(S)-12-hydroxypentadecanoic acid 12-O-(6-O-(S)-2-methylbutyryl)-β-D-glucopyranosyl-(1->3)-O-[4-O-tigloyl-α-L-rhamnopyranosyl-(1->4)]-O-[2-O-(S)-2-methylbutyryl]-α-L-rhamnopyranosyl-(1->4)-O-α-L-rhamnopyranosyl-(1->2)-β-D-glucopyranoside
A
2-Methylbutanoic acid
B
Tiglic acid
C
(S)-12-hydroxypentadecanoic acid 12-O-β-D-glucopyranosyl-(1->3)-O-[α-L-rhamnopyranosyl-(1->4)]-O-α-L-rhamnopyranosyl-(1->4)-O-α-L-rhamnopyranosyl-(1->2)-β-D-glucopyranoside
Conditions | Yield |
---|---|
With potassium hydroxide at 85℃; for 4h; pH=4; | A 98% B 98% C 3 mg |
turpethoside acid B
A
2-Methylbutanoic acid
B
Tiglic acid
C
(S)-12-hydroxyhexadecanoic acid 12-O-β-D-glucopyranosyl-(1->3)-O-[α-L-rhamnopyranosyl-(1->4)]-O-α-L-rhamnopyranosyl-(1->4)-O-α-L-rhamnopyranosyl-(1->2)-β-D-glucopyranoside
Conditions | Yield |
---|---|
With potassium hydroxide at 85℃; for 4h; pH=4; | A 98% B 98% C 3 mg |
Conditions | Yield |
---|---|
With sodium hydroxide; cetyltrimethylammonim bromide; nickel cyanide In toluene at 95℃; under 735.5 Torr; for 6h; | 89% |
With calcium hydroxide; methyl iodide; dicobalt octacarbonyl In 1,4-dioxane; water at 20℃; under 760 Torr; for 20h; | 88 % Chromat. |
dicobalt octacarbonyl
(E)-2-bromobut-2-ene
Tiglic acid
Conditions | Yield |
---|---|
With calcium hydroxide; carbon monoxide; methyl iodide In 1,4-dioxane; water 20°C, 20 h.; | 88% |
dicobalt octacarbonyl
(Z)-2-Bromo-2-butene
Tiglic acid
Conditions | Yield |
---|---|
With calcium hydroxide; carbon monoxide; methyl iodide In 1,4-dioxane; water 20°C, 20 h.; | 87% |
Tiglic acid
Conditions | Yield |
---|---|
With water In diethyl ether for 1h; Ambient temperature; | 85% |
Conditions | Yield |
---|---|
With sodium hypochlorite solution; sodium hydroxide at 55 - 60℃; for 1h; Large scale; | 84.3% |
Conditions | Yield |
---|---|
With sulfuric acid at 140℃; | 76.5% |
Erhitzen; | |
With sulfuric acid at 115 - 130℃; im geschlossenen Rohr; |
2-chloro-2-methylbutyric acid
Tiglic acid
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol for 6h; Reflux; | 70% |
Conditions | Yield |
---|---|
With water at 230℃; for 3h; | 62% |
With sulfuric acid |
Conditions | Yield |
---|---|
With methanol; calcium borate anschliessend mit methanol. Natronlauge und Erhitzen des nach dem Ansaeuern mit wss. Salzsaeure erhaltenen Reaktionsprodukts in Gegenwart von Toluol-4-sulfonsaeure; | |
Multi-step reaction with 2 steps 1: sodium amalgam; diluted alcohol / man haelt die Reaktion mit verduennter Schwefelsaeure stets schwach saurer 2: Destillation View Scheme |
Conditions | Yield |
---|---|
bei Gegenwart von Spuren Brom;in dem direkten Sonnenlicht; |
A
Tiglic acid
B
1-methylcyclopropanecarboxylic acid ethyl ester
Conditions | Yield |
---|---|
at 140℃; |
Conditions | Yield |
---|---|
an der Luft; | |
Stage #1: 2-methylbut-2-enal With palladium(II) trifluoroacetate at 10℃; for 0.166667h; Stage #2: With dihydrogen peroxide In water at 10℃; chemoselective reaction; | 47 %Chromat. |
Conditions | Yield |
---|---|
With tetrahydrofuran; magnesium anschliessend mit Kohlendioxid; | |
With diethyl ether; lithium anschliessend mit Kohlendioxid; |
Conditions | Yield |
---|---|
Kochen; | |
at 300℃; im geschlossenen Rohr; | |
With sulfuric acid at 100℃; |
Conditions | Yield |
---|---|
With sulfuric acid |
The Tiglic acid, with the CAS registry number 80-59-1, is also known as trans-2,3-Dimethylacrylic acid. It belongs to the product categories of Aromatic Cinnamic Acids, Esters and Derivatives. Its EINECS number is 201-295-0. This chemical's molecular formula is C5H8O2 and molecular weight is 100.12. What's more, its systematic name is (2E)-2-Methyl-2-butenoic acid. Its classification code is Skin / Eye Irritant. This chemical should be sealed and stored in a cool place. It is used as demulsifying agent and pharmaceutical intermediates. This substance is a volatile and crystallizable substance with a sweet, warm spicy odour. It is used in making perfumes and flavoring agents. The salts and esters of tiglic acid are called tiglates.
Physical properties of Tiglic acid are: (1)ACD/LogP: 1.076; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.49; (4)ACD/LogD (pH 7.4): -1.27; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 23.70; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 37.3 Å2; (13)Index of Refraction: 1.451; (14)Molar Refractivity: 26.678 cm3; (15)Molar Volume: 99.111 cm3; (16)Polarizability: 10.576×10-24cm3; (17)Surface Tension: 32.29 dyne/cm; (18)Density: 1.01 g/cm3; (19)Flash Point: 95.95 °C; (20)Enthalpy of Vaporization: 47.913 kJ/mol; (21)Boiling Point: 198.499 °C at 760 mmHg; (22)Vapour Pressure: 0.15 mmHg at 25°C.
Preparation: this chemical can be prepared by 2-ethyl-acrylic acid at the temperature of 230 °C. This reaction will need reagent water with the reaction time of 3 hours. The yield is about 62%.
Uses of Tiglic acid: it can be used to produce (E)-2-methyl-but-2-enoic acid methyl ester by heating. It will need reagent conc. H2SO4 with the reaction time of 24 hours. The yield is about 70%.
When you are using this chemical, please be cautious about it as the following:
This chemical can cause burns. It is irritating to eyes, respiratory system and skin. You should take off immediately all contaminated clothing. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need to wear suitable protective clothing, gloves and eye/face protection and avoid contact with skin and eyes. In case of accident or if you feel unwell, you should seek medical advice immediately (show the label where possible).
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)/C(=C/C)C
(2)Std. InChI: InChI=1S/C5H8O2/c1-3-4(2)5(6)7/h3H,1-2H3,(H,6,7)/b4-3+
(3)Std. InChIKey: UIERETOOQGIECD-ONEGZZNKSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
rabbit | LD50 | skin | > 5gm/kg (5000mg/kg) | Food and Chemical Toxicology. Vol. 20, Pg. 837, 1982. | |
rat | LD50 | oral | > 5gm/kg (5000mg/kg) | Food and Chemical Toxicology. Vol. 20, Pg. 837, 1982. |
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