Thiostrepton supplier | CasNO.1393-48-2

Name
THIOSTREPTON
EINECS 215-734-9
CAS No. 1393-48-2
Density 1.64 g/cm³
Solubility 0.24g/L(28 oC)
Melting Point 248-257°C (dec.)
Formula C72H85 N19 O18 S5
Boiling Point °Cat760mmHg
Molecular Weight 1665.06
Flash Point °C
Transport Information
Appearance
Safety Poison by intravenous route. Moderately toxic by intraperitoneal and intramuscular routes. When heated to decomposition it emits toxic fumes of SO_x and NO_x.
Risk Codes 22
Molecular Structure
Hazard Symbols Xn
Synonyms Alaninamide,L-threonyl-(4S)-2-[(1Z)-1-amino-1-propenyl]-4,5-dihydro-4-thiazolecarbonyl-2-[(1S,2S,3R)-1-amino-2,3-dihydroxy-2-methylbutyl]-4-thiazolecarbonyl-2-[(5R,6S)-6-[2-[(1S,2R)-1-amino-2-hydroxypropyl]-4-thiazolyl]-5-[[N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl]amino]-5-(4-carboxy-2-thiazolyl)-3,4,5,6-tetrahydro-2-pyridinyl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-,(1'®4)-lactone, (4®1)-lactam (9CI); Thiostrepton(7CI,8CI); Bryamycin; Gargon; NSC 170365; NSC 81722; Thiactin; Thiostrepton A
PSA 701.00000
LogP 4.08640

Thiostrepton Chemical Properties

Product Name: Thiostrepton
The MF of Thiostrepton (CAS NO.1393-48-2) is C₇₂H₈₅N₁₉O₁₈S₅.

The MW of Thiostrepton (CAS NO.1393-48-2) is 1664.8868.
Synonyms of Thiostrepton (CAS NO.1393-48-2): Antibiotic 6761-31 ; Antibiotic X 146
Index of Refraction: 1.767
Density: 1.64 g/ml
Storage temp: -20 °C
Merck: 13,9440

Thiostrepton History

Thiostrepton was discovered by Donovick et al. who described its antibacterial properties in 1955.Dorothy Crowfoot Hodgkin solved the structure of thiostrepton in 1970.A total synthesis of Thiostrepton was completed by K.C. Nicolaou, et al. in 1995.

Thiostrepton Uses

Thiostrepton (CAS NO.1393-48-2) has been used in veterinary medicine in mastitis caused by gram-negative organisms and in dermatologic disorders. It is mostly used in complex ointments containing neomycin, nystatin, Thiostrepton and topical steroids. It is also active against gram-positive bacteria. It is notable that ointments for human usage contain neomycin, nystatin, and topical steroids, but no Thiostrepton.Recently, Thiostrepton has been reported to exhibit activity against breast cancer cells through targeting the transcription factor forkhead box M1.Thiostrepton is used in molecular biology as a reagent for both positive and negative selection of genes involved in nucleotide metabolism.

Thiostrepton Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intramuscular	1gm/kg (1000mg/kg)	"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 397, 1980.
mouse	LD50	intraperitoneal	2gm/kg (2000mg/kg)	"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 396, 1980.
mouse	LD50	intravenous	41mg/kg (41mg/kg)	"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 396, 1980.
mouse	LD50	oral	> 1gm/kg (1000mg/kg)	Antibiotics and Chemotherapy Vol. 6, Pg. 63, 1956.

Thiostrepton Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal and intramuscular routes. When heated to decomposition it emits toxic fumes of SO_x and NO_x.Safety information of Thiostrepton (CAS NO.1393-48-2):
Safety Statements
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
WGK Germany 3
RTECS XN6300100
F 10-21

Thiostrepton Specification

Thiostrepton is a natural cyclic oligopeptide antibiotic, derived from several strains of strepromycetes, such as Streptomyces azureus and Streptomyces laurentii.

Product Name

THIOSTREPTON