of anesthetic deaths in victims of the attack on Pearl Harbor. These deaths, relatively soon after its discovery, were due to excessive doses given to shocked trauma patients. Evidence has become available through freedom of information legislation and has been reviewed in the "British Journal of Anaesthesia". Thiopental anaesthesia was in its early days, but nevertheless only 13 of 344 wounded admitted to the Tripler Army Hospital did not survive.
Thiopental is still rarely used as a recreational drug, usually stolen from veterinarians or other legitimate users of the drug; however, more common sedatives such as benzodiazepines are usually preferred as recreational drugs, and abuse of thiopental tends to be uncommon and opportunistic.
The Thiopental sodium, with the CAS registry number 4355-11-7,is also known as Thiopentobarbitone sodium; Thiopentone sodium; Thiothal sodium; 5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione sodium salt. It belongs to the product categories of Organic matters.Its EINECS number is 200-763-1. This chemical's molecular formula is C11H17N2O2S.Na and molecular weight is 264.32. What's more,Its systematic name is Thiopental sodium.It is a barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not produce any excitation but has poor analgesic and muscle relaxant properties. Small doses have been shown to be anti-analgesic and lower the pain threshold
Physical properties about Thiopental sodium are:
(1)ACD/LogP: 2.38; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.53; (4)ACD/LogD (pH 7.4): -0.92; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 6.70; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 4; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 4.
You can still convert the following datas into molecular structure:
(1)SMILES:[Na+].O=C1NC(=S)/N=C(/[O-])C1(C(C)CCC)CC;
(2)Std. InChI:InChI=1S/C11H18N2O2S.Na/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15;/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);/q;+1/p-1;
(3)Std. InChIKey:AWLILQARPMWUHA-UHFFFAOYSA-M.
The toxicity data of Thiopental sodium are as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | intravenous | 32500ug/kg (32.5mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 82, Pg. 212, 1953. | |
dog | LD50 | intravenous | 36mg/kg (36mg/kg) | Current Researches in Anesthesia and Analgesia. Vol. 29, Pg. 89, 1950. | |
dog | LDLo | oral | 150mg/kg (150mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 125, 1937. | |
guinea pig | LD50 | intraperitoneal | 57500ug/kg (57.5mg/kg) | Anesthesiology. Vol. 8, Pg. 589, 1947. | |
human | TDLo | intraarterial | 7mg/kg (7mg/kg) | VASCULAR: THROMBOSIS DISTANT FROM INJECTION SITE VASCULAR: ACUTE ARTERIAL OCCLUSION | Lancet. Vol. 2, Pg. 571, 1943. |
human | TDLo | rectal | 45mg/kg (45mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Anesthesia and Analgesia Vol. 46, Pg. 395, 1967. |
mouse | LD50 | intraperitoneal | 115mg/kg (115mg/kg) | Drugs in Japan Vol. 6, Pg. 457, 1982. | |
mouse | LD50 | intravenous | 57mg/kg (57mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 105, Pg. 221, 1956. | |
mouse | LD50 | oral | 208mg/kg (208mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC | Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 432, 1955. |
mouse | LD50 | subcutaneous | 225mg/kg (225mg/kg) | Toxicology and Applied Pharmacology. Vol. 27, Pg. 70, 1974. | |
rabbit | LD50 | intraperitoneal | 35mg/kg (35mg/kg) | Drugs in Japan Vol. 6, Pg. 457, 1982. | |
rabbit | LD50 | intravenous | 31mg/kg (31mg/kg) | Current Researches in Anesthesia and Analgesia. Vol. 29, Pg. 89, 1950. | |
rat | LD50 | intraperitoneal | 28410ug/kg (28.41mg/kg) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 29, Pg. 509, 1940. | |
rat | LD50 | intravenous | 43600ug/kg (43.6mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC | Journal of Pharmacology and Experimental Therapeutics. Vol. 116, Pg. 317, 1956. |
rat | LD50 | oral | 117mg/kg (117mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC | Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 432, 1955. |
rat | LD50 | rectal | 102mg/kg (102mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: GENERAL ANESTHETIC | Anesthesia and Analgesia Vol. 46, Pg. 395, 1967. |
women | TDLo | rectal | 107mg/kg (107mg/kg) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BRAIN AND COVERINGS: "CHANGES IN CIRCULATION (HEMORRHAGE, THROMBOSIS, ETC.)" | Clinical Toxicology. Vol. 2, Pg. 75, 1969. |
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