Trifluoperazine dihydrochloride supplier

Name
Trifluoperazine dihydrochloride
EINECS 207-123-0
CAS No. 440-17-5
Density
Solubility
Melting Point 243 °C (dec.)(lit.)
Formula C₂₁H₂₆Cl₂F₃N₃S
Boiling Point 506 °C at 760 mmHg
Molecular Weight 480.425
Flash Point 259.8 °C
Transport Information
Appearance Cream fine powder
Safety 36
Risk Codes 22
Molecular Structure
Hazard Symbols Xn
Synonyms 10H-Phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride(9CI);Phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride(6CI,8CI);2-Trifluoromethyl-10-[3-(1-methyl-4-piperazinyl)propyl]phenothiazinedihydrochloride;2-Trifluoromethyl-10-[3'-(1-methyl-4-piperazinyl)propyl]phenothiazinedihydrochloride;Eskazine;Eskazinyl;Fluoperazine;Jatroneural;Modalina;SKF5019;Stelazine;Terfluzine;Trazine;Trifluoperazine dihydrochloride;Trifluoperazine hydrochloride;Trifluoroperazine dihydrochloride;Trifluoroperazine hydrochloride;Triftazin;Triphthasine;Triphthazine;Triphthazine dihydrochloride;Tryptazine;Tryptazine dihydrochloride;
PSA 35.02000
LogP 6.49040

Trifluoperazine dihydrochloride Specification

The Trifluperazine dihydrochloride, with the CAS registry number 440-17-5, is also known as 2-Trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine dihydrochloride. It belongs to the product categories of Organics; Intermediates & Fine Chemicals; Pharmaceuticals. Its EINECS registry number is 207-123-0. This chemical's molecular formula is C₂₁H₂₆Cl₂F₃N₃S and molecular weight is 480.41745. Its IUPAC name is called 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine dihydrochloride. This chemical's classification codes are Antipsychotic; Drug / Therapeutic Agent; Human Data; Mutation Data; Reproductive Effect; Sedative-hypnotic. What's more, Trifluperazine dihydrochloride is used for the treatment with paranoid schizophrenia, chronic schizophrenia, mental anxiety, emotional disorders, nausea, vomiting, etc.

Physical properties of Trifluperazine dihydrochloride: (1)ACD/LogP: 5.108; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 2.66; (4)ACD/LogD (pH 7.4): 4.38; (5)ACD/BCF (pH 5.5): 16.13; (6)ACD/BCF (pH 7.4): 835.19; (7)ACD/KOC (pH 5.5): 51.43; (8)ACD/KOC (pH 7.4): 2663.08; (9)#H bond acceptors: 3; (10)#Freely Rotating Bonds: 4; (11)Flash Point: 259.8 °C; (12)Enthalpy of Vaporization: 77.58 kJ/mol; (13)Boiling Point: 506 °C at 760 mmHg; (14)Vapour Pressure: 2.32E-10 mmHg at 25°C

When you are using this chemical, please be cautious about it as the following:
This chemical may cause damage to health. It is harmful if swallowed. Whenever you will contact it, please wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl.Cl
(2)InChI: InChI=1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H
(3)InChIKey: BXDAOUXDMHXPDI-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	1143ug/kg/1D- (1.143mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	British Journal of Clinical Practice. Vol. 28, Pg. 201, 1974.
monkey	LDLo	oral	> 20mg/kg (20mg/kg)	BEHAVIORAL: REGIDITY BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 122, Pg. 129, 1959.
mouse	LD50	intraperitoneal	133mg/kg (133mg/kg)		Farmakologiya i Toksikologiya Vol. 41, Pg. 680, 1978.
mouse	LD50	intravenous	82mg/kg (82mg/kg)		Acta Pharmacologica et Toxicologica. Vol. 19, Pg. 87, 1962.
mouse	LD50	oral	424mg/kg (424mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 866, 1977.
rabbit	LD50	intravenous	65mg/kg (65mg/kg)		British Journal of Pharmacology and Chemotherapy. Vol. 25, Pg. 158, 1965.
rat	LD50	oral	543mg/kg (543mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 866, 1977.

Product Name

Trifluoperazine dihydrochloride

Trifluoperazine dihydrochloride Specification

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